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Organic CompoundsEnzymes and
Digestion
Carbonyl
Hydroxyl
Carboxyl
Amino
Phosphate
Methyl
Sulfhydryl
Hemoglobin JMOL
Monomers and Polymers
Cooperative Binding
Carbonic Anhydrase
• 104 to 106 reactions per second.
Hemoglobin JMOL
http://www.umass.edu/molvis/tutorials/hemoglobin/index.htm
Functions of Proteins
When in doubt…..proteins
Storage
Structural
Transport
Hormonal
Receptor
Contractile & Motor
Defensive
Enzymes
Restriction Enzyme
Enzymes
Enzyme Simulation
• How is the velocity of an enzyme reaction effected by:– pH– Temperature– Substrate Concentration
Initial Velocity (V0 or VI)
Initial Velocity (V0 or VI)
Vmax
Enzymatic Pathway
Starch
Glucose
Starch
Monomers vs. polymers
LACTASE: LCT (Single Mutation)
AMYLASE:AMY Gene (multiple copies)
Animal Digestion
Intracellular Digestion
Extracelluar Digestion
Gastric ulcer vs. no ulcer
2 types of enzymes: Lumen and Brush Boarder
Lipase
Atherosclerosis
Fats – inhibit Peristalsis and acid secretion
Amino acids/Fatty Acids – enzymes from pancreas and bile
Release of Sodium Bicarbonate