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Nanotechnology in Cancer Therapy
Antonio Di Martino
What is it Cancer?
Is one of the leading cause of death worldwide
Is represented by an uncontrolled cells growth
Involve many physiological pathways
Which are current cancer therapies?
Surgery Radiotherapy Chemotherapy
High efficiencyLow selectivityLow therapeutic Index
Nanotechnology in Cancer Therapy
Nanotechnology = manipulation of matter on atomic, molecular and supramolecular scale
Nanomedicine = application of nanotechnology in therapeutic and diagnostic
Drug Delivery System
Nanoparticles
Nanoliposomes Polymerics NanoshellsQuantum Dots
Metallic nanoparticles
More flexible Size Shape Structure Composition Encapsulation
Golden Nanoparticles (AuNPs)
Great chance in cancer therapy
Tunable properties
Easy to prepare
Surface modification
High encapsulation efficiency
Application of Nanotechnology in Drug Delivery
AuNPs in Cancer Therapy : Applications
Photothermal therapy
Radiotherapy
Angiogenesis Inhibition
Optical propertiesAbsorption in NUV and NIR
High accumulation Index
Chemical modification of protein involved
Conclusions Cancer is a complex disease
Different molecular pathway are involved
Nanomedicine represents a new concept of therapy
Reduction of side effects
High specificity
Improve the quality of life
Still lack of knowledge about toxicity over time
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