E health 2020 oog. Oog Melanoom "Data rentmeester"

Oog Melanoom“Data rentmeester”

eHealth 2017 27-1-2017

Bert Eussen

Oog Melanoom• ~140 patienten per jaar lft 50-70j

• Diagnose: routine onderzoek, slecht zicht

• Behandeling:

– Verwijderen oog

– Bestraling

• Ondanks behandeling 50% metastase

zeer slecht prognose

• Research: Zoektocht naar prognostische markers.

http://www.erasmusmc.nl/47457/51016/227068/oogmelanoom

Data en monsters

• ErasmusMC EPD (Elpado)

• Arts onderzoekers – ( Pathologie verslag, Opzet nieuwe assay/analyse)

• Materiaal: Bloed ( in de tijd), tumor weefsel , gezond weefsel etc --- DNA /RNA

• Testen: Array, NGS, Chromosoom, FISH, QPCR, SSEQ, IHC

Research support tool ! (mini LIMS Filemaker )

n= 900 personen

n= 10.000 monsters

n= 371/24.000 Arrays

n= 263/6.000 NGS

Inheritance model Study (smallest entity)

Clinical data X Clinical data analysis

Genesis X Front Office X Sample prep X Lab service ( Analysis 1) X Lab Staf X Counseling

Study PI ---------- Project - Sponsor Governor

DATA - Finance - Informed ConsentOOG Tumor E. KilicROMS Prof Vingerling

OOG Dashboard OOG research FM database

Data request

Data request: Assays Raw Assays Analysis Clinical data Reports ?

Data production

Arrays/NGS

Local Network

Author publication folder

Final

Optional: Analysis software, OS

Reference files

Managed Tape model

Track & Trace MyLTO service (web based)- TapeMyLTOservice Basic: data to tape + 2 copies+ index- Tape Storage, data migration, distribution, 5000 arrays or 200 wes/20WGS /LTO6 n=50

TAR- Copy - Checksums

LTO 5-6 6.25 Tb/2,5 Tb rawLTO 8 12 Tb/ 4 Tb raw ( 2017)

Tape Governance ( PI etc)Tape ID Tape type etc.

Index files Tape content

DOI publication_ID Link production/data tapes

Tape location / migration?……

pptArray

NGSClin

Index file

Production archive tapes

TAR - Copy- Checksums

Index file

Distribution: Research, Education, Healthcare ……. patient!! Governance KEYS!!

Publication archive tapes

Data production Publications

Acknowledgements:

PI(s) Emine Kilic Annelies de KleinGovernor(s) Prof VingerlingSponsor ROMSData rentmeester Bert EussenAnalisten & onderzoekers

Dashboard design Rianne Kosterman W Kooning HROBiomics NGSInt. medicine ArraysPathologieICT research Tape/index support

Carelliance Peter WalgemoedFortados Tape LTO storage service