CPC - Pathology discussant - Dr Seetha Lakshmi

IRACON 2016KOCHICPC

DR. SEETHALEKSHMY N.V. DEPT OF PATHOLOGY

AMRITA INSTITUTE OF MEDICAL SCIENCES.KOCHI

RENAL BIOPSY- SCANNER VIEW

H&E

H&E

H&E

PAS

TRICHROME

(MT)

H&E

PAS

JONES SILVER

TRICHROME (MT)

CONGO RED STAIN

CONGORED-POLARISATIO

N

CONGO RED-UV

FLUORESCENCE

IMMUNOFLUORESCENCE

• IMMUNOFLUORESCENCE STUDY NEGATIVE FOR• Ig G• Ig A • Ig M • C 3• C 1q • Both Kappa and Lambda LIGHT CHAINS

IMMUNOHISTOCHEMISTRY

• AA AMYLOID IMMUNOHISTOCHEMICAL STAIN IS POSITIVE OVER THE GLOMERULAR MESANGIUM AND AFEW BLOOD VESSELS

DIAGNOSIS

RENAL BIOPSY: SECONDARY AMYLOIDOSIS KIDNEY(SAA POSITIVE)IN A BACKGROUND OF URATE NEPHROPATHY WITH MEDULLARY TUBULOINTERSTITIAL MICROTOPHI ,MILD GLOBAL GLOMERULO SCLEROSIS AND CHRONIC TUBULOINTERSTITIAL NEPHRITIS.

CLINICAL CORRELATION……

ARTHRITIS AND RHEUMATISM, VOL. 24, NO. 11 (NOVEMBER 1981)

THE JAPANESE JOURNAL OF NEPHROLOGYVOL. 27 (1985) NO. 8 P 1201-1207

CÉCILE, CAZORLA ET AL AA AMYLOIDOSIS IN NEW CALEDONIA: AN UPDATE ,PATHOLOGY , VOLUME 46 , S97,2014

THANK YOU