CB3 Facilities and Agenda

Dennis L. Molfese, Ph.D.Mildred Francis Thompson Professor

Director: Center for Brain, Biology & BehaviorDirector: Big Ten/CIC Traumatic Brain Injury Research Consortium

Editor-In-Chief: Developmental NeuropsychologyDirector: Developmental Neuroscience Lab

University of Nebraska -Lincoln

Interdisciplinary Research Center

Center for Brain, Biology, & Behavior

Acknowledgements

–Cathryn Cortesa, BA

–Nicole Earnest

–Caitlin Hudac, MA

–Kathleen Kelsey, MA

–Srinivas Kota, Ph.D.

–Christopher Rudasill, MFA

–Nathan Petro, B.A.

–Victoria Molfese, Ph.D.

Philosophy of The Center

• Foster Interdisciplinary Collaborations. • Provide Assess to BOTH Equipment & Training.• Lead Paradigm Shift Within The Neurosciences:

–- Move from “neural phrenology” to Understanding Brain’s Neural Spatial & Temporal Interconnectivty.–- Address Characteristics of Processing In and Between Brain Regions.

New Stadium Additions

Center for Brain, Biology, & Behavior Health & Performance

Research Lab

Athletics/Academics Collaboration: An Unprecedented Initiative

• Informs:

–Medical & Behavioral Science

–Athletic & Academic Training & Competition

–Safety

–Innovations

• Consortium of 13 University Research & Sport Programs with BIG 10 CIC + 8 Ivy League Schools

• Coaches

• Trainers

• Behavior & Brain Imaging Researchers

• Shared data base for images, behavior data, test procedures & programs

• Increasing external grant funding.

BIG 10 - Ivy League Concussion Research Collaboration

Unprecedented New Information

• Screen Athletes Before Season (baseline)

• Track Performance, Neurocognition & Brain Measures

•Head Injured & Matched Controls

•Assess Impact of Multiple Concussion

•Shared Database Across Conferences

• Design Interventions

• Improve Equipment Design

• Develop Concussion Awareness Programs

Facilities

1st Floor

2nd FloorReception

2nd Floor

Internal Stairway Connecting 2nd and 3rd Floors

3rd Floor

Science Work Group Areas for 2nd and 3rd Floors

Training Plan

Model for Training in Brain Imaging Techniques

1. Workshop Introduction to Theory, Methods, Literature, Analyses (2-days)

2. Consult on research design3. Hands-on training with equipment for

setup, data collection, data processing & analysis.4. Assistance with:

a. Data analysesb. Conference presentationsc. Journal article drafts

5. Grant submissionsGOAL: Establish Dominance in Mainstream Research Areas Through Research & Grant Activities.

CB3 Training To DateOctober 1, 2010 - August, 2012

• 8 Two-Day Workshop: 227 Faculty & Students

• Advanced Imaging Training: 69 Faculty & Students

• Current Research Studies: 12 Projects

• Department Presentations: 38

Current Trainees = 2608-22-2012

Available TechnologiesfMRI

High Density Infant & Adult NIRSHigh-Density EEG/ERP

Transcranial Magnetic Stimulation -TMSBehavior Science Labs

Balance LabsComputer Labs

Developmental LabsEndocrine Lab

Eye Tracking LabsGenetics Lab

Political Science Lab

fMRI - functional Magnetic Resonance Imaging

Siemens 3 Tesla70 cm bore

Structure

Function

DTI

fMRI - functional Magnetic Resonance Imaging

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Diffusion Tensor Imaging

Magnetic Resonance Spectroscopy

fMRI Imaging

Attachment

Dyslexia

Balance Lab

Gait Testing

Videonystagmography (VNG)

Rotational Chair

Subjective Visual Vertical

Functional Evaluation of Vestibulo-Ocular Reflex (VOR)

Balance Function Testing

NIRS - Near-Infrared Spectroscopy

TMS - Transcranial Magnetic Stimulation Machine

High-Density ERP/EEG

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Event-Related Potentials (ERP)

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Newborn Infant Adult

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Front of Head

Left Side Right Side

Back of Head

NEWBORN

+

-

Front of Head

Left Side Right Side

Back of Head

Adult

+

-

Learning alters brain organization for acquisition of new information

Shape Matching Task

Different

Same

Molfese et al, 2008

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Low GRTR[GRTR less than 11]

High GRTR[GRTR more than 11]

Eye Tracker

Eye Tracker + ERP net Eye Tracking Information

Intervention

Ability to discriminate /da/ from /ga/

ERPs in 2 to 4-Year-Old Preschool SLI Children Predict Subsequent Language Gains Following 4 Month Intervention

Yoder, Molfese & Camarata, In Press

Training Task Results

Training TaskTraining Task

Additional Benefits

Concussion Intervention

Concussion

Issues in Assessing Sports Concussion• 1. Little information on brain & behavior prior to

concussion.

• 2. Little long-term follow-up following concussion using standardized testing.

• 3. Tests not comprehensive (e.g., ImPACT not effective in measuring attention, working memory).

• 4. Little information available regarding prior head injuries.

• 5. Falsification of pre-season tests by athletes.

• 6. Pressure to resume play following possible head injury.

• 7. No research-based information regarding when players can be safely returned to play.

Brain Deformation Following Side “Hit”

Pellman et al., 2006

Top View

Side View <__Directionof

Force

<__Directio

nof

Force

Brain Deformation Following Side “Hit”

Pellman et al., 2006

Top View

Side View <__Directionof

Force

<__Directio

nof

Force

Force canproduceshearing

Vestibular Tests May Help to Identify and Manage Concussion

Julie Honaker, Ph.D.

Working Memory: 2-back

N400N400

N2N2

Match Nonmatch

Match Nonmatch

Sports Concussion

Self-reported symptoms & N2

N2N2

Mat

chN

onm

atch

2.5 nA

.01 nA

No history of persistent headache (n=16)

History of persistent headache (n=19)

Normal Visual World

World at an Angle

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20-40% with TBI experience vision-disorders

Hudac et al, 2011

Post-Trauma Vision SyndromeVisual Midline Shift Syndrome

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Future Possibilities

• Use brain imaging procedures to identify distortions produced by brain injury.

• Identify intervention that can produce more normal neural processing.

• Use the successful intervention to enable individual to perceive and interact with the world in more normal fashion.

©2012 The Board of Regents of the University of Nebraska. All rights reserved.

Questions ???

fMRI - functional Magnetic Resonance Imaging

High-Density ERP/EEG: Newborn Infant

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Event-Related Potentials (ERP)

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High-Density ERP/EEG: Adult

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fMRI

DTI

Structure

Function

TracksBlood Flow inBrain

ERP

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Key et al., In press