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Cerebellar connections
Citation preview
11/04/23
Interactive cerebellar circuits
Dr Sanjoy Sanyal
MBBS, MS, MSc, ADPHA, ADHRD
Overview of cerebellar circuits• Inputs to cerebellum
• Intracerebellar circuits
• Outputs from cerebellum
• 9-click summary of cerebellar circuits
• Guide to abbreviationsIn order to make the study of cerebellum easy it has been divided into three sections, followed by a summary slide at the end. In order to make it interesting, it has been rendered as interactive as possible.
Click on any link above to go to the appropriate slide. Click on the appropriate links in individual slides (if any) to go to further slides. Click on back button at bottom right of any slide to come back to menu / sub-menu slide. The 2nd last slide summarizes the entire cerebellar circuitry in 9 clicks. Guide to abbreviations is in last slide
Inputs to cerebellum
Spinalcord
Vestibularsystem
Cerebralcortex
CBLM
Corticopontocerebellar
Cerebro-olivocerebellar
Cerebroreticulocerebellar
Dorsal spinocerebellar
Ventral spinocerebellar
Cuneocerebellar
Primary vestibular fibers
Vestibulocerebellar
Inputs to cerebellum
CBLMPons
Cerebralcortex
CORTICO-PONTO-CEREBELLAR TRACT
Inputs to cerebellum
CBLMInferior olivary
nucleus
Cerebralcortex
CEREBRO-OLIVO-CEREBELLAR TRACT
Only Climbing fibers; all others are Mossy fibers
Inputs to cerebellum
CBLM
Reticular(Pons)
Cerebralcortex
CEREBRO-RETICULO-CEREBELLAR TRACT
Inputs to cerebellum
CBLM
Reticular(Medulla)
Cerebralcortex
CEREBRO-RETICULO-CEREBELLAR TRACT
Inputs to cerebellum
CBLM
ICP
Spinal cord
DORSAL SPINO-CEREBELLAR TRACT
Uncrossed tract
Inputs to cerebellum
CBLM
SCP
Spinalcord
VENTRAL SPINO-CEREBELLAR TRACT
Crossed tract
Inputs to cerebellum
CBLM
Cuneatenucleus
(Medulla)
Spinalcord
CUNEO-CEREBELLAR TRACT
Uncrossed tract
Inputs to cerebellum
CBLM(FN lobe)
ICP
PrimaryVestibular
fibers
Inputs to cerebellum
CBLM
ICP
Vestibularnucleus
VESTIBULO-CEREBELLAR TRACT
Intracerebellar circuitsAll inputs
Mossy fibersClimbing fibers
Purkinje cell
Granular cell
Purkinje cell
Deep nucleiDeep nuclei
Specific direct
excitation
General indirect
excitation
Intracerebellar circuitsPurkinje cells from Deep nuclei in medulla
and outside
Vermis Fastigial nucleus
Intermediate hemisphere
Interposed nuclei
Lateral hemisphere Dentate nucleus
Flocculonodular lobe Lateral vestibular nucleus
Left click once outside to see all circuits, or click on any link above to see that circuit
Intracerebellar circuits
Lat vestibnucleus
Dentatenucleus
Interposednucleus
Fastigialnucleus
Purkinjecells
From Vermis
From intermediate hemisphere
From lateral hemisphere
From FN lobe
Left click once to see an individual circuit
Intracerebellar circuitsFastigialnucleus
Purkinjecells
From Vermis
Left click once to see next circuit
Intracerebellar circuits
Interposednucleus
Purkinjecells
From intermediate hemisphere
Left click once to see next circuit
Intracerebellar circuits
Dentatenucleus
Purkinjecells
From lateral hemisphere
Left click once to see next circuit
Intracerebellar circuits
Lateralvestibularnucleus
Purkinjecells
From FN lobe
Outputs from cerebellumDeep nuclei in cerebellar medulla
Nuclei outside cerebellum
Fastigial nucleus Lateral vestibular nucleus in brainstem
Fastigial nucleus Reticular formation in brainstem
Interposed nuclei (Globose, Emboliform)
Red nucleus in midbrain
Dentate nucleus VL nucleus in thalamus
Left click once outside to see all outputs, or click on any link above to see that output
Outputs from cerebellum
Motorcortex
Spinalcord
Spinal cord
Spinal cord
FastigialInterposed
Dentate
Vestib nRetic nRed n
Thalamus
Vestibulospinal
tract (uncrossed)
Reticulospinal
tract (uncrossed)
Rubrospinal tract
(double-crossed)
Thalamocortical tract
(double-crossed)
Fastigial-vestibular Fastigial-reticular
Interposed-rubral Dentato-thalamic
Left click once to see an individual output
Outputs from cerebellum
Spinal cord
Fastigialnucleus
Vestibularnuclei
ICP
Vestibulospinal
tract (uncrossed)
Left click once to see next output
Outputs from cerebellum
Spinal cord
Fastigialnucleus
Reticularformation
ICP
Reticulospinal
tract (uncrossed)
Left click once to see next output
Outputs from cerebellum
Spinalcord
Interposednuclei
Rednucleus
SCP decussation
Rubrospinal tract
(double-crossed)
Left click once to see next output
Outputs from cerebellum
Cerebralcortex(motor)
Dentatenucleus
Thalamus VL
nucleus
SCP decussationThalamocortical tract
(double-crossed)
Spinal cord
Cerebral cortex
Primary vestibular fibers
Vermis
Intermediate hemisphere
Lateral hemisphere
FN lobe
Fastigial nucleus
Interposed (Globose, Emboliform)
Dentate nucleus
Lat vestibular nucleus
Vestibular nucleus
Brainstem reticular formation
Red nucleus
VL nu thalamus
Pontine nuclei
Inf oliv n (medulla)
Br st ret formation
F-V (ICP)
F-R (ICP)
Vest spinal tract (Uncrossed)
Ret spinal (Uncrossed)
G-E Rubral (SCP decussation)
Rubro spinal (Crossed)
Dorsal SCB (ICP) Ventral SCB (SCP)
Cuneo CB (ICP)
CPC (MCP)
COC (ICP)
CRC (ICP, MCP)
Dentato-thalamic (SCP decussation)
Thalamo-cortical (Internal capsule, Corona radiata)
ICP ICP
ICP
Corticospinal (decussation)
8th cranial nerve
Click once and wait for one complete circuit animation before clicking for the next circuit. Click 9 times in total.
Abbreviations guideBr st ret: Brainstem Reticular
CB: Cerebellar
COC: Cerebro-Olivo-Cerebellar
CPC: Cortico-Ponto-Cerebellar
CRC: Cerebro-Reticulo-Cerebellar
FN: Flocculo-Nodular
FR: Fastigial-Reticular
FV: Fastigial-Vestibular
GE: Globose-Emboliform
ICP: Inferior Cerebellar Peduncle
Inf oliv n: Inferior Olivary Nucleus
Lat: Lateral
MCP: Middle Cerebellar Peduncle
Nu: Nucleus
SCB: Spinocerebellar
SCP: Superior Cerebellar Peduncle
VL: Ventral Lateral
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