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AnoverviewofMRIinbiomedicalresearch
Whatisbiomedicalresearch?
“Biomedical research is the broad area of science that involves the investigation of the biological process and the causes of disease through careful implementation, observation, laboratory work, analysis and testing”
Andgooglescholarsays….
Agenda
• OverviewofMRIsystem• Understandingofbiologicalprocess• Developmentalbiology
• Understandingthecauseofpathology
• Angiogenesisincancer
• WorkflowofanMRIprojectinbiomedicalresearch
Gradientcoils
Subject
Radiofrequency
coil
Magnet
OverviewofaMRIsystem
Imagecourtesy:MRIscannercutaway:Colinmcnulty.com
y
x
z
Larmor Equation
MagneJsm:EffectoftheB0,G.randB1fields
OverviewofaMRIsystem
Imagecourtesy:MRIscannercutaway:Colinmcnulty.com
Contrastagents&nanotubes
Developmentalbiology
Drugdelivery
Clinicaltrials
Strokeimaging
DiagnosJcs&prognosJcs
Angiography
DWI
Perfusion
Behaviour
Cancerimaging SWI
Biomaterials
DynamicsPK
TBI
DCE-MRI
Neuropathology
PrevenJvehealthcare
MIRC 7
hYp://embryo.soad.umich.edu/.
Developmentalbiology–growthofthefetus
SmithaR.S.,et.al.,ISMRM2014Imagescourtesy:Dr.SonaPungavkar,NanavaJMumbai
Pathologymanagement
C(t)=f(ΔR1(t))
T1–weightedimagesforbaseline
T1shorteningcontrastagent
[10]YankeelovTE,et.alMRI;23(4).2005*ModelimplementedbyDr.VikramKodibagkarinMATLAB
[10]
Tissueperfusion,microvasculardensityandextravascular-extracellularvolume--tumorstaging,monitortreatmentresponse
Imagingcancer–dynamiccontrastenhancedMRI
Startsatframe6(post-contrast)
CS
CS_Gauss
CS_Glines
CS_Thresh
DCEinacJon
T2w Overlay
T1wpre-contrast
T1wpost-contrast
0 10 20 30 40 50 600.150
0.175
0.200
0.225
0.250
RO
I Int
ensi
ty
Frame #
Original Keyhole Keylines Keythresh Gauss Glines Gthresh
Muscle
0 10 20 30 40 50 60
0.175
0.200
0.225
0.250
RO
I Int
ensi
ty
Frame #
Original Keyhole Keylines Keythresh Gauss Glines Gthresh
Poorlyperfusedregion
0 10 20 30 40 50 600.15
0.20
0.25
0.30
0.35
0.40
RO
I Int
ensi
ty
Frame #
Original Keyhole Keylines Keythresh Gauss Glines Gthresh
Wellperfusedregion
Imagingcancer–regionwiseanalysis
WorkflowofanMRproject
Biomedicalengg.quesJon
Hardware–RFcoils
Pulsesequencedesign–RFpulses,
trajectories
ReconstrucJon–undersampleddata
QuanJtaJon–MRparameterizaJon
MulJ-stagevalidaJon
PARTII
PARTIII
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