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Abstracts / Can J Diabetes 36 (2012) S24eS76 S69

overweight and obese children were more likely to say their bodysize was too big compared to normal weight children (OR¼7.7 and30.6, respectively). Overweight and obese children were also morelikely than normal weight children to respond “no” to ‘Do you likethe way you look now?’ (OR¼2.4 and 7.8, respectively). BMI z-scorewas associated with lower scores for global self-concept (b¼-1.3),intellectual and school status (b¼-1.5), and physical appearanceand attributes (b¼-1.3). The poor self-concept and body sizedissatisfaction of Cree children with excess weight may lead todisordered eating or psychological outcomes such as depression.The psychosocial implications of obesity in First Nations childrenmay be as important as chronic disease considerations.

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Early Overnutrition Impairs Arginine Responsivity in Diabetes-Susceptible Swiss Webster MiceMARIA M. GLAVAS*, JESSICA K. FOX, XIAOKE HU, JAMES D. JOHNSON,TIMOTHY J. KIEFFERVancouver, BC

Childhood obesity and rapid early growth increase the risk fortype 2 diabetes. Such early overnutrition can be modelled in miceby reducing litter size, which results in rapid weight gain, hyper-insulinemia and hyperleptinemia in early life. We have previouslydemonstrated that such chronic postnatal overnutrition (CPO) inSwiss Webster mice significantly increases susceptibility to dia-betes, characterized by profound hyperglycemia and subsequentbeta-cell failure. In the present studies we examined whether CPOmice exhibit altered responsivity to glucose and/or arginine inisolated islets prior to the onset of hyperglycemia.

Litters from Swiss Webster mice were culled to 3 (CPO) or 10(control, CTR) pups shortly after birth and maintained ona moderate fat (25 kcal%) diet. At 11 weeks of age islets were iso-lated from non-diabetic mice and perifused with 3 and 20 mmol/Lglucose followed by 15 mmol/L arginine, for measurement ofinsulin responsivity. Total pancreatic insulin content was measuredin a separate cohort by insulin ELISA.

Both CTR and CPO mice exhibited similar insulin secretion inresponse to 3 and 20mmol/L glucose. In contrast, whereas CTRmiceshowed a dramatic insulin response to arginine, CPO mice failed torespond. Total pancreatic insulin content did not differ between CTRand CPO mice. Thus, CPO mice exhibit impaired responsivity toarginine, but not glucose, in isolated islets. This impaired amino acidresponsivity prior to the development of diabetesmay contribute totheir increased susceptibility to diabetes.

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Sustainable Childhood Obesity Prevention Through CommunityEngagement (SCOPE): A Qualitative StudyBONNIE MCINTOSH*, AMELIA DALY, LOUISE MASSE,JOAN WHARF HIGGINS, PATTI-JEAN NAYLOR, SHAZHAN AMEDVancouver, BC; Victoria, BC

Rates of childhood obesity are on the rise and as a result, so are thenumber of children and youth with type 2 diabetes. SCOPE isa community-based participatory research (CBPR) project aimed atpreventingchildhoodobesitybysupportingcommunity-drivenaction.The objective of this studywas to describe community perspectives onSCOPE's first phase of implementation in two pilot cities in BritishColumbia (BC) e Prince George (PG) and Abbotsford (AB).

Qualitative methods were implemented to obtain perspectivesabout SCOPE from two groups: SCOPE community coordinators andcommunitystakeholders. Participantswererecruitedviaemail and/or

by telephone. Coordinators completed a telephone interview. Stake-holders completed a telephone interview and/or a questionnaire.

Of 17 participants, 2 were community coordinators and 15 werecommunity stakeholders. Coordinators and stakeholders similarlyinterpreted SCOPE as a childhood obesity prevention programfocused on community engagement that “raises awareness” aboutchildhood obesity and “engages all sectors of a community.”Overall,theprojectwasvaluedbyparticipants; particularly, related to its rolein facilitating partnerships, providing evidence-based resources,and contributing funding. Participants similarly described barriersto achieving healthy lifestyles including those related to the builtenvironment, and social, behavioural, and economic obstacles.Participants expressed positive perspectives regarding SCOPE'sCBPR approach and felt that the project is sustainable.

Study results indicate that SCOPE is a valued and successful CBPRproject that has had a positive impact on supporting childhoodobesity prevention at the community level. Further, it has a strongpotential to be sustainable and applicable to other BC cities.

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Process Evaluation of a BC Initiative: Sustainable ChildhoodObesity Prevention Through Community Engagement (SCOPE)AMELIA C. DALY*, BONNIE MCINTOSH, LOUISE MASSE,JOAN WHARF HIGGINS, PATTI-JEAN NAYLOR, SHAZHAN AMEDVancouver, BC; Victoria, BC

SCOPE focuses on the prevention of childhood obesity throughcommunity based participatory research (CBPR) and demonstratestheneed formore “up-stream” approaches. SCOPEwaspiloted in twocities in British Columbia (BC), Prince George (PG) and Abbotsford(AB). SCOPE's objective was to use an integrated communityapproach to develop aBCmodel of childhoodobesity prevention thatfocuses on multi-sectoral engagement and supports community-based, community-driven action facilitated by best evidence. Processevaluation of SCOPE included tracking community engagement (CE)activities and collecting data using surveys,website analytics, budgettracking, quarterly reports, meeting minutes, and qualitativereporting. The results yielded a total of 234 CE activities: 63% in AB,30% in PG, and 7% at the central SCOPE office. Most CE activitiesoccurred inperson (84%). SCOPE engagedmultiple sectors including:education (23%), media (7%), private business (9%), and non-governmental organizations (35%). Extensive CE activities in pilotcities led to the establishment of multi-sector, collaborative part-nerships, which subsequently led to sustainable community-ledaction that leveraged existing community strengths. For example, inAB, SCOPE partnered with the local health authority and today, allpublic health nurses administering 12-month immunizations teachyoung families about healthy behaviours using an evidence-basedhealth message. In PG, a leadership training program called ‘KidsHelpingKids’ resulted froma partnership between SCOPE, the City ofPG and Action School BC!. SCOPE, using a CBPR approach, has beeneffective in establishing multi-sector engagement and collaborativepartnerships that build on existing community strengths andresources to ensure a sustainable outcome.

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Effect of Modest Weight Loss on Long-term Health Outcomes inPatients Newly Diagnosed with Type 2 Diabetes Mellitus (T2DM)in CanadaPIERRE JOHANSEN, ANNA R. TESCHEMAKER, NICOLE C. BRAZIER*,CHERYL NESLUSAN, MICHAEL WILLISLund, Sweden; Raritan, NJ; Toronto, ON

Being overweight adversely affects health outcomes in patientswith T2DM, therefore, weight management is a cornerstone oftreatment. The objective of this study was to examine the impact ofmodest weight reduction on long-term health outcomes for