Untangling Alzheimer s Disease Hallmarks in Sensory ......Joerg Neddens1, Magdalena Temmel1,...

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Untangling Alzheimer´s Disease Hallmarks

in Sensory Systems of Rodent Models

´

β β

MATERIALS and METHODS

SUMMARY and CONCLUSION

BACKGROUND RESULTS

Joerg Neddens1, Magdalena Temmel1, Meritxell Aguilo Garcia1,2, Tina Loeffler1, Irati Aiestaran Zelaia1,

Vera Niederkofler1, Stefanie Flunkert1 and Birgit Hutter-Paier1

1QPS Austria GmbH, Parkring 12, 8074 Grambach, Austria2Institute of Molecular Biosciences, University of Graz, Graz, Austria

A BChAT GAD67

CTH

GFAP Iba1

ptau Thr231D

FE

ChATGAD67

TH DAPI

ChATGAD67

TH DAPI

A TMHT – 6 months

ChATGAD67

TH DAPI

ntg – 12 months TMHT – 12 months

ChATGAD67

TH DAPI

GFAPIba1

pTau (PH-6)DAPI

GFAPIba1

pTau (PH-6)DAPI

GFAPIba1

pTau (PH-6)DAPI

GFAPIba1

pTau (PH-6)DAPI

GCL

NFL

IPL

OPL

IPL

ntg – 6 months

TMHT – 6 months

ntg – 12 months TMHT – 12 months

ntg – 6 months

B

C D

A B

C D

RESULTS