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7/27/2019 UCSC Convegno_Milano_Oct_2013.pdf
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Overviewdieffe*dellallenamento
eccentricovs.concentrico
Mar%noFranchi
MRC-ARUKCentreofExcellenceforMusculoskeletalAgeingResearch
DivisionofClinicalandMetabolicPhysiology
SchoolofGraduateEntryMedicine
UniversityofNongham
7/27/2019 UCSC Convegno_Milano_Oct_2013.pdf
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Strengthtraining
FromNarici&Franchi,Scienza&Sport2012
7/27/2019 UCSC Convegno_Milano_Oct_2013.pdf
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MuscleCrossSec%onalArea(CSA)(Hypertrophy) Musclearchitecture Neuralcontrol MusclelengthandjointangleVelocity
Factorsinfluencingmusclestrength
7/27/2019 UCSC Convegno_Milano_Oct_2013.pdf
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Mechanismsofhypertrophy:satellitecells
FromBruusgaardetal.2009
7/27/2019 UCSC Convegno_Milano_Oct_2013.pdf
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anterior
lateral medial
Musclemorphologyandarchitecture
7/27/2019 UCSC Convegno_Milano_Oct_2013.pdf
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MaincomponentsofRET Completelydifferenttypesofcontrac%on Differentproduc%onofmuscleforce Differen%almuscleadapta%onsinresponsetotraining
EccentricandConcentriccontrac?ons
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Concentricvs.Eccentric
z
x Thin filament
Thick filament
Copyright Elsevier 2004
S2
A
S1
Actin
S1
B C
Copyright Elsevier 2004
Sarcomere
TitinActinMyosinZ line Z line
Copyright Elsevier 2004
Jonesetal.SkeletalMusclefrommoleculestomovement,2004
7/27/2019 UCSC Convegno_Milano_Oct_2013.pdf
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MVC,MRI&
Ultrasound
UnilateralECC
orCON
STUDYDESIGN
12healthyyoungmales(253y.o.)
2traininggroups:CONvs.ECC
Training:4seriesof8-10repsat80ofeitherCONorECC1RM,3%mesper
weekfor10weeks
Musclebiopsiescollectedat30mins
a_erasingleECCorCONtraining
session
7/27/2019 UCSC Convegno_Milano_Oct_2013.pdf
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CON ECC
Reeves,Maganaris,Longo&Narici.
2009,ExpPhysiol
7/27/2019 UCSC Convegno_Milano_Oct_2013.pdf
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VLfasciclebehaviourduringCONandECC
exercise
CONCENTRIC MOVEMENT ECCENTRIC MOVEMENT
Muscle Architecture during leg-press exercise
Lf (cm) PA (deg)
0.8
1.0
1.2
1.4
End/Starto
fcontraction(Normalised)
CONCENTRIC
ECCENTRIC
^^^ ^^^
***
***
*** *** P < 0.0001^^^ = significantlydifferent betweengroups P < 0.0001
Franchietal.2013,inrevision
7/27/2019 UCSC Convegno_Milano_Oct_2013.pdf
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RESULTSMorphological,funcKonalandarchitecturaladaptaKons
Franchietal.2013,inrevision
7/27/2019 UCSC Convegno_Milano_Oct_2013.pdf
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Hypertrophyofpennatemuscle
Addition ofsarcomeresin-parallelECC+, CON+++
Addition ofsarcomeresin-seriesECC+++, CON+
RusselBetal.J.Appl.Physiol.(2000)88:11271132
ECCENTRIC
CONCENTRIC
Distal Proximal
7/27/2019 UCSC Convegno_Milano_Oct_2013.pdf
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Kehat et al. Circ Res. 2011: 108: 176-183
7/27/2019 UCSC Convegno_Milano_Oct_2013.pdf
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p-p38 MAPKinase
Baseline 30 min0
2
4
615
20
25
30
Norm
alisedValues(AU) CONCENTRIC
ECCENTRIC
*** = P < 0.0001
***
p-ERK 1/2
Baseline 30 min0
2
4
6
NormalisedValues(AU) CONCENTRIC
ECCENTRIC
* = P < 0.05
*
p-p90RSK
Baseline 30 min
0
2
4
6
NormalisedValues(AU) CONCENTRIC
ECCENTRIC
** = P < 0.01
**
Franchietal.2013,inrevision
RESULTSMolecularresponsestoasingleCONvs.ECCtrainingsession
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ECC CON
VLVOLUME ++ ++
MVC ++ ++
Lf +++ +
PA + +++
p-p38 +++ x
p-ERK1/2 + x
p-p90RSK ++ x
SUMMARY
Franchietal.2013,inrevision
7/27/2019 UCSC Convegno_Milano_Oct_2013.pdf
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CONCLUSIONS
Dis%nctfasciclebehaviourduringECCandCONcontrac%on PureECCandCONtrainingproducedsimilargainsinmuscle
massandstrength
butthroughdis?nctlydifferentarchitecturaladapta?ons Differen%al acute molecular responses to ECC vs. CON
exercise(MAPKac%va%on)
Dis?nctarchitecturalandmolecularadapta?onsmaybelinked
asaresultofcontrac?on-specificresponsestoECCvs.CONRET
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Eccentric/ConcentricandSarcopenia Stretch-shorteningcycle(SCC,Plyometrics) Proteinturnoverinresponse(anabolicresponse)tospecifictraining
protocols(measuredbystableisotopetracingtechniques)
Whatsnext
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ProfMarcoNarici,UoN
ProfMFlck,UniversityofZurich
DrWKMitchell,UoN
DrMRBeltran-Valls,UniversityofRome,ForoItalico
DrASelby,UoN
Acknowledgements
DrPhilipAtherton,UoNProfNeilReeves,MMU
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Neuralcontrol
Fromomietal.2000
FromAagaardetal.2000
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