TUBALL NANOTUBES - nanocalibrate.eu · oecd 202 acute toxicity to daphnia magma no tox. in vivo...

OCSiAl S.à r.l.1 Rue de la Poudrerie, L-3364, Leudelange, Grand-Duché de Luxembourg

TUBALL™ NANOTUBESHEALTH, SAFETY & ENVIRONMENTAL STATUS

Workshop: Governance of emerging nano-risk in the semiconductor industry

26 April 2018

Diameter

1.6±4 nm

Length

±5µm

The structure of a SWCNT can beconceptualized by wrapping a one-atom-thick layer of graphene into a seamless cylinder

* Parameters are given for TUBALL™ SWCNT

DIMENSIONS OF TUBALL™ARE EXCEPTIONAL

3D NETWORK AT ULTRA-LOWCONCENTRATIONS

The same concentrationof particles (~0.1%) in the same volume

SWCNTDISPERSION IN MATRIX

METAL FILLERS CARBON FIBERS SWCNTTUBALL™

The performance space begins to expandUse less, do more, perform better

TUBALL™ EXCEPTIONAL PROPERTIES

TEM Imagesof dispersed TUBALL™:

water-basedsuspension

SWCNT MARKET

TUBALL™IS

COMMERCIALYVIABLE

€ 2000/KG

10 tonnes/year

2017

TUBALL™APPLICIATIONS:

Source: The Carbon Nanotubes, Graphene & 2D Materials Global Opportunity Report www.futuremarketsinc.com

ONE ADDITIVE FOR THOUSANDS OF MATERIALS

Based on the core technology

of SWCNT synthesis, OCSiAl has

developed a family of TUBALL™ –

based products for different

industries.

OCSiAlPRODUCTS

SALES 2017 BY REGIONS

MASS-PRODUCED SWCNT

st1

TUBALL™

POWDER SWCNT

HAZARDOUS VS NANOMATERIAL

Decision of the Board of Appeal, June 2017:• finds that being a nanomaterial is insufficient on its

own to justify it as a potential concern;• mentions that no consistent causal links have been

established between size and hazardousproperties, yet!

• notes that the definition of nanomaterials establishes a size threshold for substances to be defined as nanomaterials.

”Being a nanomaterial is insufficient on its own to

justify a potential concern”

MORPHOLOGY & FLEXIBILITY OF TUBALL™ (SWCNT) 1/2

A long rigid biopersistent who* fiber has to be considered carcinogenic

WHO dimension, length>5 µm, diameter < 3 µm, a L:D ratio larger than 3:1

Bio-persistence: the ability of a substance to remain in the lung →bio-persistent

MORPHOLOGY & FLEXIBILITY OF TUBALL™ (SWCNT) 1/2

• Currently not classifiable as carcinogenicity to humans

• TUBALL™ does not behave like asbestosfibers …. due to non-rigidity

• No indications for any carcinogenicrisks associated to our material today

TUBALL™ ARE NOT RIGID FIBERSRigid acts like asbestos high

carcinogenic potency

1 µm

FIBERS

MORPHOLOGY & FLEXIBILITY OF TUBALL™ (SWCNT) 2/2

TUBALL™

Recent IARC publication, 2017

Mainly about the inadequate evidencein experimental animals for thecarcinogenicity of SWCNTs

HS&E ASPECTS OF TUBALL™ (SWCNT)

19 NM‘s were screened on cytotoxicityDate of publication: August 2017

Main conclusions:• SWCNT is non-cytotoxic!• All CNTs do not induce potent inflammatory

responses!• SWCNT shows a lower toxicity in certain in-

vitro experiments (Cytotoxicity in THP cells)

HS&E ASPECTS OF TUBALL™ (SWCNT)

REGISTRATIONS AND COMPLIANCE

REACH(Registration, Evaluation, Authorizationand Restriction of Chemicals)

First and only SWCNT completed(29 September, 2016)

TUBALL™ is registered under the number 01-2120130006-75-0000

Allows to commercializeup to 10 t/y in Europe

EPA(Environmental Protection Agency)

EPA consented

PMN number P-17-0257

Allows to commercializeup to 25 t/y in USA

TUBALL™ nanotubes are registered to be widely used in a wide range of industries

REACH (EU) AND EPA (USA)

OCSiAl CARES ABOUT

THE HEALTH, SAFETY, AND

THE ENVIRONMENTAL

ASPECTS

TEST ITEMCIRCUM-STANCES

TEST TEST CONCLUSION

TUBALL™

H.A. PHYSICO CHEMICAL TESTING OK AVAILABLE RESULT

H.A. HAZARDOUS PHYSICO CHEMICAL TESTING OK AVAILABLE RESULT

OECD 420 ACUTE ORAL TOXICITY (FIXED DOSE PROCEDURE) N.P.

IN VITRO OECD 431 IN VITRO SKIN CORROSION: MATTEK EPIDERM NO SKIN CORROSION

IN VITRO OECD 439 DETERMINATION OF SKIN IRRITATION POTENTIAL USING THE EPISKIN TM NO SKIN IRRITATION

IN VITRO OECD 492 IN VITRO OCULAR EYE IRRITATION HUMAN EPIOCULAR TM EYE MODEL TEST EYE IRRITATION

OECD 471 REVERS MUTATION ASSAY “AMES TEST” USING SALMONELLA TYPHIMURIUM & ESCHIRICHA

NO MUTAGENIC

H.A. OCED 201 ALGAL GROWTH INHIBITION TEST NO TOX.

OECD 202 ACUTE TOXICITY TO DAPHNIA MAGMA NO TOX.

IN VIVO OECD 406 BUEHLER SENSITISING ASSESSMENT NO SKIN SENSITISING

OCSiAl CONDUCTED TESTS IN 2016

OCSiAl CONDUCTED TESTS IN 2017

TEST SUBSTANCE/

PRODUCTASSISTANCE OF TEST TEST CONCLUSION

POLYMER MATRICES CONTANED TUBALL™

VITO PRODUCT TEST — MECHANICAL ABRASION ON EP/HDPE/RUBBER (TYRE) NO EFFECT

VITO PRODUCT TEST — DRILL ON EP/HDPE NO EFFECT

VITO PRODUCT TEST — SPILL OF WATER-BASED SUSPENSION NO EFFECT

TUBALL™ OCSiAl - STATPEEL TUBALL™ HANDLING & PROCESS SIMULATIONS – 1ST SERIES NO EFFECT

Figure 2: Test set-up with Aerosol sampling tube

ONE OF THE MOST COMMON TESTS FOR SIMULATING THE ABRASIVE DAMAGE DURING THE SERVICE LIFE OF COMPONENTS,SO CALLED TABER TEST.

Figure 1: Taber abraser (schematic)

▪ Simulation of typical handling (sliding, walking, polishing, rolling)▪ Released nanoparticles detected and quantified▪ Test method from DIN68861-2:1981, ISO 5470-1:1999, ASTM D4060-95:2007▪ Taber abraser type Teledyne Taber model 5130 Other nanosafety product testings were also conducted like drilling of nanocomposites

NANOSAFETY PRODUCT TESTING: ABRASION TEST BY VITO BELGIUM

NANOSAFETY PRODUCT TESTING: ABRASION TEST RESULTS

TEM ANALYSIS SHOWED SOME MICRON SIZED PARTICLES, BUT NO PROTRUDING OR FREE STANDING SWCNT’S WERE FOUND

OCSiAl TESTPLANS FOR 2018TEST OVERVIEW 2018 ____________________(version 04/2018)

TEST SUBSTANCE/

PRODUCTASSISTANCE OF TEST TEST CONCLUSION

TUBALL™

BAuA TOXICITY STUDY BY INHALATION TO BE STARTED Q2/2018

BAuA DUSTINESS TESTING TUBALL™ SUBSTANCE TO BE STARTED Q2/2018

POLYMER MATRICES CONTAINED TUBALL™

OCSiAl - STATPEEL TUBALL™ HANDLING & PROCESS SIMULATIONS - 2nd SERIES NO EFFECT

OCSiAl - STATPEEL TUBALL™ CONTAINING PRODUCT HANDLING & PROCESS SIMULATIONS - 3rd SERIES ON GOING

VITO TUBALL™ CONTAINING PRODUCTS HANDLING & PROCESS SIMULATIONS - 4th SERIES TO BE STARTED Q2/2018

TUBALL™ - PAPER INERIS PRODUCT TEST - SLITTING PROCESS DURING PRODUCTION OF TUBALL™ PAPER TO BE STARTED Q4/2018

TUBALL™ NEED TO BE SLECTED 90 DAYS INHALATION TOXICITY IN VIVO STUDY - OECD 413 ON GOING

TUBALL™ NEED TO BE SLECTED DUSTINESS TESTING TUBALL™ SUBSTANCE (requested by EPA) ON GOING

POLYMER MATRICES CONTAINED TUBALL™

VITO LIFE CYCLE ASSESSMENT TO BE STARTED 2018

INERIS WEATHERING TESTING TO BE STARTED 2018

INERIS ECO-TOXICOLOGIC STUDY - ALGAE & DAPHNIA ON NEW/AGED EP/HDPE/RUBBER TO BE STARTED 2018-2019

INERIS INCENERATION ON EP/HDPE/RUBBER (TYRE) TO BE STARTED 2018

INERIS COMBUSTION ON EP/HDPE/RUBBER (TYRE) TO BE STARTED 2018

Case studies:exposure monitoring on different handling and processes

1. R&D - handling of Tuball executed2. R&D - handling of Tuball & Tuball containing products executed

MEASUREMENT OF EXPOSURE TO INHALEDNANOPARTICLES IN THE WORKPLACE

Conclusion: CNT release was observed during the field test sampling, however CNT amounts collected were well below the NIOSH REL of 1 μg/m3 8h TWA (< 5% NIOSH REL).

3. Handling and processing of Tuball containing products Still ongoing

Conclusion: NO CNT release was observed during this type of field test sampling!

OCSiAl’s CENTRAL HUB IN GRAND DUCHY OF LUXEMBOURG

250ton/yearcapacity

R&D CenterTOP level

150-200 new

30-50 at R&D center

working places:

Luxembourg

Differdange

PROJECT IN LUXEMBOURG

STAGE 3: 2×100 TONS/YEAR

2022 Q1STAGE 2:

2×100 TONS/YEAR2021 Q2

STAGE 1: 50 TONS/YEAR AND

R&D CENTER2020 Q1

PROJECT EXECUTION STAGES

DIFFERDANGE

LUXEMBOURG OCSiAl PRODUCTION

• COLLECTING DATA :

• SAFETY HANDLING & WASTE TREATMENT GUIDELINES

• SET-UP RISK MANAGEMENT

• RISK MANAGEMENT MEASURES

• STANDARD OPERATION PROCEDURES

• ISO 9001/14001 AND OHSAS CERTIFICATION

NANO@OCSiAl :LUX 250 PROJECT TARGETS

• exposure monitoring

• product testing & TUBALL™ handling simulations

• OCSiAl cares for people and environment, shows a pro-active attitude towards HS&E

• No cytotoxicity - No inflammation of (SW)CNT according a recent study ~ published Aug.‘17

• IARC SWCNT is not classifiable as carcinogenicity to humans ~ published Sept.‘16

• WHO criteria apply to TUBALL™? BUT WHO fibers show big differences NON RIGID

• REACH registration as the first for SWCNT ~ published Sept.‘16

• TUBALL™ EPA consented soon listed on the confidential TSCA inventory ~ planned beginning

‘19

• Professional users/consumers are not exposed of protruding nor free standing SWCNTs were found ~ published March 17

TAKE HOME MESSAGE

• A lot of mandatory studies involving tonnage band upgrade are planned to be compliant

• A lot of additional studies/testings are planned to ease the concerns of our customers

• OCSiAl is involved in many projects and different workgroups

• The board of appeal (ECHA) mentions no consistent causal links have been established between size and hazardous properties, yet! “Being a nanomaterial is insufficient on its own to justify a potential concern” ~ published Jun.’17

CONCLUSIONS ONLY VALID FOR TUBALL ™

TAKE HOME MESSAGE

H&S QUESTIONS OR PROBLEMS OR INTERESTS?

CONTACT ME:Gunther Van Kerckhove

HS&E Lead manager

+352 661 183 429Skype: gvksafety