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TNINTecnologie Non Invasive per le
Neuroscienze:Risonanza Magnetica
Federico Giovefederico.giove@roma1.infn.it
Mission
• To develop and exploit NMR approaches for the neurosciences• Visual system, Neuroenergetics• BOLD, MRS, multimodal approaches, neurocurrents• Structural (pathologies)
BOLD
… OR NEURONAL CURRENTS?
FUNCTIONAL CONNECTIVITY
MD Fox et al., PNAS 102:9673 (2005)
FUNCTIONAL CONNECTIVITY
GM atrophy
HS MCI AD
PCC
ADHS MCI
Hippocampus
Functional connectivity
HS MCI AD
L -Hippocampus
From PPC seed-region
NK Logothetis, Nature 453:869 (2008)
• To complement BOLD findings• 1H MRS drawbacks
– Limited temporal resolution– Low spatial resolution
• CREATE STATIONARY “DISENTAGLED” CONDITIONS
• Add other modalities
ASSESSING THE NEUROMETABOLIC COUPLING
VISUAL PERCEPTION
• V1 responds to invisible stimuli• Activation of V1 per se is insufficient for awareness
Viswanathan and Freeman, Nat Neurosci 10:1308 (2007)
Sig
nal
in
crea
se %
-0.5
0.0
0.5
1.0
1.5
2.0
2.5
3.0
BOLD@7.5Hz BOLD@30Hz
fMRI RESULTS
MRS RESULTS
MRS RESULTS
Marco CarnìAntonino M. CassaràMauro Di NuzzoMichela FratiniGirolamo Garreffa,Marta Moraschiand Bruno Maraviglia (Fermi Center)
Silvia Mangia (U Minnesota)Tommaso Gili (U Cardiff)Silvia Capuani, Giulia Di Pietro, Marco Palombo (U Sapienza)
EXTERNAL COLLABORATORSNEUROPHYSIOLOGY, NEUROSCIENCES:NK Logothetis, GE Hagberg, Y Murayama (MPI Tuebingen), Emiliano Macaluso (Santa Lucia IRCCS) , Richard G Wise, Silvia De Santis (U Cardiff)
CLINICAL RESEARCHM Bozzali, G Spalletta (Santa Lucia IRCCS)
MODELLING:S Vannucci (Columbia), I Simpson (U Penn) , A Carruthers (U Massachusetts),A De Martino, E Marinari (U Sapienza)
PAST COLLABORATORSM Bianciardi, S Peca, G Giulietti, M Rebuzzi, P Porcari, F Di Salle
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