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The Secrets of Zone Pasta, Pizza, and Pastries:
Secret Weapons in the War Against Diabetes
Diabetes:
The Dark Future of Medicine
Why Health Care Costs Will Be Increasing
Costs ($) = % Older than 65 x % Diabetic
Both are increasing worldwide
Diabetes Is The Wild Card
• Number of diabetics will increase by 200% in next 25 years
• Costs will increase by 300% in next 25 years
• Increases the risk of both CHD and Alzheimer’s by 2-4 times
Diabetes in the U.S.
86M are pre-diabetic– 25% of entire U.S. population
29M diabetics – 9% of entire U.S. population
26% of Americans over 65 are diabetic
The Problem is Epidemic
Zone Diet (1995)
40% low-glycemic load carbs
30% low-fat protein
30% monounsaturated fat, but low in omega-6 and saturated fats
1,200 to 1,500 calories per day
Joslin Diabetes Research Center (2007)
40% low glycemic load carbs
20-30% low-fat protein
30-40% monounsaturated fat
1,200 to 1,500 calories per day
The Secrets of Satiety:
Calorie Restriction Without Hunger or Fatigue
The Gut Is Your Second Brain
The Importance Of L-cells In The Ileum
Release satiety hormones in response to nutrients
Protein: PYY
Carbohydrate: GLP-1
PYY
Primary satiety hormone
Released if adequate levels of protein reach the L-cells in lower part of the gut
Low PYY Output May Be First Defect Leading to Diabetes
Low levels of PYY appear to earliest indicator of future development of obesity and type 2 diabetes
– Boey et al Neuropeptides 40: 317 (2006)– Viadort et al Int J Obesity 32:943 (2008)
GLP-1
Secreted from L-cells in response to carbohydrates
Increases insulin output in diabetics
Increases satiety in non-diabetics
Hunger Hormones
Insulin (blood)
Ghrelin (gut)
Endocannabinoids (brain)
NPY (brain)
AgRP (brain)
Satiety Hormones PYY (gut)
GLP-1 (gut)
Melacortin (brain)
Leptin (brain)
Insulin (brain)
How Do They Work?
Hunger NeuronsNPY/AgRP
PPY, GLP‐1 Ghrelin
Leptin Insulin
Melacortin
PVN
Satiety Neurons
Why Hormonal Balance Matters
If satiety > hunger: Calorie restriction is possible
If hunger > satiety: Calorie restriction is impossible
Why Weight Gain Is So Common After Weight Loss
One year after dietary weight loss– Ghrelin increases– PYY decreases– Hunger increases
– Sumithran et al NEJM 365:1597 (2011)
After Gastric Bypass Surgery– Ghrelin decreases– PYY increases– Hunger decreases
Why Diets Fail
Constant hunger and fatigue
Restrict your favorite foods
Too much thinking involved
Changing Diet Is Hard Must be more desirable than
current diet
Must be more convenient than current diet
Must induce satiety
Must increase energy
Can the Hormonal Benefits of Gastric Bypass Surgery Be
Achieved With Molecular Baking?
Molecular Baking
Patented technology to make unique food products to control hunger
Enhance the gut, blood, brain hormonal connections
Healthy “junk foods”
Stealth Nutrition
Understanding how gastric bypass surgery works to treat diabetes
Replication in food products that diabetics love to eat– Pizza– Pasta– Pastries
Zone Pasta Meals
Chinese Orzo Tofu Rice Bowl
Zone Pasta Meals
Shrimp Veggie Pasta American Casserole
Zone Pasta MealsAsparagus Tomato
PastaRoasted Vegetable
Fusilli
Zone Pizza
Home Made Pizzeria Made
Zone Breakfast
Zone Croissants Zone Croissants
Cooking Vegetables is Easy With Technology
Zone Pastries
Zone Pastries
Zone Pastries
Zone Mexico Prototype Is Already Operating
And There Is More
Does It Work?
Body Composition Changes
Parameter Active Placebo Significance
Weight -7.0 lbs. -5.9 lbs. p = 0.8
Lean body mass +3.1 lbs. -1.3 lbs. p < 0.05
Fat mass -10.1 lbs. -6.2 lbs. p < 0.05
Changes In Insulin Resistance
Parameter Active Placebo Significance
Insulin (uU/ml) -26% -4% p < 0.05
Insulin Resistance (HOMA)
-26% -1% p < 0.05
Powerful New Concept
The more Zone Pasta you eat, the more fat you lose
The more Zone Pasta you eat, the more lean body mass you gain
The more Zone Pasta you eat, the more your reduce insulin resistance
Benefits of Molecular Baked Foods Sustainable source of protein
Convenient and desireable
Excellent patient compliance
Reduces insulin resistance
Unlimited Number of Recipes Pasta-based meals
Rice-based meals
Pizza meals
Condiments to any meal– Desserts– Side dish
You Can’t Live On Molecular Baked Foods Alone
Super Zone Diet for Dummies
Add unlimited amounts of vegetables to any meal– 2 pound rule– T-Fal makes it easy
Take your fish oil and polyphenols
Molecular Baking Makes Reaching the Zone Easy
Why Reducing Insulin Resistance Is Important
Insulin Resistance
Obesity
Diabetes
Alzheimer’s
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