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Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
The Neuro-QoL R© Utility (NQU) ScoringSystem
Barry Dewitt, PhD
Carnegie Mellon University
June 5th, 2019
1 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
Financial support from Biogen
2 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
Key research personnel
Louis Matza (PI, Evidera)
Katie Stewart
Dennis Revicki
Janel Hanmer
David Cella
David Feeny
Deborah Miller
Glenn Phillips
3 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
Health-related quality of life (HRQL)
HRQL is multidimensional: physical functioning, cognitivefunctioning, depression, fatigue, dexterity...
Condition-specificGeneric
Figure: Wilson & Cleary (1995).
4 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
Health-related quality of life (HRQL)
HRQL is multidimensional: physical functioning, cognitivefunctioning, depression, fatigue, dexterity...
Condition-specificGeneric
Figure: Wilson & Cleary (1995).
4 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
Health-related quality of life (HRQL)
HRQL is multidimensional: physical functioning, cognitivefunctioning, depression, fatigue, dexterity...
Condition-specificGeneric
Figure: Wilson & Cleary (1995).
4 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
Utility-based HRQL
We will be focusing on utility-based HRQL measures.
Utility captures preferences for health (usually the public’spreferences).
Summarizes the value of a state of health by a singlenumber, allowing the comparison of all states of health.
Useful for many applications
Economic analyses (e.g., QALYs, cost-effectivenessanalysis)Population health
5 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
Utility-based HRQL
We will be focusing on utility-based HRQL measures.
Utility captures preferences for health (usually the public’spreferences).
Summarizes the value of a state of health by a singlenumber, allowing the comparison of all states of health.
Useful for many applications
Economic analyses (e.g., QALYs, cost-effectivenessanalysis)Population health
5 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
Utility-based HRQL
We will be focusing on utility-based HRQL measures.
Utility captures preferences for health (usually the public’spreferences).
Summarizes the value of a state of health by a singlenumber, allowing the comparison of all states of health.
Useful for many applications
Economic analyses (e.g., QALYs, cost-effectivenessanalysis)Population health
5 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
Utility-based HRQL
We will be focusing on utility-based HRQL measures.
Utility captures preferences for health (usually the public’spreferences).
Summarizes the value of a state of health by a singlenumber, allowing the comparison of all states of health.
Useful for many applications
Economic analyses (e.g., QALYs, cost-effectivenessanalysis)Population health
5 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
Utility-based HRQL
We will be focusing on utility-based HRQL measures.
Utility captures preferences for health (usually the public’spreferences).
Summarizes the value of a state of health by a singlenumber, allowing the comparison of all states of health.
Useful for many applications
Economic analyses (e.g., QALYs, cost-effectivenessanalysis)Population health
5 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
Utility-based HRQL
We will be focusing on utility-based HRQL measures.
Utility captures preferences for health (usually the public’spreferences).
Summarizes the value of a state of health by a singlenumber, allowing the comparison of all states of health.
Useful for many applications
Economic analyses (e.g., QALYs, cost-effectivenessanalysis)Population health
5 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
Summary of a utility-based HRQL measure
“Rarely get enough sleep”
Sleep wellSleep poorly 0
“Never in distressing pain”
No painWorst pain 0
-1.0 1.2
6 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
Summary of a utility-based HRQL measure
“Rarely get enough sleep”
Sleep wellSleep poorly 0
“Never in distressing pain”
No painWorst pain 0
-1.0 1.2
��1.0sleep, 1.2pain, cognition, physical functioning, . . .
�
7 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
Summary of a utility-based HRQL measure
“Rarely get enough sleep”
Sleep wellSleep poorly 0
“Never in distressing pain”
No painWorst pain 0
-1.0 1.2
��1.0sleep, 1.2pain, cognition, physical functioning, . . .
�
Worst utility Best utility (i.e., the value of full health)
10
8 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
Summary of a utility-based HRQL measure
“Rarely get enough sleep”
Sleep wellSleep poorly 0
“Never in distressing pain”
No painWorst pain 0
-1.0 1.2
��1.0sleep, 1.2pain, cognition, physical functioning, . . .
�
Worst utility Best utility (i.e., the value of full health)
10
9 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
Summary of a utility-based HRQL measure
“Rarely get enough sleep”
Sleep wellSleep poorly 0
“Never in distressing pain”
No painWorst pain 0
-1.0 1.2
��1.0sleep, 1.2pain, cognition, physical functioning, . . .
�
Worst utility Best utility (i.e., the value of full health)
10
10 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
Summary of a utility-based HRQL measure
“Rarely get enough sleep”
Sleep wellSleep poorly 0
“Never in distressing pain”
No painWorst pain 0
-1.0 1.2
��1.0sleep, 1.2pain, cognition, physical functioning, . . .
�
Worst utility Best utility (i.e., the value of full health)
10
11 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
Summary of a utility-based HRQL measure
“Rarely get enough sleep”
Sleep wellSleep poorly 0
“Never in distressing pain”
No painWorst pain 0
-1.0 1.2
��1.0sleep, 1.2pain, cognition, physical functioning, . . .
�
Worst utility Best utility (i.e., the value of full health)
10
12 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
NQU Overview
The Neuro-QoL R© Utility (NQU) Scoring System is autility-based HRQL measure that uses the Neuro-QoL todescribe states of health.
It allows studies to collect patient-reported outcomes datathrough the Neuro-QoL and automatically have the capabilityto perform preference-based analyses without extra datacollection.
Developed with a particular focus on multiple sclerosis.
13 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
NQU Overview
The Neuro-QoL R© Utility (NQU) Scoring System is autility-based HRQL measure that uses the Neuro-QoL todescribe states of health.
It allows studies to collect patient-reported outcomes datathrough the Neuro-QoL and automatically have the capabilityto perform preference-based analyses without extra datacollection.
Developed with a particular focus on multiple sclerosis.
13 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
NQU Overview
The Neuro-QoL R© Utility (NQU) Scoring System is autility-based HRQL measure that uses the Neuro-QoL todescribe states of health.
It allows studies to collect patient-reported outcomes datathrough the Neuro-QoL and automatically have the capabilityto perform preference-based analyses without extra datacollection.
Developed with a particular focus on multiple sclerosis.
13 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
NQU Overview, cont’d
Most utility-based HRQL measures describe health usingclassical test theory-based instruments. The NQU benefitsfrom the psychometric advances of the Neuro-QoL.
The PROMIS R©-Preference (PROPr) project produced a genericutility score for health states described by PROMIS domains.
The NQU project follows a similar methodology to PROPr.
14 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
NQU Overview, cont’d
Most utility-based HRQL measures describe health usingclassical test theory-based instruments. The NQU benefitsfrom the psychometric advances of the Neuro-QoL.
The PROMIS R©-Preference (PROPr) project produced a genericutility score for health states described by PROMIS domains.
The NQU project follows a similar methodology to PROPr.
14 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
NQU Overview, cont’d
Most utility-based HRQL measures describe health usingclassical test theory-based instruments. The NQU benefitsfrom the psychometric advances of the Neuro-QoL.
The PROMIS R©-Preference (PROPr) project produced a genericutility score for health states described by PROMIS domains.
The NQU project follows a similar methodology to PROPr.
14 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
NQU Overview, cont’d
Most utility-based HRQL measures describe health usingclassical test theory-based instruments. The NQU benefitsfrom the psychometric advances of the Neuro-QoL.
The PROMIS R©-Preference (PROPr) project produced a genericutility score for health states described by PROMIS domains.
The NQU project follows a similar methodology to PROPr.
14 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
NQU development: A bird’s-eye view
Neuro-QoL domain selection
Survey development, sample recruitment, and datacollection
Calculation of the scoring function
Validation
15 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
NQU development: A bird’s-eye view
Neuro-QoL domain selection
Survey development, sample recruitment, and datacollection
Calculation of the scoring function
Validation
15 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
NQU development: A bird’s-eye view
Neuro-QoL domain selection
Survey development, sample recruitment, and datacollection
Calculation of the scoring function
Validation
15 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
NQU development: A bird’s-eye view
Neuro-QoL domain selection
Survey development, sample recruitment, and datacollection
Calculation of the scoring function
Validation
15 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
NQU development: A bird’s-eye view
Neuro-QoL domain selection
Survey development, sample recruitment, and datacollection
Calculation of the scoring function
Validation
15 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
Neuro-QoL domain selection: Focus on MS
Six Neuro-QoL domains were selected:
depression (mood)
fatigue
ability to participate in social roles and activities (socialroles)
cognitive function (thinking)
upper extremity function (upper limbs)
lower extremity function (lower limbs)
16 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
Neuro-QoL domain selection: Focus on MS
Six Neuro-QoL domains were selected:
depression (mood)
fatigue
ability to participate in social roles and activities (socialroles)
cognitive function (thinking)
upper extremity function (upper limbs)
lower extremity function (lower limbs)
16 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
Neuro-QoL domain selection: Focus on MS
Six Neuro-QoL domains were selected:
depression (mood)
fatigue
ability to participate in social roles and activities (socialroles)
cognitive function (thinking)
upper extremity function (upper limbs)
lower extremity function (lower limbs)
16 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
Neuro-QoL domain selection: Focus on MS
Six Neuro-QoL domains were selected:
depression (mood)
fatigue
ability to participate in social roles and activities (socialroles)
cognitive function (thinking)
upper extremity function (upper limbs)
lower extremity function (lower limbs)
16 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
Neuro-QoL domain selection: Focus on MS
Six Neuro-QoL domains were selected:
depression (mood)
fatigue
ability to participate in social roles and activities (socialroles)
cognitive function (thinking)
upper extremity function (upper limbs)
lower extremity function (lower limbs)
16 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
Neuro-QoL domain selection: Focus on MS
Six Neuro-QoL domains were selected:
depression (mood)
fatigue
ability to participate in social roles and activities (socialroles)
cognitive function (thinking)
upper extremity function (upper limbs)
lower extremity function (lower limbs)
16 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
Neuro-QoL domain selection: Focus on MS
Six Neuro-QoL domains were selected:
depression (mood)
fatigue
ability to participate in social roles and activities (socialroles)
cognitive function (thinking)
upper extremity function (upper limbs)
lower extremity function (lower limbs)
16 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
Neuro-QoL domain selection: Focus on MS
Six Neuro-QoL domains were selected:
depression (mood)
fatigue
ability to participate in social roles and activities (socialroles)
cognitive function (thinking)
upper extremity function (upper limbs)
lower extremity function (lower limbs)
16 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
Survey development: Preference elicitation
17 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
Sample recruitment and data collection
In-person administration in the UK.
Two groups: general population (n = 203) and MSpatients (n = 62)
Survey included:
Preference elicitationsNeuro-QoLLegacy measures (EQ-5D, HUI)PDDS (for MS group)Clinical characteristicsDemographic characteristics
18 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
Sample recruitment and data collection
In-person administration in the UK.
Two groups: general population (n = 203) and MSpatients (n = 62)
Survey included:
Preference elicitationsNeuro-QoLLegacy measures (EQ-5D, HUI)PDDS (for MS group)Clinical characteristicsDemographic characteristics
18 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
Sample recruitment and data collection
In-person administration in the UK.
Two groups: general population (n = 203) and MSpatients (n = 62)
Survey included:
Preference elicitationsNeuro-QoLLegacy measures (EQ-5D, HUI)PDDS (for MS group)Clinical characteristicsDemographic characteristics
18 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
Sample recruitment and data collection
In-person administration in the UK.
Two groups: general population (n = 203) and MSpatients (n = 62)
Survey included:
Preference elicitationsNeuro-QoLLegacy measures (EQ-5D, HUI)PDDS (for MS group)Clinical characteristicsDemographic characteristics
18 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
Sample recruitment and data collection
In-person administration in the UK.
Two groups: general population (n = 203) and MSpatients (n = 62)
Survey included:
Preference elicitationsNeuro-QoLLegacy measures (EQ-5D, HUI)PDDS (for MS group)Clinical characteristicsDemographic characteristics
18 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
Sample recruitment and data collection
In-person administration in the UK.
Two groups: general population (n = 203) and MSpatients (n = 62)
Survey included:
Preference elicitationsNeuro-QoLLegacy measures (EQ-5D, HUI)PDDS (for MS group)Clinical characteristicsDemographic characteristics
18 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
Sample recruitment and data collection
In-person administration in the UK.
Two groups: general population (n = 203) and MSpatients (n = 62)
Survey included:
Preference elicitationsNeuro-QoLLegacy measures (EQ-5D, HUI)PDDS (for MS group)Clinical characteristicsDemographic characteristics
18 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
Sample recruitment and data collection
In-person administration in the UK.
Two groups: general population (n = 203) and MSpatients (n = 62)
Survey included:
Preference elicitationsNeuro-QoLLegacy measures (EQ-5D, HUI)PDDS (for MS group)Clinical characteristicsDemographic characteristics
18 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
Sample recruitment and data collection
In-person administration in the UK.
Two groups: general population (n = 203) and MSpatients (n = 62)
Survey included:
Preference elicitationsNeuro-QoLLegacy measures (EQ-5D, HUI)PDDS (for MS group)Clinical characteristicsDemographic characteristics
18 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
Sample recruitment and data collection
In-person administration in the UK.
Two groups: general population (n = 203) and MSpatients (n = 62)
Survey included:
Preference elicitationsNeuro-QoLLegacy measures (EQ-5D, HUI)PDDS (for MS group)Clinical characteristicsDemographic characteristics
18 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
Utility-based HRQL in practice
Health status: Describe health states as
Θ = (θmood , θfatigue , θsocial , θthinking , θupperlimb, θlowerlimb),
where θdomain is a score on one of the chosen Neuro-QoLdomains.
⇒ Attach a utility value u(Θ) to Θ, for every possible Θ.
19 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
Utility-based HRQL in practice
Health status: Describe health states as
Θ = (θmood , θfatigue , θsocial , θthinking , θupperlimb, θlowerlimb),
where θdomain is a score on one of the chosen Neuro-QoLdomains.
⇒ Attach a utility value u(Θ) to Θ, for every possible Θ.
19 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
Utility-based HRQL in practice
Health status: Describe health states as
Θ = (θmood , θfatigue , θsocial , θthinking , θupperlimb, θlowerlimb),
where θdomain is a score on one of the chosen Neuro-QoLdomains.
⇒ Attach a utility value u(Θ) to Θ, for every possible Θ.
19 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
Single-attribute utility functions
−3.0 −2.5 −2.0 −1.5 −1.0 −0.5 0.0 0.5
0.0
0.2
0.4
0.6
0.8
1.0
Social
theta
utili
ty
20 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
Multi-attribute summary score
The NQU scoring function is defined via a multiplicative model:
NQU(Θ) = 1− c
C
[ ∏
d∈domains
(1 + C · cd (1− ud (θd)))− 1
],
where
Θ = (θmood , θfatigue , θsocial , θthinking , θupperlimb, θlowerlimb)
is a health state formed from Neuro-QoL measurements, andc ,C , cd are constants.
21 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
Some highlights of the validation analyses
Mean NQU score of the general population sample is 0.94(on a 0-1 scale). Mean NQU score of the MS sample is0.82. Variation is small enough that the difference issignificant (p < 0.01).
Positively correlated (≈ 0.6) with generic legacy measures(EQ-5D and HUI) in the MS sample.
In the general population sample, the EQ-5D and HUIwere more highly correlated than either measure’scorrelation with the NQU.NQU provides different information than generic measures
Lower PDDS scores ⇒ higher NQU scores
22 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
Some highlights of the validation analyses
Mean NQU score of the general population sample is 0.94(on a 0-1 scale). Mean NQU score of the MS sample is0.82. Variation is small enough that the difference issignificant (p < 0.01).
Positively correlated (≈ 0.6) with generic legacy measures(EQ-5D and HUI) in the MS sample.
In the general population sample, the EQ-5D and HUIwere more highly correlated than either measure’scorrelation with the NQU.NQU provides different information than generic measures
Lower PDDS scores ⇒ higher NQU scores
22 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
Some highlights of the validation analyses
Mean NQU score of the general population sample is 0.94(on a 0-1 scale). Mean NQU score of the MS sample is0.82. Variation is small enough that the difference issignificant (p < 0.01).
Positively correlated (≈ 0.6) with generic legacy measures(EQ-5D and HUI) in the MS sample.
In the general population sample, the EQ-5D and HUIwere more highly correlated than either measure’scorrelation with the NQU.NQU provides different information than generic measures
Lower PDDS scores ⇒ higher NQU scores
22 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
Some highlights of the validation analyses
Mean NQU score of the general population sample is 0.94(on a 0-1 scale). Mean NQU score of the MS sample is0.82. Variation is small enough that the difference issignificant (p < 0.01).
Positively correlated (≈ 0.6) with generic legacy measures(EQ-5D and HUI) in the MS sample.
In the general population sample, the EQ-5D and HUIwere more highly correlated than either measure’scorrelation with the NQU.NQU provides different information than generic measures
Lower PDDS scores ⇒ higher NQU scores
22 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
Some highlights of the validation analyses
Mean NQU score of the general population sample is 0.94(on a 0-1 scale). Mean NQU score of the MS sample is0.82. Variation is small enough that the difference issignificant (p < 0.01).
Positively correlated (≈ 0.6) with generic legacy measures(EQ-5D and HUI) in the MS sample.
In the general population sample, the EQ-5D and HUIwere more highly correlated than either measure’scorrelation with the NQU.NQU provides different information than generic measures
Lower PDDS scores ⇒ higher NQU scores
22 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
Some highlights of the validation analyses
Mean NQU score of the general population sample is 0.94(on a 0-1 scale). Mean NQU score of the MS sample is0.82. Variation is small enough that the difference issignificant (p < 0.01).
Positively correlated (≈ 0.6) with generic legacy measures(EQ-5D and HUI) in the MS sample.
In the general population sample, the EQ-5D and HUIwere more highly correlated than either measure’scorrelation with the NQU.NQU provides different information than generic measures
Lower PDDS scores ⇒ higher NQU scores
22 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Background
Overview
Domainselection
Survey andsample
Scoringfunction
Validation
Wrapping up
A summary score for 6 domains of the Neuro-QoL will soon beavailable, allowing anyone collecting Neuro-QoL data toundertake preference-based analyses, such as comparativeeffectiveness analyses.
Barry DewittDepartment of Engineering & Public PolicyCarnegie Mellon Universityemail: barrydewitt@cmu.edu
23 / 23 Barry Dewitt Neuro-QoL Utility Score
Neuro-QoLUtility Score
Barry Dewitt
Preference elicitation: What’s your utility for agiven health state?
The Standard Gamble (SG)
Choice A
BestWorst
Worst Health
Chance 60%
Best Health
Chance 40%
Choice B
MiddleMiddle Health
Guaranteed
Barry Dewitt (Carnegie Mellon University) Neuro-QoL Utility Score June 5th, 2019 24
Neuro-QoLUtility Score
Barry Dewitt
Example health states
Barry Dewitt (Carnegie Mellon University) Neuro-QoL Utility Score June 5th, 2019 25
Neuro-QoLUtility Score
Barry Dewitt
Barry Dewitt (Carnegie Mellon University) Neuro-QoL Utility Score June 5th, 2019 26
Neuro-QoLUtility Score
Barry Dewitt
Barry Dewitt (Carnegie Mellon University) Neuro-QoL Utility Score June 5th, 2019 27
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