View
31
Download
0
Category
Preview:
DESCRIPTION
Technological Advances in Longer-Acting Factor Replacement Therapy for Hemophilia. Program Goals. Factor Replacement Therapy. Challenges of Factor Replacement Therapy. Half-Life Extension Technology. rFIX Fc Fusion Protein (rFIX-Fc). rFIX-Fc (cont). rFIX Albumin Fusion Protein (rFIX-FP). - PowerPoint PPT Presentation
Citation preview
Technological Advances in Longer-Acting Factor
Replacement Therapy for Hemophilia
Program Goals
Factor Replacement Therapy
Challenges of Factor Replacement Therapy
Half-Life Extension Technology
rFIX Fc Fusion Protein (rFIX-Fc)
rFIX-Fc (cont)
rFIX Albumin Fusion Protein (rFIX-FP)
rFIX-FP (cont)
GlycoPEGylated rFIX (N9-GP)
N9-GP (cont)
GlycoPEGylated rFVIII (N8-GP)
rFVIII Fc Fusion Protein (rFVIII-Fc)
rFVIII-Fc (cont)
rFIX-Fc: Phase 3 Studies Dosing
rFIX-Fc: Bleeding Rate by Dose
rFVIII-Fc: Bleeding Rate by Dose
rFVIII-Fc: Dosing Frequency at the End of the Study Period
Summary
Clinical Impact of Half-life Extension
Abbreviations
References
References (cont)
Recommended