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SFE Bio-Botanical Extraction SystemA supercritical fluid extraction system that rapidly extracts and fractionates botanical matrices
Get the highest product quality, and in less time■■ Computer-controlled
system, meaning less
user-intervention
■■ Precise control of
pressure, temperature,
and time
■■ Up to 200 g/min flow,
at 8700 psi
■■ Can perform sub-critical
or super-critical
extractions
RAPIDLY EX T RACT AND FRACT IONAT E LARGE QUANTIT IES OF DESIRED COMPONENT S FROM A MULT ITUDE OF MAT RIC ES
The Waters® SFE Bio-Botanical Extraction System (BBES) functions as a bulk-scale,
high-pressure separator for collecting extracted compounds. It provides extraction
efficiency and selective fractionation of an extract in a single run. With the SFE BBES,
you’ll see increased consistency of final product, from run-to-run.
Because of the ability to run at increased pressure, extractions can happen faster –
up to four times faster than in other systems – and at a decreased temperature,
which means cleaner extracts due to less decarboxylation.
Extracting with carbon dioxide
By manipulating the pressure and temperature, CO2 can selectively extract the desired
material. The sample is placed in an extraction vessel and pressurized with CO2 and,
depending on the application, a small percentage of co-solvent, to extract the compounds
of interest. These dissolved compounds are then transferred from the extraction vessel to
a series of collection cyclones. The SFE BBES features either a 5-L extraction vessel (which
can hold up to 4.5 lbs of material) or a 10-L extraction vessel (up to 9 lbs of material).
The automated back-pressure regulator (ABPR), located between the vessel and cyclones,
allows for controlled pressurization of the compounds of interest and the CO2.
After exiting the ABPR, the system pressure is reduced,
causing the CO2 to lose its solvating power. When the
manual back-pressure regulators (MBPR) are properly
set, the extracted material precipitates out of the solution
into the collection cyclones. The cyclones are arranged
in consecutive order to enable a series of decreasing
pressure steps to isolate the collected compounds – this
allows for extract fractionation, giving you purer, cleaner
fractions requiring less post process.
The condensed CO2, now a gas, is sent to vent
or a Recycler.
SFE Bio-Botanical Extraction System.
Benefits of using carbon dioxide
Waters SFE systems extract chemical compounds using
supercritical CO2 instead of an organic solvent or a hydrocarbon.
The supercritical fluid state occurs when a fluid is above
its critical temperature (Tc) and critical pressure (Pc). This
supercritical state allows CO2 to take on the properties of a gas
(high diffusivity, low surface tension), while maintaining the
solvating power of a liquid. Manipulating the temperature and
pressure of CO2 alters the solvent power and allows the materials
of interest to be selectively extracted.
The biggest advantage of SFE is that it leaves no traces in the
product. After extraction, the CO2 is either depressurized and
vented, or recycled for further extraction use. Any residual trace
of CO2 in the product dissipates into the atmosphere within a few
hours. As a tunable solvent, CO2 is non-toxic, non-flammable,
and physiologically compatible.
ON/OFF VALVE
GAUGE
FLOW METER
MIXER
COOLINGHEAT
EXCHANGER
HEAT
JAC
KET
HEAT
JAC
KET
HEATEXCHANGER
COOLING BATH
CO2 PUMP
CO-SOLVENT PUMP
CO-SOLVENTRESERVOIR
CO2 SUPPLY IN
DRAIN VALVE
GAUGE
MANUALBPR
EXTR
ACTI
ONVE
SSEL
EXTR
ACTI
ONVE
SSEL V ENT
FRACTIONCOLLECTOR
HEATJACKET
HEATJACKET
DRAIN VALVE
GAUGE
MANUALBPR
VENT
FRACTIONCOLLECTOR
HEATJACKET
DRAIN VALVE
GAUGE
MANUALBPR
VENT
FRACTIONCOLLECTOR
BLEED VALVE
ON/OFF VALVE
GAUGE
BLEED VALVE
AUTOMATEDBPR
Schematic of the SFE BBES.
SFE Bio-Botanical Vessel.
SFE BBES system components
The system consists of a CO2 pump, a mass flow meter, one or two
extraction vessels, an automated back pressure regulator, two
heat exchangers, and three fraction collection vessels. Options
include a co-solvent pump and mixer, and a CO2 Recycler.
CO2 pump – Ideal for high pressure, supercritical fluids, and
pulseless flow applications.
Co-solvent pump – Pumps a co-solvent as a percentage of the
carbon dioxide flow rate up to its maximum flow rate and pressure
rating. Adding a co-solvent like food grade ethanol allows one to
extract polar compounds.
Cooling heat exchanger – Cool and liquefy CO2 before it enters
the pump for maximum efficiency.
Flow meter – Located on the inlet of the carbon dioxide pump,
the pump, for flow control, uses measured liquefied CO2 mass
output from the flow meter.
Heat exchanger – Located upstream from the vessel to ensure
that the fluid is heated prior to entering the vessel.
Extraction vessels – Caps with spring-loaded seal enhances
safety, and lend to automation for efficient loading and
unloading of large vessels. There can be up to two in a system.
Automated BPR – Motor-driven and temperature-controlled
to compensate for cooling during depressurization. A built-in
pressure sensor provides closed loop feedback for control
and pressure alarm monitoring.
Collection vessels with manual BPR – The mixed fluid is
introduced into the high pressure collection vessels, efficiently
separated, and collected at the bottom of the vessels. There are
three in a system, allowing for efficient collection of different
extracts by varying pressure between collection vessels with
the MBPR’s.
Recycler – Reclaims vented CO2 from extraction process. This
system consists of storage vessel with level sensor for CO2 storage,
level sensor module to display level, condensing heat exchanger,
condensing cooling bath, and valves. The system also features a
pressure relief valve that can be piped to vent to relieve pressure in
case of over-pressurization or overfill conditions.
Software – Uses intuitive ChromScope™ Software to automate
the system, including pressure, temperature, flow rate, and
extraction time. Methods can be saved to be run again or used
in ‘manual’ mode.
Waters Corporation 34 Maple Street Milford, MA 01757 U.S.A. T: 1 508 478 2000 F: 1 508 872 1990 www.waters.com
Waters and The Science of What’s Possible are registered trademarks of Waters Corporation. ChromScope is a trademark of Waters Corporation. All other trademarks are the property of their respective owners.
©2016 Waters Corporation. Printed in the U.S.A. November 2016 720005302EN LM-SIG
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