Sajeel Chowdhary, MD Program Director, Neuro Oncology ...web.brrh.com/msl/Practical Neuroscience for...

Sajeel Chowdhary, MD

Program Director, Neuro – Oncology / Neurology Lynn Cancer Institute (LCI)

Marcus Neuroscience Institute (MNI) Boca Raton Regional Hospital (BRRH)

Medical Staff, Delray Medical Center

Associate Professor of Neuro – Oncology and Neurology Charles E Schmidt COM

Florida Atlantic University (FAU)

HARVEY CUSHING, MD (1869-1939): FATHER OF MODERN NEURO-SURGERY AND BRAIN TUMOR CLASSIFICATION.

PATIENT “VT” 53 YEAR OLD MAN

NEW ONSET SEIZURE

PRESENTS TO THE EMERGENCY ROOM

MRI BRAIN COMPLETED

ROLE OF SURGERY: MAXIMAL SAFE SURGICAL RESECTION

BULK REDUCTION

SEIZURE CONTROL

PATHOLOGICAL DIAGNOSIS

CLINICAL TRIAL ENROLLMENT

BETTER PATIENT OUTCOME

PATHOLOGY: WHO GRADE IV GLIOBLASTOMA

Lacroix M, et al. J Neurosurg. 2001;95:190-198.

BETTER TUMOR REMOVAL = BETTER OUTCOMES

RADIATION (IMRT, PROTON BEAM, SRS, CYBERKNIFE)

TARGETED THERAPY

MOLECULAR PROFILING OF TUMOR

MATCHING THERAPIES TO MOLECULAR PROFILE

CLINICAL TRIALS

TREATMENT STRATEGY:

MRI brain with contrast:

EXPERIMENTAL THERAPEUTICS AND MOLECULAR PROFILING: NRG / RTOG TRIALS

ALLIANCE TRIALS

PHARMA TRIALS

CONVECTION ENHANCED DELIVERY (CED) TRIALS (MEDICENNA MDNA 55 TRIAL, PVS RIPO POLIO VIRUS TRIAL)

TISSUE REGISTRY TRIALS (FCBTR, SCRIPPS, SE GLIOMA TRIAL, NEMERE TRIAL)

COLLABORATE WITH OTHER ACADEMIC CENTERS AND SUCCEED TOGETHER