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395bc medical journal vol. 60 no. 8, october 2018 bcmj.org
A quick-reference guide for prescribing buprenorphine/naloxone (Suboxone) in the outpatient setting
Prescribing suboxone in the outPatient settinga quick-reference guide to in-office induction
By Patricia Caddy, MD, and Kesh Smith, MDAdapted from A Guideline for the Clinical Management of Opioid Use Disorder published by
the British Columbia Centre on Substance Abuse and the BC Ministry of Health, June 2017
assessment✓ Confirm opioid use disorder using DSM–5
Check PharmaNet
Obtain substance use history
• Alldrugsused,includingethanol(EtOH),nicotine,benzodiazapines
•Ageandamountoffirstuse,currentuse
•Anyperiodsofabstinence• Treatmenthistory•Goals
Rule out contraindications
•AllergytoSuboxone•Pregnancy(relativecontra-indicationtoinductionbutnottocontinuation)
•Severeliverdysfunction•Severerespiratorydistress•AcuteEtOHintoxication
+
•CBC•Electrolytes•Renalpanel• Liverpanel
•HepA/B/Cserologies•STIpanel(includingHIV)•Urinedrugtest
Suboxone •Combinationofbuprenorphineandnaloxoneatratioof4:1
•Availablein2.0mg/0.5mgand8mg/2mgsublingual(SL)tablets
• Tabletsmaybesplitifnecessary
•Maytakeupto10mintodissolvecompletely(notalking,smoking,orswallowingatthistime)
•Absorptionbetterwithmoistenedmouth
•NaloxonepreventsIM/IVdiversionofdrugandisnotactivewhentakenSL,so does not protect patient from overdose
•MaxdoseapprovedinCanada24mg/6mgdaily
+
Precipitated withdrawal•Canoccurduetoreplacementoffullopioidreceptoragonist(e.g.,heroin,fentanyl,morphine)withpartialagonistthatbindswithahigheraffinity(e.g.,Suboxone,methadone)
Symptoms•Similartoopiatewithdrawal(i.e.,increasedheartrate,sweating,agitation,diarrhea,tremor,unease,restlessness,tearing,runnynose,vomiting,gooseflesh)
•Canrangefrommildtosevere•Canbeverydistressinganddiscouragingforpatients•LargelyreversiblewithhigherdosesofSuboxoneorotheropioid
•Avoidbyensuringadequatewithdrawalbeforeinduction(COWS>12),startingSuboxoneatalowerdose(2.0mg/0.5mg),andreassessingmorefrequently
Treatment•Explainwhathashappened•Provideempathetic/compassionate/apologeticsupport•Managesymptomswithclonidine,loperamide.Avoidbenzodiazepines
•Encourage/motivatepatienttotryagainsoon
*COWS = clinical opiate withdrawal scale Avalidatedclinicaltoolusedtodetermineseverityofopiatewithdrawal,availablefreeonlineatwww.bccsu.ca/wp-content/uploads/2017/06/BC-OUD-Guidelines_June2017.pdf(seeAppendix6ofA Guideline for the Clinical Management of Opioid Use Disorder)
induction: day 1• 1–2daysrequiredforbaselineassessmentandinitiation•Day1maxdose12mg/3mg
Confirm√COWS*score>12
√Nocontraindications
√Nolong-actingopioidsusedfor>30hours
Give Suboxone SL 4 mg/1 mg
NoAdditional doses needed
YesGo to Day 2
~ 2 hoursWithdrawal symptoms
gone?
Order/review lab test results
Figure (Page 1 of 2). In-office assessment, Suboxone induction, and maintenance document
396 bc medical journal vol. 60 no. 8, october 2018 bcmj.org
A quick-reference guide for prescribing buprenorphine/naloxone (Suboxone) in the outpatient setting
To speak to an expert in BC:RapidAccesstoConsultativeExpertise(RACE)line:1877696-2131
To see the latest guidelines, research, and provincial resources:BritishColumbiaCentreonSubstanceUsewww.bccsu.ca
To test your new knowledge of Suboxone induction, go to www.surveymonkey.com/r/BXHVWVT
Tohelpusimprovethisguide,pleasesendyourfeedbacktoSuboxoneInfographic@gmail.com.Senderinformationwillnotbeincludedwhenfeedbackisconsidered.
for additional suPPort and resources...
induction: day 2 onwards• IfadequatesymptomreliefnotachievedoverDay1and2,additionaldays(usuallynomorethan2)mayberequired•Day2maxdose16mg/4mg
maintenance Goal=once-dailydosing,nowithdrawalbetweendoses.Ideally,dose≥12mg/3mg
Monitor •CheckPharmaNetregularlytoensureprescriptionsarefilled,nodoctorshopping,etc.
Withdrawal symptoms recurred since last dose?
No•GiveDay1totaldoseagaintocompleteinduction.Thiswillbetheongoingdailydose
•Considertitrationuptooptimaldose(≥12mg/3mg)forimprovedretentionintreatment
•Mayincreasedoseevery1–3days,orlessfrequently
Yes•GiveDay1totalplusanotherdoseSuboxoneSL4mg/1mg Yes
• Inductioncomplete•GiveDay2totalasongoingdose,ortitrateupto≥12mg/3mgforimprovedretentionintreatment
No•Additionaldosesneeded•GiveSuboxoneSL4mg/1mg
~ 2 hours
~ 2 hours
Withdrawal symptoms gone?
considerations
Urine drug testing (UDT):•UrinedrugtestingexpectedforpatientsonSuboxonetoobjectivelydocumentlicit/illicitdruguse
•UDTnottobeusedpunitivelybuttofacilitateopencommunication
•Performpoint-of-careUDTatleastmonthly•Considerorderingconfirmatorytestingforunexpectedresults(falsepositivesdooccur)
take-home doses (“carries”)
•Suboxoneingestioncommonlywitnessedatthepharmacybuttake-homedosesmaybeprescribed
•Take-home“carries”appropriateforpatientswhodemonstratebiopsychosocialstability,havenotmisseddoses,areabstinentfromillicitdrugs,haveasecureplacetostoretheirmedication
•Orderurinedrugtesting(UDT)•Assessforreadinessfortake-homedosing(“carries”),seebelow
Figure (Page 2 of 2). In-office assessment, Suboxone induction, and maintenance document
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