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toxico

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1.Determinarea conc plasmatice a glicozidelor digitalice prin dozare radioimunologica (RIA)-toxicitate a peste 2,5-3ng/ml pt digoxin sau 35ng/ml pt digitoxin-nivele serice la cel putin 6 h de la ultima doza pt intox cronica, si la 1-2h pt intox acuta-nivelele plasmatice nu sunt correlate obligtoriu cu severitatea toxicitatii2. Determinarea electrolitilor-K crescut in intox acute. K normal sau scazut in intox cronica3. Investigatia fct renale :uree creatinina4.EKG: toxicitatea digitalica trebuie diferentiata de efectul digitalic care apare la conc terapeutice*effect digitalic: adancimea segm ST in ghirlanda*scurtarea intervalului QT*scaderea amplitudinii undei T*alungirea inrevalului PR

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