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TDMS No. 20304 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2008
Test Type: CHRONIC TEF evaluation (PCB 118) Time Report Requested: 13:39:56
Route: GAVAGE CAS Number: 31508-00-6 First Dose M/F: NA / 03/26/04
Species/Strain: RATS/SD Lab: BAT
31 Wk_SSAC_R8
C Number: C20304
Lock Date: 10/12/2006
Cage Range: ALL
Date Range: ALL
Reasons For Removal: 25017 SSAC
Removal Date Range: 27-Oct-2004 - 27-Oct-2004
Treatment Groups: Include 001 0 UG/KG Include 002 10 UG/KG Include 003 30 UG/KG
Include 004 100 UG/KG Include 005 220 UG/KG Include 006 460 UG/KG
Include 007 1000 UG/KG Include 008 4600 UG/KG
Study Gender: Female
TDMSE Version: 2.0.0
ALIMENTARY SYSTEM.........................................................................................................................................................................................................
Liver + + + + + + + + + + 10Clear Cell Focus X X 2Inflammation 1 1 1 1 1 1 1 1 1 1 10 1.0Bile Duct, Fibrosis 1 1 1.0
.........................................................................................................................................................................................................
Pancreas + + + + + + + + + + 10Inflammation, Chronic Active 1 1 1.0
.........................................................................................................................................................................................................
Stomach, Forestomach + + + + + + + + + + 10.........................................................................................................................................................................................................
Stomach, Glandular + + + + + + + + + + 10
CARDIOVASCULAR SYSTEM.........................................................................................................................................................................................................
Blood Vessel + 1
ENDOCRINE SYSTEM.........................................................................................................................................................................................................
Adrenal Cortex + + + + + + + + + + 10Hyperplasia 1 1 1.0Hypertrophy 1 1 2 1.0
.........................................................................................................................................................................................................
Adrenal Medulla + + + + + + + + + + 10
TDMS No. 20304 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2008
Test Type: CHRONIC TEF evaluation (PCB 118) Time Report Requested: 13:39:56
Route: GAVAGE CAS Number: 31508-00-6 First Dose M/F: NA / 03/26/04
Species/Strain: RATS/SD Lab: BAT
DAY ON TEST0216
0216
0216
0216
0216
0216
0216
0216
0216
0216
.................................................................................................................................................................
SPRAGUE-DAWLEY RATSFEMALE
ANIMAL ID0 UG/KG
00061
00062
00063
00064
00065
00071
00072
00073
00074
00075 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 2
.........................................................................................................................................................................................................
Pituitary Gland + + + + + + + + + + 10.........................................................................................................................................................................................................
Thyroid Gland + + + + + + + + + + 10Follicular Cell, Hypertrophy 2 1 2.0
GENERAL BODY SYSTEMNONE
GENITAL SYSTEM.........................................................................................................................................................................................................
Ovary + + + + + + + + + + 10.........................................................................................................................................................................................................
Uterus + + + + + + + + + + 10Inflammation 2 1 2.0Metaplasia, Squamous 1 1 1 1 4 1.0Endometrium, Hyperplasia, Cystic 1 1 1.0
.........................................................................................................................................................................................................
Vagina + + + + + + + + + + 10
HEMATOPOIETIC SYSTEM.........................................................................................................................................................................................................
Spleen + + + + + + + + + + 10Pigmentation 1 1 1 1 1 1 1 1 2 1 10 1.1
.........................................................................................................................................................................................................
TDMS No. 20304 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2008
Test Type: CHRONIC TEF evaluation (PCB 118) Time Report Requested: 13:39:56
Route: GAVAGE CAS Number: 31508-00-6 First Dose M/F: NA / 03/26/04
Species/Strain: RATS/SD Lab: BAT
DAY ON TEST0216
0216
0216
0216
0216
0216
0216
0216
0216
0216
.................................................................................................................................................................
SPRAGUE-DAWLEY RATSFEMALE
ANIMAL ID0 UG/KG
00061
00062
00063
00064
00065
00071
00072
00073
00074
00075 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 3
Thymus + + + + + + + + + + 10
INTEGUMENTARY SYSTEM.........................................................................................................................................................................................................
Mammary Gland + + + + + + + + + + 10
MUSCULOSKELETAL SYSTEMNONE
NERVOUS SYSTEMNONE
RESPIRATORY SYSTEM.........................................................................................................................................................................................................
Lung + + + + + + + + + + 10Inflammation 1 1 1.0Alveolus, Infiltration Cellular, Histiocyte 1 1 1 1 4 1.0
SPECIAL SENSES SYSTEMNONE
URINARY SYSTEMNONE
TDMS No. 20304 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2008
Test Type: CHRONIC TEF evaluation (PCB 118) Time Report Requested: 13:39:56
Route: GAVAGE CAS Number: 31508-00-6 First Dose M/F: NA / 03/26/04
Species/Strain: RATS/SD Lab: BAT
DAY ON TEST0216
0216
0216
0216
0216
0216
0216
0216
0216
0216
.................................................................................................................................................................
SPRAGUE-DAWLEY RATSFEMALE
ANIMAL ID0 UG/KG
00061
00062
00063
00064
00065
00071
00072
00073
00074
00075 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 4
ALIMENTARY SYSTEM.........................................................................................................................................................................................................
Liver + + + + + + + + + + 10Clear Cell Focus X X X 3Inflammation 1 1 1 1 1 1 1 1 1 1 10 1.0
.........................................................................................................................................................................................................
Pancreas + + + + + + + + + + 10
CARDIOVASCULAR SYSTEMNONE
ENDOCRINE SYSTEM.........................................................................................................................................................................................................
Adrenal Cortex + + + + + + + + + + 10.........................................................................................................................................................................................................
Adrenal Medulla + + + + + + + + + + 10.........................................................................................................................................................................................................
Thyroid Gland + + + + + + + + + + 10
GENERAL BODY SYSTEMNONE
GENITAL SYSTEM.........................................................................................................................................................................................................
TDMS No. 20304 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2008
Test Type: CHRONIC TEF evaluation (PCB 118) Time Report Requested: 13:39:56
Route: GAVAGE CAS Number: 31508-00-6 First Dose M/F: NA / 03/26/04
Species/Strain: RATS/SD Lab: BAT
DAY ON TEST0216
0216
0216
0216
0216
0216
0216
0216
0216
0216
.................................................................................................................................................................
SPRAGUE-DAWLEY RATSFEMALE
ANIMAL ID10 UG/KG
00111
00112
00113
00114
00115
00126
00127
00128
00129
00130 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 5
Uterus + + + + + + + + + + 10Dilatation 3 4 2 3.5Inflammation, Suppurative 1 1 1.0Metaplasia, Squamous 1 1 1 3 1.0
HEMATOPOIETIC SYSTEM.........................................................................................................................................................................................................
Thymus + + + + + + + + + + 10Atrophy 2 1 2.0
INTEGUMENTARY SYSTEMNONE
MUSCULOSKELETAL SYSTEMNONE
NERVOUS SYSTEMNONE
RESPIRATORY SYSTEM.........................................................................................................................................................................................................
Lung + + + + + + + + + + 10Alveolus, Infiltration Cellular, Histiocyte 1 1 1.0
TDMS No. 20304 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2008
Test Type: CHRONIC TEF evaluation (PCB 118) Time Report Requested: 13:39:56
Route: GAVAGE CAS Number: 31508-00-6 First Dose M/F: NA / 03/26/04
Species/Strain: RATS/SD Lab: BAT
DAY ON TEST0216
0216
0216
0216
0216
0216
0216
0216
0216
0216
.................................................................................................................................................................
SPRAGUE-DAWLEY RATSFEMALE
ANIMAL ID10 UG/KG
00111
00112
00113
00114
00115
00126
00127
00128
00129
00130 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 6
SPECIAL SENSES SYSTEMNONE
URINARY SYSTEMNONE
TDMS No. 20304 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2008
Test Type: CHRONIC TEF evaluation (PCB 118) Time Report Requested: 13:39:56
Route: GAVAGE CAS Number: 31508-00-6 First Dose M/F: NA / 03/26/04
Species/Strain: RATS/SD Lab: BAT
DAY ON TEST0216
0216
0216
0216
0216
0216
0216
0216
0216
0216
.................................................................................................................................................................
SPRAGUE-DAWLEY RATSFEMALE
ANIMAL ID10 UG/KG
00111
00112
00113
00114
00115
00126
00127
00128
00129
00130 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 7
ALIMENTARY SYSTEM.........................................................................................................................................................................................................
Liver + + + + + + + + + + 10Clear Cell Focus X X X X 4Inflammation 1 1 1 1 1 1 1 1 1 1 10 1.0Mixed Cell Focus X 1Hepatocyte, Hypertrophy 1 1 1.0
.........................................................................................................................................................................................................
Pancreas + + + + + + + + + + 10
CARDIOVASCULAR SYSTEMNONE
ENDOCRINE SYSTEM.........................................................................................................................................................................................................
Adrenal Cortex + + + + + + + + + + 10Hypertrophy 1 1 1.0
.........................................................................................................................................................................................................
Adrenal Medulla + + + + + + + + + + 10.........................................................................................................................................................................................................
Thyroid Gland + + + + + + + + + + 10
GENERAL BODY SYSTEMNONE
TDMS No. 20304 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2008
Test Type: CHRONIC TEF evaluation (PCB 118) Time Report Requested: 13:39:56
Route: GAVAGE CAS Number: 31508-00-6 First Dose M/F: NA / 03/26/04
Species/Strain: RATS/SD Lab: BAT
DAY ON TEST0216
0216
0216
0216
0216
0216
0216
0216
0216
0216
.................................................................................................................................................................
SPRAGUE-DAWLEY RATSFEMALE
ANIMAL ID30 UG/KG
00201
00202
00203
00204
00205
00216
00217
00218
00219
00220 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 8
GENITAL SYSTEM.........................................................................................................................................................................................................
Uterus + + + + + + + + + + 10Metaplasia, Squamous 1 1 2 1.0Endometrium, Hyperplasia, Cystic 1 1 2 1.0
HEMATOPOIETIC SYSTEM.........................................................................................................................................................................................................
Thymus + + + + + + + + + + 10Atrophy 2 1 2.0
INTEGUMENTARY SYSTEM.........................................................................................................................................................................................................
Mammary Gland + 1
MUSCULOSKELETAL SYSTEMNONE
NERVOUS SYSTEMNONE
RESPIRATORY SYSTEM.........................................................................................................................................................................................................
Lung + + + + + + + + + + 10
TDMS No. 20304 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2008
Test Type: CHRONIC TEF evaluation (PCB 118) Time Report Requested: 13:39:56
Route: GAVAGE CAS Number: 31508-00-6 First Dose M/F: NA / 03/26/04
Species/Strain: RATS/SD Lab: BAT
DAY ON TEST0216
0216
0216
0216
0216
0216
0216
0216
0216
0216
.................................................................................................................................................................
SPRAGUE-DAWLEY RATSFEMALE
ANIMAL ID30 UG/KG
00201
00202
00203
00204
00205
00216
00217
00218
00219
00220 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 9
Inflammation 1 1 1.0
SPECIAL SENSES SYSTEMNONE
URINARY SYSTEMNONE
TDMS No. 20304 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2008
Test Type: CHRONIC TEF evaluation (PCB 118) Time Report Requested: 13:39:56
Route: GAVAGE CAS Number: 31508-00-6 First Dose M/F: NA / 03/26/04
Species/Strain: RATS/SD Lab: BAT
DAY ON TEST0216
0216
0216
0216
0216
0216
0216
0216
0216
0216
.................................................................................................................................................................
SPRAGUE-DAWLEY RATSFEMALE
ANIMAL ID30 UG/KG
00201
00202
00203
00204
00205
00216
00217
00218
00219
00220 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 10
ALIMENTARY SYSTEM.........................................................................................................................................................................................................
Liver + + + + + + + + + + 10Inflammation 1 1 1 1 1 1 1 1 1 1 10 1.0Hepatocyte, Hypertrophy 1 1 1.0
.........................................................................................................................................................................................................
Pancreas + + + + + + + + + + 10
CARDIOVASCULAR SYSTEMNONE
ENDOCRINE SYSTEM.........................................................................................................................................................................................................
Adrenal Cortex + + + + + + + + + + 10Hyperplasia 1 1 1.0Hypertrophy 1 1 1.0
.........................................................................................................................................................................................................
Adrenal Medulla + + + + + + + + + + 10.........................................................................................................................................................................................................
Thyroid Gland + + + + + + + + + + 10
GENERAL BODY SYSTEMNONE
TDMS No. 20304 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2008
Test Type: CHRONIC TEF evaluation (PCB 118) Time Report Requested: 13:39:56
Route: GAVAGE CAS Number: 31508-00-6 First Dose M/F: NA / 03/26/04
Species/Strain: RATS/SD Lab: BAT
DAY ON TEST0216
0216
0216
0216
0216
0216
0216
0216
0216
0216
.................................................................................................................................................................
SPRAGUE-DAWLEY RATSFEMALE
ANIMAL ID100 UG/KG
00361
00362
00363
00364
00365
00376
00377
00378
00379
00380 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 11
GENITAL SYSTEM.........................................................................................................................................................................................................
Uterus + + + + + + + + + + 10Inflammation, Suppurative 1 1 1.0Metaplasia, Squamous 1 1 1 3 1.0
HEMATOPOIETIC SYSTEM.........................................................................................................................................................................................................
Thymus + + + + + + + + + + 10Atrophy 1 1 1.0
INTEGUMENTARY SYSTEMNONE
MUSCULOSKELETAL SYSTEMNONE
NERVOUS SYSTEMNONE
RESPIRATORY SYSTEM.........................................................................................................................................................................................................
Lung + + + + + + + + + + 10Inflammation 1 1 2 1.0
TDMS No. 20304 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2008
Test Type: CHRONIC TEF evaluation (PCB 118) Time Report Requested: 13:39:56
Route: GAVAGE CAS Number: 31508-00-6 First Dose M/F: NA / 03/26/04
Species/Strain: RATS/SD Lab: BAT
DAY ON TEST0216
0216
0216
0216
0216
0216
0216
0216
0216
0216
.................................................................................................................................................................
SPRAGUE-DAWLEY RATSFEMALE
ANIMAL ID100 UG/KG
00361
00362
00363
00364
00365
00376
00377
00378
00379
00380 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 12
Alveolar Epithelium, Infiltration Cellular,Histiocyte 1 1 1.0
SPECIAL SENSES SYSTEMNONE
URINARY SYSTEMNONE
TDMS No. 20304 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2008
Test Type: CHRONIC TEF evaluation (PCB 118) Time Report Requested: 13:39:56
Route: GAVAGE CAS Number: 31508-00-6 First Dose M/F: NA / 03/26/04
Species/Strain: RATS/SD Lab: BAT
DAY ON TEST0216
0216
0216
0216
0216
0216
0216
0216
0216
0216
.................................................................................................................................................................
SPRAGUE-DAWLEY RATSFEMALE
ANIMAL ID100 UG/KG
00361
00362
00363
00364
00365
00376
00377
00378
00379
00380 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 13
ALIMENTARY SYSTEM.........................................................................................................................................................................................................
Liver + + + + + + + + + + 10Clear Cell Focus X X 2Inflammation 1 1 1 2 1 1 1 1 1 1 10 1.1Hepatocyte, Hypertrophy 1 1 1 3 1.0
.........................................................................................................................................................................................................
Pancreas + + + + + + + + + + 10.........................................................................................................................................................................................................
Stomach, Glandular + 1Hyperplasia 2 1 2.0
CARDIOVASCULAR SYSTEMNONE
ENDOCRINE SYSTEM.........................................................................................................................................................................................................
Adrenal Cortex + + + + + + + + + + 10Hypertrophy 1 1 2 3 1.3
.........................................................................................................................................................................................................
Adrenal Medulla + + + + + + + + + + 10.........................................................................................................................................................................................................
Thyroid Gland + + + + + + + + + + 10
GENERAL BODY SYSTEM
TDMS No. 20304 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2008
Test Type: CHRONIC TEF evaluation (PCB 118) Time Report Requested: 13:39:56
Route: GAVAGE CAS Number: 31508-00-6 First Dose M/F: NA / 03/26/04
Species/Strain: RATS/SD Lab: BAT
DAY ON TEST0216
0216
0216
0216
0216
0216
0216
0216
0216
0216
.................................................................................................................................................................
SPRAGUE-DAWLEY RATSFEMALE
ANIMAL ID220 UG/KG
00401
00402
00403
00404
00405
00426
00427
00428
00429
00430 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 14
NONE
GENITAL SYSTEM.........................................................................................................................................................................................................
Uterus + + + + + + + + + + 10Dilatation 3 1 3.0Inflammation, Suppurative 1 1 1.0Metaplasia, Squamous 1 1 1.0Endometrium, Hyperplasia, Cystic 1 1 1.0
HEMATOPOIETIC SYSTEM.........................................................................................................................................................................................................
Thymus + + + + + + + + + + 10Atrophy 1 2 1 3 1.3
INTEGUMENTARY SYSTEMNONE
MUSCULOSKELETAL SYSTEMNONE
NERVOUS SYSTEMNONE
TDMS No. 20304 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2008
Test Type: CHRONIC TEF evaluation (PCB 118) Time Report Requested: 13:39:56
Route: GAVAGE CAS Number: 31508-00-6 First Dose M/F: NA / 03/26/04
Species/Strain: RATS/SD Lab: BAT
DAY ON TEST0216
0216
0216
0216
0216
0216
0216
0216
0216
0216
.................................................................................................................................................................
SPRAGUE-DAWLEY RATSFEMALE
ANIMAL ID220 UG/KG
00401
00402
00403
00404
00405
00426
00427
00428
00429
00430 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 15
RESPIRATORY SYSTEM.........................................................................................................................................................................................................
Lung + + + + + + + + + + 10
SPECIAL SENSES SYSTEMNONE
URINARY SYSTEMNONE
TDMS No. 20304 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2008
Test Type: CHRONIC TEF evaluation (PCB 118) Time Report Requested: 13:39:56
Route: GAVAGE CAS Number: 31508-00-6 First Dose M/F: NA / 03/26/04
Species/Strain: RATS/SD Lab: BAT
DAY ON TEST0216
0216
0216
0216
0216
0216
0216
0216
0216
0216
.................................................................................................................................................................
SPRAGUE-DAWLEY RATSFEMALE
ANIMAL ID220 UG/KG
00401
00402
00403
00404
00405
00426
00427
00428
00429
00430 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 16
ALIMENTARY SYSTEM.........................................................................................................................................................................................................
Liver + + + + + + + + + + 10Clear Cell Focus X 1Clear Cell Focus, Multiple X 1Inflammation 1 1 1 1 1 1 1 1 1 9 1.0Mixed Cell Focus X 1Pigmentation 1 1 1.0Hepatocyte, Hypertrophy 1 2 1 1 1 1 1 1 8 1.1
.........................................................................................................................................................................................................
Pancreas + + + + + + + + + + 10
CARDIOVASCULAR SYSTEMNONE
ENDOCRINE SYSTEM.........................................................................................................................................................................................................
Adrenal Cortex + + + + + + + + + + 10.........................................................................................................................................................................................................
Adrenal Medulla + + + + + + + + + + 10.........................................................................................................................................................................................................
Pituitary Gland + 1Pars Distalis, Cyst 3 1 3.0
.........................................................................................................................................................................................................
Thyroid Gland + + + + + + + + + + 10C-cell, Hyperplasia 3 1 3.0
TDMS No. 20304 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2008
Test Type: CHRONIC TEF evaluation (PCB 118) Time Report Requested: 13:39:56
Route: GAVAGE CAS Number: 31508-00-6 First Dose M/F: NA / 03/26/04
Species/Strain: RATS/SD Lab: BAT
DAY ON TEST0216
0216
0216
0216
0216
0216
0216
0216
0216
0216
.................................................................................................................................................................
SPRAGUE-DAWLEY RATSFEMALE
ANIMAL ID460 UG/KG
00546
00547
00548
00549
00550
00571
00572
00573
00574
00575 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 17
GENERAL BODY SYSTEMNONE
GENITAL SYSTEM.........................................................................................................................................................................................................
Uterus + + + + + + + + + + 10Dilatation 3 4 2 3.5Inflammation, Suppurative 1 2 2 1.5Metaplasia, Squamous 1 1 2 1.0
HEMATOPOIETIC SYSTEM.........................................................................................................................................................................................................
Thymus + + + + + + + + + + 10Atrophy 1 1 2 1.0
INTEGUMENTARY SYSTEMNONE
MUSCULOSKELETAL SYSTEMNONE
NERVOUS SYSTEMNONE
TDMS No. 20304 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2008
Test Type: CHRONIC TEF evaluation (PCB 118) Time Report Requested: 13:39:56
Route: GAVAGE CAS Number: 31508-00-6 First Dose M/F: NA / 03/26/04
Species/Strain: RATS/SD Lab: BAT
DAY ON TEST0216
0216
0216
0216
0216
0216
0216
0216
0216
0216
.................................................................................................................................................................
SPRAGUE-DAWLEY RATSFEMALE
ANIMAL ID460 UG/KG
00546
00547
00548
00549
00550
00571
00572
00573
00574
00575 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 18
RESPIRATORY SYSTEM.........................................................................................................................................................................................................
Lung + + + + + + + + + + 10Inflammation 1 1 2 1.0
SPECIAL SENSES SYSTEMNONE
URINARY SYSTEMNONE
TDMS No. 20304 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2008
Test Type: CHRONIC TEF evaluation (PCB 118) Time Report Requested: 13:39:56
Route: GAVAGE CAS Number: 31508-00-6 First Dose M/F: NA / 03/26/04
Species/Strain: RATS/SD Lab: BAT
DAY ON TEST0216
0216
0216
0216
0216
0216
0216
0216
0216
0216
.................................................................................................................................................................
SPRAGUE-DAWLEY RATSFEMALE
ANIMAL ID460 UG/KG
00546
00547
00548
00549
00550
00571
00572
00573
00574
00575 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 19
ALIMENTARY SYSTEM.........................................................................................................................................................................................................
Liver + + + + + + + + + + 10Clear Cell Focus X X X 3Hematopoietic Cell Proliferation 1 1 1.0Inflammation 2 3 1 2 1 1 1 1 2 1 10 1.5Mixed Cell Focus X 1Necrosis 1 1 1.0Pigmentation 1 1 1 1 1 1 6 1.0Hepatocyte, Hypertrophy 1 2 1 1 2 1 1 2 2 1 10 1.4Oval Cell, Hyperplasia 1 1 1.0
.........................................................................................................................................................................................................
Pancreas + + + + + + + + + + 10Inflammation, Chronic Active 2 1 2.0
CARDIOVASCULAR SYSTEMNONE
ENDOCRINE SYSTEM.........................................................................................................................................................................................................
Adrenal Cortex + + + + + + + + + + 10Degeneration, Cystic 2 1 2.0Hypertrophy 1 2 2 3 1.7
.........................................................................................................................................................................................................
Adrenal Medulla + + + + + + + + + + 10.........................................................................................................................................................................................................
TDMS No. 20304 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2008
Test Type: CHRONIC TEF evaluation (PCB 118) Time Report Requested: 13:39:56
Route: GAVAGE CAS Number: 31508-00-6 First Dose M/F: NA / 03/26/04
Species/Strain: RATS/SD Lab: BAT
DAY ON TEST0216
0216
0216
0216
0216
0216
0216
0216
0216
0216
.................................................................................................................................................................
SPRAGUE-DAWLEY RATSFEMALE
ANIMAL ID1000 UG/KG
00621
00622
00623
00624
00625
00631
00632
00633
00634
00635 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 20
Thyroid Gland + + + + + + + + + + 10C-cell, Hyperplasia 1 1 1.0Follicular Cell, Hypertrophy 2 2 2 2.0
GENERAL BODY SYSTEMNONE
GENITAL SYSTEM.........................................................................................................................................................................................................
Uterus + + + + + + + + + + 10Dilatation 2 3 3 3 2.7Inflammation, Suppurative 1 1 1.0Metaplasia, Squamous 1 1 1 1 4 1.0
HEMATOPOIETIC SYSTEM.........................................................................................................................................................................................................
Thymus + + + + + + + + + + 10Atrophy 1 1 1.0
INTEGUMENTARY SYSTEMNONE
MUSCULOSKELETAL SYSTEMNONE
TDMS No. 20304 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2008
Test Type: CHRONIC TEF evaluation (PCB 118) Time Report Requested: 13:39:56
Route: GAVAGE CAS Number: 31508-00-6 First Dose M/F: NA / 03/26/04
Species/Strain: RATS/SD Lab: BAT
DAY ON TEST0216
0216
0216
0216
0216
0216
0216
0216
0216
0216
.................................................................................................................................................................
SPRAGUE-DAWLEY RATSFEMALE
ANIMAL ID1000 UG/KG
00621
00622
00623
00624
00625
00631
00632
00633
00634
00635 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 21
NERVOUS SYSTEMNONE
RESPIRATORY SYSTEM.........................................................................................................................................................................................................
Lung + + + + + + + + + + 10Alveolar Epithelium, Hyperplasia 1 1 1.0Alveolus, Infiltration Cellular, Histiocyte 1 1 1.0
SPECIAL SENSES SYSTEMNONE
URINARY SYSTEMNONE
TDMS No. 20304 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2008
Test Type: CHRONIC TEF evaluation (PCB 118) Time Report Requested: 13:39:56
Route: GAVAGE CAS Number: 31508-00-6 First Dose M/F: NA / 03/26/04
Species/Strain: RATS/SD Lab: BAT
DAY ON TEST0216
0216
0216
0216
0216
0216
0216
0216
0216
0216
.................................................................................................................................................................
SPRAGUE-DAWLEY RATSFEMALE
ANIMAL ID1000 UG/KG
00621
00622
00623
00624
00625
00631
00632
00633
00634
00635 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 22
ALIMENTARY SYSTEM.........................................................................................................................................................................................................
Liver + + + + + + + + + + 10Cholangiofibrosis 2 1 2.0Fatty Change, Diffuse 3 3 3 3 2 3 3 2 3 3 10 2.8Inflammation 2 2 3 2 2 2 2 2 2 2 10 2.1Mixed Cell Focus X 1Pigmentation 1 1 2 2 2 2 2 1 1 2 10 1.6Toxic Hepatopathy 1 1 1 1 1 1 1 1 1 1 10 1.0Bile Duct, Hyperplasia 1 1 2 1.0Hepatocyte, Hypertrophy 3 3 3 3 3 3 3 3 3 3 10 3.0Hepatocyte, Multinucleated 1 1 1 1 1 1 2 1 1 1 10 1.1Oval Cell, Hyperplasia 1 1 1 1 1 2 1 1 1 9 1.1
.........................................................................................................................................................................................................
Pancreas + + + + + + + + + + 10Acinus, Atrophy, Focal 1 1 1.0Acinus, Vacuolization Cytoplasmic 2 1 1 1 1 1 6 1.2
.........................................................................................................................................................................................................
Stomach, Forestomach + + + + + + + + + + 10Edema 1 1 1.0Inflammation 1 2 2 1.5
.........................................................................................................................................................................................................
Stomach, Glandular + + + + + + + + + + 10
CARDIOVASCULAR SYSTEM.........................................................................................................................................................................................................
Blood Vessel + 1
TDMS No. 20304 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2008
Test Type: CHRONIC TEF evaluation (PCB 118) Time Report Requested: 13:39:56
Route: GAVAGE CAS Number: 31508-00-6 First Dose M/F: NA / 03/26/04
Species/Strain: RATS/SD Lab: BAT
DAY ON TEST0216
0216
0216
0216
0216
0216
0216
0216
0216
0216
.................................................................................................................................................................
SPRAGUE-DAWLEY RATSFEMALE
ANIMAL ID4600 UG/KG
00736
00737
00738
00739
00740
00761
00762
00763
00764
00765 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 23
ENDOCRINE SYSTEM.........................................................................................................................................................................................................
Adrenal Cortex + + + + + + + + + + 10Atrophy 2 1 2.0Degeneration, Cystic 1 1 1.0Hypertrophy 2 1 2 1.5
.........................................................................................................................................................................................................
Adrenal Medulla + + + + + + + + + + 10.........................................................................................................................................................................................................
Pituitary Gland + + + + + + + + + + 10.........................................................................................................................................................................................................
Thyroid Gland + + + + + + + + + + 10Follicular Cell, Hypertrophy 3 1 2 2 1 1 3 1 8 1.8
GENERAL BODY SYSTEMNONE
GENITAL SYSTEM.........................................................................................................................................................................................................
Ovary + + + + + + + + + + 10.........................................................................................................................................................................................................
Uterus + + + + + + + + + + 10Dilatation 4 1 4.0
.........................................................................................................................................................................................................
TDMS No. 20304 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2008
Test Type: CHRONIC TEF evaluation (PCB 118) Time Report Requested: 13:39:56
Route: GAVAGE CAS Number: 31508-00-6 First Dose M/F: NA / 03/26/04
Species/Strain: RATS/SD Lab: BAT
DAY ON TEST0216
0216
0216
0216
0216
0216
0216
0216
0216
0216
.................................................................................................................................................................
SPRAGUE-DAWLEY RATSFEMALE
ANIMAL ID4600 UG/KG
00736
00737
00738
00739
00740
00761
00762
00763
00764
00765 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 24
Vagina + + + + + + + + + + 10
HEMATOPOIETIC SYSTEM.........................................................................................................................................................................................................
Spleen + + + + + + + + + + 10Pigmentation 1 1 1 1 1 2 2 1 1 1 10 1.2
.........................................................................................................................................................................................................
Thymus + + + + + + + + + + 10Atrophy 2 2 2 2.0
INTEGUMENTARY SYSTEM.........................................................................................................................................................................................................
Mammary Gland + + + + + + + + + + 10
MUSCULOSKELETAL SYSTEMNONE
NERVOUS SYSTEMNONE
RESPIRATORY SYSTEM.........................................................................................................................................................................................................
Lung + + + + + + + + + + 10Hemorrhage 1 1 2 1.0Alveolus, Infiltration Cellular, Histiocyte 1 1 1 3 1.0
TDMS No. 20304 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2008
Test Type: CHRONIC TEF evaluation (PCB 118) Time Report Requested: 13:39:56
Route: GAVAGE CAS Number: 31508-00-6 First Dose M/F: NA / 03/26/04
Species/Strain: RATS/SD Lab: BAT
DAY ON TEST0216
0216
0216
0216
0216
0216
0216
0216
0216
0216
.................................................................................................................................................................
SPRAGUE-DAWLEY RATSFEMALE
ANIMAL ID4600 UG/KG
00736
00737
00738
00739
00740
00761
00762
00763
00764
00765 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 25
SPECIAL SENSES SYSTEMNONE
URINARY SYSTEMNONE
*** END OF REPORT ***
TDMS No. 20304 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2008
Test Type: CHRONIC TEF evaluation (PCB 118) Time Report Requested: 13:39:56
Route: GAVAGE CAS Number: 31508-00-6 First Dose M/F: NA / 03/26/04
Species/Strain: RATS/SD Lab: BAT
DAY ON TEST0216
0216
0216
0216
0216
0216
0216
0216
0216
0216
.................................................................................................................................................................
SPRAGUE-DAWLEY RATSFEMALE
ANIMAL ID4600 UG/KG
00736
00737
00738
00739
00740
00761
00762
00763
00764
00765 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 26
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