Ovarian cancer 7 L A V I 60% - AstraZeneca · for ge ntic s 3 BRCA1 and BRCA2 belong to a type of...

with aBRCA2 mutation

11-17%of women

Up to

References:1 Cancer Research UK: Risk Factors for Ovarian Cancer. Available at: http://www.cancerresearchuk.org/cancer-info/cancerstats/types/ovary/riskfactors/ Last accessed: March 20172 SEER Cancer Factsheets: Ovary cancer. SEER 18 2003-2009. Available at: http://seer.cancer.gov/statfacts/html/ovary.html Last accessed: March 20173 Gadzicki D, et al. Genetic testing for familial/hereditary breast cancer—comparison of guidelines and recommendations from the UK, France, the Netherlands and Germany. J Community Genet. 2011;2:53-69.4 National Cancer Institute. BRCA1 and BRCA2: Cancer Risk and Genetic Testing. http://www.cancer.gov/cancertopics/factsheet/Risk/BRCA Last accessed: March 20175 Cancer Genome Atlas Network. Integrated genomic analyses of ovarian carcinoma. Nature. 2011;474:609-15.6 World Cancer Research Fund. Ovarian cancer statistics. Available from: http://www.wcrf.org/int/cancer-facts-figures/data-specific-cancers/ovarian-cancer-statistics Last accessed; March 2017

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Ovarian cancer is the 7th most commonly diagnosed cancer in women worldwide 6

Several factors may influence the development and prognosis of ovarian cancer, including 1,2:

of ovarian cancers are diagnosed at the advanced stage 2

Familyhistory

92%

73%

28%

Stage I

StageII/III

StageIV

5-YE

AR S

URV

IVAL

5-year survival

decreases significantly

with stage of diagnosis2

Lifestylefactors

Environmental factors

Age Earlydiagnosis

OVARIAN CANCER AND GENETIC TESTINGGenetic mutations can play a role in the development and treatment of cancerIndividuals at risk of carrying a genetic mutation can be referred for genetic testing3

BRCA1 and BRCA2 belong to a type of genes

known as tumour suppressors 4

The risk of developing ovarian cancer is increased in women with specific inherited genetic abnormalities. One of these risks is associated with BRCA mutations5

will develop ovarian cancer

by age 70 years

4

in the generalpopulation

About 1.3% of women

with aBRCA1 m ationut

Up to 39% of women

60% Up to

of women who inherit a BRCA1

mutation are likely to develop ovarian

cancer

4

Up to

of women who inherit a BRCA2

mutation are likely to develop ovarian

cancer

39%

11 - 17%

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