Membrane Membrane receptors. Single-pass membrane receptors membrane

membrane

Membrane receptors

Single-pass membrane receptors

membrane

membrane

Multi-pass membrane receptors

Ion channel membrane receptors

membranemembrane

+

+

Ion channel membrane receptors

Receptor kinases

Kinase activities associated with receptors

intrinsic tyrosine kinase activity

JAK tyrosine kinase activity

G-protein-linked receptors

GTP

hormone

membrane

G-protein-linked receptors

GDP

G-protein-linked receptors

adapter

adenylate adenylate cyclasecyclase

Insulin activation of glucose response

IRS-1

PP P P

PP

GLUT

GLUT

Follicle Stimulating Hormone & Receptor

FSH subunit mRNAs

Huhtaniemi and Aittomaki (1998) Eur.J.Endo. 138: 473– 481

FSH subunit polypeptides

Huhtaniemi and Aittomaki (1998) Eur.J.Endo. 138: 473– 481

FSH

Fox, et al. Mol Endocrinol (2001) 15:378-389

FSH Receptor

Huhtaniemi and Aittomaki (1998) Eur.J.Endo. 138: 473– 481

mRNA

FSH Receptor

Huhtaniemi and Aittomaki (1998) Eur.J.Endo. 138: 473– 481

FSH Receptor

(C, cysteine; S, serine; K, lysine; R, arginine; N, asparagine; A, alanine; D, aspartic acid; F, phenylalanine).

Mann, et al. (2000) Biol. Reprod. 62: 1240-1247

FSH Receptor

Mann, et al. (2000) Biol. Reprod. 62: 1240-1247

FSH Receptor

Sohn, et al. (2003) J. Biol. Chem. 278: 47868 –47876

FSH Receptor

Sohn, et al. (2003) J. Biol. Chem. 278: 47868 –47876

FSH Receptor

Gay et al. (2006) Nature Reviews Immunology 6: 693-698

Natural mutations of FSH & Receptor

Huhtaniemi and Aittomaki (1998) Eur.J.Endo. 138: 473– 481