Mehdi AbdollahiDeema Annyuk Jeff ChenConnor Gillan Graham LavertyTony Tsai Members: Lumen Medical...

Mehdi Abdollahi Deema AnnyukJeff Chen Connor GillanGraham Laverty Tony Tsai

Members:

Lumen Medical Technologies Inc.Lumen Medical Technologies Inc.Team Presentation

Non-Invasive Glucose Measuring Device

Lumen Medical Technologies Inc.

Introduction

Vision

System Description

Test Results

Problems Encountered

Project Finances

Production Cost

Conclusion

Questions?

Introduction:

• In British Columbia, approximately 248,000 people are known to be living with diabetes.

• The number is expected to increase to 305,000 by 2010. • In 2004, diabetes cost B.C.’s health care system $760 million,

which is more than $2 million a day.

• The complications of diabetes include heart disease and stroke, kidney disease, amputation and blindness. (There are more than 1,000 amputations each year in B.C. )

Estimated Direct Costs of Treating Diabetes in British Columbia, Canadian Diabetes Association [1]

Introduction:

A June 2005 online survey of Canadian Diabetes Association members revealed:[1]

– Over one in two Association members with diabetes (52%) reported that they pay personally for diabetes medications and supplies.

– Almost one in two (46%) of Association members reported paying out-of-pocket expenses between $50 and $200 per month; one in four (25%) spent less than $50 a month.

– Almost one in four (24%) of Association members reported there were diabetes drugs, supplies or devices that their doctor recommended, but that they could not afford to purchase and could not access through their insurance plan.

– Those under age 40 with type 1 diabetes were more likely to be unable to afford medications and supplies recommended by their doctors.

Introduction:

• The current devices require blood samples.– Painful– Inconvenient – Messy– Risk of infection, other implications– Must buy test strips (very costly – approximate $1 each)

Solution? A non-invasive device

Vision:

At Lumen Medical Technologies, we believe in using innovative solutions to build a device that can measure a patient’s blood sugar level without the need for any blood samples. This device can detect blood glucose concentration on skin contact.

Radio Frequency Spectroscopy:

• A source of electromagnetic signals - preferably a high frequency pulse train that is rich in harmonics that generates a comb spectra is coupled via a probe pair to a sample that contains the target chemical.

• The spectra of the original signal is then compared with the spectra of the signal that passed through the solution.

• The signal that travels through the solution can have spectra with different energy levels than were present in the source signal. For example, some harmonic frequencies of the transmitted source signal may be returned attenuated or even amplified, probably due to certain non-linear dielectric processes occurring within the sample.

System Description:

Oscillator

BP filter

Amplifier

Amplifier

Phase/Gain comparator

Transmitter

Receiver

LCD Display

ADC/LCD Driver

Amplifier

BP filter

System Description:

• Digital vs. Analog

– Why we chose analog:• Gain experience on analog design• Contain the size of the project• Cost

Oscillator:ECS Inc. - ECS100AC

The fundamental frequency is 10MHz. The oscillator is designed with 2nd overtone, 3rd harmonic.

Oscillator:

Possible Solutions for the overshoot problem in the square wave

• Schmitt Trigger• Improper loading will

cause the overshoot. We

need the probe

capacitance way below

15pF, however, the

minimum probe capacitance we have is 16pF.

System Description:

Oscillator

BP filter

Amplifier

Amplifier

Phase/Gain comparator

Transmitter

Receiver

LCD Display

ADC/LCD Driver

Amplifier

BP filter

Band-pass Filter:

• Centre Freq = 30 MHz• Bandwidth = 500kHz• Pass Band Ripple = 1dB

Band-pass Filter:• Expected Response

Band-pass Filter:• Actual Response

30MHz

1 dB

System Description:

Oscillator

BP filter

Amplifier

Amplifier

Phase/Gain comparator

Transmitter

Receiver

LCD Display

ADC/LCD Driver

Amplifier

BP filter

Amplifier:

• Gain=3

System Description:

Oscillator

BP filter

Amplifier

Amplifier

Phase/Gain comparator

Transmitter

Receiver

LCD Display

ADC/LCD Driver

Amplifier

BP filter

Phase/Gain Comparator:

Ideal Transfer Characteristics

Ideal Transfer Characteristics

System Description:

Oscillator

BP filter

Amplifier

Amplifier

Phase/Gain comparator

Transmitter

Receiver

LCD Display

ADC/LCD Driver

Amplifier

BP filter

LCD Driver/Display:

• 0-2V input range• Low power consumption (500uA at 9V)• Low battery indicator built in

Test Solutions:

• Human blood has 4-10mmol/L of glucose

• Samples from 0 (Control) to 4, 6, 8, 10, High

• Chem stores: dilute, dilute, dilute• Less than 1 mL per 50mL – had to

get special small 1mL pipet• Very thorough mixing

Test Results:

• Non Linear (can use stock solutions for calibration)

• Promising

Problems Encountered:

• Wasted funds

• Timing issues

• Noise/Interference

Finances:

• Total funding: $400

• Costs: $387.41

• Balance: $12.59

Production Cost:

• Screen/LCD Driver: $10

• Gain Detection Unit: $30

• Signal Generator: $2

• Misc components: $5

– Cost (non bulk): $47

Conclusion:

• Inconclusive results

• Require additional development and testing

• Emerging market with no major players– Still time for development

References:• [1] Canadian Diabetes Association, Diabetes Report, 2005.

[online]. Available: http://www.diabetes.ca/section_advocacy/index.asp

[accessed: April 16, 2006]

http://www.freepatentsonline.com/5508203.html

Q&A:

Thank you!Thank you!Thank you!