link.springer.com3A978-3-540-29805-2%2F… · Preface As all medical studentsknow,pain is the most...

Encyclopedia of Pain

Volume 1

With 713 Figures and 211 Tables

Professor em. Dr. Robert F. SchmidtPhysiological InstituteUniversity of WürzburgRöntgenring 997070 WürzburgGermanyrfs@mail.uni-wuerzburg.de

Professor Dr. William D. WillisDepartment of Neuroscience and Cell BiologyUniversity of Texas Medical Branch301 University BoulevardGalvestonTX 77555-1069USAwdwillis@utmb.edu

ISBN-13: 978-3-540-43957-8 Springer Berlin Heidelberg New York

This publication is available also as:Electronic publication under 978-3-540-29805-2 andPrint and electronic bundle under ISBN 978-3-540-33447-7Library of Congress Control Number: 2006925866

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Preface

As all medical students know, pain is the most common reason for a person to consult a physician. Under ordinarycircumstances, acutepain hasauseful,protectivefunction. Itdiscourages the individual fromactivities thataggravatethe pain, allowing faster recovery from tissue damage. The physician can often tell from the nature of the pain whatits source is. In most cases, treatment of the underlying condition resolves the pain. By contrast, children born withcongenital insensitivity to pain suffer repeated physical damage and die young (see Sweet WH (1981) Pain 10:275).

Pain resulting from difficult to treat or untreatable conditions can become persistent. Chronic pain “never has abiologic function but is a malefic force that often imposes severe emotional, physical, economic, and social stresseson the patient and on the family. . . ” (Bonica JJ (1990) The Management of Pain, vol 1, 2nd edn. Lea & Febiger,Philadelphia, p 19). Chronic pain can be considered a disease in its own right.

Pain is a complex phenomenon. It has been defined by the Taxonomy Committee of the International Associationfor the Study of Pain as “An unpleasant sensory and emotional experience associated with actual or potential tissuedamage, or described in terms of such damage” (Merskey H and Bogduk N (1994) Classification of Chronic Pain,2nd edn. IASP Press, Seattle). It is often ongoing, but in some cases it may be evoked by stimuli. Hyperalgesia occurswhen there is an increase in pain intensity in response to stimuli that are normally painful. Allodynia is pain thatis evoked by stimuli that are normally non-painful.

Acute pain is generally attributable to the activation of primary afferent neurons called nociceptors (SherringtonCS (1906) The Integrative Action of the Nervous System. Yale University Press, New Haven; 2nd edn, 1947). Thesesensory nerve fibers have high thresholds and respond to strong stimuli that threaten or cause injury to tissues of thebody. Chronic pain may result from continuous or repeated activation of nociceptors, as in some forms of canceror in chronic inflammatory states, such as arthritis.

However, chronic pain can also be produced by damage to nervous tissue. If peripheral nerves are injured, peripheralneuropathicpainmaydevelop.Damagetocertainpartsof thecentralnervoussystemmayresult incentralneuropathicpain. Examples of conditions that can cause central neuropathic pain include spinal cord injury, cerebrovascularaccidents, and multiple sclerosis.

Research on pain in humans has been an importantclinical topic for many years.Basic science studies were relativelyfew in number until experimental work on pain accelerated following detailed descriptions of peripheral nocicep-tors and central nociceptive neurons that were made in the 1960’s and 70’s, by the discovery of the endogenousopioid compounds and the descending pain control systems in the 1970’s and the application of modern imagingtechniques to visualize areas of the brain that are affected by pain in the 1990’s. Accompanying these advances hasbeen the development of a number of animal models of human pain states, with the goal of using these to examinepain mechanisms and also to test analgesic drugs or non-pharmacologic interventions that might prove useful forthe treatment of pain in humans. Basic research on pain now emphasizes multidisciplinary approaches, includingbehavioral testing, electrophysiology and the application of many of the techniques of modern cell and molecularbiology, including the use of transgenic animals.

The “Encyclopedia of Pain” is meant to provide a source of information that spans contemporary basic and clinicalresearch on pain and pain therapy. It should be useful not only to researchers in these fields but also to practicingphysiciansandotherhealthcareprofessionalsandtohealthcareeducatorsandadministrators.Theworkissubdividedinto 35 Fields, and the Field Editor of each of these describes the areas covered in the Fields in a brief review chapter.The topics included in a Field are the subject of a series of short essays, accompanied by key words, definitions,

VI Preface

illustrations, and a list of significant references. The number of authors who have contributed to the encyclopediaexceeds 550. The plan of the publisher, Springer-Verlag, is to produce both print and electronic versions of thisencyclopedia. Numerous links within the electronic version should make comprehensive searches easy to manage.The electronic version will be updated at sufficiently short intervals to ensure that the content remains current.

The editors thank the staff at Springer-Verlag who have provided oversight for this project, including Rolf Lange,Thomas Mager, Claudia Lange, Natasja Sheriff, and Michaela Bilic. Working with these outstanding individualshas been a pleasure.

July 2006

ROBERT F. SCHMIDT WILLIAM D. WILLIS

Würzburg, Germany Galveston, Texas, USA

Editors-in-Chief

ROBERT R. SCHMIDT

Physiological InstituteUniversity of WürzburgWürzburgGermanyrfs@mail.uni-wuerzburg.de

WILLIAM D. WILLIS

Department of Neuroscience and Cell BiologyUniversity of Texas Medical BranchGalveston, TXUSAwdwillis@utmb.edu

Field Editors

A. VANIA APKARIAN

Department of PhysiologyNorthwestern University Feinberg School of MedicineChicago, ILUSAa-apkarian@northwestern.edu

LARS ARENDT-NIELSEN

Laboratory for Experimental Pain ResearchCenter for Sensory-Motor InteractionAalborg UniversityAalborgDenmarklan@hst.aau.dk

CARLOS BELMONTE

Instituto de Neurociencias de AlicanteUniversidad Miguel Hernández-CSICSan Juan de AlicanteSpaincarlos.belmonte@umh.es

PHILLIP BERRYHILL

PMG Cedar NeurosurgeryAlbuquerque, NMUSAphillip.berryhill@mac.com

NIELS BIRBAUMER

Institute of Medical Psychology and BehavioralNeurobiologyUniversity of TübingenTübingenGermanyniels.birbaumer@uni-tuebingen.de

NIKOLAI BOGDUK

Department of Clinical ResearchRoyal Newcastle Hospital NewcastleUniversity of NewcastleNewcastle, NSWAustraliamichelle.gillam@newcastle.edu.au

SIR MICHAEL R. BOND

University of GlasgowGlasgowUKm.bond@admin.gla.ac.uk

KIM J. BURCHIEL

Department of Neurological SurgeryThe Oregon Health Sciences UniversityPortland, ORUSAburchiek@ohsu.edu

KENNETH L. CASEY

Department of Neurology andDepartment of Molecular and Integrative PhysiologyUniversity of MichiganandConsultant in NeurologyVeterans Administration Medical CenterAnn Arbor, MIUSAkencasey@umich.edu

JIN MO CHUNG

Department of Neuroscience and Cell BiologyUniversity of Texas Medical BranchGalveston, TXUSAjmchung@utmb.edu

MICHAEL J. COUSINS

Department of Anesthesia and Pain ManagementRoyal North Shore HospitalUniversity of SydneySt. Leonards, NSWAustraliamcousins@nsccahs.health.nsw.gov.au

MARSHALL DEVOR

Department of Cell and Animal BiologyInstitute of Life Sciences andCenter for Research on PainHebrew University of JerusalemJerusalemIsraelmarshlu@vms.huji.ac.il

X Field Editors

HANS-CHRISTOPH DIENER

Deptartment of NeurologyUniversity of Duisburg-EssenEssenGermanyh.diener@uni-essen.de

JONATHAN O. DOSTROVSKY

Department of PhysiologyFaculty of MedicineUniversity of TorontoToronto, ONCanadaj.dostrovsky@utoronto.ca

RONALD DUBNER

Department of Biomedical SciencesUniversity of MarylandBaltimore, MDUSArdubner@umaryland.edu

HERTA FLOR

Department of Neuropsychology at theUniversity of HeidelbergCentral Institute of Mental HealthMannheimGermanyflor@zi-mannheim.de

GERALD F. GEBHART

Department of PharmacologyUniversity of IowaIowa City, IAUSAgf-gebhart@uiowa.edu

GERD GEISSLINGER

Institute for Clinical Pharmacologypharmazentrum frankfurt/ZAFESClinical Centre of the Johann Wolfgang GoetheUniversity Frankfurt am MainFrankfurtGermanygeisslinger@em.uni-frankfurt.de

GLENN J. GIESLER JR.Department of NeuroscienceUniversity of MinnesotaMinneapolis, MNUSAgiesler@mail.ahc.umn.edu

PETER J. GOADSBY

Institute of NeurologyThe National Hospital for Neurology andNeurosurgeryLondonUKpeterg@ion.ucl.ac.uk

HERMANN O. HANDWERKER

Department of Physiology and PathophysiologyUniversity of Erlangen/NürnbergErlangenGermanyhandwerker@physiologie1.uni-erlangen.de

WILFRID JÄNIG

Physiology InstituteChristian Albrechts University KielKielGermanyw.janig@physiologie.uni-kiel.de

MARTIN KOLTZENBURG

Institute of Child Health and Institute of NeurologyUniversity College LondonLondonUKm.koltzenburg@ich.ucl.ac.uk

FRED A. LENZ

Departments of NeurosurgeryJohns Hopkins UniversityBaltimore, MDUSAflenz1@jhmi.edu

ROSS MACPHERSON

Department of Anesthesia and Pain ManagementRoyal North Shore HospitalUniversity of SydneySt. Leonards, NSWAustraliarmacpher@nsccahs.health.nsw.gov.au

PATRICIA A. MCGRATH

Department of AnaesthesiaDivisional Centre of Pain Management and ResearchThe Hospital for Sick ChildrenandBrain and Behavior ProgramResearch Institute at The Hospital for Sick ChildrenandDepartment of AnaesthesiaUniversity of TorontoToronto, ONCanada

FRANK PORRECA

Departments of Pharmacology and AnesthesiologyUniversity of ArizonaHealth Sciences CenterTucson, AZUSAfrankp@u.arizona.edu

Field Editors XI

RUSSELL K. PORTENOY

Department of Pain Medicine and Palliative CareBeth Israel Medical CenterNew York, NYUSArportenoy@chpnet.org

JAMES P. ROBINSON

Department of AnesthesiologyUniversity of Washington School of MedicineSeattle, WAUSAjimrob@u.washington.edu

HANS-GEORG SCHAIBLE

Department of PhysiologyUniversity of JenaJenaGermanyhans-georg.schaible@mti.uni-jena.de

BARRY J. SESSLE

Department of PhysiologyFaculty of MedicineandFaculty of DentistryUniversity of TorontoToronto, ONCanadabarry.sessle@utoronto.ca

BENGT H. SJÖLUND

Rehabilitation and Research Centre for TortureVictimsSouth Danish UniversityCopenhagenDenmarkbsj@rct.dk

DENNIS C. TURK

Department of AnesthesiologyUniversity of Washington School of MedicineSeattle, WAUSAturkdc@u.washington.edu

URSULA WESSELMANN

Departments of NeurologyNeurological Surgery and Biomedical EngineeringThe Johns Hopkins University School of MedicineBaltimore, MDUSApain@jhmi.edu

GEORGE L. WILCOX

Department of NeurosciencePharmacology and DermatologyUniversity of Minnesota Medical SchoolMinneapolis, MNUSAgeorge@umn.edu

ROBERT P. YEZIERSKI

Department of OrthodonticsComprehensive Center for Pain Research andThe McKnight Brain InstituteUniversity of FloridaGainesville, FLUSAryezierski@dental.ufl.edu

List of Contributors

TIPU AAMIR

The Auckland Regional Pain ServiceAuckland HospitalAucklandNew Zealandbobl@adhb.govt.nz

CATHERINE ABBADIE

Department of PharmacologyMerck Research LaboratoriesRahway, NJUSAcatherine_abbadie@merck.com

FRANCES V. ABBOTT

Department of Psychiatry and PsychologyMcGill UniversityMontreal, QCCanada

HEATHER ADAMS

Department of PsychologyUniversity of MontrealMontreal, QCCanadaheather.adams@umontreal.ca

ROLF H. ADLER

Prof. em. MedicineKehrsatzSwitzerland

CLAIRE D. ADVOKAT

Department of PsychologyLouisiana State UniversityBaton Rouge, LAUSAcadvoka@lsu.edu

SHEFALI AGARWAL

Department of Anesthesiology and Critical CareMedicineThe Johns Hopkins University School of MedicineBaltimore, MDUSA

RETO M. AGOSTI

Headache Center HirlsandenZürichSwitzerlandreto.agosti@kopfwww.ch

HUGO VAN AKEN

Clinic and Policlinic for Anaesthesiology andoperative Intensive MedicineUniversity Hospital MünsterMünsterGermany

ELIE D. AL-CHAER

Neurobiology and Developmental SciencesCollege of MedicineUniversity of Arkansas for Medical SciencesCenter for Pain ResearchPediatricsLittle Rock, ARUSAealchaer@uams.edu

MARIE-CLAIRE ALBANESE

Department of PsychologyMcGill UniversityMontreal, QCCanadamclaire@bic.mni.mcgill.ca

KATHRYN M. ALBERS

Department of MedicineUniversity of Pittsburgh School of MedicinePittsburgh, PAUSAkaa2@pitt.edu

TERRY ALTILIO

Department of Pain Medicine and Palliative CareBeth Israel Medical CenterNew York, NYUSAtaltilio@chpnet.org

XIV List of Contributors

RAINER AMANN

Medical University GrazGrazAustriarainer.amann@meduni-graz.at

RON AMIR

Institute of Life Sciences andCenter for Research on PainHebrew University of JerusalemJerusalemIsraelronamir@pob.huji.ac.il

PRAVEEN ANAND

Peripheral Neuropathy UnitImperial College LondonHammersmith HospitalLondonUKp.anand@imperial.ac.uk

OLE K. ANDERSEN

Department of Health Science & TechnologyCenter for Sensory-Motor InteractionAalborg UniversityAalborgDenmarkoka@hst.aau.dk

STAN ANDERSON

Departments of NeurosurgeryJohns Hopkins UniversityBaltimore, MDUSA

WILLIAM S. ANDERSON

Department of Neurological SurgeryJohns Hopkins HospitalBaltimore, MDUSAwanderso@jhmi.edu

KARL-ERIK ANDERSSON

Departments of Clinical PharmacologyAnesthesiology and Intensive CareLund University HospitalLundSweden

FRANK ANDRASIK

University of West FloridaPensacola, FLUSAfandrasik@uwf.edu

A. VANIA APKARIAN

Department of PhysiologyFeinberg School of MedicineNorthwestern UniversityChicago, ILUSAa-apkarian@northwestern.edu

LARS ARENDT-NIELSEN

Laboratory for Experimental Pain ResearchCenter for Sensory-Motor InteractionAalborg UniversityAalborgDenmarklan@hst.aau.dk

KIRSTEN ARNDT

CNS PharmacologyPain ResearchBoehringer Ingelheim Pharma GmbH & Co. KGBiberach/RissGermanykirsten.arndt@bc.boehringer-ingelheim.de

ERIK ASKENASY

Health Science Center at HoustonNeurobiology and AnatomyUniversity of TexasHouston, TXUSA

CHRISTOPH AUFENBERG

Functional NeurosurgeryNeurosurgical ClinicUniversity HospitalZürichSwitzerland

BEATE AVERBECK

Sanofi–Aventis Deutschland GmbHFrankfurtGermanybeate.averbeck@sanofi-aventis.com

QASIM AZIZ

Section of GI SciencesHope HospitalUniversity of ManchesterSalfordUK

F. W. BACH

Danish Pain Research Center andDepartment of NeurologyAarhus University HospitalAarhusDenmark

List of Contributors XV

S. K. BACK

Medical Science Research Center and Department ofPhysiologyKorea University College of MedicineSeoulKorea

MISHA-MIROSLAV BACKONJA

Department of NeurologyUniversity of Wisconsin-MadisonMadison, WIUSAbackonja@neurology.wisc.edu

CARSTEN BANTEL

Magill Department of AnaestheticsChelsea and Westminster CampusImperial College of ScienceTechnology and MedicineLondonUKc.bantel@imperial.ac.uk

ALEX BARLING

Department of NeurologyBirmingham Muscle and Nerve CentreQueen Elizabeth HospitalBirminghamUKcorisanderoad@aol.com

RALF BARON

Department of Neurological Pain Research andTherapyDepartment of NeurologyChristian Albrechts University KielKielGermanyr.baron@neurologie.uni-kiel.de

GORDON A. BARR

Department of PsychologyHunter CollegeGraduate CenterCity University of New YorkandDepartment of Developmental PsychobiologyNew York State Psychiatric InstituteDepartment of PsychiatryMedical CenterColumbia UniversityNew York, NYUSAgbarr@hunter.cuny.edu

JEFFREY R. BASFORD

Department of Physical Medicine and RehabilitationMayo Clinic and Mayo FoundationRochester, MNUSAbasford.jeffrey@mayo.edu

HEINZ-DIETER BASLER

Institute of Medical PsychologyUniversity of MarburgMarburgGermanybasler@med.uni-marburg.de

MICHELE C. BATTIÉ

Department of Physical TherapyUniversity of AlbertaEdmonton, ABCanadamichele.critesbattie@ualberta.ca

ULF BAUMGÄRTNER

Institute of Physiology and PathophysiologyJohannes Gutenberg UniversityMainzGermany

JOLENE D. BEAN-LIJEWSKI

Department of AnesthesiologyScott and White Memorial HospitalTemple, TXUSAjbean-lijewski@swmail.sw.org

ALAIN BEAUDET

Montreal Neurological InstituteMcGill UniversityMontreal, QCCanadaabeaudet@frsq.gouv.gc.ca

LINO BECERRA

Brain Imaging CenterMcLean Hospital-Harvard Medical SchoolBelmont, MAUSAlbecerra@mclean.harvard.edu

YAAKOV BEILIN

Department of Anesthesiology and ObstetricsGynecology and Reproductive SciencesMount Sinai School of MedicineNew York, NYUSAyaakov.beilin@mountsinai.org

XVI List of Contributors

ALVIN J. BEITZ

Department of Veterinary and Biomedical SciencesUniversity of MinnesotaSt. Paul, MNUSAbeitz001@tc.umn.edu

MILES J. BELGRADE

Fairview Pain & Palliative CareUniversity of Minnesota Medical CenterandDepartment of NeurologyUniversity of Minnesota Medical SchoolMinneapolis, MNUSAmbelgra1@fairview.org

CARLO VALERIO BELLIENI

Neonatal Intensive Care UnitUniversity HospitalSienaItalybellieni@iol.it

CARLOS BELMONTE

Instituto de Neurociencias de AlicanteUniversidad Miguel Hernández-CSICSan Juan de AlicanteSpaincarlos.belmonte@umh.es

ALLAN J. BELZBERG

Department of NeurosurgeryJohns Hopkins School of MedicineBaltimore, MDUSAabelzber@jhmi.edu

FABRIZIO BENEDETTI

Department of NeuroscienceClinical and Applied Physiology ProgramUniversity of Turin Medical SchoolTurinItalyfabrizio.benedetti@unito.it

ROBERT BENNETT

Department of MedicineOregon Health and Science UniversityPortland, ORUSAbennetrob1@comcast.net

DAVID BENNETT

Department of NeurologyKing’s College HospitalLondonUKdlhbennett@talk21.com

MAURICE F. BENSIGNOR

Centre Catherine de SienneRezeFrancedr.ben@wanadoo.fr

EDWARD BENZEL

The Cleveland Clinic FoundationDepartment of NeurosurgeryCleveland Clinic Spine InstituteCleveland, OHUSAbenzele@ccf.org

DAVID A. BEREITER

Department of SurgeryBrown Medical SchoolProvidence, RIUSAdavid_bereiter@brown.edu

ELMAR BERENDES

Clinic and Policlinic for Anaesthesiology andoperative Intensive MedicineUniversity Hospital MünsterMünsterGermanyberendes@klinikum-krefeld.de

KAREN J. BERKLEY

Program in NeuroscienceFlorida State UniversityTallahassee, FLUSAkberkley@darwin.psy.fsu.edu

PETER BERLIT

Department of NeurologyAlfried Krupp HospitalEssenGermanypeter.berlit@krupp-krankenhaus.de

JEAN-FRANÇOIS BERNARD

Faculté de Médecine Pitié-SalpêtrièreInstitut National de la Santé et de la RechercheMédicaleINSERM U-677ParisFrancejfbernar@ext.jussieu.fr

ANNE KJØRSVIK BERTELSEN

Department of NeurologyHaukeland University HospitalBergenNorwayanne.kjorsvik@biomed.uib.no

List of Contributors XVII

MARCELO E. BIGAL

Department of NeurologyAlbert Einstein College of MedicineBronx, NYandThe New England Center for HeadacheStamford, CTandMontefiore Headache Unit,Bronx, NYUSA

YITZCHAK M. BINIK

McGill UniversityMontreal, QCCanadabinik@ego.psych.mcgill.ca

NIELS BIRBAUMER

Institute of Medical Psychology and BehavioralNeurobiologyUniversity of TübingenTübingenGermanyniels.birbaumer@uni-tuebingen.de

FRANK BIRKLEIN

Department of NeurologyUniversity of MainzMainzGermanybirklein@neurologie.klinik.uni-mainz.de

THOMAS BISHOP

Centre for NeuroscienceKing’s College LondonLondonUKthomas.bishop@kcl.ac.uk

HENNING BLIDDAL

The Parker InstituteFrederiksberg HospitalCopenhagenDenmarkhb@fh.hosp.dk

RONALD H. BLUM

Beth Israel Medical CenterNew York, NYUSArblum@bethisraelny.org

JAMES A. BLUNK

Clinic for AnaesthesiologyUniversity of ErlangenErlangenGermanyblunk@physiologie1.uni-erlangen.de

NIKOLAI BOGDUK

Department of Clinical ResearchRoyal Newcastle HospitalNewcastle, NSWAustraliamichelle.gillam@newcastle.edu.au

JÖRGEN BOIVIE

Department of NeurologyUniversity HospitalLinköpingSwedenjorgen.boivie@lio.se

SIR MICHAEL R. BOND

University of GlasgowGlasgowUKm.bond@admin.gla.ac.uk

RICHARD L. BOORTZ-MARX

Department of NeurosciencesGundersen Lutheran Health Care SystemLa Crosse, WIUSArlboortz@gundluth.org

JAMES M. BOROWCZYK

Department of Orthopaedics and MusculoskeletalMedicineChristchurch Public HospitalChristchurch Clinical School of Medicine and HealthSciencesChristchurchNew Zealandjmbor@clear.net.nz

DAVID BORSOOK

Brain Imaging CenterMcLean Hospital-Harvard Medical SchoolBelmont, MAUSA

GEORGE S. BORSZCZ

Department of PsychologyWayne State UniversityDetroit, MIUSAborszcz@wayne.edu

JASENKA BORZAN

Department of Anesthesiology andCritical Care MedicineJohns Hopkins UniversityBaltimore, MDUSAjborzan1@jhmi.edu

XVIII List of Contributors

REGINA M. BOTTING

The William Harvey Research InstituteThe John Vane Science CentreQueen Mary University of LondonSt Bartholomew’s and the London School ofMedicine and DentistryLondonUKr.m.botting@qmul.ac.uk

DAVID BOWSHER

Pain Research InstituteUniversity Hospital AintreeLiverpoolUKpri@liv.ac.uk or bowsher@liv.ac.uk

EMMA L. BRANDON

Royal Perth Hospital andUniversity of Western AustraliaCrawley, WAAustralia

HARALD BREIVIK

Rikshospitalet University HospitalRikshospitaletNorwayharald.breivik@klinmed.uio.no

CHRISTOPHER R. BRIGHAM

Brigham and Associates Inc.Portland, ORUSAcbrigham@brighamassociates.com

STEPHEN C. BROWN

Department of AnesthesiaDivisional Centre of Pain Management and PainResearchThe Hospital for Sick ChildrenToronto, ONCanadastephen.brown@sickkids.ca

JEFFREY A. BROWN

Department of Neurological SurgeryWayne State UniversitySchool of MedicineDetroit and Neurological SurgeryNY, USAjbrown@neurosurgery.wayne.edu

EDUARDO BRUERA

Department of Palliative Care and RehabilitationMedicineThe University of Texas M. D. Anderson CancerCenterHouston, TXUSAebruera@mdanderson.org

PABLO BRUMOVSKY

Department of NeuroscienceKarolinska InstituteStockholmSwedenandNeuroscience LaboratoryAustral UniversityBuenos AiresArgentina

KAY BRUNE

Institute for Experimental and Clinical Pharmacologyand ToxicologyFriedrich Alexander University Erlangen-NürnbergErlangenGermanykay.brune@pharmakologie.uni-erlangen.de

MARIA BURIAN

Pharmacological Center FrankfurtClinical Center Johann-Wolfgang Goethe UniversityFrankfurtGermanyburian@em.uni-frankfurt.de

RICHARD BURSTAL

John Hunter Royal HospitalNewcastle, NSWAustraliarichard.burstal@hnehealth.nsw.gov.au

DAN BUSKILA

Rheumatic Disease UnitFaculty of Health SciencesSoroka Medical CenterBen Gurion UniversityBeer ShevaIsraeldbuskila@bgumail.bgu.ac.il

CATHERINE M. CAHILL

Queen’s UniversityKingston, ONCanadacahillc@post.queensu.ca

BRIAN E. CAIRNS

Faculty of Pharmaceutical SciencesUniversity of British ColumbiaVancouver, BCCanadabrcairns@interchange.ubc.ca

NIGEL A. CALCUTT

Department of PathologyUniversity of California San DiegoLa Jolla, CAUSAncalcutt@ucsd.edu

List of Contributors XIX

KATHARINE ANDREWS CAMPBELL

Department of Anatomy and Developmental BiologyUniversity College LondonLondonUKk.campbell@ich.ucl.ac.uk

JAMES N. CAMPBELL

Department of NeurosurgeryThe Johns Hopkins University School of MedicineBaltimore, MDUSAjcampbel@jhmi.edu

ADAM CARINCI

Department of Anesthesiology and Critical CareMedicineThe Johns Hopkins University School of MedicineBaltimore, MDUSA

GIANCARLO CARLI

Department of PhysiologyUniversity of SienaSienaItalycarlig@unisi.it

CHRISTER P.O. CARLSSON

Rehabilitation DepartmentLunds University HosptialLundSwedenakusyd@swipnet.se

SUSAN M. CARLTON

Marine Biomedical InstituteUniversity of Texas Medical BranchGalveston, TXUSAsmcarlto@utmb.edu

KENNETH L. CASEY

Department of NeurologyUniversity of MichiganandNeurology Research LaboratoryVA Medical CenterAnn Arbor, MIUSAkencasey@umich.edu

CHRISTINE T. CHAMBERS

Departments of Pediatrics and PsychologyDalhousie University and IWK Health CentreHalifax, NSCanadachristine.chambers@dal.ca

SANDRA CHAPLAN

Johnson & Johnson Pharmaceutical Research &DevelopmentSan Diego, CAUSAschaplan@prius.jnj.com

C. RICHARD CHAPMAN

Pain Research CenterDepartment of AnesthesiologyUniversity of Utah School of MedicineSalt Lake City, UTUSAcrc20@utah.edu

SANTOSH K. CHATURVEDI

National Institute of Mental Health & NeurosciencesBangaloreIndiachatur@nimhans.kar.nic.in

ANDREW C. N. CHEN

Human Brain Mapping and Cortical ImagingLaboratoryAalborg UniversityAalborgDenmarkac@smi.auc.dk

ANDREA CHEVILLE

Department of Rehabilitation MedicineUniversity of Pennsylvania School of MedicinePhiladelphia, PAUSAacheville@aol.com

NAOMI L. CHILLINGWORTH

Department of PhysiologySchool of Medical SciencesUniversity of BristolBristolUK

CATHERINE CHO

Clinical Neurophysiology LaboratoriesMount Sinai Medical CenterNew York, NYUSA

EDWARD CHOW

Toronto Sunnybrook Regional Cancer CenterUniversity of TorontoToronto, ONCanadaedward.chow@sw.ca

JULIE A. CHRISTIANSON

University of PittsburghPittsburgh, PAUSAjcc26+@pitt.edu

XX List of Contributors

MACDONALD J. CHRISTIE

Pain Management Research Institute and KollingInstituteUniversity of SydneySydney, NSWAustraliamacc@med.usyd.edu.au

KYUNGSOON CHUNG

Department of Neuroscience and Cell BiologyUniversity of Texas Medical BranchGalveston, TXUSAkchung@utmb.edu

JIN MO CHUNG

Department of Neuroscience and Cell BiologyUniversity of Texas Medical BranchGalveston, TXUSAjmchung@utmb.edu

W. CRAWFORD CLARK

College of Physicians and Surgeons, ColumbiaUniversityNew York, NYUSAUSAclarkcr@pi.cpmc.columbia.edu

JUDY CLARKE

Institute for Work & HealthToronto, ONCanadajclarke@iwh.on.ca

JAMES F. CLEARY

University of Wisconsin Comprehensive CancerCenterMadison, WIUSAjfcleary@wisc.edu

CHARLES S. CLEELAND

The University of Texas M. D.Anderson Cancer CenterHouston, TXUSAccleeland@mdanderson.org

JOHN DE CLERCQ

Department of Rehabilitation Sciences andPhysiotherapyGhent University HospitalGhentBelgium

TERENCE J. CODERRE

Department of AnesthesiaNeurology, Neurosurgery and PsychologyMcGill UniversityMontreal, QCCanadaterence.coderre@mcgill.ca

ROBERT C. COGHILL

Department of Neurobiology and AnatomyWake Forest University School of MedicineWinston-Salem, NCUSArcoghill@wfubmc.edu

ALAN L. COLLEDGE

Utah Labor CommissionInternational Association of Industrial AccidentBoards and CommissionsSalt Lake City, UTUSAfarmboyac@msn.com

BEVERLY J. COLLETT

University Hospitals of LeicesterLeicesterUKbeverly.collett@uhl.tr-nhs.uk

LESLEY A. COLVIN

Department of AnaesthesiaCritical Care and Pain MedicineWestern General HospitalEdinburghUKlesley.colvin@ed.ac.uk

KEVIN C. CONLON

Trinity College DublinUniversity of DublinandThe Adelaide and Meath Hospital incorporatingThe National Children’s HospitalDublinIrelandprofsurg@tcd.ie

BRIAN Y. COOPER

Department of Oral and Maxillofacial SurgeryUniversity of FloridaGainesville, FLUSAbcooper@dental.ufl.edu

CHRISTINE CORDLE

University Hospitals of LeicesterLeicesterUK

List of Contributors XXI

MICHAEL J. COUSINS

Department of Anesthesia and Pain ManagementRoyal North Shore HospitalUniversity of SydneySt. Leonards, NSWAustraliamcousins@nsccahs.health.nsw.gov.au

VERNE C. COX

Department of PsychologyUniversity of Texas at ArlingtonArlington, TXUSA

REBECCA M. CRAFT

Washington State UniversityPullman, WAUSAcraft@wsu.edu

KENNETH D. CRAIG

Department of PsychologyUniversity of British ColumbiaVancouver, BCCanadakcraig@psych.ubc.ca

GEERT CROMBEZ

Department of Experimental Clinical andHealth PsychologyGhent UniversityGhentBelgiumgeert.crombez@ugent.be

JOAN CROOK

Hamilton Health Sciences CorporationHamilton, ONCanada

GIORGIO CRUCCU

Department of Neurological SciencesLa Sapienza UniversityRomeItalycruccu@uniroma1.it

MICHELE CURATOLO

Department of AnesthesiologyDivision of Pain TherapyUniversity Hospital of BernInselspitalBernSwitzerlandmichele.curatolo@insel.ch

F. MICHAEL CUTRER

Department of NeurologyMayo ClinicRochester, MNUSAcutrer.michael@mayo.edu

NACHUM DAFNY

Health Science Center at HoustonNeurobiology and AnatomyUniversity of TexasHouston, TXUSAnachum.dafny@uth.tmc.edu

JØRGEN B. DAHL

Department of AnaesthesiologyGlostrup University HospitalHerlevDenmarkjbdahl@dadlnet.dk

YI DAI

Department of Anatomy and NeuroscienceHyogo College of MedicineHyogoJapan

STEFAAN VAN DAMME

Department of Experimental Clinical andHealth PsychologyGhent UniversityGhentBelgiumstefaan.vandamme@ugent.be

ALEXANDRE F. M. DASILVA

Martinos Center for Biomedical ImagingMassachusetts General HospitalHarvard Medical SchoolCharlestown, MAUSAalexandr@nmr.mgh.harvard.edu

BRIAN DAVIS

University of PittsburghPittsburgh, PAUSAdavisb@dom.pitt.edu

KAREN D. DAVIS

University of Toronto and theToronto Western Research InstituteUniversity Health NetworkToronto, ONCanadakdavis@uhnres.utoronto.ca

XXII List of Contributors

RICHARD O. DAY

Department of Physiology and PharmacologySchool of Medical SciencesUniversity of New South WalesandDepartment of Clinical PharmacologySt Vincent’s HospitalSydney, NSWAustraliar.day@unsw.edu.au

ISABELLE DECOSTERD

Anesthesiology Pain Research GroupDepartment of AnesthesiologyUniversity Hospital (CHUV) and Departmentof Cell Biology and MorphologyLausanne UniversityLausanneSwitzerlandisabelle.decosterd@chuv.ch

JOYCE A. DELEO

Dartmouth Hitchcock Medical CenterDartmouth Medical SchoolLebanon, NHUSAjoyce.a.deleo@dartmouth.edu

A. LEE DELLON

Johns Hopkins UniversityBaltimore, MDUSAaldellon@starpower.net

MARSHALL DEVOR

Institute of Life Sciences andCenter for Research on PainHebrew University of JerusalemJerusalemIsraelmarshlu@vms.huji.ac.il

DAVID DIAMANT

Neurological and Spinal SurgeryLincoln, NEUSAddiamant@neb.rr.com

ANTHONY H. DICKENSON

Department of PharmacologyUniversity College LondonLondonUKanthony.dickenson@ucl.ac.uk

HANS-CHRISTOPH DIENER

Department of NeurologyUniversity Hospital of EssenEssenGermanyh.diener@uni-essen.de

ADAM VAN DIJK

Department of AnesthesiologyQueen’s UniversityKingston General HospitalKingston, ONCanada

NATALIA DMITRIEVA

Program in NeuroscienceFlorida State UniversityTallahassee, FLUSAdmitrieva@darwin.psy.fsu.edu

REGINALD J. DOCHERTY

Wolfson Centre for Age-Related DiseasesKing’s College LondonLondonUKreginald.docherty@kcl.ac.uk

LUCY F. DONALDSON

Department of PhysiologySchool of Medical SciencesUniversity of BristolBristolUKlucy.donaldson@bris.ac.uk

HENRI DOODS

CNS PharmacologyPain ResearchBoehringer Ingelheim Pharma GmbH & Co.KGBiberach/RissGermany

VICTORIA DORF

Social Security AdministrationBaltimore, MDUSAvictoria.dorf@ssa.gov

MICHAEL J. DORSI

Department of NeurosurgeryJohns Hopkins School of MedicineBaltimore, MDUSA

List of Contributors XXIII

JONATHAN O. DOSTROVSKY

Department of PhysiologyFaculty of MedicineUniversity of TorontoToronto, ONCanadaj.dostrovsky@utoronto.ca

PAUL DREYFUSS

Department of Rehabilitation MedicineUniversity of WashingtonSeattle, WAUSApauldspine@aol.com

PETER D. DRUMMOND

School of PsychologyMurdoch UniversityPerth, WAAustraliap.drummond@murdoch.edu.au

RONALD DUBNER

University of MarylandDepartment of Biomedical SciencesBaltimore, MDUSArdubner@umaryland.edu

ANNE DUCROS

Headache Emergency Department andInstitute National de la Santé et de la RechercheMédicale (INSERM)Faculté de Médecine LariboisièreLariboisière HospitalParisFranceanne.ducros@lrb.ap-hop-paris.fr

GARY DUNCAN

Department of PsychologyMcGill UniversityMontreal, QCCanada

MARY J. EATON

Miller School of MedicineUniversity of MiamiMiami, FLUSAmeaton@miami.edu

ANDREA EBERSBERGER

Department of PhysiologyFriedrich Schiller University of JenaJenaGermanyandrea.ebersberger@mti.uni-jena.de

CHRISTOPHER ECCLESTON

Pain Management UnitUniversity of BathBathUKc.eccleston@bath.ac.uk

JOHN EDMEADS

Sunnybrook and Woman’s College HealthSciences CentreUniversity of TorontoToronto, ONCanadajohn.edmeads@sw.ca

ROBERT R. EDWARDS

Department of Psychiatry and Behavioral SciencesThe Johns Hopkins University School of MedicineBaltimore, MDUSAredwar10@jhmi.edu

EVAN R. EISENBERG

Department of UrologyLong Island Jewish Medical CenterNew York, NYUSA

JANET W. M. ELLIS

Department of AnaesthesiaDivisional Centre for Pain ManagementandPain ResearchThe Hospital for Sick ChildrenToronto, ONCanadajoostjanet@rogers.com

JOYCE M. ENGEL

Department of Rehabilitation MedicineUniversity of WashingtonSeattle, WAUSAknowles@u.washington.edu

MATTHEW ENNIS

Deptartment of Anatomy and NeurobiologyUniversity of Tennessee Health Science CenterMemphis, TNUSAmennis@utmem.edu

EDZARD ERNST

Complementary MedicinePeninsula Medical SchoolUniversities of Exeter and PlymouthExeterUKedzard.ernst@pms.ac.uk

XXIV List of Contributors

LYDIA ESTANISLAO

Clinical Neurophysiology LaboratoriesMount Sinai Medical CenterNew York, NYUSA

THOMAS EWERT

Department of Physical Medicine and RehabilitationLudwig-Maximilians UniversityMunichGermany

KERI L. FAKATA

College of Pharmacy and Pain Management CenterUniversity of UtahSalt Lake City, UTUSAkeri.fakata@hsc.utah.edu

MARIE FALLON

Department of OncologyEdinburgh Cancer CenterUniversity of EdinburghEdinburghScotlandmarie.fallon@ed.ac.uk

GILBERT J. FANCIULLO

Pain Management CenterDartmouth-Hitchcock Medical CenterLebanon, NHUSAgilbert.j.fanciullo@hitchcock.org

ANDREW J. FARACI

Virginia Mason Medical CenterSeattle, WAUSA

CHARLOTTE FEINMANN

Eastman Dental Institute and Department ifPsychiatry and Behavioural SciencesUniversity College LondonLondonUKrejucfe@ucl.ac.uk

ELIZABETH ROY FELIX

The Miami Project to Cure ParalysisUniversity of Miami Miller School of MedicineMiami, FLUSAefelix@miamiproject.med.miami.edu

YI FENG

Department of AnesthesiologyPeking University People’s HospitalPekingP. R. Chinayifeng65@263.net

ANDRES FERNANDEZ

ANTONIO VICENTE FERRER-MONTIEL

Institute of Molecular and Cell BiologyUniversity Miguel HernándezElcheAlicanteSpainaferrer@umh.es

MICHAEL FEUERSTEIN

Department of Medical and Clinical PsychologyUniformed Services University of the HealthSciencesBethesda, MDandDepartment of Preventive Medicine & BiometricsUSUHSBethesda, MDandGeorgetown University Medical CenterWashington, DCUSAmfeuerstein@usuhs.mil

VERONIKA FIALKA-MOSER

Department of Physical Medicine and RehabilitationUniversity ViennaViennaAustriaPmr.office@meduniwien.ac.at

PERRY G. FINE

Pain Management and Research CenterUniversity of UtahSalt Lake City, UTUSAfine@aros.net

DAVID J. FINK

Department of NeurologyUniversity of Michigan and VA Ann ArborHealthcare SystemAnn Arbor, MIUSAdfink@pitt.edu

NANNA BRIX FINNERUP

Department of Neurology andDanish Pain Research CentreAarhus University HospitalAarhusDenmarkfinnerup@ki.au.dk

List of Contributors XXV

DAVID A. FISHBAIN

Department of Psychiatry and Department ofNeurological Surgery and AnesthesiologyUniversity of MiamiSchool of Medicine and H. Rosomoff PainCenter at South Shore HospitalMiami, FLUSAdfishbain@miami.edu

PER FLISBERG

Royal Perth HospitalUniversity of Western AustraliaPerth, WAAustralia

HERTA FLOR

Department of Clinical and Cognitive NeuroscienceUniversity of HeidelbergCentral Institute of Mental HealthMannheimGermanyflor@zi-mannheim.de

CHRISTOPHER M. FLORES

Drug DiscoveryJohnson and Johnson Pharmaceutical Research andDevelopmentSpring House, PAUSA

WILBERT E. FORDYCE

Department of RehabilitationUniversity of Washington School of MedicineSeattle, WAUSAwfordyce@msn.com

ROBERT D. FOREMAN

University of Oklahoma Health Sciences CenterOklahoma City, OKUSArobert-foreman@ouhsc.edu

GARY M. FRANKLIN

Department of Environmental and OccupationalHealth SciencesUniversity of WashingtonSeattle, WAandWashington State Department of Labor and IndustriesOlympia, WAUSAmeddir@u.washington.edu

JAN FRIDÉN

Department of Hand SurgerySahlgrenska University HospitalGöteborgSwedenjan.friden@orthop.gu.se

ALLAN H. FRIEDMAN

Division of NeurosurgeryDuke University Medical CenterDurham, NCUSA

PERRY N. FUCHS

Department of PsychologyUniversity of Texas at ArlingtonArlington, TXUSAfuchs@uta.edu

DEBORAH FULTON-KEHOE

Department of Health ServicesUniversity of WashingtonSeattle, WAUSA

ARNAUD FUMAL

Departments of Neurology and NeuroanatomyUniversity of LiègeCHR CitadelleLiegeBelgium

ANDREA D. FURLAN

Institute for Work & HealthToronto, ONCanada

VASCO GALHARDO

Institute of Histology and EmbryologyFaculty of Medicine of PortoUniversity of PortoPortoPortugalgalhardo@med.up.pt

ANDREAS R. GANTENBEIN

Headache & Pain UnitUniversity Hospital ZurichZurichSwitzerlandandy.gantenbein@gmx.ch

ELVIRA DE LA PEÑA GARCÍA

Instituto de NeurocienciasUniversidad Miguel Hernández-CSICAlicanteSpainelvirap@umh.es

XXVI List of Contributors

I. GARONZIK

Johns Hopkins Medical InstitutionsDepartment of NeurosurgeryBaltimore, MDUSA

ROBERT GASSIN

Musculoskeletal Medicine ClinicFrankston, VICAustraliargassin@pen.hotkey.net.au

ROBERT J. GATCHEL

Department of PsychologyCollege of ScienceUniversity of Texas at ArlingtonAirlington, TXUSAgatchel@uta.edu

GERALD F. GEBHART

Department of PharmacologyUniversity of IowaIowa City, IAUSAgf-gebhart@uiowa.edu

GERD GEISSLINGER

Institute for Clinical Pharmacologypharmazentrum frankfurt/ZAFESClinical Centre of the Johann Wolfgang GoetheUniversity Frankfurt am MainFrankfurtGermanygeisslinger@em.uni-frankfurt.de

ROBERT D. GERWIN

Department of NeurologyJohns Hopkins UniversityBethesda, MDUSAgerwin@painpoints.com

MARIA ADELE GIAMBERARDINO

Dipartimento di Medicina e Scienzedell’InvecchiamentoUniversity of ChietiChietiItalymag@unich.it

GLENN J. GIESLER JR

Department of NeuroscienceUniversity of MinnesotaMinneapolis, MNUSAgiesler@mail.ahc.umn.edu

PHILIP L. GILDENBERG

Baylor Medical CollegeHouston, TXUSAhsc@stereotactic.net

MYRA GLAJCHEN

Department of Pain Medicine and Palliative CareBeth Israel Medical CenterNew York, NYUSAmglajchen@bethisraelny.org

PETER J. GOADSBY

Institute of NeurologyThe National Hospital for Neurology andNeurosurgeryLondonUKpeterg@ion.ucl.ac.uk

HARTMUT GÖBEL

Kiel Pain CenterKielGermanyhg@schmerzklinik.de

PHILIPPE GOFFAUX

Faculty of MedicineNeurochirurgyUniversity of SherbrookeSherbrooke, QCCanadaphilippe.goffaux@chus.qc.ca

ANA GOMIS

Instituto de Neurociencias de AlicanteUniversidad Miguel Hernandez-CSICSan Juan de AlicanteSpainagomis@umh.es

VIVEKANANDA GONUGUNTA

The Cleveland Clinic FoundationDepartment of NeurosurgeryCleveland, OHUSA

GILBERT R. GONZALES

Department of NeurologyMemorial Sloan-Kettering Cancer CenterNew York, NYUSA

List of Contributors XXVII

ALLAN GORDON

Wasser Pain Management CentreMount Sinai HospitalUniversity of TorontoToronto, ONCanadaallan.gordon@utoronto.ca

LIESBET GOUBERT

Ghent UniversityDepartment of Experimental Clinical andHealth PsychologyGhentBelgiumliesbet.goubert@ugent.be

JAYANTILAL GOVIND

Pain ClinicDepartment of AnaesthesiaUniversity of New South WalesSydney, NSWAustraliajaygovind@bigpond.com

RICHARD H. GRACELY

Ann Arbor Veterans Administration Medical CenterDepartments of Medicine-Rheumatology andNeurologyand Chronic Pain and Fatigue Research CenterUniversity of Michigan Health SystemAnn Arbor, MIUSArgracely@umich.edu

GARRY G. GRAHAM

Department of Physiology and PharmacologySchool of Medical SciencesUniversity of New South WalesandDepartment of Clinical PharmacologySt. Vincent’s HospitalSydney, NSWAustraliaggraham@stvincents.com.au

DAVID K. GRANDY

Department of Physiology and PharmacologySchool of MedicineOregon Health and Science UniversityPortland, ORUSAgrandyd@ohsu.edu

THOMAS GRAVEN-NIELSEN

Laboratory for Experimental Pain ResearchCenter for Sensory-Motor Interaction (SMI)Aalborg UniversityDenmarktgn@hst.aau.dk

BARRY GREEN

Pierce LaboratoryYale School of MedicineNew Haven, CTUSAgreen@jbpierce.org

PAUL G. GREEN

NIH Pain Center (UCSF)University of CaliforniaSan Francisco, CAUSApaul@itsa.ucsf.edu

JOEL D. GREENSPAN

Department of Biomedical SciencesUniversity of Maryland Dental SchoolBaltimore, MDUSAjgreenspan@umaryland.edu

JOHN W. GRIFFIN

Department of NeurologyDepartments of Neuroscience and PathologyThe Johns Hopkins University School of MedicineJohns Hopkins HospitalBaltimore, MDUSAjgriffi@jhmi.edu

SABINE GRÖSCH

Pharmacological Center FrankfurtClinical Center Johann-Wolfgang Goethe UniversityFrankfurtGermanygroesch@em.uni-frankfurt.de

DOUGLAS P. GROSS

Department of Physical TherapyUniversity of AlbertaEdmonton, ABAustraliadoug.gross@ualberta.ca

BLAIR D. GRUBB

Department of Cell Physiology and PharmacologyUniversity of LeicesterLeicesterUKbdg1@leicester.ac.uk

RUTH ECKSTEIN GRUNAU

Centre for Community Child Health ResearchChild and Family Research InstituteandUniversity of British ColumbiaVancouver, BCCanadargrunau@cw.bc.ca

XXVIII List of Contributors

MICHEL GUERINEAU

NeurosurgeryHotel DieuNantes Cedex 1France

CHRISTOPH GUTENBRUNNER

Department of Physical Medicine and RehabilitationHanover Medical SchoolHanoverGermanygutenbrunner.christoph@mh-hannover.de

MAIJA HAANPÄÄ

Department of Anaesthesiology and Department ofNeurosurgeryPain ClinicHelsinki University HospitalHelsinkiFinland

UTE HABEL

RWTH Aachen UniversityDepartment of Psychiatry and PsychotherapyAachenGermanyuhabel@ukaachen.de

HEINZ-JOACHIM HÄBLER

FH Bonn-Rhein-SiegRheinbachGermanyheinz-joachim.haebler@fh-bonn-rhein-sieg.de

THOMAS HACHENBERG

Clinic for Anaesthesiology and Intensive TherapyOtto-von-Guericke UniversityMagdeburgGermany

NOUCHINE HADJIKHANI

Martinos Center for Biomedical ImagingMassachusetts General HospitalHarvard Medical SchoolCharlestown, MAUSAnouchine@nmr.mgh.harvard.edu

OLE HAEGG

Department of Orthopedic SurgerySahlgren University HospitalGoteborgSwedenollehagg@hotmail.com

BRYAN C. HAINS

The Center for Neuroscience and RegenerationResearchDepartment of NeurologyYale University School of MedicineWest Haven, CTUSAbryan.hains@yale.edu

DARRYL T. HAMAMOTO

University of MinnesotaMinneapolis, MNUSA

DONNA L. HAMMOND

Department of AnesthesiologyUniversity of IowaIowa, IAUSAdonna-hammond@uiowa.edu

H. C. HAN

Medical Science Research Center andDepartment of PhysiologyKorea University College of MedicineSeoulKorea

HERMANN O. HANDWERKER

Department of Physiology and PathophysiologyUniversity of Erlangen/NürnbergErlangenGermanyhandwerker@physiologie1.uni-erlangen.de

JING-XIA HAO

Karolinska InstituteStockholmSweden

ELENI G. HAPIDOU

Department of Psychiatry andBehavioural NeurosciencesMcMaster University and Hamilton Health SciencesHamilton, ONCanadahapidou@hhsc.ca

GEOFFREY HARDING

Sandgate, QLDAustraliageoffharding@uq.net.au

LOUISE HARDING

Hospitals NHS Foundation TrustUniversity College LondonLondonUKlouise.harding@uclh.org

List of Contributors XXIX

KENNETH M. HARGREAVES

Department of EndodonticsUniversity of Texas Health Science Centerat San AntonioSan Antonio, TXUSAhargreaves@uthscsa.edu

SARAH J. HARPER

Royal Perth Hospital andUniversity of Western AustraliaPerth, WAAustralia

D. PAUL HARRIES

Pain Care CenterSamaritan Hospital LexingtonLexington, KYUSApharries@kypain.com

S. E. HARTE

Department of Internal MedicineChronic Pain and Fatigue Research CenterRheumatology University of Michigan Health SystemAnn Arbor, MIUSAseharte@umich.edu

SAMUEL J. HASSENBUSCH

The University of Texas M. D. Anderson CancerCenterHouston, TXUSAsamuel@neosoft.com

BRIDGET E. HAWKINS

Department of Anatomy and NeurosciencesUniversity of Texas Medical BranchGalveston, TXUSAbehawkin@utmb.edu

JENNIFER A. HAYTHORNTHWAITE

Johns Hopkins UniversityBaltimore, MDUSAjhaytho1@jhmi.edu

JOHN H. HEALEY

Memorial Sloan Kettering Cancer Center andWeill Medical College of Cornell UniversityNew York, NYUSAhealeyj@mskcc.org

ALICIA A. HEAPY

VA Connecticut Healthcare System and YaleUniversityWesthaven, CTUSAalicia.heapy@va.gov

ANNE M. HEFFERNAN

The Adelaide and Meath Hospital incorporatingThe National Children’s HospitalDublinIreland

MARY M. HEINRICHER

Department of Neurological SurgeryOregon Health Science UniversityPortland, ORUSAheinricm@ohsu.edu

ROBERT D. HELME

Centre for Pain ManagementSt Vincent’s HospitalMelbourne, VICAustraliarhelme@bigpond.net.au

ROBERT D. HERBERT

School of PhysiotherapyUniversity of SydneySydney, NSWAustraliar.herbert@fhs.usyd.edu.au

CHRISTIANE HERMANN

Department of Clinical and Cognitive Neuroscienceat the University of HeidelbergCentral Institute of Mental HealthMannheimGermanychermann@zi-mannheim.de

JUAN F. HERRERO

Department of PhysiologyEdificio de MedicinaUniversity of AlcaláMadridSpainjuanf.herrero@uah.es

AKI J. HIETAHARJU

Department of Neurology and RehabilitationPain ClinicTampere University HospitalTampereFinlandaki.hietaharju@pshp.fi

XXX List of Contributors

KARIN N. WESTLUND HIGH

Department of Neuroscience and Cell BiologyUniversity of Texas Medical BranchGalveston, TXUSAkwhigh@utmb.edu

MARITA HILLIGES

Halmstad UniversityHalmstadSwedenmarita.hilliges@set.hh.se

MAX J. HILZ

University of Erlangen-NuernbergErlangenGermanymax.hilz@neuro.imed.uni-erlangen.de

BURKHARD HINZ

Department of Experimental and ClinicalPharmacology and ToxicologyFriedrich Alexander University Erlangen-NürnbergErlangenGermanyhinz@pharmakologie.uni-erlangen.de

ANTHONY R. HOBSON

Section of GI SciencesHope HospitalUniversity of ManchesterSalfordUKahobson@fs1.ho.man.ac.uk

TOMAS HÖKFELT

Department of NeuroscienceKarolinska InstitutetStockholmSwedentomas.hokfelt@neuro.ki.se

ANITA HOLDCROFT

Imperial College LondonLondonUKaholdcro@imperial.ac.uk

SARAH V. HOLDRIDGE

Department of Pharmacology and ToxicologyQueen’s UniversityKinston, ONCanada

KJELL HOLE

University of BergenBergenNorwaykjell.hole@fys.uib.no

GRAHAM R. HOLLAND

Department of CariologyRestorative Sciences & EndodonticsSchool of DentistryUniversity of MichiganAnn Arbor, MIUSArholland@umich.edu

ULRIKE HOLZER-PETSCHE

Department of Experimental and ClinicalPharmacologyMedical University of GrazGrazAustriaulrike.holzer@meduni-graz.at

CHANG-ZERN HONG

Department of Physical Medicine and RehabilitationUniversity of California IrvineIrvine, CAUSAczhong88@ms49.hinet.net

S. K. HONG

Medical Science Research Center and Department ofPhysiologyKorea University College of MedicineSeoulKorea

MINORU HOSHIYAMA

Department of Integrative PhysiologyNational Institute for Physiological SciencesOkazakiJapan

FRED M. HOWARD

Department of Obstetrics and GynecologyUniversity of RochesterRochester, NYUSAfred_howard@urmc.rochester.edu

SUNG-TSANG HSIEH

Department of Anatomy and Cell BiologyNational Taiwan UniversityandDepartment of NeurologyNational Taiwan University HospitalTaipeiTaiwansthsieh@ha.mc.ntu.edu.tw

JAMES W. HU

Faculty of DentistryUniversity of TorontoToronto, ONCanadajames.hu@utoronto.ca

List of Contributors XXXI

CLAIRE E. HULSEBOSCH

Spinal Cord Injury ResearchUniversity of Texas Medical BranchGalveston, TXUSAcehulseb@utmb.edu

THOMAS HUMMEL

Department of OthorhinolaryngologySmell and Taste ClinicUniversity of Dresden Medical SchoolDresdenGermanythummel@rcs.urz.tu-dresden.de

WALTER J. MEYER IIIDepartment of Psychiatry and Behavioral ScienceShriners Hospitals for ChildrenShriners Burns HospitalGalveston, TXUSAwmeyer@utmb.edu

ROSE-ANNE INDELICATO

Department of Pain and Palliative CareBeth Israel Medical CenterNew York, NYUSA

CHARLES E. INTURRISI

Department of PharmacologyWeill Medical College of Cornell Universityceintur@med.cornell.edu

KOJI INUI

SUHAYL J. JABBUR

Neuroscience ProgramFaculty of MedicineAmerican University of BeirutBeirutLebanon

CAROL JAMES

Department of Neurological SurgeryJohns Hopkins HospitalBaltimore, MDUSA

WILFRID JÄNIG

Institute of PhysiologyChristian Albrechts University KielKielGermanyw.janig@physiologie.uni-kiel.de

NORA JANJAN

University of Texas M. D. Anderson Cancer CenterHouston, TXUSA

LUC JASMIN

Department of AnatomyUniversity of California San FranciscoSan Francisco, CAUSAucpain@itsa.ucsf.edu

ANNE JAUMEES

Royal North Shore HospitalSt. Leonards, NSWAustralia

DANIEL JEANMONOD

Functional NeurosurgeryNeurosurgical ClinicUniversity HospitalZürichSwitzerlanddaniel.jeanmonod@usz.ch

ANDREW JEFFREYS

Department of AnaesthesiaWestern HealthMelbourne, NSWAustraliaandrew.jeffreys@wh.org.au

TROELS S. JENSEN

Danish Pain Research Center andDepartment of NeurologyAarhus University HospitalAarhusDenmarktsj@akhphd.au.dk

MARK P. JENSEN

Department of Rehabilitation MedicineUniversity of WashingtonSeattle, WAUSAmjensen@u.washington.edu

MARK JOHNSON

Musculoskeletal PhysicianHibiscus Coast HighwayOrewaNew Zealandmarkjohn@ihug.co.nz

XXXII List of Contributors

MARK I. JOHNSON

School of Health and Human SciencesFaculty of HealthLeeds Metropolitan UniversityLeedsUKm.johnson@leedsmet.ac.uk

KURT L. JOHNSON

Department of Rehabilitation MedicineSchool of MedicineUniversity of WashingtonSeattle, WAUSAkjohnson@u.washington.edu

MARK JOHNSTON

Musculoskeletal PhysicianHibiscus Coast HighwayOrewaNew Zealandmarkjohn@ihug.co.nz

DAVID S. JONES

Division of Adolescent Medicine and BehavioralSciencesVanderbilt University Medical CenterNashville, TNUSAdavid.s.jones@vanderbilt.edu

EDWARD JONES

Center for NeuroscienceUniversity of CaliforniaDavies, CAUSAejones@ucdavis.edu

JEROEN R. DE JONG

Department of Rehabilitation and Department ofMedical PsychologyUniversity of MaastrichtandDepartment of Medical, Clinical andExperimental PsychologyMaastricht UniversityMaastrichtThe Netherlandsjdjo@smps.azm.nl

SVEN-ERIC JORDT

Department of PharmacologyYale University School of MedicineNew Haven, CTUSAsven.jordt@yale.edu

ELLEN JØRUM

The Laboratory of Clinical NeurophysiologyRikshospitalet UniversityOsloNorwayellen.jorum@rikshospitalet.no

STEFAN JUST

CNS PharmacologyPain ResearchBoehringer Ingelheim Pharma GmbH & Co. KGBiberach/RissGermany

NOUFISSA KABLI

Department of Pharmacology and ToxicologyQueen’s UniversityKinston, ONCanada

RYUSUKE KAKIGI

Department of Integrative PhysiologyNational Institute for Physiological SciencesOkazakiJapankakigi@nips.ac.jp

PETER C. A. KAM

Department of AnaesthesiaSt. George HospitalUniversity of New South WalesKogorah, NSWAustraliap.kam@unsw.edu.au

GIRESH KANJI

WellingtonNew Zealanddr.kanji@actrix.co.nz

Z. KARIM

ZAZA KATSARAVA

Department of NeurologyUniversity Hospital of EssenEssenGermanyzaza.katsarava@uni-essen.de

JOEL KATZ

Department of PsychologyMcGill UniversityMontreal, QCCanada

List of Contributors XXXIII

VALERIE KAYSER

NeuroPsychoPharmacologie MédecineINSERM U677Faculté de Medécine Pitié-SalpêtrièreParisFrancekayser@ext.jussieu.fr

FRANCIS J. KEEFE

Pain Prevention and Treatment ResearchDepartment of Psychiatry and Behavioral SciencesDuke University Medical CenterDurham, NCUSAkeefe003@mc.duke.edu

LOIS J. KEHL

Department of AnesthesiologyUniversity of MinnesotaMinneapolis, MNUSAlois@mail.ahc.umn.edu

WILLIAM N. KELLEY

Department of NeurologyThe University of Pennsylvania Medical SchoolPhiladelphia, PAUSA

STEPHEN KENNEDY

Nuffield Department of Obstetrics and GynaecologyUniversity of OxfordJohn Radcliffe HospitalOxfordUKstephen.kennedy@obs-gyn.ox.ac.uk

ELIZABETH VAN DEN KERKHOF

Department of Community Health and EpidemiologyQueen’s UniversityKingston, ONCanada2anv1@qlink.queensu.ca

ROBERT D. KERNS

VA Connecticut Healthcare System and YaleUniversityWesthaven, CTUSArobert.kerns@med.va.gov

SANJAY KHANNA

Department of PhysiologyNational University of SingaporeSingaporephsks@nus.edu.sg

KOK E. KHOR

Department of Pain ManagementPrince of Wales HospitalRandwick, NSWAustraliakekhor@bigpond.net.au

H. J. KIM

Department of Life ScienceYonsei University Wonju CampusWonjuKorea

Y. I. KIM

Medical Science Research Center and Departmentof PhysiologyKorea University College of MedicineSeoulKorea

WADE KING

Department of Clinical ResearchRoyal Newcastle HospitalUniversity of NewcastleNewcastle, NSWAustraliawmbaking@tpg.com.au

K. L. KIRSH

Markey Cancer CenterUniversity of Kentucky College of MedicineLexington, KYUSA

RICARDO J. KOMOTAR

Department of Neurological SurgeryNeurological InstituteColumbia UniversityNew York, NYUSA

RHONDA K. KOTARINOS

Long Grove, ILUSArkotarinos@msn.com

KATALIN J. KOVÁCS

Department of Veterinary and Biomedical SciencesUniversity of MinnesotaSt. Paul, MNUSA

MALGORZATA KRAJNIK

St. Elizabeth HospiceIpswichSuffolkUK

XXXIV List of Contributors

AJIT KRISHNANEY

The Cleveland Clinic FoundationDepartment of NeurosurgeryCleveland, OHUSA

GREGORY KROH

Utah Labor CommissionInternational Association of Industrial AccidentBoards and CommissionsSalt Lake City, UTUSA

M. M. TER KUILE

Department of GynecologyLeiden University Medical CenterLeidenThe Netherlands

ALICE KVÅLE

Section for Physiotherapy ScienceDepartment of Public Health and PrimaryHealth CareFaculty of MedicineUniversity of BergenBergenNorwayalice.kvale@isf.uib.no

ANTOON F. C. DE LAAT

Department of Oral/Maxillofacial SurgeryCatholic University of LeuvenLeuvenBelgiumantoon.delaat@med.kuleuven.ac.be

JEAN-JACQUES LABAT

Neurology and RehabilitationClinique UrologiqueNantes Cedex 1France

GASTON LABRECQUE

Faculty of PharmacyUniversité LavalQuebec CityMontreal, QCCanadagaston.labrecque@videotron.ca

MARCO LACERENZA

Scientific Institute San RaffaelePain Medicine CenterMilanoItaly

URI LADABAUM

Division of GastroenterologyUniversity of CaliforniaSan Francisco, CAUSAuri.ladabaum@ucsf.edu

MARIE ANDREE LAHAIE

McGill UniversityMontreal, QCCanada

MIGUEL J. A. LÁINEZ-ANDRÉS

Department of NeurologyUniversity of ValenciaValenciaSpainjlainez@meditex.es

TIMOTHY R. LAIR

Department of AnesthesiologyUniversity of Vermont College of MedicineBurlington, VTUSA

ROBERT H. LAMOTTE

Department of AnesthesiologyYale School of MedicineNew Haven, CTUSArobert.lamotte@yale.edu

JAMES W. LANCE

Institute of Neurological SciencesPrince of Wales Hospital and University ofNew South WalesSydney, NSWAustraliajimlance@bigpond.com

ROBERT G. LARGE

The Auckland Regional Pain ServiceAuckland HospitalAucklandNew Zealandboblarge@actrix.co.nz

ALICE A. LARSON

Department of Veterinary and Biomedical SciencesUniversity of MinnesotaSt. Paul, MNUSAlarso011@umn.edu

PETER LAU

Department of Clinical ResearchRoyal Newcastle HospitalUniversity of NewcastleNewcastle, NSWAustraliapetercplau@hotmail.com

List of Contributors XXXV

STEFAN A. LAUFER

Institute of PharmacyEberhard-Karls University of TuebingenTuebingenGermanystefan.laufer@uni-tuebingen.de

GILES J. LAVIGNE

Facultés de Médecine Dentaire et de MédecineUniversité de MontréalMontréal, QCCanadagilles.lavigne@umontreal.ca

PETER G. LAWLOR

Our Lady’s HospiceMedical DepartmentDublinIrelandplawlor@olh.ie

MICHEL LAZDUNSKI

Institut de Pharmacologie Moleculaire et CellulaireValbonneFrance

VINCENCO DI LAZZARO

FENNSI GroupNational Hospital of ParapléjicosSESCAM Finca “La Peraleda”ToledoSpain

MAAIKE LEEUW

Department of MedicalClinical and Experimental PsychologyMaastricht UniversityMaastrichtThe Netherlandsm.leeuw@dmkep.unimaas.nl

SIRI LEKNES

Pain Imaging Neuroscience (PaIN) GroupDepartment of Physiology, Anatomy and GeneticsandCentre for Functional Magnetic Resonance Imaging ofthe BrainOxford UniversityOxfordUKirene.tracey@anat.ox.ac.uk

TOBIAS LENIGER

Department of NeurologyUniversity EssenEssenGermanytobias.leniger@uni-essen.de

FREDERICK A. LENZ

Department of NeurosurgeryJohns Hopkins HospitalBaltimore, MDUSAflenz1@jhmi.edu

PAULINE LESAGE

Department of Pain Medicine and Palliative CareBeth Israel Medical Center andAlbert Einstein College of MedicineNew York, NYUSAplesage@bethisraelny.org

ISOBEL LEVER

Neural Plasticity UnitInstitute of Child HealthUniversity College LondonLondonUKi.lever@ich.ucl.ac.uk

KHAN W. LI

Department of NeurosurgeryJohns Hopkins HospitalBaltimore, MDUSA

ALAN R. LIGHT

Department of AnesthesiologyUniversity of UtahSalt Lake City, UTUSAalan.light@hsc.utah.edu

DEOLINDA LIMA

Instituto de Histologia e EmbriologiaFaculdade de Medicina da Universidade do PortoPortoPortugallimad@med.up.pt

VOLKER LIMMROTH

Department of NeurologyUniversity of EssenEssenGermanyvolker.limmroth@uni-essen.de

STEVEN J. LINTON

Department of Occupational andEnvironmental MedicineDepartment of Behavioral, Social and Legal SciencesÖrebro University HospitalÖrebroSwedensteven.linton@orebroll.se

XXXVI List of Contributors

CHRISTINA LIOSSI

School of PsychologyUniversity of Southampton and Great OrmondStreet Hospital for Sick ChildrenLondonUKcliossi@soton.ac.uk

ARTHUR G. LIPMAN

College of Pharmacy and Pain ManagementCenterUniversity of UtahSalt Lake City, UTUSAarthur.lipman@hsc.utah.edu

RICHARD B. LIPTON

Departments of Neurology, Epidemiology andPopulation HealthAlbert Einstein College of Medicineand Montefiore Headache UnitBronxNew York, NYUSArlipton@aecom.yu.edu

KENNETH M. LITTLE

Division of NeurosurgeryDuke University Medical CenterDurham, NCUSAlittl023@mc.duke.edu

SPENCER S. LIU

Virginia Mason Medical CenterSeattle, WAUSAanessl@vmmc.org

ANNE ELISABETH LJUNGGREN

Section for Physiotherapy ScienceDepartment of Public Health and Primary Health CareFaculty of MedicineUniversity of BergenBergenNorwayelisabeth.ljunggren@isf.uib.no

JOHN D. LOESER

Department of Neurological SurgeryUniversity of WashingtonSeattle, WAUSAjdloeser@u.washington.edu

PATRICK LOISEL

Disability Prevention Research and Training CentreUniversité de SherbrookeLongueuil, QCCanadapatrick.loisel@usherbrooke.ca

ELISA LOPEZ-DOLADO

FENNSI GroupNational Hospital of ParapléjicosSESCAM Finca “La Peraleda”ToledoSpain

JÜREGEN LORENZ

Hamburg University of Applied SciencesHamburgGermanyjuergen.lorenz@rzbd.haw-hamburg.de

JÖRN LÖTSCH

Institute for Clinical PharmacologyPharmaceutical Center FrankfurtJohann Wolfgang Goethe UniversityFrankfurtGermanyj.loetsch@em.uni-frankfurt.de

DAYNA R. LOYD

Center for Behavioral NeuroscienceGeorgia State UniversityAtlanta, GAUSA

DAVID LUSSIER

McGill UniversityMontreal, QCCanadadavid.lussier@muhc.mcgill.ca

STEPHEN LUTZ

Blanchard Valley Regional Cancer CenterFindlay, OHUSA

BRUCE LYNN

Department of PhysiologyUniversity College LondonLondonUKb.lynn@ucl.ac.uk

ROSS MACPHERSON

Department of Anesthesia and Pain ManagementUniversity of SydneySydney, NSWAustraliarmacpher@nsccahs.health.nsw.gov.au

List of Contributors XXXVII

MICHEL MAGNIN

INSERMNeurological HospitalLyonFrance

THORSTEN J. MAIER

Pharmacological Center FrankfurtClinical Center Johann-Wolfgang Goethe UniversityFrankfurtGermany

STEVEN F. MAIER

Department of Psychology and the Center forNeuroscienceUniversity of Colorado at BoulderBoulder, COUSA

CHRIS J. MAIN

University of ManchesterManchesterUKcjm@fs1.ho.man.ac.uk

MARZIA MALCANGIO

Wolfson CARD King’s College LondonLondonUKmarzia.malcangio@kcl.ac.uk

PAOLO L. MANFREDI

Essex Woodlands Health VenturesNew York, NYUSAggonzales@ewhv.com

KAISA MANNERKORPI

Department of Rheumatology andInflammation ResearchSahlgrenska AcademyGöteborg UniversityGöteborgSwedenkaisa.mannerkorpi@rheuma.gu.se

BARTON H. MANNING

Amgen Inc.Thousand Oaks, CAUSAbmanning@amgen.com

PATRICK W. MANTYH

Department Prevential ScienceUniversity of MinnesotaMinneapolis, MNUSAmanty001@umn.edu

JIANREN MAO

Pain Research GroupMGH Pain CenterandDepartment of Anesthesia and Critical CareMassachusetts General HospitalHarvard Medical SchoolBoston, MAUSAjmao@partners.org

SERGE MARCHAND

Faculty of MedicineNeurochirurgyUniversity of SherbrookeSherbrooke, QCCanadaserge.marchand@usherbrooke.ca

PAOLO MARCHETTINI

Pain Medicine CenterScientific Institute San RaffaeleMilanoItalymarchettini.paolo@hsr.it

PEGGY MASON

Department of NeurobiologyPharmacology and PhysiologyUniversity of ChicagoChicago, ILUSAp-mason@uchicago.edu

SCOTT MASTERS

Caloundra Spinal and Sports Medicine CentreCaloundra, QLDAustraliascotty1@ozemail.com.au

LAURENCE E. MATHER

Department of Anaesthesia and Pain ManagementUniversity of Sydney atRoyal North Shore HospitalSydney, NSWAustralialmather@med.usyd.edu.au

MERVYN MAZE

Magill Department of AnaestheticsChelsea and Westminster CampusImperial College of Science, Technology andMedicine, London, UKm.maze@imperial.ac.uk

XXXVIII List of Contributors

BILL MCCARBERG

Pain ServicesKaiser Permanente and Univesrity of CaliforniaSchool of MedicineSan Diego, CAUSAbill.h.mccarberg@kp.org

JOHN S. MCDONALD

Department of AnesthesiologyObstetrics and GynecologyTorrance, CAUSAjsm5525@ucla.edu

PATRICIA A. MCGRATH

Department of AnaesthesiaDivisional Centre of Pain Management and ResearchThe Hospital for Sick ChildrenandBrain and Behavior ProgramResearch Institute at The Hospital for Sick ChildrenandDepartment of AnaesthesiaUniversity of TorontoToronto, ONCanadapatricia.mcgrath@sickkids.ca

BRIAN MCGUIRK

Occupational (Musculoskeletal) MedicineHunter Area Health ServiceNewcastle, NSWAustraliamgillam@mail.newcastle.edu.au

GREG MCINTOSH

Canadian Back InstituteToronto, ONCanadagmcintosh@cbi.ca

PETER MCINTYRE

Department of PharmacologyUniversity of MelbourneMelbourne, VICAustraliapmci@unimelb.edu.au

PETER A. MCNAUGHTON

Department of PharmacologyUniversity of CambridgeCambridgeUKpam42@cam.ac.uk

J. MARK MELHORN

Section of OrthopaedicsDepartment of SurgeryUniversity of Kansas School of MedicineWichita, KSUSAmelhorn@ctdmap.com

RONALD MELZACK

Department of PsychologyMcGill UniversityMontreal, QCCanadarmelzack@ego.psych.mcgill.ca

LORNE M. MENDELL

Department of Neurobiology and BehaviorState University of New York at Stony BrookStony Brook, NYUSAlorne.mendell@sunysb.edu

GEORGE MENDELSON

Department of Psychological MedicineMonash University and Caulfield Pain Management &Research CentreCaulfield General Medical CentreCaulfield, VICAustraliageorge.mendelson@med.monash.edu.au

DANIEL MENÉTREY

CNRSUniversité René DescartesBiomédicaleParisFrancemenetrey@biomedicale.univ-paris5.fr

SIEGFRIED MENSE

Institute for Anatomy and Cell Biology IIIUniversity HeidelbergHeidelbergGermanymense@urz.uni-heidelberg.de

SEBASTIANO MERCADANTE

La Maddalena Cancer Pain Relief & PalliativeCare Unit CenterPalermoItalyterapiadeldolore@la-maddalena.it

SUSAN MERCER

School of Biomedical SciencesUniversity of QueenslandBrisbane, QLDAustraliasusan.mercer@stonebow.otago.ac.nz

List of Contributors XXXIX

HAROLD MERSKEY

Department of PsychiatryUniversity of Western OntarioLondon, ONCanada

KARL MESSLINGER

University of Erlangen-NürnbergNürnbergGermanymesslinger@physiologie1.uni-erlangen.de

RICHARD A. MEYER

Department of NeurosurgergySchool of MedicineJohns Hopkins UniversityBaltimore, MDUSArmeyer@jhmi.edu

BJÖRN A. MEYERSON

Department of Clinical NeuroscienceSection of NeurosurgeryKarolinska Institute/University HospitalStockholmSwedenbjorn.meyerson@karolinska.se

MARTIN MICHAELIS

Sanofi-Aventis Deutschland GmbHFrankfurt/MainGermanymartin.michaelis@sanofi-aventis.com

JUDITH A. MIKACICH

Department of Obstetrics and GynecologyUniversity of CaliforniaLos Angeles Medical CenterLos Angeles, CAUSAjmikacich@mednet.ucla.edu

KENSAKU MIKI

VJEKOSLAV MILETIC

School of Veterinary MedicineUniversity of Wisconsin-MadisonMadison, WIUSAvam@svm.vetmed.wisc.edu

ERIN D. MILLIGAN

Department of Psychology and theCenter for NeuroscienceUniversity of ColoradoBoulder, COUSAemilligan@psych.colorado.edu

ADRIAN MIRANDA

Division of Gastroenterology and Hepatology andPediatric GastroenterologyMedical College of WisconsinMilwaukee, WIUSA

J. MOCCO

Department of Neurological SurgeryNeurological InstituteColumbia UniversityNew York, NYUSA

JEFFREY S. MOGIL

Department of PsychologyMcGill UniversityMontreal, QCCanadajeffrey.mogil@mcgill.ca

HARVEY MOLDOFSKY

Sleep Disorders ClinicCentre for Sleep and ChronobiologyToronto, ONCanadah.moldofsky@utoronto.ca

ROBERT M. MOLDWIN

Department of UrologyLong Island Jewish Medical CenterNew York, NYUSA

DEREK C. MOLLIVER

Department of MedicineUniversity of Pittsburgh School of MedicinePittsburgh, PAUSA

LENAIC MONCONDUIT

INSERMUniversity of Clermont-FerrandClermont-FerrandFrance

JACQUELINE MONTAGNE-CLAVEL

InsermParisFrance

XL List of Contributors

ROBERT D. MOOTZ

Department of Environmental and OccupationalHealth SciencesWashington State Department of Labor and IndustriesOlympia, WAUSA

ANNE MOREL

ANNE MORINVILLE

Montreal Neurological InstituteMcGill UniversityMontreal, QCCanadaannemorinville@yahoo.ca

STEPHEN MORLEY

Academic Unit of Psychiatry and Behavioral SciencesUniversity of LeedsLeedsUKs.j.morley@leeds.ac.uk

DAVID B. MORRIS

University of VirginiaCharlottesville, VAUSAdbm6e@virginia.edu

JOACHIM MÖSSNER

Medical Clinic and Policlinic IIUniversity Clinical Center Leipzig AöRLeipzigGermanymoej@medizin.uni-leipzig.de

ERIC A. MOULTON

Program in NeuroscienceUniversity of MarylandBaltimore, MDUSAemoulton@mclean.harvard.edu

ANNE Z. MURPHY

Center for Behavioral NeuroscienceGeorgia State UniversityAtlanta, GAUSAamurphy@gsu.edu

PAUL M. MURPHY

Department of Anaesthesia and Pain ManagementRoyal North Shore HospitalSt. Leonard’s, NSWAustraliadrpmurphy@hotmail.com

ALISON MURRAY

Foothills Medical CenterCalgary, ABCanadaamurray@ucalgary.ca

H. S. NA

Medical Science Research Center andDepartment of PhysiologyKorea University College of MedicineSeoulKoreahsna@korea.ac.kr

DAISUKE NAKA

YOSHIO NAKAMURA

Pain Research CenterDepartment of AnesthesiologyUniversity of Utah School of MedicineSalt Lake City, UTUSA

MATTI V. O. NÄRHI

Department of PhysiologyUniversity of KuopioKuopioFinlandmatti.narhi@uku.fi

H.J. W. NAUTA

University of Texas Medical BranchGalveston, TXUSAhjnauta@utmb.edu

LUCIA NEGRI

Department of Human Physiology and PharmacologyUniversity “La Sapienza” of RomeRomeItalylucia.negri@uniroma1.it

GARY NESBIT

Department of RadiologyOregon Health and Science UniversityPortland, ORUSAnesbitg@ohsu.edu

List of Contributors XLI

TIMOTHY NESS

Department of AnesthesiologyUniversity of Alabama at BirminghamBirmingham, ALUSAloch@uab.edu

VOLKER NEUGEBAUER

Department of Neuroscience and Cell BiologyUniversity of Texas Medical BranchGalveston, TXUSAvoneugeb@utmb.edu

LAWRENCE C. NEWMAN

Albert Einstein College of MedicineNew York, NYUSAlnewman@chpnet.org

CHARLES NG

Musculoskeletal Medicine SpecialistAustralasian Faculty of Musculoskeletal MedicineAucklandNew Zealandcng@xtra.co.nz

MICHAEL K. NICHOLAS

Pain Management and Research CentreRoyal North Shore HospitalUniversity of SydneySt. Leonards, NSWAustraliamiken@med.usyd.edu.au

ELLEN NIEDERBERGER

Pharmacological Center FrankfurtClinical Center Johann-Wolfgang Goethe UniversityFrankfurtGermanye.niederberger@em.uni-frankfurt.de

LONE NIKOLAJSEN

Department of AnaesthesiologyAarhus University HospitalAarhusDenmarknikolajsen@dadlnet.dk

DONALD R. NIXDORF

Department of Diagnostic and Biological SciencesSchool of DentistryUniversity of MinnesotaMinneapolis, MNUSAnixdorf@umn.edu

CARL E. NOE

Baylor University Medical CenterTexas Tech University Health Science CenterLubbock, TXUSA

KOICHI NOGUCHI

Department of Anatomy and NeuroscienceHyogo College of MedicineHyogoJapan

RICHARD B. NORTH

NeurosurgeryThe Johns Hopkins University School of MedicineBaltimore, MDUSARNorth@jhmi.edu

TURO J. NURMIKKO

Department of Neurological Science and PainResearch InstituteUniversity of LiverpoolLiverpoolUKtjn@liv.ac.uk

ANNE LOUISE OAKLANDER

Nerve Injury UnitDepartments of Anesthesiology, Neurology andNeuropathologyMassachusetts General HospitalHarvard Medical SchoolBoston, MAUSAaoaklander@partners.org

KOICHI OBATA

Department of Anatomy and NeuroscienceHyogo College of MedicineHyogoJapannoguchi@hyo-med.ac.jp

TIM F. OBERLANDER

Division of Developmental PediatricsCentre for Community Child Health Research andThe University of British ColumbiaVancouver, BCCanadatoberlander@cw.bc.ca

BRUNO OERTEL

Institute for Clinical PharmacologyPharmaceutical Center FrankfurtJohann Wolfgang Goethe UniversityFrankfurtGermany

XLII List of Contributors

ALFRED T. OGDEN

Deptartment of Neurological SurgeryNeurological InstituteColumbia UniversityNew York, NYUSA

PETER T. OHARA

Department of AnatomyUniversity of California San FranciscoSan Francisco, CAUSApto@itsa.ucsf.edu

SHINJI OHARA

AKIKO OKIFUJI

Department of Anesthesiology, Psychology andClinical PharmacyUniversity of UtahSalt Lake City, UTUSAakiko.okifuji@hsc.utah.edu

JEAN-LOUIS OLIVÉRAS

InsermParisFrancejean-louis.oliveras@tolbiac.inserm.fr

ANTONIO OLIVIERO

FENNSI GroupNational Hospital of ParapléjicosSESCAM Finca “La Peraleda” ToledoToledoSpainantonioo@sescam.jccm.es

GUNNAR L. OLSSON

Pain Treatment ServicesAstrid Lindgren Children’s Hospital/KarolinksaHospitalStockholmSwedengunnar.olsson@ks.se

P. B. OSBORNE

Pain Management Research Institute andKolling InstituteUniversity of SydneySydney, NSWAustralia

MICHAEL H. OSSIPOV

Department of PharmacologyUniversity of ArizonaHealth Sciences CenterTucson, AZUSAmichaelo@u.arizona.edu

SEAN O’MAHONY

Montefiore Medical Center andAlbert Einstein College of MedicineBronxNew York, NYUSAsomahony@montefiore.org

DEBORAH A. O’ROURKE

College of Nursing and Health SciencesUniversity of VermontBurlington, VTUSAdeborah.orourke@uvm.edu

JUDITH A. PAICE

Division of Hematology-OncologyNorthwestern UniversityFeinberg School of MedicineChicago, ILUSAj-paice@northwestern.edu

JUAN A. PAREJA

Department of NeurologyFundación Hospital AlcorcónMadridSpainjpg03m@saludalia.com

ANA M. PASCUAL-LOZANO

Clinical HospitalUniversity of ValenciaValenciaSpain

STEVEN D. PASSIK

Markey Cancer CenterUniversity of Kentucky College of MedicineLexington, KYUSAspassik@uky.edu

GAVRIL W. PASTERNAK

Department of NeurologyMemorial Sloan-Kettering Cancer CenterNew York, NYUSApasterng@mskcc.org

List of Contributors XLIII

S. H. PATEL

ELLIOT M. PAUL

Department of UrologyLong Island Jewish Medical CenterNew York, NYUSAeliepaul@yahoo.com

KEVIN PAUZA

Tyler Spine and Joint HospitalTyler, TXUSAkevinpauza@tyler.net

ERIC M. PEARLMAN

Pediatric EducationMercer University School of MedicineSavannah, GAUSApearlmane@aol.com

ELVIRA DE LA PEÑA

Instituto de Neurociencias de AlicanteUniversidad Miguel Hernández-CSICAlicanteSpainelvirap@umh.es

YUAN BO PENG

Department of PsychologyUniversity of Texas at ArlingtonArlington, TXUSA

JOSE PEREIRA

Foothills Medical CenterCalgary, ABCanadapereiraj@ucalgary.ca

EDWARD PERL

Department of Cell and Molecular PhysiologySchool of MedicineUniversity of North CarolinaChapel Hill, NCUSAerp@med.unc.edu

ANTTI PERTOVAARA

Department of PhysiologyUniversity of HelsinkiHelsinkiFinlandantti.pertovaara@helsinki.fi

PRAMIT PHAL

Department of RadiologyOregon Health and Science UniversityPortland, ORUSA

ISSY PILOWSKY

Emeritus Professor of PsychiatryUniversity of AdelaideAdelaide, SAAustraliaissyp@med.usyd.edu.au

LEON PLAGHKI

Cliniques Universitaires St. LucBrusselsBelgiumplaghki@read.ucl.ac.be

MARKUS PLONER

Department of NeurologyHeinrich–Heine–UniversityDüsseldorfGermanyploner@neurologie.uni-duesseldorf.de

ESTHER M. POGATZKI-ZAHN

Department of Anesthesiology and Intensive CareMedicineUniversity MuensterMuensterGermanypogatzi@anit.uni-muenster.de

K. M. POLLOCK

MICHAEL POLYDEFKIS

Department of NeurologyThe Johns Hopkins University School of MedicineBaltimore, MDUSAmpolyde@jhmi.edu

JAMES D. POMONIS

Algos Therapeutics Inc.St. Paul, MNUSAjpomonis@algosinc.com

XLIV List of Contributors

DIETER PONGRATZ

Friedrich Baur InstituteMedical Faculty at the Neurological Clinic andPoliclinicLudwig Maximilians UniversityMunichGermanydieter.pongratz@fbs.med.uni-muenchen.de

FRANK PORRECA

Department of PharmacologyCollege of MedicineUniversity of ArizonaTucson, AZUSAfrankp@u.arizona.edu

RUSSELL K. PORTENOY

Department of Pain and Palliative CareBeth Israel Medical CenterNew York, NYUSArportenoy@chpnet.org

IAN POWER

Anaesthesia Critical Care and Pain MedicineUniversity of EdinburghEdinburghUKian.power@ed.ac.uk

DONALD D. PRICE

Department of Oral and Maxillofacial SurgeryUniversity of FloridaGainesville, FLUSAdprice@dental.ufl.edu

HERBERT K. PROUDFIT

Department of AnesthesiologyUniversity of IowaIowa, IAUSAhk-proudfit@uiowa.edu

REBECCA W. PRYOR

Pain Prevention and Treatment ResearchDepartment of Psychiatry and Behavioral SciencesDuke University Medical CenterDurham, NCUSA

DARYL PULLMAN

Medical EthicsMemorial University of NewfoundlandSt. John’s, NLCanadadpullman@mun.ca

CHAO QIN

Health Sciences CenterUniversity of OklahomaOklahoma City, OKUSA

YUNHAI QIU

MICHAEAL QUITTAN

Department of Physical Medicine and RehabilitationKaiser-Franz-Joseph HospitalViennaAustriamichael.quittan@wienkav.at

RAYMOND M. QUOCK

Department of Pharmaceutical SciencesWashington State UniversityPullman, WAUSAquockr@wsu.edu

GABOR B. RACZ

Baylor University Medical CenterTexas Tech University Health Science CenterLubbock, TXUSAgabor.racz@ttuhsc.edu

LUKAS RADBRUCH

Department of Palliative MedicineUniversity of AachenAachenGermanylradbruch@ukaachen.de

ROBERT B. RAFFA

Department of PharmacologyTemple University School of PharmacyPhiladelphia, PAUSArobert.raffa@temple.edu

VASUDEVA RAGHAVENDRA

Algos Therapeutics Inc.Saint Paul, MNUSArvasudeva@algosinc.com

FRANCINE RAINONE

Montefiore Medical Center and Albert EinsteinCollege of MedicineBronxNew York, NYUSAfrainone@montefiore.org

List of Contributors XLV

PIERRE RAINVILLE

Department of StomatologyUniversity of MontrealMontreal, QCCanadapierre.rainville@umontreal.ca

SRINIVASA N. RAJA

Department of Anesthesiology andCritical Care MedicineThe Johns Hopkins University School of MedicineBaltimore, MDUSAsraja@jhmi.edu

ALAN RANDICH

University of AlabamaBirmingham, ALUSAarandich@uab.edu

ANDREA J. RAPKIN

Department of Obstetrics and GynecologyUniversity of CaliforniaLos Angeles Medical CenterLos Angeles, CAUSAarapkin@mednet.ucla.edu

Z. HARRY RAPPAPORT

Department of NeurosurgeryRabin Medical CenterTel-Aviv UniversityPetah TikvaIsraelzhr1@internet-zahav.net

MATTHEW N. RASBAND

University of Connecticut Health CenterFarmington, CTUSArasband@uchc.edu

DOUGLAS RASMUSSON

Department of Physiology and BiophysicsDalhousie UniversityHalifax, NSCanada

JAMES P. RATHMELL

Department of AnesthesiologyUniversity of Vermont College of MedicineBurlington, VTUSAjames.rathmell@vtmednet.org

K. RAVISHANKAR

The Headache and Migraine ClinicJaslok Hospital and Research CentreLilavati Hospital and Research CentreMumbaiIndiadr_k_ravishankar@vsnl.com

KE REN

Department of Biomedical SciencesUniversity of MarylandBaltimore, MDUSAkren@umaryland.edu

CIELITO C. REYES-GIBBY

The University of Texas M. D. Anderson CancerCenterHouston, TXUSAcreyes@mdanderson.org

REBECCA PILLAI RIDDELL

York University andThe Hospital for Sick KidsToronto, ONCanadarpr@yorku.ca

MATTHIAS RINGKAMP

Department of NeurosurgerySchool of MedicineJohns Hopkins UniversityBaltimore, MDUSAplatelet@jhmi.edu

MARGARITA SANCHEZ DEL RIO

Neurology DepartmentHospital Ruber InternacionalMadridSpainmsanchezdelrio@ruberinternacional.es

DANIEL RIRIE

Department of RadiologyOregon Health and Science UniversityPortland, ORUSA

PIERRE J. M. RIVIÈRE

Ferring Research InstituteSan Diego, CAUSApierre.riviere@ferring.com

XLVI List of Contributors

ROGER ROBERT

NeurosurgeryHotel DieuNantes Cedex 1France

JAMES P. ROBINSON

University of Washington Pain CenterUniversity of WashingtonSeattle, WAUSAjimrob@u.washington.edu

JOHN ROBINSON

Pain Management ClinicBurwood HospitalChristchurchNew Zealandjon.r@xtra.co.nz

HEATHER L. ROGERS

Department of Medical and Clinical PsychologyUniformed Services University of the Health SciencesBethesda, MDUSA

DAVID ROSELT

Aberdovy ClinicBundaberg, QLDAustraliadroselt@aberdovy.com.au

SHLOMO ROTSHENKER

Department of Anatomy & Cell BiologyFaculty of MedicineHebrew University of JerusalemJerusalemIsraelrotsh@md.huji.ac.il

PAUL C. ROUSSEAU

VA Medical CenterPhoenix, AZUSApalliativedoctor@aol.com

RANJAN ROY

Faculty of Social Work andDepartment of Clinical Health PsychologyFaculty of MedicineUniversity of ManitobaWinnipeg, MBCanadarroy@cc.umanitoba.CA

CAROLINA ROZA

Institute of NeuroscienceUniversity Miguel Hernández-CSICAlicanteSpaincroza@umh.es

TODD D. ROZEN

Michigan Head-Pain and Neurological InstituteAnn Arbor, MIUSAtdrozmigraine@yahoo.com

ROMAN RUKWIED

Department of Anaesthesiology and Intensive CareMedicineFaculty of Clinical Medicine MannheimUniversity of HeidelbergMannheimGermanyroman.rukwied@anaes.ma.uni-heidelberg.de

I. JON RUSSELL

Division of Clinical Immunology and RheumatologyDepartment of MedicineThe University of Texas Health Science CenterSan Antonio, TXUSArussell@uthscsa.edu

NAYEF E. SAADÉ

Neuroscience ProgramFaculty of MedicineAmerican University of BeirutBeirutLebanonnesaade@aub.edu.lb

MARY ANN C. SABINO

Department Prevential ScienceUniversity of MinnesotaMinneapolis, MNUSA

THOMAS E. SALT

Institute of OphthalmologyUniversity College LondonLondonUKt.salt@ucl.ac.uk

A. SAMDANI

Department of NeurosurgeryJohns Hopkins Medical InstitutionsBaltimore, MDUSA

List of Contributors XLVII

JÜRGEN SANDKÜHLER

Department of NeurophysiologyCenter for Brain ResearchMedical University of ViennaViennaAustriajuergen.sandkuehler@meduniwien.ac.at

PETER S. SÁNDOR

Headache & Pain UnitUniversity Hospital ZurichZürichSwitzerlandpeter.sandor@usz.ch

JOHANNES SARNTHEIN

SUSANNE K. SAUER

Department of Physiology and PathophysiologyUniversity of ErlangenErlangenGermanysauer@physiology1.uni-erlangen.de

JANA SAWYNOK

Department of PharmacologyDalhousie UniversityHalifax, NFCanada

JOHN W. SCADDING

The National Hospital for Neurology andNeurosurgeryLondonUKjwscadding@hotmail.com

M. SCHÄFER

Clinic for Anesthesiology andOperative Intensive MedicineCharité-University Clinical Center BerlinCampus Benjamin FranklinBerlinGermanymischaefer@zop-admin.ukbf.fu-berlin.de

HANS-GEORG SCHAIBLE

Department of PhysiologyFriedrich Schiller University of JenaJenaGermanyhans-georg.schaible@mti.uni-jena.de

JÖRN SCHATTSCHNEIDER

Department of NeurologyUniversity Hospital Schleswig-HolsteinKielGermanyj.schattschneider@neurologie.uni-kiel.de

NEIL SCHECHTER

Department of PediatricsUniversity of Connecticut School of Medicine andPain Relief ProgramConnecticut Children’s Medical CenterHartford, CTUSAnschecht@stfranciscare.org

STEVEN S. SCHERER

Department of NeurologyThe University of Pennsylvania Medical SchoolPhiladelphia, PAUSAsscherer@mail.med.upenn.edu

MARTIN SCHMELZ

Institute of AnaesthesiologyOperative Intensive Medicine and Pain ResearchFaculty for Clinical Medicine MannheimUniversity of HeidelbergMannheimGermanymartin.schmelz@anaes.ma.uni-heidelberg.de

ROBERT F. SCHMIDT

Institute of PhysiologyUniversity of WürzburgWürzburgGermanyrfs@mail.uni-wuerzburg.de

SUZAN SCHNEEWEISS

The Hospital for Sick Children andThe University of TorontoToronto, ONCanadasuzan.schneeweiss@sickkids.ca

FRANK SCHNEIDER

RWTH Aachen UniversityDepartment of Psychiatry and PsychotherapyAachenGermanyfschneider@ukaachen.de

ALFONS SCHNITZLER

Department of NeurologyHeinrich Heine UniversityDüsseldorfGermany

XLVIII List of Contributors

JEAN SCHOENEN

Departments of Neurology and NeuroanatomyUniversity of LiègeCHR CitadelleLiegeBelgiumjschoenen@ulg.ac.be

EVA SCHONSTEIN

School of PhysiotherapyFaculty of Health ScienceThe University of SydneyLidcombeSydney, NSWAustraliae.schonstein@fhs.usyd.edu.au

JENS SCHOUENBORG

Section for NeurophysiologyDepartment of Physiological SciencesLund UniversityLundSwedenJens.Schouenborg@mphy.lu.se

STEPHAN A. SCHUG

Royal Perth Hospital andUniversity of Western AustraliaPerth, WAAustraliaschug@cyllene.uwa.edu.au

ANTHONY C. SCHWARZER

Faculty of Medicine and Health SciencesThe University of NewcastleNewcastle, NSWAustraliamsi5@ozemail.com.au

ZE’EV SELTZER

Centre for the Study of PainFaculty of DentistryUniversity of TorontoToronto, ONCanada

PETER SELWYN

Montefiore Medical Center andAlbert Einstein College of MedicineBronxNew York, NYUSAselwyn@aecom.yu.edu

PATRICK B. SENATUS

Deptartment of Neurological SurgeryNeurological InstituteColumbia UniversityNew York, NYUSA

JYOTI N. SENGUPTA

Division of Gastroenterology and Hepatology andPediatric GastroenterologyMedical College of WisconsinMilwaukee, WIUSAsengupta@mcw.edu

MARIANO SERRAO

Department of Neurology and OtorinolaringoiatryUniversity of Rome La SapienzaRomeItalyvictor.m@mclink.it

BARRY J. SESSLE

Department of PhysiologyFaculty of MedicineandFaculty of DentistryUniversity of TorontoToronto, ONCanadabarry.sessle@utoronto.ca

VIRGINIA S. SEYBOLD

Department of NeuroscienceUniversity of MinnesotaMinneapolis, MNUSAvseybold@umn.edu

T. SHAH

REZA SHAKER

Division of Gastroenterology and Hepatology andPediatric GastroenterologyMedical College of WisconsinMilwaukee, WIUSA

YAIR SHARAV

Department of Oral MedicineSchool of Dental MedicineHebrew University-HadassahJerusalemIsraelsharav@cc.huji.ac.il

MARNIE SHAW

Brain Imaging CenterMcLean Hospital-Harvard Medical SchoolBelmont, MAUSA

List of Contributors XLIX

S. MURRAY SHERMAN

Department of NeurobiologyState University of New YorkStony Brook, NYUSAs.sherman@sunysb.edu

YOSHIO SHIGENAGA

Department of Oral Anatomy and NeurobiologyOsaka UniversityOsakaJapansigenaga@dent.osaka-u.ac.jp

EDWARD A. SHIPTON

Department of AnaesthesiaChristchurch School of MedicineUniversity of OtagoChristchurchNew Zealandshiptonea@xtra.co.nz

YORAM SHIR

Pain CentreDepartment of AnesthesiaMcGill University Health CentreMontreal General HospitalMontreal, QCCanadayoram.shir@muhc.mcgill.ca

PETER SHRAGER

Deptartment of Neurobiology and AnatomyUniversity of Rochester Medical CenterRochester, NYUSApshr@mail.rochester.edu

MARC J. SHULMAN

VA Connecticut Healthcare SystemYale UniversityNew Haven, CTUSAmarc.shulman@med.va.gov

DAVID M. SIBELL

Comprehensive Pain CenterOregon Health and Science UniversityPortland, ORUSAsibelld@ohsu.edu

PHILIP J. SIDDALL

Pain Management Research InstituteRoyal North Shore HospitalUniversity of SydneySydney, NSWAustraliaphils@med.usyd.edu.au

STEPHEN D. SILBERSTEIN

Jefferson Medical CollegeThomas Jefferson University andJefferson Headache CenterThomas Jefferson University HospitalPhiladelphia, PAUSAstephen.silberstein@jefferson.edu

DONALD A. SIMONE

University of MinnesotaMinneapolis, MNUSAsimon003@umn.edu

DAVID G. SIMONS

Department of Rehabilitation MedicineEmory UniversityAtlanta, GAUSAloisanddavesimons@earthlink.net

DAVID SIMPSON

Clinical Neurophysiology LaboratoriesMount Sinai Medical CenterNew York, NYUSAdavid.simpson@mssm.edu

MARC SINDOU

Department of NeurosurgeryHopital NeurologiquePierre Wertheimer University of LyonLyonFrancemarc.sindou@chu-lyon.fr

SØREN HEIN SINDRUP

Department of NeurologyOdense University HospitalOdenseDenmarks.sindrup@dadlnet.dk

BENGT H. SJÖLUND

Rehabilitation and Research Centre forTorture VictimsSouth Danish UniversityCopenhagenDenmarkbsj@rct.dk

CARSTEN SKARKE

Institute of Clinical Pharmacologypharmazentrum frankfurt/ZAFESInstitute of Clinical PharmacologyJohann-Wolfgang Goethe UniversityFrankfurtGermanyskarke@em.uni-frankfurt.de

L List of Contributors

KATHLEEN A. SLUKA

Physical Therapy and Rehabilitation ScienceGraduate ProgramUniversity of IowaIowa City, IAUSAkathleen-sluka@uiowa.edu

INGRID SÖDERBACK

Department of Public Health and Caring SciencesUppsala UniversityUppsalaSwedeningrid.soderback@pubcare.uu.se

SEYMOUR SOLOMON

Montefiore Medical CenterAlbert Einstein College of MedicineBronxNew York, NYUSAssolomon@montefiore.org

CLAUDIA SOMMER

Department of NeurologyUniversity of WürzburgWürzburgGermanysommer@mail.uni-wuerzburg.de

LINDA S. SORKIN

Anesthesia Research LaboratoriesUniversity of CaliforniaSan Diego, CAUSAlsorkin@ucsd.edu

MICHAEL SPAETH

Friedrich-Baur-InstituteUniversity of MunichMunichGermanyspaeth.m5@t-online.demichael.spaeth@lrz.uni-muenchen.de

PEREGRIN O. SPIELHOLZ

SHARP ProgramWashington State Department of Labor and IndustriesOlympia, WAUSAspip235@lni.wa.gov

BENJAMIN S. CARSON SR.Department of Neurological SurgeryJohns Hopkins HospitalBaltimore, MDUSA

PETER S. STAATS

Division of Pain MedicineThe Johns Hopkins UniversityBaltimore, MDUSApstaats@jhmi.edu

BRETT R. STACEY

Comprehensive Pain CenterOregon Health and Science UniversityPortland, ORUSA

WENDY M. STEIN

San Diego Hospice and Palliative CareUCSDSan Diego, CAUSAwstein@sdhospice.org

CHRISTOPH STEIN

Department of Anaesthesiology andIntensive Care MedicineCampus Benjamin FranklinCharité – University Medicine BerlinBerlinGermanychristoph.stein@charite.de

MICHAEL STEINMETZ

Department of NeurosurgeryThe Cleveland Clinic FoundationCleveland, OHUSA

JAIR STERN

BONNIE J. STEVENS

University of Toronto andThe Hospital for Sick ChildrenToronto, ONCanadab.stevens@utoronto.ca

CARL-OLAV STILLER

Division of Clinical PharmacologyDepartment of MedicineKarolinska University HospitalStockholmSwedencarl-olav.stiller@ki.se

List of Contributors LI

JENNIFER N. STINSON

The Hospital for Sick Children andThe University of TorontoToronto, ONCanadajennifer.stinson@sickkids.ca

HENRY STOCKBRIDGE

Health and Community MedicineUniversity of Washington School of PublicSeattle, WAUSAstoh235@lni.wa.gov

CHRISTIAN S. STOHLER

Baltimore College of Dental SurgeryUniversity of MarylandBaltimore, MDUSAcstohler@dental.umaryland.edu

LAURA STONE

Department of NeuroscienceUniversity of MinnesotaMinneapolis, MNUSAstone@med.umn.edu

R. WILLIAM STONES

Princess Anne HospitalUniversity of SouthamptonSouthamptonUKr.w.stones@soton.ac.uk

ANDREAS STRAUBE

Department of NeurologyLudwig Maximilians UniversityMunichGermanyastraube@nefo.med.uni-muenchen.de

JENNY STRONG

University of QueenslandBrisbane, QLDAustraliaj.strong@uq.edu.au

GEROLD STUCKI

Department of Physical Medicine and RehabilitationLudwig-Maximilians UniversityMunichGermanygerold.stucki@med.uni-muenchen.de

CHERYL L. STUCKY

Department of Cell BiologyNeurobiology and AnatomyMedical College of WisconsinMilwaukee, WIUSAcstucky@mcw.edu

MATHIAS STURZENEGGER

Department of NeurologyUniversity of BernBernSwitzerlandmatthias.sturzenegger@insel.ch

YASUO SUGIURA

Nagoya University School of MedicineGraduate School of MedicineDepartment of Functional Anatomy & NeuroscienceNagoyaJapanysugiura@med.nagoya-u.ac.jp

MARK D. SULLIVAN

Psychiatry and Behavioral SciencesUniversity of WashingtonSeattle, WAUSAsullimar@u.washington.edu

MICHAEL J. L. SULLIVAN

Department of PsychologyUniversity of MontrealMontreal, QCCanadamichael.jl.sullivan@umontreal.ca

B. SUNG

RIE SUZUKI

Department of PharmacologyUniversity College LondonLondonUKucklrsu@ucl.ac.uk

KRISTINA B. SVENDSEN

Danish Pain Research CenterAarhus University HospitalAarhusDenmarkkristina@akhphd.au.dk

LII List of Contributors

PETER SVENSSON

Department of Clinical Oral PhysiologyUniversity of AarhusAarhusDenmarkpsvensson@odont.au.dk

NIGEL P. SYKES

St. Christopher’s Hospice and King’s CollegeUniversity of LondonLondonUKnigelsykes@doctors.org.uk

A. TAGHVA

KERSI TARAPOREWALLA

Royal Brisbane and Womens’ HospitalUniversity of QueenslandBrisbane, QLDAustraliaKersi_taraporewalla@health.qld.gov.au

RONALD R. TASKER

University of TorontoToronto Western HospitalToronto, ONCanada

IRMGARD TEGEDER

Pharmacological Center FrankfurtClinical Center Johann-Wolfgang Goethe UniversityFrankfurtGermanytegeder@em.uni-frankfurt.de

ASTRID J. TERKELSEN

Danish Pain Research Center and Department ofNeurologyAarhus University HospitalAarhusDenmarkastrid@akhphd.au.dk

GREGORY W. TERMAN

Department of Anesthesiology and theGraduate Program in Neurobiology and BehaviorUniversity of WashingtonSeattle, WAUSAgwt@u.washington.edu

ALISON THOMAS

Lismore, NSWAustraliaalison.thomas@crsrehab.gov.au

BEVERLY E. THORN

University of AlabamaTuscaloosa, ALUSAbthorn@bama.ua.edu

CINDY L. THURSTON-STANFIELD

Department of Biomedical SciencesUniversity of South AlabamaMobile, ALUSActhursto@usouthal.edu

ARNE TJØLSEN

University of BergenBergenNorwayarne.tjolsen@fys.uib.no

ANDREW J. TODD

Spinal Cord GroupInstitute of Biomedical and Life SciencesUniversity of GlasgowGlasgowUKa.todd@bio.gla.ac.uk

MAKOTO TOMINAGA

Department of Cellular and Molecular PhysiologyMie University School of MedicineTsu MieJapantominaga@doc.medic.mie-u.ac.jp

IRENE TRACEY

Pain Imaging Neuroscience (PaIN) GroupDepartment of Physiology, Anatomy and GeneticsandCentre for Functional Magnetic ResonanceImaging of the BrainOxford UniversityOxfordUKirene.tracey@anat.ox.ac.uk

TUAN DIEP TRAN

Department of NeurologyUniversity of MichiganandNeurology Research LaboratoryVA Medical CenterAnn Arbor, MIUSAandDepartment of PediatricsUniversity of Medicine and Pharmacy of HoChi Minh CityHo Chi Minh CityVietnam

List of Contributors LIII

DIEP TUAN TRAN

ROLF-DETLEF TREEDE

Institute of Physiology and PathophysiologyJohannes Gutenberg UniversityMainzGermanytreede@uni-mainz.de

JENNIE C. I. TSAO

Pediatric Pain ProgramDepartment of PediatricsDavid Geffen School of Medicine at UCLALos Angeles, CAUSA

JEANNA TSENTER

Department of Physical Medicine and RehabilitationHadassah University HospitalJerusalemIsrael

MAURITS VAN TULDER

Institute for Research in Extramural MedicineFree University AmsterdamAmsterdamThe Netherlandsmw.vantulder@vumc.nl

ELDON TUNKS

Hamilton Health Sciences CorporationHamilton, ONCanadatunks@hhsc.ca

DENNIS C. TURK

Department of AnesthesiologyUniversity of WashingtonSeattle, WAUSAturkdc@u.washington.edu

JUDITH A. TURNER

Department of Psychiatry and Behavioral SciencesUniversity of WashingtonSeattle, WAUSA

O. J. TWEEDIE

STEPHEN P. TYRER

Royal Victoria InfirmaryUniversity of Newcastle upon TyneNewcastle-on-TyneUKs.p.tyrer@ncl.ac.uk

ALEXANDER TZABAZIS

Department of AnesthesiaUniversity of ErlangenErlangenGermanytzabazis@web.de

KENE UGOKWE

Department of NeurosurgeryThe Cleveland Clinic FoundationCleveland, OHUSA

LINDSAY S. UMAN

Department of PsychologyDalhousie UniversityHalifax, NSCanadaluman@dal.ca

ANITA M. UNRUH

Health and Human Performance andOccupational TherapyDalhousie UniversityHalifax, NSCanadaaunruh@dal.ca

CHRISTIANE VAHLE-HINZ

Institute of Neurophysiology and PathophysiologyUniversity Hospital Hamburg-EppendorfHamburgGermanyvahle-hinz@uke.uni-hamburg.de

MUTHUKUMAR VAIDYARAMAN

Division of Pain MedicineThe Johns Hopkins UniversityBaltimore, MDUSAmvaidya2@jhmi.edu

TODD W. VANDERAH

Department of PharmacologyCollege of MedicineUniversity of ArizonaTucson, AZUSAvanderah@u.arizona.edu

LIV List of Contributors

GUY VANDERSTRAETEN

Department of Rehabilitation Sciences andPhysiotherapyGhent University HospitalGhentBelgiumguy.vanderstraeten@ugent.be

HORACIO VANEGAS

Instituto Venezolano de Investigaciones Cientificas(IVIC)CaracasVenezuelahvanegas@ivic.ve

JEAN-JACQUES VATINE

Outpatient and Research DivisionReuth Medical CenterTel AvivIsraelvatinejj@reuth.org.il

LINDA K. VAUGHN

Department of Biomedical SciencesMarquette UniversityMilwaukee, WIUSAlinda.vaughn@marquette.edu

LOUIS VERA-PORTOCARRERO

Department of PharmacologyCollege of MedicineUniversity of ArizonaTucson, AZUSAloverapo@email.arizona.edu

PAUL VERRILLS

Metropolitan Spinal ClinicPrahran, VICAustraliaverrills@bigpond.net.au

FÉLIX VIANA

Instituto de Neurociencias de AlicanteUniversidad Miguel Hernández-CSICSan Juan de AlicanteSpain

CHARLES J. VIERCK JR.Department of Neuroscience andMcKnight Brain InstituteUniversity of Florida College of MedicineGainesville, FLUSAvierck@mbi.ufl.edu

LUIS VILLANUEVA

INSERMUniversity of Clermont-FerrandClermont-FerrandFranceluis.villanueva@u-clermont1.fr

MARCELO VILLAR

Neuroscience LaboratoryAustral UniversityBuenos AiresArgentina

DAVID VIVIAN

Metro Spinal ClinicCaulfield, VICAustraliadvivian@metrospinal.com.au

JOHAN W. S. VLAEYEN

Department of Medical, Clinical and ExperimentalPsychologyMaastricht UniversityMaastrichtThe Netherlandsj.vlaeyen@dep.unimaas.nl

NICOLAS VOILLEY

Institut de Pharmacologie Moleculaire et CellulaireValbonneFrancevoilley@ipmc.cnrs.fr

ERNEST VOLINN

Pain Research CenterUniversity of UtahSalt Lake City, UTUSAepaulv@yahoo.com

LUCY VULCHANOVA

Department of Veterinary and Biomedical SciencesUniversity of MinnesotaSt. Paul, MNUSAlucy@med.umn.edu

PAUL W. WACNIK

Department of PharmacologyCollege of MedicineUniversity of MinnesotaMinneapolis, MNUSApaul.w.wacnik@medtronic.com

GORDON WADDELL

University of GlasgowGlasgowUKgordon.waddell@virgin.net

List of Contributors LV

GARY A. WALCO

Hackensack University Medical CenterUniversity of Medicine and Dentistry of New JerseyNew Jersey Medical SchoolHackensack, NJUSAgwalco@humed.com

BARBARA WALKER

Centre for Pain ManagementSt Vincent’s HospitalMelbourne, VICAustralia

SUELLEN M. WALKER

University of Sydney Pain Management andResearch CentreRoyal North Shore HospitalSt. Leonards, NSWAustraliaswalker@anatomy.usyd.edu.ausuellen.walker@ucl.ac.uk

LYNN S. WALKER

Division of Adolescent Medicine andBehavioral SciencesVanderbilt University Medical CenterNashville, TNUSAlynn.walker@vanderbilt.edu

VICTORIA C. J. WALLACE

Department of AnaestheticsPain Medicine and Intensive CareChelsea and Westminster Hospital CampusLondonUKv.wallace@imperial.ac.uk

XIAOHONG WANG

FAY WARNOCK

Children’s and Women’s Hospital andThe University of British ColumbiaVancouver, BCCanadawarnock@nursing.ubc.ca

GUNNAR WASNER

Department of Neurological Pain Research andTherapyNeurological ClinicKielGermanyandPrince of Wales Medical Research InstituteUniversity of New South WalesRandwick, NSWAustraliag.wasner@neurologie.uni-kiel.de

SHOKO WATANABE

LINDA R. WATKINS

Department of Psychology andCenter for NeuroscienceUniversity of Colorado at BoulderBoulder, COUSAlwatkins@psych.colorado.edu

CHRISTOPHER J. WATLING

The University of Western OntarioLondon, ONCanadachris.watling@lhsc.on.ca

PAUL J. WATSON

University Department of AnaesthesiaUniversity of LeicesterLeicesterUKpjw25@le.ac.uk

PETER N. WATSON

University of TorontoToronto, ONCanadapeter.watson@utoronto.ca

JAMES WATT

North Shore HospitalAucklandNew Zealandjameswatt@clear.net.nz

LVI List of Contributors

STEPHEN G. WAXMAN

Department of NeurologyYale School of MedicineNew Haven, CTandVA Medical CenterWest Haven, CTUSAstephen.waxman@yale.edu

CHRISTIAN WEIDNER

Department of Physiology and ExperimentalPathophysiologyUniversity ErlangenErlangenGermanyweidner@physiologie1.uni-erlangen.de

PH. TH. M. WEIJENBORG

Department of GynecologyLeiden University Medical CenterLeidenThe Netherlandsp.t.m.weijenborg@lumc.nl

ROBIN WEIR

Hamilton Health Sciences CorporationHamilton, ONCanada

NIRIT WEISS

URSULA WESSELMANN

Departments of NeurologyNeurological Surgery and Biomedical EngineeringThe Johns Hopkins University School of MedicineBaltimore, MDUSApain@jhmi.edu

DAGMAR WESTERLING

Departments of Clinical PharmacologyAnesthesiology and Intensive CareLund University HospitalLundSwedenDagmar.westerling@skane.se

KARIN N. WESTLUND

Department of Anatomy and NeurosciencesUniversity of Texas Medical BranchGalveston, TXUSAkwhigh@utmb.edu

THOMAS M. WICKIZER

Department of Rehabilitation MedicineUniversity of WashingtonSeattle, WAUSA

EVA WIDERSTRÖM-NOGA

The Miami Project to Cure ParalysisDepartment of Neurological SurgeryUniversity of MiamiVAMCMiami, FLUSAewiderstrom-noga@miami.edu

JULIE WIESELER-FRANK

Department of Psychology and Center forNeuroscienceUniversity of Colorado at BoulderBoulder, COUSA

ZSUZSANNA WIESENFELD-HALLIN

Karolinska InstituteStockholmSwedenzsuzsanna.wiesenfeld-hallin@labmed.ki.se

ANN WIGHAM

McCoull ClinicPrudhoe HospitalNorthumberlandUKann_wigham@hotmail.com

GEORGE L. WILCOX

Department of NeurosciencePharmacology and DermatologyUniversity of Minnesota Medical SchoolMinneapolis, MNUSAgeorge@umn.edu

OLIVER H. G. WILDER-SMITH

Pain and Nociception Research GroupPain CentreDepartment of AnaesthesiologyRadboud University Nijmegen Medical CentreNijmegenThe Netherlandso.wildersmith@anes.umcn.nl

KJERSTI WILHELMSEN

Section for Physiotherapy ScienceDepartment of Public Health and Primary Health CareFaculty of MedicineUniversity of BergenBergenNorwaykjersti.wilhelmsen@isf.uib.no

List of Contributors LVII

VICTOR WILK

Brighton Spinal GroupBrighton, VICAustraliavicwilk@tpg.com.au

W. A. WILLIAMS

WILLIAM D. WILLIS

Department of Neuroscience and Cell BiologyUniversity of Texas Medical BranchGalveston, TXUSAwdwillis@utmb.edu

JOHN B. WINER

Department of NeurologyBirmingham Muscle and Nerve CentreQueen Elizabeth HospitalBirminghamUKj.b.winer@bham.ac.uk

CHRISTOPHER J. WINFREE

Department of Neurological SurgeryNeurological InstituteColumbia UniversityNew York, NYUSAcjw12@columbia.edu

JANET WINTER

Novartis Institute for Medical ScienceLondonUKjanet.winter@novartis.com

ALAIN WODA

Faculté de Chirurgie DentaireUniversity Clermont-FerrandClermont-FerrandFrancealain.woda@u-clermont1.fr

SUNG TAE KOO WONKWANG

Korea Institute of Oriental MedicineKoreastkoo@klom.re.kr

LEE WOODSON

Department of AnesthesiologyUniversity of Texas Medical BranchandShriners Hospitals for ChildrenShriners Burns HospitalGalveston, TXUSA

XIAO-JUN XU

Karolinska InstituteStockholmSweden

HIROSHI YAMASAKI

MICHAEL YELLAND

School of MedicineGriffith UniversityLogan, QLDAustraliamyelland@bigpond.com

S. YENNURAJALINGAM

Department of Palliative Care andRehabilitation MedicineThe University of Texas M. D. Anderson CancerCenterHouston, TXUSA

DAVID C. YEOMANS

Department of AnesthesiaStanford UniversityStanford, CAUSAdcyeomans@stanford.edu

ROBERT P. YEZIERSKI

Comprehensive Center for Pain Research andDepartment of NeuroscienceMcKnight Brain InstituteGainesville, FLUSAryezierski@dental.ufl.edu

WAY YIN

Department of AnesthesiologyUniversity of WashingtonSeattle, WAUSAwyin@nospinepain.com

Y. W. YOON

LVIII List of Contributors

ATSUSHI YOSHIDA

Department of Oral Anatomy and NeurobiologyOsaka UniversityOsakaJapanyoshida@dent.osaka-u.ac.jp

JOANNA M. ZAKRZEWSKA

Clinical Diagnostic and Oral SciencesInstitute of DentistryBarts and the LondonQueen Mary’s School of Medicine & DentistryUniversity of LondonLondonUKj.m.zakrzewska@qmul.ac.uk

HANNS ULRICH ZEILHOFER

Institute for Pharmacology and ToxicologyUniversity of ZürichZürichSwitzerlandzeilhofer@pharma.unizh.ch

LONNIE K. ZELTZER

Pediatric Pain ProgramDepartment of PediatricsDavid Geffen School of Medicine at UCLALos Angeles, CAUSAlzeltzer@mednet.ucla.edu.

GIOVAMBATTISTA ZEPPETELLA

St. Clare HospiceHastingwoodUKjzeppetella@stclare-hospice.co.uk

YI-HONG ZHANG

Deptartment of Anatomy and NeurobiologyUniversity of Tennessee Health Science CenterMemphis, TNUSAyzhang32@utmem.edu

XIJING J. ZHANG

Department of NeuroscienceUniversity of MinnesotaMinneapolis, MNUSAzhang036@umn.edu

MIN ZHUO

Department of PhysiologyUniversity of TorontoToronto, ONCanadamin.zhuo@utoronto.ca

C. ZÖLLNER

Clinic for Anesthesiology and Operative IntensiveMedicineCharité-University Clinical Center BerlinCampus Benjamin FranklinBerlinGermanyzoellner@zop-admin.ukbf.fu-berlin.de

KRINA ZONDERVAN

Wellcome Trust Centre for Human GeneticsOxfordUK

ZBIGNIEW ZYLICZ

St. Elizabeth HospiceIpswichSuffolkUKzzylicz@onetel.net

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