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Knowledge Driven Software & Knowledge Driven Software & “Fractal Tailoring”:“Fractal Tailoring”:
Ontologies in Development Environments Ontologies in Development Environments for Clinical Systemsfor Clinical Systems
Where are the boundaries of ontology?Where are the boundaries of ontology?
How to get back where we were in 1985?How to get back where we were in 1985?
Alan Rector
School of Computer Science, University of Manchesterrector@cs.manchester.ac.uk
http://www.cs.manchester.ac.uk/~rector
2
Background: Background: A common set of problems observed A common set of problems observed in implementing practical systemsin implementing practical systems
► Two industrial projects & one major research application using Ontologies & OWL with software
► Documentation & order entry software
► Make the right information / forms / widgets available at the right time tailored to patient, task and setting
► Minimize cognitive overload
► Links to many medical terminologies► ICD, SNOMED, Ontology for Clinical Research and other statistical ontologies, National Center
for Biomedical Ontology. GALEN, …
► Work on Protégé-OWL, OWL, and related formalisms► And living in a hot-bed of DL experts
► Experiments with NHS National Programme for IT standards & specifications
► Plus a question from one of the most prominent and successful researchers in Health Informatics
►Why can’t we get back to 1985? (hands thrown up in despair)
• Zak Kohane: Harvard based, MIT trained in AI & CS, amongst most experienced & successful NIH bioinformatics and translational medicine researchers
3
… … and the obvious observation:and the obvious observation:Ontologies have had little impact on software:Ontologies have had little impact on software:
► Artifacts called “Ontologies” have become ubiquitous►“Everybody thinks they need one” – sometimes just a
synonym for good
► …but…(outside this room)►Ontological methods and OWL remain niche markets
• Compare to “Model Driven Architecture” (MDA)‣ Where are the “Ontology Driven Architectures”
►Constant questions about how OWL relates to UML• … and few helpful responses
►Constant queries about relevance of ontologies• Minimal impact outside of “annotation”‣And limited there
- compare with XML, UML, and even RDF(S)
Why?Why?
4
Plan of this talkPlan of this talk
► Where I come from► And my slant on the history of KR and Ontologies in Information Systems
► Our use cases► And why clinical systems are hard
► Architecture issues ► Dual use of ontologies and “Fractal tailoring”
► Ontologies, data structures, and user interfaces
► Knowledge issues► Language
► Generic Knowledge Representation & Contingent Knowledge
► Ontology issues► Ontology issues that do (and don’t) matter to clinical systems
► What’s in a code
► Metadata, Annotations, Higher order representations
► Evidence for choosing options, evaluation and quality assurance
► Summary of requirements and issue
5
Where I come fromWhere I come from
Best Practice
Clinical Terminology
Data Entry
Clinical Record
Clinical research &Decision Support
Best Practice
Data Entry
Electronic Health
Records
GALEN Ontologies
&Descriptio
nlogics
Healthcare
Mr Ivor BigunMr Ivor BigunDun RoaminDun RoaminAnytownAnytownAny countryAny country4431 3654 902734431 3654 90273
Clinical research
Decision Support &Knowledge Presentation
6
By way of User Centred DesignBy way of User Centred DesignKR was a solution, not a goalKR was a solution, not a goal
7
… … and a long struggle with: and a long struggle with: Poor fit between problem & solution spacesPoor fit between problem & solution spaces
``
Guidelines, Patterns, Tools, Views, Transformations
Problem space
Solutionspace
8
Three guiding principlesThree guiding principles
► The user is always right
… but the user is usually wrong►about the problem space – the problems they have
►about the solution space – how to fix them
► There is no one way!► But there are wrong ways
► Enumeration does not scale ► Medicine is a field of niches
• Easily lead to combinatorial explosions
9
… … and pragmatic software and pragmatic software development development Clinergy/ Pen&PAD (1997) Clinergy/ Pen&PAD (1997)
10
>50K potential forms and subforms>50K potential forms and subforms
From a tiny KB based on a normalised ontology
The scaling problem: The scaling problem: The combinatorial explosion The combinatorial explosion
Predicted
Actual
►It keeps happening!►“Simple” brute force
solutions do not scale up!
Conditions anatomy modifiers task setting user type … ►Huge number of niches Terms to author / Data structures to specify / GUI Screens to construct
►Software CHAOS
►Massive indexing
►Massive task for quality assurance
12
The (combinatorially) exploding The (combinatorially) exploding bicyclebicycle(codes for injuries involving cyclists)(codes for injuries involving cyclists)
►1972 ICD-9 (E826) 8
►READ-2 (T30..) 81
►READ-3 87
►1999 ICD-10 ……
ICD = International Classification of diseases
13
topClassI Certain infectious and parasitic diseasesII NeoplasmsIII Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanismIV Endocrine, nutritional and metabolic diseasesV Mental and behavioural disordersVI Diseases of the nervous systemVII Diseases of the eye and adnexaVIII Diseases of the ear and mastoid processIX Diseases of the circulatory systemsX Diseases of the respiratory systemXI Diseases of the digestive systemXII Diseases of the skin and subcutaneous tissueXIII Diseases of the musculoskeletal system and connective tissueXIV Diseases of the genitourinary systemXV Pregnancy, childbirth and the puerperiumXVI Certain conditions originating in the perinatal periodXVII Congenital malformations, deformations and chromosomal abnormalitiesXVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classifiedXIX Injury, poisoning and certain other consequences of external causesXX External causes of morbidity and mortality
V01-V99 Transport accidentsV01-V09 Pedestrian injured in transport accidentV10-V19 Pedal cyclist injured in transport accident
V10 Pedal cyclist injured in collision with pedestrian or animalV10.0 Pedal cyclist injured in collision with pedestrian or animal, driver, nontraffic accident
V10.00 Pedal cyclist injured in collision with pedestrian or animal, driver, nontraffic accident, while engaged in sports activityV10.01 Pedal cyclist injured in collision with pedestrian or animal, driver, nontraffic accident, while engaged in leisure activityV10.02 Pedal cyclist injured in collision with pedestrian or animal, driver, nontraffic accident, while working for an incomeV10.03 Pedal cyclist injured in collision with pedestrian or animal, driver, nontraffic accident, while engaged in other types of workV10.04 Pedal cyclist injured in collision with pedestrian or animal, driver, nontraffic accident, while resting, sleeping, eating or engaging in other vital activitiesV10.08 Pedal cyclist injured in collision with pedestrian or animal, driver, nontraffic accident, while engaged in other specified activitiesV10.09 Pedal cyclist injured in collision with pedestrian or animal, driver, nontraffic accident, during unspecified activity
V10.1 Pedal cyclist injured in collision with pedestrian or animal, passenger, nontraffic accidentV10.10 Pedal cyclist injured in collision with pedestrian or animal, passenger, nontraffic accident, while engaged in sports activityV10.11 Pedal cyclist injured in collision with pedestrian or animal, passenger, nontraffic accident, while engaged in leisure activityV10.12 Pedal cyclist injured in collision with pedestrian or animal, passenger, nontraffic accident, while working for an incomeV10.13 Pedal cyclist injured in collision with pedestrian or animal, passenger, nontraffic accident, while engaged in other types of workV10.14 Pedal cyclist injured in collision with pedestrian or animal, passenger, nontraffic accident, while resting, sleeping, eating or engaging in other vital activitiesV10.18 Pedal cyclist injured in collision with pedestrian or animal, passenger, nontraffic accident, while engaged in other specified activitiesV10.19 Pedal cyclist injured in collision with pedestrian or animal, passenger, nontraffic accident, during unspecified activity
V10.2 Pedal cyclist injured in collision with pedestrian or animal, unspecified pedal cyclist, nontraffic accidentV10.20 Pedal cyclist injured in collision with pedestrian or animal, unspecified pedal cyclist, nontraffic accident, while engaged in sports activityV10.21 Pedal cyclist injured in collision with pedestrian or animal, unspecified pedal cyclist, nontraffic accident, while engaged in leisure activityV10.22 Pedal cyclist injured in collision with pedestrian or animal, unspecified pedal cyclist, nontraffic accident, while working for an incomeV10.23 Pedal cyclist injured in collision with pedestrian or animal, unspecified pedal cyclist, nontraffic accident, while engaged in other types of workV10.24 Pedal cyclist injured in collision with pedestrian or animal, unspecified pedal cyclist, nontraffic accident, while resting, sleeping, eating or engaging in other vital activitiesV10.28 Pedal cyclist injured in collision with pedestrian or animal, unspecified pedal cyclist, nontraffic accident, while engaged in other specified activitiesV10.29 Pedal cyclist injured in collision with pedestrian or animal, unspecified pedal cyclist, nontraffic accident, during unspecified activity
V10.3 Pedal cyclist injured in collision with pedestrian or animal, while boarding or alightingV10.30 Pedal cyclist injured in collision with pedestrian or animal, while boarding or alighting, while engaged in sports activityV10.31 Pedal cyclist injured in collision with pedestrian or animal, while boarding or alighting, while engaged in leisure activityV10.32 Pedal cyclist injured in collision with pedestrian or animal, while boarding or alighting, while working for an incomeV10.33 Pedal cyclist injured in collision with pedestrian or animal, while boarding or alighting, while engaged in other types of workV10.34 Pedal cyclist injured in collision with pedestrian or animal, while boarding or alighting, while resting, sleeping, eating or engaging in other vital activitiesV10.38 Pedal cyclist injured in collision with pedestrian or animal, while boarding or alighting, while engaged in other specified activitiesV10.39 Pedal cyclist injured in collision with pedestrian or animal, while boarding or alighting, during unspecified activity
V10.4 Pedal cyclist injured in collision with pedestrian or animal, driver, traffic accidentV10.40 Pedal cyclist injured in collision with pedestrian or animal, driver, traffic accident, while engaged in sports activityV10.41 Pedal cyclist injured in collision with pedestrian or animal, driver, traffic accident, while engaged in leisure activityV10.42 Pedal cyclist injured in collision with pedestrian or animal, driver, traffic accident, while working for an incomeV10.43 Pedal cyclist injured in collision with pedestrian or animal, driver, traffic accident, while engaged in other types of workV10.44 Pedal cyclist injured in collision with pedestrian or animal, driver, traffic accident, while resting, sleeping, eating or engaging in other vital activitiesV10.48 Pedal cyclist injured in collision with pedestrian or animal, driver, traffic accident, while engaged in other specified activitiesV10.49 Pedal cyclist injured in collision with pedestrian or animal, driver, traffic accident, during unspecified activity
V10.5 Pedal cyclist injured in collision with pedestrian or animal, passenger, traffic accidentV10.50 Pedal cyclist injured in collision with pedestrian or animal, passenger, traffic accident, while engaged in sports activityV10.51 Pedal cyclist injured in collision with pedestrian or animal, passenger, traffic accident, while engaged in leisure activityV10.52 Pedal cyclist injured in collision with pedestrian or animal, passenger, traffic accident, while working for an incomeV10.53 Pedal cyclist injured in collision with pedestrian or animal, passenger, traffic accident, while engaged in other types of workV10.54 Pedal cyclist injured in collision with pedestrian or animal, passenger, traffic accident, while resting, sleeping, eating or engaging in other vital activitiesV10.58 Pedal cyclist injured in collision with pedestrian or animal, passenger, traffic accident, while engaged in other specified activitiesV10.59 Pedal cyclist injured in collision with pedestrian or animal, passenger, traffic accident, during unspecified activity
V10.9 Pedal cyclist injured in collision with pedestrian or animal, unspecified pedal cyclist, traffic accidentV10.90 Pedal cyclist injured in collision with pedestrian or animal, unspecified pedal cyclist, traffic accident, while engaged in sports activityV10.91 Pedal cyclist injured in collision with pedestrian or animal, unspecified pedal cyclist, traffic accident, while engaged in leisure activityV10.92 Pedal cyclist injured in collision with pedestrian or animal, unspecified pedal cyclist, traffic accident, while working for an incomeV10.93 Pedal cyclist injured in collision with pedestrian or animal, unspecified pedal cyclist, traffic accident, while engaged in other types of workV10.94 Pedal cyclist injured in collision with pedestrian or animal, unspecified pedal cyclist, traffic accident, while resting, sleeping, eating or engaging in other vital activitiesV10.98 Pedal cyclist injured in collision with pedestrian or animal, unspecified pedal cyclist, traffic accident, while engaged in other specified activitiesV10.99 Pedal cyclist injured in collision with pedestrian or animal, unspecified pedal cyclist, traffic accident, during unspecified activity
V11 Pedal cyclist injured in collision with other pedal cycleV11.0 Pedal cyclist injured in collision with other pedal cycle, driver, nontraffic accident
V11.00 Pedal cyclist injured in collision with other pedal cycle, driver, nontraffic accident, while engaged in sports activityV11.01 Pedal cyclist injured in collision with other pedal cycle, driver, nontraffic accident, while engaged in leisure activityV11.02 Pedal cyclist injured in collision with other pedal cycle, driver, nontraffic accident, while working for an incomeV11.03 Pedal cyclist injured in collision with other pedal cycle, driver, nontraffic accident, while engaged in other types of workV11.04 Pedal cyclist injured in collision with other pedal cycle, driver, nontraffic accident, while resting, sleeping, eating or engaging in other vital activitiesV11.08 Pedal cyclist injured in collision with other pedal cycle, driver, nontraffic accident, while engaged in other specified activitiesV11.09 Pedal cyclist injured in collision with other pedal cycle, driver, nontraffic accident, during unspecified activity
V11.1 Pedal cyclist injured in collision with other pedal cycle, passenger, nontraffic accidentV11.10 Pedal cyclist injured in collision with other pedal cycle, passenger, nontraffic accident, while engaged in sports activityV11.11 Pedal cyclist injured in collision with other pedal cycle, passenger, nontraffic accident, while engaged in leisure activityV11.12 Pedal cyclist injured in collision with other pedal cycle, passenger, nontraffic accident, while working for an incomeV11.13 Pedal cyclist injured in collision with other pedal cycle, passenger, nontraffic accident, while engaged in other types of workV11.14 Pedal cyclist injured in collision with other pedal cycle, passenger, nontraffic accident, while resting, sleeping, eating or engaging in other vital activitiesV11.18 Pedal cyclist injured in collision with other pedal cycle, passenger, nontraffic accident, while engaged in other specified activitiesV11.19 Pedal cyclist injured in collision with other pedal cycle, passenger, nontraffic accident, during unspecified activity
V11.2 Pedal cyclist injured in collision with other pedal cycle, unspecified pedal cyclist, nontraffic accidentV11.20 Pedal cyclist injured in collision with other pedal cycle, unspecified pedal cyclist, nontraffic accident, while engaged in sports activityV11.21 Pedal cyclist injured in collision with other pedal cycle, unspecified pedal cyclist, nontraffic accident, while engaged in leisure activityV11.22 Pedal cyclist injured in collision with other pedal cycle, unspecified pedal cyclist, nontraffic accident, while working for an incomeV11.23 Pedal cyclist injured in collision with other pedal cycle, unspecified pedal cyclist, nontraffic accident, while engaged in other types of workV11.24 Pedal cyclist injured in collision with other pedal cycle, unspecified pedal cyclist, nontraffic accident, while resting, sleeping, eating or engaging in other vital activitiesV11.28 Pedal cyclist injured in collision with other pedal cycle, unspecified pedal cyclist, nontraffic accident, while engaged in other specified activitiesV11.29 Pedal cyclist injured in collision with other pedal cycle, unspecified pedal cyclist, nontraffic accident, during unspecified activity
V11.3 Pedal cyclist injured in collision with other pedal cycle, while boarding or alightingV11.30 Pedal cyclist injured in collision with other pedal cycle, while boarding or alighting, while engaged in sports activityV11.31 Pedal cyclist injured in collision with other pedal cycle, while boarding or alighting, while engaged in leisure activityV11.32 Pedal cyclist injured in collision with other pedal cycle, while boarding or alighting, while working for an incomeV11.33 Pedal cyclist injured in collision with other pedal cycle, while boarding or alighting, while engaged in other types of workV11.34 Pedal cyclist injured in collision with other pedal cycle, while boarding or alighting, while resting, sleeping, eating or engaging in other vital activitiesV11.38 Pedal cyclist injured in collision with other pedal cycle, while boarding or alighting, while engaged in other specified activitiesV11.39 Pedal cyclist injured in collision with other pedal cycle, while boarding or alighting, during unspecified activity
V11.4 Pedal cyclist injured in collision with other pedal cycle, driver, traffic accidentV11.40 Pedal cyclist injured in collision with other pedal cycle, driver, traffic accident, while engaged in sports activityV11.41 Pedal cyclist injured in collision with other pedal cycle, driver, traffic accident, while engaged in leisure activityV11.42 Pedal cyclist injured in collision with other pedal cycle, driver, traffic accident, while working for an incomeV11.43 Pedal cyclist injured in collision with other pedal cycle, driver, traffic accident, while engaged in other types of workV11.44 Pedal cyclist injured in collision with other pedal cycle, driver, traffic accident, while resting, sleeping, eating or engaging in other vital activitiesV11.48 Pedal cyclist injured in collision with other pedal cycle, driver, traffic accident, while engaged in other specified activitiesV11.49 Pedal cyclist injured in collision with other pedal cycle, driver, traffic accident, during unspecified activity
V11.5 Pedal cyclist injured in collision with other pedal cycle, passenger, traffic accidentV11.50 Pedal cyclist injured in collision with other pedal cycle, passenger, traffic accident, while engaged in sports activityV11.51 Pedal cyclist injured in collision with other pedal cycle, passenger, traffic accident, while engaged in leisure activityV11.52 Pedal cyclist injured in collision with other pedal cycle, passenger, traffic accident, while working for an incomeV11.53 Pedal cyclist injured in collision with other pedal cycle, passenger, traffic accident, while engaged in other types of workV11.54 Pedal cyclist injured in collision with other pedal cycle, passenger, traffic accident, while resting, sleeping, eating or engaging in other vital activitiesV11.58 Pedal cyclist injured in collision with other pedal cycle, passenger, traffic accident, while engaged in other specified activitiesV11.59 Pedal cyclist injured in collision with other pedal cycle, passenger, traffic accident, during unspecified activity
V11.9 Pedal cyclist injured in collision with other pedal cycle, unspecified pedal cyclist, traffic accidentV11.90 Pedal cyclist injured in collision with other pedal cycle, unspecified pedal cyclist, traffic accident, while engaged in sports activityV11.91 Pedal cyclist injured in collision with other pedal cycle, unspecified pedal cyclist, traffic accident, while engaged in leisure activityV11.92 Pedal cyclist injured in collision with other pedal cycle, unspecified pedal cyclist, traffic accident, while working for an incomeV11.93 Pedal cyclist injured in collision with other pedal cycle, unspecified pedal cyclist, traffic accident, while engaged in other types of workV11.94 Pedal cyclist injured in collision with other pedal cycle, unspecified pedal cyclist, traffic accident, while resting, sleeping, eating or engaging in other vital activitiesV11.98 Pedal cyclist injured in collision with other pedal cycle, unspecified pedal cyclist, traffic accident, while engaged in other specified activitiesV11.99 Pedal cyclist injured in collision with other pedal cycle, unspecified pedal cyclist, traffic accident, during unspecified activity
V12 Pedal cyclist injured in collision with two- or three-wheeled motor vehicleV12.0 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle, driver, nontraffic accident
V12.00 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle, driver, nontraffic accident, while engaged in sports activityV12.01 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle, driver, nontraffic accident, while engaged in leisure activityV12.02 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle, driver, nontraffic accident, while working for an incomeV12.03 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle, driver, nontraffic accident, while engaged in other types of workV12.04 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle, driver, nontraffic accident, while resting, sleeping, eating or engaging in other vital activitiesV12.08 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle, driver, nontraffic accident, while engaged in other specified activitiesV12.09 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle, driver, nontraffic accident, during unspecified activity
V12.1 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle, passenger, nontraffic accidentV12.10 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle, passenger, nontraffic accident, while engaged in sports activityV12.11 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle, passenger, nontraffic accident, while engaged in leisure activityV12.12 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle, passenger, nontraffic accident, while working for an incomeV12.13 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle, passenger, nontraffic accident, while engaged in other types of workV12.14 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle, passenger, nontraffic accident, while resting, sleeping, eating or engaging in other vital activitiesV12.18 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle, passenger, nontraffic accident, while engaged in other specified activitiesV12.19 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle, passenger, nontraffic accident, during unspecified activity
V12.2 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle, unspecified pedal cyclist, nontraffic accidentV12.20 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle, unspecified pedal cyclist, nontraffic accident, while engaged in sports activityV12.21 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle, unspecified pedal cyclist, nontraffic accident, while engaged in leisure activityV12.22 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle, unspecified pedal cyclist, nontraffic accident, while working for an incomeV12.23 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle, unspecified pedal cyclist, nontraffic accident, while engaged in other types of workV12.24 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle, unspecified pedal cyclist, nontraffic accident, while resting, sleeping, eating or engaging in other vital activitiesV12.28 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle, unspecified pedal cyclist, nontraffic accident, while engaged in other specified activitiesV12.29 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle, unspecified pedal cyclist, nontraffic accident, during unspecified activity
V12.3 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle, while boarding or alighting
V12.30 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle, while boarding or alighting, while engaged in sports activity
V12.31 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle, while boarding or alighting, while engaged in leisure activity
V12.32 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle, while boarding or alighting, while working for an income
V12.33 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle, while boarding or alighting, while engaged in other types of work
V12.34 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle, while boarding or alighting, while resting, sleeping, eating or engaging in other vital activities
V12.38 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle, while boarding or alighting, while engaged in other specified activities
V12.39 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle, while boarding or alighting, during unspecified activity
V12.4 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle, driver, traffic accident
V12.40 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle, driver, traffic accident, while engaged in sports activity
V12.41 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle, driver, traffic accident, while engaged in leisure activity
V12.42 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle, driver, traffic accident, while working for an income
V12.43 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle, driver, traffic accident, while engaged in other types of work
V12.44 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle, driver, traffic accident, while resting, sleeping, eating or engaging in other vital activities
V12.48 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle, driver, traffic accident, while engaged in other specified activities
V12.49 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle, driver, traffic accident, during unspecified activity
V12.5 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle, passenger, traffic accident
V12.50 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle, passenger, traffic accident, while engaged in sports activity
V12.51 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle, passenger, traffic accident, while engaged in leisure activity
V12.52 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle, passenger, traffic accident, while working for an income
V12.53 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle, passenger, traffic accident, while engaged in other types of work
V12.54 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle, passenger, traffic accident, while resting, sleeping, eating or engaging in other vital activities
V12.58 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle, passenger, traffic accident, while engaged in other specified activities
V12.59 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle, passenger, traffic accident, during unspecified activity
V12.9 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle, unspecified pedal cyclist, traffic accident
V12.90 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle, unspecified pedal cyclist, traffic accident, while engaged in sports activity
V12.91 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle, unspecified pedal cyclist, traffic accident, while engaged in leisure activity
V12.92 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle, unspecified pedal cyclist, traffic accident, while working for an income
V12.93 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle, unspecified pedal cyclist, traffic accident, while engaged in other types of work
V12.94 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle, unspecified pedal cyclist, traffic accident, while resting, sleeping, eating or engaging in other vital activities
V12.98 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle, unspecified pedal cyclist, traffic accident, while engaged in other specified activities
V12.99 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle, unspecified pedal cyclist, traffic accident, during unspecified activity
V13 Pedal cyclist injured in collision with car, pick-up truck or van
V13.0 Pedal cyclist injured in collision with car, pick-up truck or van, driver, nontraffic accident
V13.00 Pedal cyclist injured in collision with car, pick-up truck or van, driver, nontraffic accident, while engaged in sports activity
V13.01 Pedal cyclist injured in collision with car, pick-up truck or van, driver, nontraffic accident, while engaged in leisure activity
V13.02 Pedal cyclist injured in collision with car, pick-up truck or van, driver, nontraffic accident, while working for an income
V13.03 Pedal cyclist injured in collision with car, pick-up truck or van, driver, nontraffic accident, while engaged in other types of work
V13.04 Pedal cyclist injured in collision with car, pick-up truck or van, driver, nontraffic accident, while resting, sleeping, eating or engaging in other vital activities
V13.08 Pedal cyclist injured in collision with car, pick-up truck or van, driver, nontraffic accident, while engaged in other specified activities
V13.09 Pedal cyclist injured in collision with car, pick-up truck or van, driver, nontraffic accident, during unspecified activity
V13.1 Pedal cyclist injured in collision with car, pick-up truck or van, passenger, nontraffic accident
V13.10 Pedal cyclist injured in collision with car, pick-up truck or van, passenger, nontraffic accident, while engaged in sports activity
V13.11 Pedal cyclist injured in collision with car, pick-up truck or van, passenger, nontraffic accident, while engaged in leisure activity
V13.12 Pedal cyclist injured in collision with car, pick-up truck or van, passenger, nontraffic accident, while working for an income
V13.13 Pedal cyclist injured in collision with car, pick-up truck or van, passenger, nontraffic accident, while engaged in other types of work
V13.14 Pedal cyclist injured in collision with car, pick-up truck or van, passenger, nontraffic accident, while resting, sleeping, eating or engaging in other vital activities
V13.18 Pedal cyclist injured in collision with car, pick-up truck or van, passenger, nontraffic accident, while engaged in other specified activities
V13.19 Pedal cyclist injured in collision with car, pick-up truck or van, passenger, nontraffic accident, during unspecified activity
V13.2 Pedal cyclist injured in collision with car, pick-up truck or van, unspecified pedal cyclist, nontraffic accident
V13.20 Pedal cyclist injured in collision with car, pick-up truck or van, unspecified pedal cyclist, nontraffic accident, while engaged in sports activity
V13.21 Pedal cyclist injured in collision with car, pick-up truck or van, unspecified pedal cyclist, nontraffic accident, while engaged in leisure activity
V13.22 Pedal cyclist injured in collision with car, pick-up truck or van, unspecified pedal cyclist, nontraffic accident, while working for an income
V13.23 Pedal cyclist injured in collision with car, pick-up truck or van, unspecified pedal cyclist, nontraffic accident, while engaged in other types of work
V13.24 Pedal cyclist injured in collision with car, pick-up truck or van, unspecified pedal cyclist, nontraffic accident, while resting, sleeping, eating or engaging in other vital activities
V13.28 Pedal cyclist injured in collision with car, pick-up truck or van, unspecified pedal cyclist, nontraffic accident, while engaged in other specified activities
V13.29 Pedal cyclist injured in collision with car, pick-up truck or van, unspecified pedal cyclist, nontraffic accident, during unspecified activity
V13.3 Pedal cyclist injured in collision with car, pick-up truck or van, while boarding or alighting
V13.30 Pedal cyclist injured in collision with car, pick-up truck or van, while boarding or alighting, while engaged in sports activity
V13.31 Pedal cyclist injured in collision with car, pick-up truck or van, while boarding or alighting, while engaged in leisure activity
V13.32 Pedal cyclist injured in collision with car, pick-up truck or van, while boarding or alighting, while working for an income
V13.33 Pedal cyclist injured in collision with car, pick-up truck or van, while boarding or alighting, while engaged in other types of work
V13.34 Pedal cyclist injured in collision with car, pick-up truck or van, while boarding or alighting, while resting, sleeping, eating or engaging in other vital activities
V13.38 Pedal cyclist injured in collision with car, pick-up truck or van, while boarding or alighting, while engaged in other specified activities
V13.39 Pedal cyclist injured in collision with car, pick-up truck or van, while boarding or alighting, during unspecified activity
V13.4 Pedal cyclist injured in collision with car, pick-up truck or van, driver, traffic accident
V13.40 Pedal cyclist injured in collision with car, pick-up truck or van, driver, traffic accident, while engaged in sports activity
V13.41 Pedal cyclist injured in collision with car, pick-up truck or van, driver, traffic accident, while engaged in leisure activity
V13.42 Pedal cyclist injured in collision with car, pick-up truck or van, driver, traffic accident, while working for an income
V13.43 Pedal cyclist injured in collision with car, pick-up truck or van, driver, traffic accident, while engaged in other types of work
V13.44 Pedal cyclist injured in collision with car, pick-up truck or van, driver, traffic accident, while resting, sleeping, eating or engaging in other vital activities
V13.48 Pedal cyclist injured in collision with car, pick-up truck or van, driver, traffic accident, while engaged in other specified activities
V13.49 Pedal cyclist injured in collision with car, pick-up truck or van, driver, traffic accident, during unspecified activity
V13.5 Pedal cyclist injured in collision with car, pick-up truck or van, passenger, traffic accident
V13.50 Pedal cyclist injured in collision with car, pick-up truck or van, passenger, traffic accident, while engaged in sports activity
V13.51 Pedal cyclist injured in collision with car, pick-up truck or van, passenger, traffic accident, while engaged in leisure activity
V13.52 Pedal cyclist injured in collision with car, pick-up truck or van, passenger, traffic accident, while working for an income
V13.53 Pedal cyclist injured in collision with car, pick-up truck or van, passenger, traffic accident, while engaged in other types of work
V13.54 Pedal cyclist injured in collision with car, pick-up truck or van, passenger, traffic accident, while resting, sleeping, eating or engaging in other vital activities
V13.58 Pedal cyclist injured in collision with car, pick-up truck or van, passenger, traffic accident, while engaged in other specified activities
V13.59 Pedal cyclist injured in collision with car, pick-up truck or van, passenger, traffic accident, during unspecified activity
V13.9 Pedal cyclist injured in collision with car, pick-up truck or van, unspecified pedal cyclist, traffic accident
V13.90 Pedal cyclist injured in collision with car, pick-up truck or van, unspecified pedal cyclist, traffic accident, while engaged in sports activity
V13.91 Pedal cyclist injured in collision with car, pick-up truck or van, unspecified pedal cyclist, traffic accident, while engaged in leisure activity
V13.92 Pedal cyclist injured in collision with car, pick-up truck or van, unspecified pedal cyclist, traffic accident, while working for an income
V13.93 Pedal cyclist injured in collision with car, pick-up truck or van, unspecified pedal cyclist, traffic accident, while engaged in other types of work
V13.94 Pedal cyclist injured in collision with car, pick-up truck or van, unspecified pedal cyclist, traffic accident, while resting, sleeping, eating or engaging in other vital activities
V13.98 Pedal cyclist injured in collision with car, pick-up truck or van, unspecified pedal cyclist, traffic accident, while engaged in other specified activities
V13.99 Pedal cyclist injured in collision with car, pick-up truck or van, unspecified pedal cyclist, traffic accident, during unspecified activity
V14 Pedal cyclist injured in collision with heavy transport vehicle or bus
V14.0 Pedal cyclist injured in collision with heavy transport vehicle or bus, driver, nontraffic accident
V14.00 Pedal cyclist injured in collision with heavy transport vehicle or bus, driver, nontraffic accident, while engaged in sports activity
V14.01 Pedal cyclist injured in collision with heavy transport vehicle or bus, driver, nontraffic accident, while engaged in leisure activity
V14.02 Pedal cyclist injured in collision with heavy transport vehicle or bus, driver, nontraffic accident, while working for an income
V14.03 Pedal cyclist injured in collision with heavy transport vehicle or bus, driver, nontraffic accident, while engaged in other types of work
V14.04 Pedal cyclist injured in collision with heavy transport vehicle or bus, driver, nontraffic accident, while resting, sleeping, eating or engaging in other vital activities
V14.08 Pedal cyclist injured in collision with heavy transport vehicle or bus, driver, nontraffic accident, while engaged in other specified activities
V14.09 Pedal cyclist injured in collision with heavy transport vehicle or bus, driver, nontraffic accident, during unspecified activity
V14.1 Pedal cyclist injured in collision with heavy transport vehicle or bus, passenger, nontraffic accident
V14.10 Pedal cyclist injured in collision with heavy transport vehicle or bus, passenger, nontraffic accident, while engaged in sports activity
V14.11 Pedal cyclist injured in collision with heavy transport vehicle or bus, passenger, nontraffic accident, while engaged in leisure activity
V14.12 Pedal cyclist injured in collision with heavy transport vehicle or bus, passenger, nontraffic accident, while working for an income
V14.13 Pedal cyclist injured in collision with heavy transport vehicle or bus, passenger, nontraffic accident, while engaged in other types of work
V14.14 Pedal cyclist injured in collision with heavy transport vehicle or bus, passenger, nontraffic accident, while resting, sleeping, eating or engaging in other vital activities
V14.18 Pedal cyclist injured in collision with heavy transport vehicle or bus, passenger, nontraffic, while engaged in other specified activities accident
V14.19 Pedal cyclist injured in collision with heavy transport vehicle or bus, passenger, nontraffic, during unspecified activity accident
V14.2 Pedal cyclist injured in collision with heavy transport vehicle or bus, unspecified pedal cyclist, nontraffic accident
V14.20 Pedal cyclist injured in collision with heavy transport vehicle or bus, unspecified pedal cyclist, nontraffic accident, while engaged in sports activity
V14.21 Pedal cyclist injured in collision with heavy transport vehicle or bus, unspecified pedal cyclist, nontraffic accident, while engaged in leisure activity
V14.22 Pedal cyclist injured in collision with heavy transport vehicle or bus, unspecified pedal cyclist, nontraffic accident, while working for an income
V14.23 Pedal cyclist injured in collision with heavy transport vehicle or bus, unspecified pedal cyclist, nontraffic accident, while engaged in other types of work
V14.24 Pedal cyclist injured in collision with heavy transport vehicle or bus, unspecified pedal cyclist, nontraffic accident, while resting, sleeping, eating or engaging in other vital activities
V14.28 Pedal cyclist injured in collision with heavy transport vehicle or bus, unspecified pedal cyclist, nontraffic accident, while engaged in other specified activities
V14.29 Pedal cyclist injured in collision with heavy transport vehicle or bus, unspecified pedal cyclist, nontraffic accident, during unspecified activity
V14.3 Pedal cyclist injured in collision with heavy transport vehicle or bus, while boarding or alighting
V14.30 Pedal cyclist injured in collision with heavy transport vehicle or bus, while boarding or alighting, while engaged in sports activity
V14.31 Pedal cyclist injured in collision with heavy transport vehicle or bus, while boarding or alighting, while engaged in leisure activity
V14.32 Pedal cyclist injured in collision with heavy transport vehicle or bus, while boarding or alighting, while working for an income
V14.33 Pedal cyclist injured in collision with heavy transport vehicle or bus, while boarding or alighting, while engaged in other types of work
V14.34 Pedal cyclist injured in collision with heavy transport vehicle or bus, while boarding or alighting, while resting, sleeping, eating or engaging in other vital activities
V14.38 Pedal cyclist injured in collision with heavy transport vehicle or bus, while boarding or alighting, while engaged in other specified activities
V14.39 Pedal cyclist injured in collision with heavy transport vehicle or bus, while boarding or alighting, during unspecified activity
V14.4 Pedal cyclist injured in collision with heavy transport vehicle or bus, driver, traffic accident
V14.40 Pedal cyclist injured in collision with heavy transport vehicle or bus, driver, traffic accident, while engaged in sports activity
V14.41 Pedal cyclist injured in collision with heavy transport vehicle or bus, driver, traffic accident, while engaged in leisure activity
V14.42 Pedal cyclist injured in collision with heavy transport vehicle or bus, driver, traffic accident, while working for an income
V14.43 Pedal cyclist injured in collision with heavy transport vehicle or bus, driver, traffic accident, while engaged in other types of work
V14.44 Pedal cyclist injured in collision with heavy transport vehicle or bus, driver, traffic accident, while resting, sleeping, eating or engaging in other vital activities
V14.48 Pedal cyclist injured in collision with heavy transport vehicle or bus, driver, traffic accident, while engaged in other specified activities
V14.49 Pedal cyclist injured in collision with heavy transport vehicle or bus, driver, traffic accident, during unspecified activity
V14.5 Pedal cyclist injured in collision with heavy transport vehicle or bus, passenger, traffic accident
V14.50 Pedal cyclist injured in collision with heavy transport vehicle or bus, passenger, traffic accident, while engaged in sports activity
V14.51 Pedal cyclist injured in collision with heavy transport vehicle or bus, passenger, traffic accident, while engaged in leisure activity
V14.52 Pedal cyclist injured in collision with heavy transport vehicle or bus, passenger, traffic accident, while working for an income
V14.53 Pedal cyclist injured in collision with heavy transport vehicle or bus, passenger, traffic accident, while engaged in other types of work
V14.54 Pedal cyclist injured in collision with heavy transport vehicle or bus, passenger, traffic accident, while resting, sleeping, eating or engaging in other vital activities
V14.58 Pedal cyclist injured in collision with heavy transport vehicle or bus, passenger, traffic accident, while engaged in other specified activities
V14.59 Pedal cyclist injured in collision with heavy transport vehicle or bus, passenger, traffic accident, during unspecified activity
V14.9 Pedal cyclist injured in collision with heavy transport vehicle or bus, unspecified pedal cyclist, traffic accident
V14.90 Pedal cyclist injured in collision with heavy transport vehicle or bus, unspecified pedal cyclist, traffic accident, while engaged in sports activity
V14.91 Pedal cyclist injured in collision with heavy transport vehicle or bus, unspecified pedal cyclist, traffic accident, while engaged in leisure activity
V14.92 Pedal cyclist injured in collision with heavy transport vehicle or bus, unspecified pedal cyclist, traffic accident, while working for an income
V14.93 Pedal cyclist injured in collision with heavy transport vehicle or bus, unspecified pedal cyclist, traffic accident, while engaged in other types of work
V14.94 Pedal cyclist injured in collision with heavy transport vehicle or bus, unspecified pedal cyclist, traffic accident, while resting, sleeping, eating or engaging in other vital activities
V14.98 Pedal cyclist injured in collision with heavy transport vehicle or bus, unspecified pedal cyclist, traffic accident, while engaged in other specified activities
V14.99 Pedal cyclist injured in collision with heavy transport vehicle or bus, unspecified pedal cyclist, traffic accident, during unspecified activity
V15 Pedal cyclist injured in collision with railway train or railway vehicle
V15.0 Pedal cyclist injured in collision with railway train or railway vehicle, driver, nontraffic accident
V15.00 Pedal cyclist injured in collision with railway train or railway vehicle, driver, nontraffic accident, while engaged in sports activity
V15.01 Pedal cyclist injured in collision with railway train or railway vehicle, driver, nontraffic accident, while engaged in leisure activity
V15.02 Pedal cyclist injured in collision with railway train or railway vehicle, driver, nontraffic accident, while working for an income
V15.03 Pedal cyclist injured in collision with railway train or railway vehicle, driver, nontraffic accident, while engaged in other types of work
V15.04 Pedal cyclist injured in collision with railway train or railway vehicle, driver, nontraffic accident, while resting, sleeping, eating or engaging in other vital activities
V15.08 Pedal cyclist injured in collision with railway train or railway vehicle, driver, nontraffic accident, while engaged in other specified activities
V15.09 Pedal cyclist injured in collision with railway train or railway vehicle, driver, nontraffic accident, during unspecified activity
V15.1 Pedal cyclist injured in collision with railway train or railway vehicle, passenger, nontraffic accident
V15.10 Pedal cyclist injured in collision with railway train or railway vehicle, passenger, nontraffic accident, while engaged in sports activity
V15.11 Pedal cyclist injured in collision with railway train or railway vehicle, passenger, nontraffic accident, while engaged in leisure activity
V15.12 Pedal cyclist injured in collision with railway train or railway vehicle, passenger, nontraffic accident, while working for an income
V15.13 Pedal cyclist injured in collision with railway train or railway vehicle, passenger, nontraffic accident, while engaged in other types of work
V15.14 Pedal cyclist injured in collision with railway train or railway vehicle, passenger, nontraffic accident, while resting, sleeping, eating or engaging in other vital activities
V15.18 Pedal cyclist injured in collision with railway train or railway vehicle, passenger, nontraffic accident, while engaged in other specified activities
V15.19 Pedal cyclist injured in collision with railway train or railway vehicle, passenger, nontraffic accident, during unspecified activity
V15.2 Pedal cyclist injured in collision with railway train or railway vehicle, unspecified pedal cyclist, nontraffic accident
V15.20 Pedal cyclist injured in collision with railway train or railway vehicle, unspecified pedal cyclist, nontraffic accident, while engaged in sports activity
V15.21 Pedal cyclist injured in collision with railway train or railway vehicle, unspecified pedal cyclist, nontraffic accident, while engaged in leisure activity
V15.22 Pedal cyclist injured in collision with railway train or railway vehicle, unspecified pedal cyclist, nontraffic accident, while working for an income
V15.23 Pedal cyclist injured in collision with railway train or railway vehicle, unspecified pedal cyclist, nontraffic accident, while engaged in other types of work
V15.24 Pedal cyclist injured in collision with railway train or railway vehicle, unspecified pedal cyclist, nontraffic accident, while resting, sleeping, eating or engaging in other vital activities
V15.28 Pedal cyclist injured in collision with railway train or railway vehicle, unspecified pedal cyclist, nontraffic accident, while engaged in other specified activities
V15.29 Pedal cyclist injured in collision with railway train or railway vehicle, unspecified pedal cyclist, nontraffic accident, during unspecified activity
V15.3 Pedal cyclist injured in collision with railway train or railway vehicle, while boarding or alighting
V15.30 Pedal cyclist injured in collision with railway train or railway vehicle, while boarding or alighting, while engaged in sports activity
V15.31 Pedal cyclist injured in collision with railway train or railway vehicle, while boarding or alighting, while engaged in leisure activity
V15.32 Pedal cyclist injured in collision with railway train or railway vehicle, while boarding or alighting, while working for an income, while working for an income
V15.33 Pedal cyclist injured in collision with railway train or railway vehicle, while boarding or alighting, while engaged in other types of work
V15.34 Pedal cyclist injured in collision with railway train or railway vehicle, while boarding or alighting, while resting, sleeping, eating or engaging in other vital activities
V15.38 Pedal cyclist injured in collision with railway train or railway vehicle, while boarding or alighting, while engaged in other specified activities
V15.39 Pedal cyclist injured in collision with railway train or railway vehicle, while boarding or alighting, during unspecified activity
V15.4 Pedal cyclist injured in collision with railway train or railway vehicle, driver, traffic accident
V15.40 Pedal cyclist injured in collision with railway train or railway vehicle, driver, traffic accident, while engaged in sports activity
V15.41 Pedal cyclist injured in collision with railway train or railway vehicle, driver, traffic accident, while engaged in leisure activity
V15.42 Pedal cyclist injured in collision with railway train or railway vehicle, driver, traffic accident, while working for an income
V15.43 Pedal cyclist injured in collision with railway train or railway vehicle, driver, traffic accident, while engaged in other types of work
V15.44 Pedal cyclist injured in collision with railway train or railway vehicle, driver, traffic accident, while resting, sleeping, eating or engaging in other vital activities
V15.48 Pedal cyclist injured in collision with railway train or railway vehicle, driver, traffic accident, while engaged in other specified activities
V15.49 Pedal cyclist injured in collision with railway train or railway vehicle, driver, traffic accident, during unspecified activity
V15.5 Pedal cyclist injured in collision with railway train or railway vehicle, passenger, traffic accident
V15.50 Pedal cyclist injured in collision with railway train or railway vehicle, passenger, traffic accident, while engaged in sports activity
V15.51 Pedal cyclist injured in collision with railway train or railway vehicle, passenger, traffic accident, while engaged in leisure activity
V15.52 Pedal cyclist injured in collision with railway train or railway vehicle, passenger, traffic accident, while working for an income
V15.53 Pedal cyclist injured in collision with railway train or railway vehicle, passenger, traffic accident, while engaged in other types of work
V15.54 Pedal cyclist injured in collision with railway train or railway vehicle, passenger, traffic accident, while resting, sleeping, eating or engaging in other vital activities
V15.58 Pedal cyclist injured in collision with railway train or railway vehicle, passenger, traffic accident, while engaged in other specified activities
V15.59 Pedal cyclist injured in collision with railway train or railway vehicle, passenger, traffic accident, during unspecified activity
V15.9 Pedal cyclist injured in collision with railway train or railway vehicle, unspecified pedal cyclist, traffic accident
V15.90 Pedal cyclist injured in collision with railway train or railway vehicle, unspecified pedal cyclist, traffic accident, while engaged in sports activity
V15.91 Pedal cyclist injured in collision with railway train or railway vehicle, unspecified pedal cyclist, traffic accident, while engaged in leisure activity
V15.92 Pedal cyclist injured in collision with railway train or railway vehicle, unspecified pedal cyclist, traffic accident, while working for an income
V15.93 Pedal cyclist injured in collision with railway train or railway vehicle, unspecified pedal cyclist, traffic accident, while engaged in other types of work
V15.94 Pedal cyclist injured in collision with railway train or railway vehicle, unspecified pedal cyclist, traffic accident, while resting, sleeping, eating or engaging in other vital activities
V15.98 Pedal cyclist injured in collision with railway train or railway vehicle, unspecified pedal cyclist, traffic accident, while engaged in other specified activities
V15.99 Pedal cyclist injured in collision with railway train or railway vehicle, unspecified pedal cyclist, traffic accident, during unspecified activity
V16 Pedal cyclist injured in collision with other nonmotor vehicle
V16.0 Pedal cyclist injured in collision with other nonmotor vehicle, driver, nontraffic accident
V16.00 Pedal cyclist injured in collision with other nonmotor vehicle, driver, nontraffic accident, while engaged in sports activity
V16.01 Pedal cyclist injured in collision with other nonmotor vehicle, driver, nontraffic accident, while engaged in leisure activity
V16.02 Pedal cyclist injured in collision with other nonmotor vehicle, driver, nontraffic accident, while working for an income
V16.03 Pedal cyclist injured in collision with other nonmotor vehicle, driver, nontraffic accident, while engaged in other types of work
V16.04 Pedal cyclist injured in collision with other nonmotor vehicle, driver, nontraffic accident, while resting, sleeping, eating or engaging in other vital activities
V16.08 Pedal cyclist injured in collision with other nonmotor vehicle, driver, nontraffic accident, while engaged in other specified activities
V16.09 Pedal cyclist injured in collision with other nonmotor vehicle, driver, nontraffic accident, during unspecified activity
V16.1 Pedal cyclist injured in collision with other nonmotor vehicle, passenger, nontraffic accident
V16.10 Pedal cyclist injured in collision with other nonmotor vehicle, passenger, nontraffic accident, while engaged in sports activity
V16.11 Pedal cyclist injured in collision with other nonmotor vehicle, passenger, nontraffic accident, while engaged in leisure activity
V16.12 Pedal cyclist injured in collision with other nonmotor vehicle, passenger, nontraffic accident, while working for an income
V16.13 Pedal cyclist injured in collision with other nonmotor vehicle, passenger, nontraffic accident, while engaged in other types of work
V16.14 Pedal cyclist injured in collision with other nonmotor vehicle, passenger, nontraffic accident, while resting, sleeping, eating or engaging in other vital activities
V16.18 Pedal cyclist injured in collision with other nonmotor vehicle, passenger, nontraffic accident, while engaged in other specified activities
V16.19 Pedal cyclist injured in collision with other nonmotor vehicle, passenger, nontraffic accident, during unspecified activity
V16.2 Pedal cyclist injured in collision with other nonmotor vehicle, unspecified pedal cyclist, nontraffic accident
V16.20 Pedal cyclist injured in collision with other nonmotor vehicle, unspecified pedal cyclist, nontraffic accident, while engaged in sports activity
V16.21 Pedal cyclist injured in collision with other nonmotor vehicle, unspecified pedal cyclist, nontraffic accident, while engaged in leisure activity
V16.22 Pedal cyclist injured in collision with other nonmotor vehicle, unspecified pedal cyclist, nontraffic accident, while working for an income
V16.23 Pedal cyclist injured in collision with other nonmotor vehicle, unspecified pedal cyclist, nontraffic accident, while engaged in other types of work
V16.24 Pedal cyclist injured in collision with other nonmotor vehicle, unspecified pedal cyclist, nontraffic accident, while resting, sleeping, eating or engaging in other vital activities
V16.28 Pedal cyclist injured in collision with other nonmotor vehicle, unspecified pedal cyclist, nontraffic accident, while engaged in other specified activities
V16.29 Pedal cyclist injured in collision with other nonmotor vehicle, unspecified pedal cyclist, nontraffic accident, during unspecified activity
V16.3 Pedal cyclist injured in collision with other nonmotor vehicle, while boarding or alighting
V16.30 Pedal cyclist injured in collision with other nonmotor vehicle, while boarding or alighting, while engaged in sports activity
V16.31 Pedal cyclist injured in collision with other nonmotor vehicle, while boarding or alighting, while engaged in leisure activity
V16.32 Pedal cyclist injured in collision with other nonmotor vehicle, while boarding or alighting, while working for an income
V16.33 Pedal cyclist injured in collision with other nonmotor vehicle, while boarding or alighting, while engaged in other types of work
V16.34 Pedal cyclist injured in collision with other nonmotor vehicle, while boarding or alighting, while resting, sleeping, eating or engaging in other vital activities
V16.38 Pedal cyclist injured in collision with other nonmotor vehicle, while boarding or alighting, while engaged in other specified activities
V16.39 Pedal cyclist injured in collision with other nonmotor vehicle, while boarding or alighting, during unspecified activity
V16.4 Pedal cyclist injured in collision with other nonmotor vehicle, driver, traffic accident
V16.40 Pedal cyclist injured in collision with other nonmotor vehicle, driver, traffic accident, while engaged in sports activity
V16.41 Pedal cyclist injured in collision with other nonmotor vehicle, driver, traffic accident, while engaged in leisure activity
V16.42 Pedal cyclist injured in collision with other nonmotor vehicle, driver, traffic accident, while working for an income
V16.43 Pedal cyclist injured in collision with other nonmotor vehicle, driver, traffic accident, while engaged in other types of work
V16.44 Pedal cyclist injured in collision with other nonmotor vehicle, driver, traffic accident, while resting, sleeping, eating or engaging in other vital activities
V16.48 Pedal cyclist injured in collision with other nonmotor vehicle, driver, traffic accident, while engaged in other specified activities
V16.49 Pedal cyclist injured in collision with other nonmotor vehicle, driver, traffic accident, during unspecified activity
V16.5 Pedal cyclist injured in collision with other nonmotor vehicle, passenger, traffic accident
V16.50 Pedal cyclist injured in collision with other nonmotor vehicle, passenger, traffic accident, while engaged in sports activity
V16.51 Pedal cyclist injured in collision with other nonmotor vehicle, passenger, traffic accident, while engaged in leisure activity
V16.52 Pedal cyclist injured in collision with other nonmotor vehicle, passenger, traffic accident, while working for an income
V16.53 Pedal cyclist injured in collision with other nonmotor vehicle, passenger, traffic accident, while engaged in other types of work
V16.54 Pedal cyclist injured in collision with other nonmotor vehicle, passenger, traffic accident, while resting, sleeping, eating or engaging in other vital activities
V16.58 Pedal cyclist injured in collision with other nonmotor vehicle, passenger, traffic accident, while engaged in other specified activities
V16.59 Pedal cyclist injured in collision with other nonmotor vehicle, passenger, traffic accident, during unspecified activity
V16.9 Pedal cyclist injured in collision with other nonmotor vehicle, unspecified pedal cyclist, traffic accident
V16.90 Pedal cyclist injured in collision with other nonmotor vehicle, unspecified pedal cyclist, traffic accident, while engaged in leisure activity
V16.91 Pedal cyclist injured in collision with other nonmotor vehicle, unspecified pedal cyclist, traffic accident, while engaged in sports activity
V16.92 Pedal cyclist injured in collision with other nonmotor vehicle, unspecified pedal cyclist, traffic accident, while working for an income
V16.93 Pedal cyclist injured in collision with other nonmotor vehicle, unspecified pedal cyclist, traffic accident, while engaged in other types of work
V16.94 Pedal cyclist injured in collision with other nonmotor vehicle, unspecified pedal cyclist, traffic accident, while resting, sleeping, eating or engaging in other vital activities
V16.98 Pedal cyclist injured in collision with other nonmotor vehicle, unspecified pedal cyclist, traffic accident, while engaged in other specified activities
V16.99 Pedal cyclist injured in collision with other nonmotor vehicle, unspecified pedal cyclist, traffic accident, during unspecified activity
V17 Pedal cyclist injured in collision with fixed or stationary object
V17.0 Pedal cyclist injured in collision with fixed or stationary object, driver, nontraffic accident
V17.00 Pedal cyclist injured in collision with fixed or stationary object, driver, nontraffic accident, while engaged in sports activity
V17.01 Pedal cyclist injured in collision with fixed or stationary object, driver, nontraffic accident, while engaged in leisure activity
V17.02 Pedal cyclist injured in collision with fixed or stationary object, driver, nontraffic accident, while working for an income
V17.03 Pedal cyclist injured in collision with fixed or stationary object, driver, nontraffic accident, while engaged in other types of work
V17.04 Pedal cyclist injured in collision with fixed or stationary object, driver, nontraffic accident, while resting, sleeping, eating or engaging in other vital activities
V17.08 Pedal cyclist injured in collision with fixed or stationary object, driver, nontraffic accident, while engaged in other specified activities
V17.09 Pedal cyclist injured in collision with fixed or stationary object, driver, nontraffic accident, during unspecified activity
V17.1 Pedal cyclist injured in collision with fixed or stationary object, passenger, nontraffic accident
V17.10 Pedal cyclist injured in collision with fixed or stationary object, passenger, nontraffic accident, while engaged in sports activity
V17.11 Pedal cyclist injured in collision with fixed or stationary object, passenger, nontraffic accident, while engaged in leisure activity
V17.12 Pedal cyclist injured in collision with fixed or stationary object, passenger, nontraffic accident, while working for an income
V17.13 Pedal cyclist injured in collision with fixed or stationary object, passenger, nontraffic accident, while engaged in other types of work
V17.14 Pedal cyclist injured in collision with fixed or stationary object, passenger, nontraffic accident, while resting, sleeping, eating or engaging in other vital activities
V17.18 Pedal cyclist injured in collision with fixed or stationary object, passenger, nontraffic accident, while engaged in other specified activities
V17.19 Pedal cyclist injured in collision with fixed or stationary object, passenger, nontraffic accident, during unspecified activity
V17.2 Pedal cyclist injured in collision with fixed or stationary object, unspecified pedal cyclist, nontraffic accident
V17.20 Pedal cyclist injured in collision with fixed or stationary object, unspecified pedal cyclist, nontraffic accident, while engaged in sports activity
V17.21 Pedal cyclist injured in collision with fixed or stationary object, unspecified pedal cyclist, nontraffic accident, while engaged in leisure activity
V17.22 Pedal cyclist injured in collision with fixed or stationary object, unspecified pedal cyclist, nontraffic accident, while working for an income
V17.23 Pedal cyclist injured in collision with fixed or stationary object, unspecified pedal cyclist, nontraffic accident, while engaged in other types of work
V17.24 Pedal cyclist injured in collision with fixed or stationary object, unspecified pedal cyclist, nontraffic accident, while resting, sleeping, eating or engaging in other vital activities
V17.28 Pedal cyclist injured in collision with fixed or stationary object, unspecified pedal cyclist, nontraffic accident, while engaged in other specified activities
V17.29 Pedal cyclist injured in collision with fixed or stationary object, unspecified pedal cyclist, nontraffic accident, during unspecified activity
V17.3 Pedal cyclist injured in collision with fixed or stationary object, while boarding or alighting
V17.30 Pedal cyclist injured in collision with fixed or stationary object, while boarding or alighting, while engaged in sports activity
V17.31 Pedal cyclist injured in collision with fixed or stationary object, while boarding or alighting, while engaged in leisure activity
V17.32 Pedal cyclist injured in collision with fixed or stationary object, while boarding or alighting, while working for an income
V17.33 Pedal cyclist injured in collision with fixed or stationary object, while boarding or alighting, while engaged in other types of work
V17.34 Pedal cyclist injured in collision with fixed or stationary object, while boarding or alighting, while resting, sleeping, eating or engaging in other vital activities
V17.38 Pedal cyclist injured in collision with fixed or stationary object, while boarding or alighting, while engaged in other specified activities
V17.39 Pedal cyclist injured in collision with fixed or stationary object, while boarding or alighting, during unspecified activity
V17.4 Pedal cyclist injured in collision with fixed or stationary object, driver, traffic accident
V17.40 Pedal cyclist injured in collision with fixed or stationary object, driver, traffic accident, while engaged in sports activity
V17.41 Pedal cyclist injured in collision with fixed or stationary object, driver, traffic accident, while engaged in leisure activity
V17.42 Pedal cyclist injured in collision with fixed or stationary object, driver, traffic accident, while working for an income
V17.43 Pedal cyclist injured in collision with fixed or stationary object, driver, traffic accident, while engaged in other types of work
V17.44 Pedal cyclist injured in collision with fixed or stationary object, driver, traffic accident, while resting, sleeping, eating or engaging in other vital activities
V17.48 Pedal cyclist injured in collision with fixed or stationary object, driver, traffic accident, while engaged in other specified activities
V17.49 Pedal cyclist injured in collision with fixed or stationary object, driver, traffic accident, during unspecified activity
V17.5 Pedal cyclist injured in collision with fixed or stationary object, passenger, traffic accident
V17.50 Pedal cyclist injured in collision with fixed or stationary object, passenger, traffic accident, while engaged in sports activity
V17.51 Pedal cyclist injured in collision with fixed or stationary object, passenger, traffic accident, while engaged in leisure activity
V17.52 Pedal cyclist injured in collision with fixed or stationary object, passenger, traffic accident, while working for an income
V17.53 Pedal cyclist injured in collision with fixed or stationary object, passenger, traffic accident, while engaged in other types of work
V17.54 Pedal cyclist injured in collision with fixed or stationary object, passenger, traffic accident, while resting, sleeping, eating or engaging in other vital activities
V17.58 Pedal cyclist injured in collision with fixed or stationary object, passenger, traffic accident, while engaged in other specified activities
V17.59 Pedal cyclist injured in collision with fixed or stationary object, passenger, traffic accident, during unspecified activity
V17.9 Pedal cyclist injured in collision with fixed or stationary object, unspecified pedal cyclist, traffic accident
V17.90 Pedal cyclist injured in collision with fixed or stationary object, unspecified pedal cyclist, traffic accident, while engaged in sports activity
V17.91 Pedal cyclist injured in collision with fixed or stationary object, unspecified pedal cyclist, traffic accident, while engaged in leisure activity
V17.92 Pedal cyclist injured in collision with fixed or stationary object, unspecified pedal cyclist, traffic accident, while working for an income
V17.93 Pedal cyclist injured in collision with fixed or stationary object, unspecified pedal cyclist, traffic accident, while engaged in other types of work
V17.94 Pedal cyclist injured in collision with fixed or stationary object, unspecified pedal cyclist, traffic accident, while resting, sleeping, eating or engaging in other vital activities
V17.98 Pedal cyclist injured in collision with fixed or stationary object, unspecified pedal cyclist, traffic accident, while engaged in other specified activities
V17.99 Pedal cyclist injured in collision with fixed or stationary object, unspecified pedal cyclist, traffic accident, during unspecified activity
V18 Pedal cyclist injured in noncollision transport accident
V18.0 Pedal cyclist injured in noncollision transport accident, driver, nontraffic accident
V18.00 Pedal cyclist injured in noncollision transport accident, driver, nontraffic accident, while engaged in sports activity
V18.01 Pedal cyclist injured in noncollision transport accident, driver, nontraffic accident, while engaged in leisure activity
V18.02 Pedal cyclist injured in noncollision transport accident, driver, nontraffic accident, while working for an income
V18.03 Pedal cyclist injured in noncollision transport accident, driver, nontraffic accident, while engaged in other types of work
V18.04 Pedal cyclist injured in noncollision transport accident, driver, nontraffic accident, while resting, sleeping, eating or engaging in other vital activities
V18.08 Pedal cyclist injured in noncollision transport accident, driver, nontraffic accident, while engaged in other specified activities
V18.09 Pedal cyclist injured in noncollision transport accident, driver, nontraffic accident, during unspecified activity
V18.1 Pedal cyclist injured in noncollision transport accident, passenger, nontraffic accident
V18.10 Pedal cyclist injured in noncollision transport accident, passenger, nontraffic accident, while engaged in sports activity
V18.11 Pedal cyclist injured in noncollision transport accident, passenger, nontraffic accident, while engaged in leisure activity
V18.12 Pedal cyclist injured in noncollision transport accident, passenger, nontraffic accident, while working for an income
V18.13 Pedal cyclist injured in noncollision transport accident, passenger, nontraffic accident, while engaged in other types of work
V18.14 Pedal cyclist injured in noncollision transport accident, passenger, nontraffic accident, while resting, sleeping, eating or engaging in other vital activities
V18.18 Pedal cyclist injured in noncollision transport accident, passenger, nontraffic accident, while engaged in other specified activities
V18.19 Pedal cyclist injured in noncollision transport accident, passenger, nontraffic accident, during unspecified activity
V18.2 Pedal cyclist injured in noncollision transport accident, unspecified pedal cyclist, nontraffic accident
V18.20 Pedal cyclist injured in noncollision transport accident, unspecified pedal cyclist, nontraffic accident, while engaged in sports activity
V18.21 Pedal cyclist injured in noncollision transport accident, unspecified pedal cyclist, nontraffic accident, while engaged in leisure activity
V18.22 Pedal cyclist injured in noncollision transport accident, unspecified pedal cyclist, nontraffic accident, while working for an income
V18.23 Pedal cyclist injured in noncollision transport accident, unspecified pedal cyclist, nontraffic accident, while engaged in other types of work
V18.24 Pedal cyclist injured in noncollision transport accident, unspecified pedal cyclist, nontraffic accident, while resting, sleeping, eating or engaging in other vital activities
V18.28 Pedal cyclist injured in noncollision transport accident, unspecified pedal cyclist, nontraffic accident, while engaged in other specified activities
V18.29 Pedal cyclist injured in noncollision transport accident, unspecified pedal cyclist, nontraffic accident, during unspecified activity
V18.3 Pedal cyclist injured in noncollision transport accident, while boarding or alighting
V18.30 Pedal cyclist injured in noncollision transport accident, while boarding or alighting, while engaged in sports activity
V18.31 Pedal cyclist injured in noncollision transport accident, while boarding or alighting, while engaged in leisure activity
V18.32 Pedal cyclist injured in noncollision transport accident, while boarding or alighting, while working for an income
V18.33 Pedal cyclist injured in noncollision transport accident, while boarding or alighting, while engaged in other types of work
V18.34 Pedal cyclist injured in noncollision transport accident, while boarding or alighting, while resting, sleeping, eating or engaging in other vital activities
V18.38 Pedal cyclist injured in noncollision transport accident, while boarding or alighting, while engaged in other specified activities
V18.39 Pedal cyclist injured in noncollision transport accident, while boarding or alighting, during unspecified activity
V18.4 Pedal cyclist injured in noncollision transport accident, driver, traffic accident
V18.40 Pedal cyclist injured in noncollision transport accident, driver, traffic accident, while engaged in sports activity
V18.41 Pedal cyclist injured in noncollision transport accident, driver, traffic accident, while engaged in leisure activity
V18.42 Pedal cyclist injured in noncollision transport accident, driver, traffic accident, while working for an income
V18.43 Pedal cyclist injured in noncollision transport accident, driver, traffic accident, while engaged in other types of work
V18.44 Pedal cyclist injured in noncollision transport accident, driver, traffic accident, while resting, sleeping, eating or engaging in other vital activities
V18.48 Pedal cyclist injured in noncollision transport accident, driver, traffic accident, while engaged in other specified activities
V18.49 Pedal cyclist injured in noncollision transport accident, driver, traffic accident, during unspecified activity, during unspecified activity
V18.5 Pedal cyclist injured in noncollision transport accident, passenger, traffic accident
V18.50 Pedal cyclist injured in noncollision transport accident, passenger, traffic accident, while engaged in sports activity
V18.51 Pedal cyclist injured in noncollision transport accident, passenger, traffic accident, while engaged in leisure activity
V18.52 Pedal cyclist injured in noncollision transport accident, passenger, traffic accident, while working for an income, while working for an income
V18.53 Pedal cyclist injured in noncollision transport accident, passenger, traffic accident, while engaged in other types of work
V18.54 Pedal cyclist injured in noncollision transport accident, passenger, traffic accident, while resting, sleeping, eating or engaging in other vital activities
V18.58 Pedal cyclist injured in noncollision transport accident, passenger, traffic accident, while engaged in other specified activities
V18.59 Pedal cyclist injured in noncollision transport accident, passenger, traffic accident, during unspecified activity, during unspecified activity
V18.9 Pedal cyclist injured in noncollision transport accident, unspecified pedal cyclist, traffic accident
V18.90 Pedal cyclist injured in noncollision transport accident, unspecified pedal cyclist, traffic accident, while engaged in sports activity
V18.91 Pedal cyclist injured in noncollision transport accident, unspecified pedal cyclist, traffic accident, while engaged in leisure activity
V18.92 Pedal cyclist injured in noncollision transport accident, unspecified pedal cyclist, traffic accident, while working for an income, while working for an income
V18.93 Pedal cyclist injured in noncollision transport accident, unspecified pedal cyclist, traffic accident, while engaged in other types of work
V18.94 Pedal cyclist injured in noncollision transport accident, unspecified pedal cyclist, traffic accident, while resting, sleeping, eating or engaging in other vital activities
V18.98 Pedal cyclist injured in noncollision transport accident, unspecified pedal cyclist, traffic accident, while engaged in other specified activities
V18.99 Pedal cyclist injured in noncollision transport accident, unspecified pedal cyclist, traffic accident, during unspecified activity, during unspecified activity
V19 Pedal cyclist injured in other and unspecified transport accidents
V19.0 Driver injured in collision with other and unspecified motor vehicles in nontraffic accident
V19.00 Driver injured in collision with other and unspecified motor vehicles in nontraffic accident, while engaged in sports activity
V19.01 Driver injured in collision with other and unspecified motor vehicles in nontraffic accident, while engaged in leisure activity
V19.02 Driver injured in collision with other and unspecified motor vehicles in nontraffic accident, while working for an income
V19.03 Driver injured in collision with other and unspecified motor vehicles in nontraffic accident, while engaged in other types of work
V19.04 Driver injured in collision with other and unspecified motor vehicles in nontraffic accident, while resting, sleeping, eating or engaging in other vital activities
V19.08 Driver injured in collision with other and unspecified motor vehicles in nontraffic accident, while engaged in other specified activities
V19.09 Driver injured in collision with other and unspecified motor vehicles in nontraffic accident, during unspecified activity
V19.1 Passenger injured in collision with other and unspecified motor vehicles in nontraffic accident
V19.10 Passenger injured in collision with other and unspecified motor vehicles in nontraffic accident, while engaged in sports activity
V19.11 Passenger injured in collision with other and unspecified motor vehicles in nontraffic accident, while engaged in leisure activity
V19.12 Passenger injured in collision with other and unspecified motor vehicles in nontraffic accident, while working for an income
V19.13 Passenger injured in collision with other and unspecified motor vehicles in nontraffic accident, while engaged in other types of work
V19.14 Passenger injured in collision with other and unspecified motor vehicles in nontraffic accident, while resting, sleeping, eating or engaging in other vital activities
V19.18 Passenger injured in collision with other and unspecified motor vehicles in nontraffic accident, while engaged in other specified activities
V19.19 Passenger injured in collision with other and unspecified motor vehicles in nontraffic accident, during unspecified activity
V19.2 Unspecified pedal cyclist injured in collision with other and unspecified motor vehicles in nontraffic accident
V19.20 Unspecified pedal cyclist injured in collision with other and unspecified motor vehicles in nontraffic accident, while engaged in sports activity
V19.21 Unspecified pedal cyclist injured in collision with other and unspecified motor vehicles in nontraffic accident, while engaged in leisure activity
V19.22 Unspecified pedal cyclist injured in collision with other and unspecified motor vehicles in nontraffic accident, while working for an income
V19.23 Unspecified pedal cyclist injured in collision with other and unspecified motor vehicles in nontraffic accident, while engaged in other types of work
V19.24 Unspecified pedal cyclist injured in collision with other and unspecified motor vehicles in nontraffic accident, while resting, sleeping, eating or engaging in other vital activities
V19.28 Unspecified pedal cyclist injured in collision with other and unspecified motor vehicles in nontraffic accident, while engaged in other specified activities
V19.29 Unspecified pedal cyclist injured in collision with other and unspecified motor vehicles in nontraffic accident, during unspecified activity
V19.3 Pedal cyclist [any] injured in unspecified nontraffic accident
V19.30 Pedal cyclist [any] injured in unspecified nontraffic accident, while engaged in sports activity
V19.31 Pedal cyclist [any] injured in unspecified nontraffic accident, while engaged in leisure activity
V19.32 Pedal cyclist [any] injured in unspecified nontraffic accident, while working for an income
V19.33 Pedal cyclist [any] injured in unspecified nontraffic accident, while engaged in other types of work
V19.34 Pedal cyclist [any] injured in unspecified nontraffic accident, while resting, sleeping, eating or engaging in other vital activities
V19.38 Pedal cyclist [any] injured in unspecified nontraffic accident, while engaged in other specified activities
V19.39 Pedal cyclist [any] injured in unspecified nontraffic accident, during unspecified activity
V19.4 Driver injured in collision with other and unspecified motor vehicles in traffic accident
V19.40 Driver injured in collision with other and unspecified motor vehicles in traffic accident, while engaged in sports activity
V19.41 Driver injured in collision with other and unspecified motor vehicles in traffic accident, while engaged in leisure activity
V19.42 Driver injured in collision with other and unspecified motor vehicles in traffic accident, while working for an income
V19.43 Driver injured in collision with other and unspecified motor vehicles in traffic accident, while engaged in other types of work
V19.44 Driver injured in collision with other and unspecified motor vehicles in traffic accident, while resting, sleeping, eating or engaging in other vital activities
V19.48 Driver injured in collision with other and unspecified motor vehicles in traffic accident, while engaged in other specified activities
V19.49 Driver injured in collision with other and unspecified motor vehicles in traffic accident, during unspecified activity
V19.5 Passenger injured in collision with other and unspecified motor vehicles in traffic accident
V19.50 Passenger injured in collision with other and unspecified motor vehicles in traffic accident, while engaged in sports activity
V19.51 Passenger injured in collision with other and unspecified motor vehicles in traffic accident, while engaged in leisure activity
V19.52 Passenger injured in collision with other and unspecified motor vehicles in traffic accident, while working for an income
V19.53 Passenger injured in collision with other and unspecified motor vehicles in traffic accident, while engaged in other types of work
V19.54 Passenger injured in collision with other and unspecified motor vehicles in traffic accident, while resting, sleeping, eating or engaging in other vital activities
V19.58 Passenger injured in collision with other and unspecified motor vehicles in traffic accident, while engaged in other specified activities
V19.59 Passenger injured in collision with other and unspecified motor vehicles in traffic accident, during unspecified activity
V19.6 Unspecified pedal cyclist injured in collision with other and unspecified motor vehicles in traffic accident
V19.60 Unspecified pedal cyclist injured in collision with other and unspecified motor vehicles in traffic accident, while engaged in sports activity
V19.61 Unspecified pedal cyclist injured in collision with other and unspecified motor vehicles in traffic accident, while engaged in leisure activity
V19.62 Unspecified pedal cyclist injured in collision with other and unspecified motor vehicles in traffic accident, while working for an income
V19.63 Unspecified pedal cyclist injured in collision with other and unspecified motor vehicles in traffic accident, while engaged in other types of work
V19.64 Unspecified pedal cyclist injured in collision with other and unspecified motor vehicles in traffic accident, while resting, sleeping, eating or engaging in other vital activities
V19.68 Unspecified pedal cyclist injured in collision with other and unspecified motor vehicles in traffic accident, while engaged in other specified activities
V19.69 Unspecified pedal cyclist injured in collision with other and unspecified motor vehicles in traffic accident, during unspecified activity
V19.8 Pedal cyclist [any] injured in other specified transport accidents
V19.80 Pedal cyclist [any] injured in other specified transport accidents, while engaged in sports activity
V19.81 Pedal cyclist [any] injured in other specified transport accidents, while engaged in leisure activity
V19.82 Pedal cyclist [any] injured in other specified transport accidents, while working for an income
V19.83 Pedal cyclist [any] injured in other specified transport accidents, while engaged in other types of work
V19.84 Pedal cyclist [any] injured in other specified transport accidents, while resting, sleeping, eating or engaging in other vital activities
V19.88 Pedal cyclist [any] injured in other specified transport accidents, while engaged in other specified activities
V19.89 Pedal cyclist [any] injured in other specified transport accidents, during unspecified activity
V19.9 Pedal cyclist [any] injured in unspecified traffic accident
V19.90 Pedal cyclist [any] injured in unspecified traffic accident, while engaged in sports activity
V19.91 Pedal cyclist [any] injured in unspecified traffic accident, while engaged in leisure activity
V19.92 Pedal cyclist [any] injured in unspecified traffic accident, while working for an income
V19.93 Pedal cyclist [any] injured in unspecified traffic accident, while engaged in other types of work
V19.94 Pedal cyclist [any] injured in unspecified traffic accident, while resting, sleeping, eating or engaging in other vital activities
V19.98 Pedal cyclist [any] injured in unspecified traffic accident, while engaged in other specified activities
V19.99 Pedal cyclist [any] injured in unspecified traffic accident, during unspecified activity
1999 ICD10: 587 codes1999 ICD10: 587 codes
•V31.22 Occupant of three-wheeled motor vehicle injured in collision with pedal cycle, person on outside of vehicle, nontraffic accident, while working for income
•W65.40 Drowning and submersion while in bath-tub, street and highway, while engaged in sports activity
•X35.44 Victim of volcanic eruption, street and highway, while resting, sleeping, eating or engaging in other vital activities
•V31.22 Occupant of three-wheeled motor vehicle injured in collision with pedal cycle, person on outside of vehicle, nontraffic accident, while working for income
•W65.40 Drowning and submersion while in bath-tub, street and highway, while engaged in sports activity
•X35.44 Victim of volcanic eruption, street and highway, while resting, sleeping, eating or engaging in other vital activities
14
Beating the Combinatorial Beating the Combinatorial Explosion with “Conceptual Lego”Explosion with “Conceptual Lego”
hand
extremity
body
acute
chronic
abnormalnormal
ischaemicdeletion
bacterium
polymorphism
cell
protein
gene
infection
inflammation
Lung
expression
virusmucus
polysacharide
15
A grammar rather than a phrase bookA grammar rather than a phrase bookComposition rather than enumerationComposition rather than enumeration
“SNPolymorphism of CFTRGene causing Defect in MembraneTransport of Chloride Ion causing Increase in Viscosity of Mucus in CysticFibrosis…”
“Hand which isanatomically normal”
16
Normalisation &Normalisation &Modularisation:Modularisation:
Building complex Building complex representations from representations from modularisedmodularisedprimitives – primitives –
Reasoner as Reasoner as terminonologyterminonologyCompilerCompiler
GenesSpecies
Protein
Function
Disease
Protein coded bygene in humans
Function ofProtein coded bygene in humans
Disease caused by abnormality inFunction ofProtein coded bygene in humans
Gene in humans
17
Our use cases Our use cases and what role ontologies and reasoners play in and what role ontologies and reasoners play in solving themsolving them
18
In general, Why might one want a In general, Why might one want a “Knowledge Driven Architecture”?“Knowledge Driven Architecture”?
► Consistency of vocabulary and meaning►Controlled vocabulary and ID management
►Composition of new entities from old (“post coordination”)
► Adaptability & context sensitivity►Dynamic extension of data structures
► Scalable maintenance and localisation►Common context-sensitive index for all resources
►Transparent declarative representation
►Logical Organisation, indexing & Consistency checking• Changes made declaratively in exactly one place with predictable
consequences
19
Fundamental Approach:Fundamental Approach:Dual use of ontologiesDual use of ontologies
► Content of the information systemWhat is carried by the data structures
►The model of meaning for the information • What can be said and when
►Classifier acts as a “Terminology Compiler”
►Index to the information system:Which data structures / UIs / Procedures to use whenBrachman’s “conceptual coatrack”
►“Fractal tailoring” & dynamic assembly based on context• Context may include setting, task, user, etc.
►Classifier acts as an “Index Compiler” • for components to assemble
20
Idiopathic Hypertensionin our co’s Phase 2 study
Dual use for ontologies: Indexing & contentDual use for ontologies: Indexing & content
Hypertension
Idiopathic Hypertension
In our company’s studies
In Phase 2 studies
Hypertension
Idiopathic Hypertension`
In our company’s studies
In Phase 2 studies
Age
Adult
21
Some issues in the approachSome issues in the approach
22
Separation of Lexicon / Language and Separation of Lexicon / Language and Symbolic Model of “Ontology”Symbolic Model of “Ontology”
► “Ontologies” are symbolic models implemented in software / logic► Behaviour unchanged under any consistent relabelling
► Good practice is that every entity have a clear linguistic description as well as a label• But the descriptions and labels do not affect behaviour of the ontology in software
► Language and Logic use different principles► Lexicons are about word usage, grammar, etc.
► Many ways to express the same symbolic expression in language
► Synonymy, polysemy, metonymy etc. are linguistic phenomena and language specific
► Linguists and ontologists have surprising difficulty understanding each other
► Research on relation between language and formal ontology still limited despite• John Bateman, Pelletier
• MONNET project (UPM Asun Gomez Perez, Oscar Corho, …)
• Udo Hahn et al.
• SWAT project: Donia Scott, Richard Power, …
• Cyc’s work on language understanding
23
Language is often misleading wrt model &Language is often misleading wrt model &Arguments about words tend to dogmatismArguments about words tend to dogmatism
► Misleading►“Heart valve” ≠ “valve located the heart”
• Means one of the four “great heart valves”
►“Cardiomyopathy” ≠ “Disorder of cardiac muscle”• Otherwise a “Myocardial Infarction” would be a “Cardiomyopathy”.
► Words lead to more dogmatic arguments than substance►“Does ‘neoplastic’ imply ‘malignant’?”
‣ bitter controversy
►“Do we need expressions for all of…? - “Benign tumour” - “Malignant tumour” - “Tumour, benign or malignant”
‣ No controversy
►Separating substance and labelling can reduce meeting time by 75%!
24
Language Generation for Language Generation for ontologiesontologies
► How does an ordinary user understand a complex expression in an ontology
►Procedure that includes(Removal that has_target some Appendix and
occurs_in some (Situation that includes some (Inflammation that has_locus some Peritoneum )))
• “Appendicectomy in the presence of Peritonitis” or “Appendectomy with co-occuring Peritonitis” or …
►Disorder that has_locus some Great_heart_valve
• “Disorder of heart valve”, or“Valvular heart disease”, or…
► Powerful mechanism for QA• GALEN used extensively for definitions that often ran to 20 lines or more
25
Language generation & Multilingual Language generation & Multilingual ontologiesontologies
In original languages
In generated English
26
General background knowledge:General background knowledge:The flesh on the ontological skeletonThe flesh on the ontological skeleton
► Knowledge driven systems require more background knowledge than just “ontologies”
►“Ontologies” are about what is universally true• Almost the only thing that ‘ontologists can agree on
‣ Otherwise “ontology” is just a synonym for “logical theory”
►In all ontological formalisms, all statements begin with “for all…”
• Implied in DLs
• Explicit in predicate logic based formulations
• Expressed as lambda abstraction in Conceptual Graphs
• Generally true in frames, but ambiguous
►Much (most) background knowledge is contingent:i.e. of the forms:
• “Generally…”, “Typically…”, “… may …”
• Or Conventional facts
27
The issue of “may”The issue of “may”
► “What may cause pneumonia?”►Conventional answer (e.g. on a med school exam):
• Bacteria, Virus, Yeast, Fungus, …
►Drill down and you get specific lists, e.g.• Bacteria
Pneumococci, Haemophilus, Staphylococcus, …• Virus
Respiratory syncitial virus, …
► But►Not all pneumococci cause pneumonia
• … or even have the “disposition” to cause pneumonia
►There are other things that can cause pneumonia• E.g. Pneumocystis in immunosuppressed patients
‣ Indeed nearly any micro-organism in weird enough circumstances- Biology is rarely absolute! Almost never exhaustive!
Rarely even mutually exclusive
28
““May” and “Typically” May” and “Typically” Characteristics of “May” statementsCharacteristics of “May” statements
► Reciprocal
►If “A may cause B”, then “B may be caused by A”.• Some alternative FoL approximations
‣ xy . A(x) & B(y) & causes(x,y)
‣ A(x) & B(y) & causes(x,y) is satisfiable
‣ There is a subclass of causal associations CAB such that(all) CAB has_topic some A & has_target some B.
‣ (pun) Class A causally_associated_with value (pun) Class B
‣ (all) A may_cause some B;(all) B may_be_caused_by some A;cause may_cause
► Metalogical / procedural / uncertainty Implicatures: The mentioned entities are “distinguished”
► When a text book says:
“Pneumonia may be caused by Bacteria, Virus, …”
it means more than
xy . Pneumonia(x) & Bacteria(y) & causes(x,y)
29
Many sources of contingent knowledge, e.g.Many sources of contingent knowledge, e.g.Statistical co-occurenceStatistical co-occurence
From http://barabasilab.neu.edu/projects/hudine/
The nodes may Come from an
ontology; The contingent
links do not.
30
Associations by Common Metabolic Associations by Common Metabolic PathwayPathway
From D-.S Lee et al. 2008
31
Characteristics of “typical” statementsCharacteristics of “typical” statements
► Not reciprocal
►“A typically causes B” does not imply that “B is typically caused by A”, or visa versa
► No first order interpretation
►“Defeasible logics still a research topic - not yet (if ever) for implementation
► Inherited down the left side with exceptions
►If A typically has C, then unless otherwise specified it is typical of subclasses of A
► Metalogical: procedural / uncertainty
►Around notions like normative, statistical, probabilistic
► Historically, the key function of “frames”
►The precursors of modern ontology systems
32
Experience: Normalised ontologies Experience: Normalised ontologies lead to clean default inheritancelead to clean default inheritance
use of beta blocker
in asthma
beta blocker asthma
(typically)serious
contraindication
(exception)mild
contraindication
cardioselective cardioselectivebeta blocker
use of cardioselectivebeta blocker
in asthma
34
Facts: A-boxes vs DatabasesFacts: A-boxes vs Databases
► Much of medical knowledge is just data►Product A is licensed for Condition B►The clinics in this hospital are…►The specialists eligible to perform X are …►The allowed values for this field are…►The proformas for this condition are …►The services available to perform this analysis are…
► Questions are closed world►Negation as failure
• Even if they may use the classification hierarchy as a framework
► A common pattern is an open world ontology as schema for a closed world data base
►But rarely supported by tools or formalism• “Conjunctive queries” come close, but those still involve an A-Box.• Querying of an RDF store according to OWL should be easy but isn’t• OWL to UML consistency testing understood, but not always the point
35
Procedural Knowledge, Procedural Knowledge, e.g.e.g.
► Prototypical sequences►Plans and partial plans
► Calculations & attached procedures
► Links to external services►Service Oriented
Architectures►Workflows & Business
Process Rules
► Helpful to index via “ontology”;
Unhelpful to try to represent in an “ontology”
From http://www.mapofmedicine.com
36
Summary of architectural issuesSummary of architectural issues
► Dual role for ontologies►Content
►Indexing
► Inheritance with defaults works for normalised “ontologies” bases
►gives a basis for “fractal tailoring”
► … but “ontologies” are only a small part of the knowledge required for knowledge driving systems
37
““Ontological Issues” – Ontological Issues” – Intended & unintended Intended & unintended consequences of borrowing a word consequences of borrowing a word (a metaphor)(a metaphor)
► Useful, not so useful, and counterproductive “ontological” notions & dogmas
► User oriented views, transformations and intermediate representations
► Issues too often ignored and need further research
► Linking ontologies to information systems►What’s in a code?
38
Example useful “ontological” distinctionsExample useful “ontological” distinctions
► “Kind” and “Role”►E.g. “Diagnosis” and “Conditions”; “Evidence” and
“Observation”
► “Parthood” and “containment”►E.g. “Brain” and “Skull”
► “Mode” and “Modifier” (“Generic Dependent” vs “Quality”)
►e.g. “Family history of X” and “severe X”
► “Observation”: ►“method” vs “result” vs “observed” vs “copy of data”
► …
39
Where “ontology” / logic can help, Where “ontology” / logic can help, e.g.e.g.
The “equivalence problem” in SNOMEDThe “equivalence problem” in SNOMED
► Almost all attribute-value pairs can be transformed into (quasi) independent entities
►A patient has a “haemoglobin” that is “elevated”
► Iff
►The patient has “elevated hemoglobin”
40
Formally (in OWL): Method 1Formally (in OWL): Method 1
► An equivalence►“Has some (Hemolglobin that has_interpreatation some
Elevated)” ==
►“has some (Elevated that is_interpretation_of some Hemoglobin)”
• given the axioms:‣ has o has_interpretation has
has o is_interpretation_of has‣ Is_interpretation_of == inv(has_interpretation)
► …while maintaining:►Haemoglobin that has_interpretatation some Elevated
=\= Elevated that is_interpretation_of some Haemoglobin
41
Alternative: “creative ambiguity” in Alternative: “creative ambiguity” in formalism:formalism:……analogous to “role groups” in SNOMEDanalogous to “role groups” in SNOMED
► “Patient with a fracture of the leg” equivalent to “Patient with a leg that is fractured”
►Disorder that has_morphology some Fracture &
has_locus some Leg
► Potential advantage of regularity for software with simpler reasoners
► Measurement that has_target some Haemoglobin & has_interpretation some Elevated
42
The issue of Context:The issue of Context: Large of elephant vs Large mouse Large of elephant vs Large mouse
►OWL and related languages give a useful solution
► Use defined classes and classifier to define and organise consistent hierarchies of context, e.g.
►has_mass range Mass_quantity
►Criterion for some (Large that is_size_of some Elephant) has_mass some [>= 3500Kg]
►Criterion for some (Large that is_size_of some Mouse) has_mass some [>= 30gms]
► Equally important for selection of data structures, procedures, … …
43
Conflict between clinical and ontological usage: Conflict between clinical and ontological usage: Why should ontologists claim monopoly on correct use of words?Why should ontologists claim monopoly on correct use of words?
► Example: parthood►Medical usage does not follow mereological theory
‣ Best modelled by a different relation: language is ambiguous
►“The thyroid is part of the endocrine system” is a matter of function rather than physical connectedness
• “faults in parts are faults in the whole” comes closer to clinical intuition• FMA driven to “Sets of heterogeneous structures” as a kluge
& the “immune system” has no parts!‣ Lack of functional information is major limitation on the use of the FMA
► The way we bridge the gap by a hierarchy of parthood relations
►Clinical_part Functional_part Physical_part …
44
Example 2: Clinical distinctions that cut across Example 2: Clinical distinctions that cut across ontological distinctions :ontological distinctions :Example - found in almost all clinical systemsExample - found in almost all clinical systems
► “Observables” ►Attribute-value pairs, e.g.
• Serum haemoglobin has_measure value 13mg%‣ has intepretation some Normal”
►vs
► “Findings”►Things normally absent that may be present
(or vice versa), e.g.• Lump, tumour, diabetes, elevated temperature, fever,
- has some Diabetesnot has some Diabetes
45
… … but ontological categories mixedbut ontological categories mixed users require alternative views users require alternative views
► “Observables” may be• Qualities of‣ the body, of parts of the body, of functions, of roles, of
processes, etc
• Relations to independent entities – ‣ e.g. “site of radiation of pain”
• …
► “Findings” may be• Independent• Generic dependent • Reified values of interpretations• Reified relations• …
46
Bridging the gapBridging the gap
► Provide alternative organisations of the ontology►Let the classifier do the work
• But requires strict logical consistency & users’ intuitions are not always strictly logical
► Provide separate user organisation►Separate browsing / searching layer overlayed on ontology
• Thesauri and SKOS seem the natural candidates
• Systematic transformations between thesauri and ontologies a critical research area
47
Ontological dogma counterproductive for clinical Ontological dogma counterproductive for clinical systemssystems
Potential epistemic status is fundamental to Potential epistemic status is fundamental to medical reporting and reasoningmedical reporting and reasoning
► Most clinical systems distinguish at least two of: ►Observation: “Serum Haemoglobin = 7 mg%”
►Interpretation: “Serum Haemoglobin ~ low”
►Belief (diagnosis): “Anaemia”
► Ignoring potential epistemic status cripples an ontology for use in clinical systems
►Because different behaviours are required depending on the potential epistemic status
48
Prohibition of entities that that have no instances:Prohibition of entities that that have no instances:Science is driven by hypotheses & medicine by differential diagnosesScience is driven by hypotheses & medicine by differential diagnoses
An “ontology” for an information system must represent the entities in it: An “ontology” for an information system must represent the entities in it:
Whether they exist in the world is irrelevant Whether they exist in the world is irrelevant
► The information system may contain a representation of a nonexistent entity so that:
►Test for its existence ►Describe it if it is suddenly found to exist– ►Hold data “about it” when it was thought to exist►…
► Examples►The toxin responsible for AIDS►The gene for X ►Pneumonia caused by Trypanosome►The Higgs Boson►(even Unicorns – e.g. to say that “Narwhale may have been the origin
of the myth of the unicorn” – or just to have a catalogue of mythical creatures
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““Metadata”: Metadata”: Many ontologies exist primarily to carry metadataMany ontologies exist primarily to carry metadataNot mere “annotations”; Not just “not first order”: Not mere “annotations”; Not just “not first order”:
► Metadata about the artifact, e.g.►Mappings - to other ontologies, terminologies, coding systems,
UMLS, standards, Web resources, …
►Textual definitions, IDs,
►…
► Editorial Information, e.g.►Authorship, provenance, authority, ...
► Meta-models / Schemas: ►The structure of the artifact itself to aid in authoring, editing, QA,
Interfaces, …• Why don’t ontologies have schemas?
► Higher order domain information, (NOT metadata) e.g.►“Endangered species”, “Category first described by”, …
►“Two different types of injury”
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Ontological issues needing more attentionOntological issues needing more attention““Prototypes”:Prototypes”:
► Relation of prototypes, individuals fulfilling those prototypes, and collections of those individuals
►“Prototypes” authored pre-hoc and then realised in individual• Blueprints and buildings• Protocols for a trial, individual patient’s histories in the trial, data from the trial,
analysis and description of the data, description of the trial
►“Prototypes” abstracted post-hoc from observations of individuals
• Normative anatomy and biology• Almost all scientific “laws”
►Does the distinction matter? In theory? In practice? If so how?
► What does it mean to be “conformant” or “normal”? “abnormal”? “missing”?
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Ontologies and Software EngineeringOntologies and Software EngineeringTowards multi layer models and Towards multi layer models and defined interfacesdefined interfaces
► “Ontologies” are not data models►Although data models may be motivated by “ontologies”
► Our understanding of the world vs how to store information about the world
►A data structure can have a missing entry for “heart beat”
►A (live) person cannot have a missing heart beat
► Ontology languages are really general logic languages
►Can be used to describe either,BUT NOT AT THE SAME TIME
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OWL / Ontologies and Template languages OWL / Ontologies and Template languages for Data Structuresfor Data Structures
► How to integrate more effectively with UML & Model Driven Architectures ( MDA)?
►How to use ontologies to derive “value sets”
►How to relate ontologies to user interfaces
► Detailed analysis in Beradi et al 2005(http://www.inf.unibz.it/~calvanese/papers-html/AIJ-2005.html)
►Described how to use DLs to describe data structures• Not the relation between Ontologies and Data structures
►Numerous tools and schemes since - but the same fault• E.g. OWL2XMI
• OMG Profile is largely syntactic and results in translations with unforeseen consequences
►…and none deal with difference between logical axioms and specification templates or both OWL and UML semantics
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Fitting with Software Engineering Practice: Fitting with Software Engineering Practice: e.g.e.g. Ontology Programming InterfaceOntology Programming Interface
The only things the application needs to know about the ontology;
Equivalence axiomsthat bind the source to the application
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Evidence: Evaluation of proposals and Evidence: Evaluation of proposals and options and for Quality Assuranceoptions and for Quality Assurance
► What counts as evidence wrt “ontologies” for information systems
►The consequences for the information systems, e.g.• Expressivity, inferences
• Correspondence to users’ intuitions and usability
• Relation to standards and common practices
• Transformations between alternatives (morphisms)
• Flexibility, effort required for maintenance
• Complexity of queries
• Scaling
• …
►Consistency with the world as we best understand it• Are any of the consequences refuted when tested; unacceptable to users
►Implementations• Until implemented, it isn’t yet an “ontology for information systems”
► Where are the papers & theses comparing options?►Analogous to those in the software, logic and other academic
communities
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Summary: Summary: Dual use of “ontologies” in Information Systems:Dual use of “ontologies” in Information Systems:
► As the definitions and universal knowledge of the content►And a framework for the other background knowledge required by
the system
► As the index of the information system itself for “Fractal Tailoring”
►Scalable software that beats the combinatorial explosion
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ChallengesChallenges
► Relation of ontologies to software engineering► Relationship of ontologies to data structures
► Effective interaction with UML family of representations
► Ontology & software interfaces, versioning, and co-evolution
► Reconciling ontologists’ and clinicians’ viewpoints► Ontology views, intermediate representations & transformations
► Relation to SKOS, thesauri and other browsing / searching
► Relation to language – both understaning and generation
► Focusing on problems clinicians see as important► Capturing the epistemic essence of clinical entities
► Relation of protocols, patients courses, data, and analyses (“prototypes”/”patterns”)
► Equivalences in electronic health records
► Heuristic hybrid architectures for broader knowledge representation► “may”, “typical”, probabilities, …
► Reviving heuristic approaches to defaults and exceptions
► Interaction with rules, procedures, …
► Establishing standards of evidence and scholarship
► Tooling, tooling, and tooling…
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EndEnd
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Other Open Ontological QuestionsOther Open Ontological QuestionsWhat are the alternatives?What are the alternatives?
► Normal, abnormal, pathological, conformant, present, absent…
► Handling of collective and mass phenomena ►Cells, tissues, substances, mixtures, etc.
► Homogeneity vs Heterogeneity►How to represent “All of the same kind”;
“of two different kinds”
► What does a “code” really stand for?►“DisorderX”
►“having DisorderX”
► Analysis and specification of “may”, “typically”, etc.
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