Keith R. Holden, M.D. Resonance Center Jacksonville Beach, FL

Keith R. Holden, M.D.Resonance Center

Jacksonville Beach, FLwww.ResonanceCenterJax.com

Integrative Biophysics.

Pulsed Electromagnetic Field (PEMF) Therapy as an instrument of integrative biophysics.

◦ Biomolecular effects.

◦ Epigenetic effects.

◦ Cellular physiologic effects.

◦ Optimal tissue frequencies.

◦ Proof of efficacy via peer reviewed studies, including RDBPC clinical trials.

◦ Ondamed® as a powerful instrument of integrative biophysics.

Holistic integration of quantum energetic, molecular, biochemical, and physiologic processes.

Reflects the web-like interconnectedness of all biologic systems within the body and that of the body with its environment.

Honors energetic and biochemical individuality.

PEMF = instrument for integrative biophysics.

◦ Larmor Precession Model

External pulsed electromagnetic field matches the (Larmor) spin frequency of hydrogen atom causing energized electrons to emit a photon, which act as a vital energy carrier for tissue repair.

Ion/ligand binding at cell membrane. Alters cascade of biological processes for tissue growth

and repair.

Amplification of the tissue repair field (current of injury).

◦ Upregulation of genes involved in normal cell growth.

(Goodwin, 2003)

Increases osteoblast intracellular calcium & alters response to epidermal growth factor.

(Shigaku,1990)

Stimulates production of type-I collagen, osteocalcin, & osteopontin.

(Cornaglia, et al., 2006)

Antiinflammatory effect via restoration of plasma membrane calcium ATPase activity.

(Selvam, et al., 2007)

Nerve‐2 Hz Bone‐75 Hz

Ligament‐10 Hz Capillaries and skin‐15 Hz

(Sisken, et al., 1995) (Shupak, 2003)

Fracture non-union – 65-75Hz Congenital pseudoarthrosis – 15Hz Osteoporosis – 72Hz Hip arthroplasty – 50Hz Arthritis – 50Hz Tinnitus – 0.5-17Hz Rotator Cuff Tendonitis – 71-75Hz Venous skin ulcers – 75Hz Multiple sclerosis – 4-13Hz

(Shupak, 2003)

Randomized, Double Blind, Placebo Controlled

Randomized double blind placebo controlled (RDBPC) clinical trial.

PEMF 3X a week for 3 weeks for chronic lower back pain.

Significant reduction in pain and disability over placebo.

(Lee, 2006)

RDBPC clinical trial.

Chronic generalized pain from fibromyalgia or chronic localized musculoskeletal pain.

PEMF twice daily 40 min. for 7 days.

PEMF effect over sham for fibromyalgia approached statistical significance.

(Thomas, et al., 2007)

RDBPC clinical trial.

PEMF 30 min. 2X a day for 3 weeks.

Neck pain, PVMS, and disability scale scores decreased, and AROM increased significantly in the PEMF group.

No change in the sham group.

(Sutbeyaz, et al., 2006)

RDBPC clinical trial.

86 patients with OA of knee. 81 patients with OA of cervical spine.

Statistically significant improvement in treated patients for pain and ADLs at end of treatment and at one month follow up.

(Trock, et al.,1994)

RDBPC clinical trial.

Group I (PEMF), Group II (sham PEMF), Group III (corticosteroid + anesthestic inj.)

Group III had lower pain than Group I and Group II at third week.

Group I (PEMF) patients had lower pain than Groups II and III at third month.

(Uzunca, et al., 2007)

RDBPC clinical trial.

Preclinical studies show that PEMF limits catabolic effects of pro-inflammatory cytokines on articular cartilage.

PEMF 75 Hz 4 hours per day for 60 days.

Functional recovery occurs earlier with PEMF group.

(Benazzo, et al., 2008)

RDBPC clinical trial.

PEMF 30 min. twice a day for 3 weeks.

At 12 weeks follow up, PEMF group showed significant improvements in pain compared to sham PEMF.

(Sutbeyaz, et al., 2009)

RDBPC clinical trial.

PEMF for 90 days 6 hours per day. PEMF group statistically significant improvement at

90 days.

NSAID use – PEMF (26%) & sham (75%).

3 year follow up, number of patients who completely recovered was higher in PEMF.

(Zorzi, et al., 2007)

RDBPC clinical trial.

PEMF 4 weeks.

Assessed MSQLI- fatigue, bladder control, spasticity, & QOL composite.

Statistically significant improvement in fatigue & QOL; none bladder control; mixed spasticity.

(Lappin, et al., 2003)

RDBPC clinical trial.

PEMF 84 sessions for 30 min.

WOMAC index dec. 84.1 to 49.7 in PEMF and 73.7 to 66.9 in sham.

Secondary parameters improved over sham – gait speed, stride length, & acceleration time.

(Nicolakis, et al., 2002)

RDBPC clinical trial.

Active group – 92% success rate.

Sham group – 65% success rate.

(Mooney, 1990)

RDBPC clinical trial.

Refractory rotator cuff tendinitis.

PEMF showed significant improvement over sham during the first four weeks.

No significant difference between groups when both received PEMF.

End of study – 65% were asymptomatic.

(Binder, 1984)

CONDITION FDA APPROVED SUCCESS RATE

Fracture nonunion Yes 75-95%

Failed joint fusions Yes 85-90%

Spinal fusions Yes 90-95%

Congenital pseudoarthrosis

Yes 70-80%

Osteonecrosis (hip) No 80-100%

Osteochondritis dessicans

No 85-90%

Osteoporosis No 85-90%

Chronic tendinitis No 85-90%

Chronic skin ulcers No 85-90%

Bassett, CA, Beneficial Effects of Electromagnetic Fields. J of Cell Biochemistry. 1993; 51:387-393.

T mineralization

T angiogenesis T collagen + GAG production

Endochondral ossification

(T osteoclasis for pseudoarthrosis)

T angiogenesis

T osteoblastic activity

T angiogenesis

T collagen + GAG production

Bassett, CA, Beneficial Effects of Electromagnetic Fields. J of Cell Biochemistry. 1993; 51:387-393.

Animal data showing decrease in infarct size.

Acute affects on blood flow and angiogenesis.

Questionable effect on superoxide dismutase and nitrous oxide.

Animal data demonstrate decreased growth and invasiveness of Meth A sarcoma in Balb C mice, encapsulation and nuclear changes.

Animal data show decrease in bone resorption in jaws.

Increased osteogenesis in tooth extraction sockets.

Improved bacterial flora spectrum.

Clinical benefits on blood glucose reported.

? Secondary to Ca++ effects on insulin secretion.

Effects on axoplasmic transport.

Neuronal protein synthesis.

Ca++/neurotransmitter effects at synapse.

Angiogenesis.

Animal data showing improved healing.

Increased collagen and GAG synthesis.

Increased angiogenesis.

Animal data showing increased protein synthesis.

Increased axon migration and function.

No direct evidence.

Data on neuropathy and nerve transection may prove beneficial.

Particularly in crush injuries when sensory and motor potential evoked potentials are still present.

An integrative biophysics instrument that changes the energetic terrain.

Positive affects on biologic systems with low level specific pulsed electromagnetic frequencies.

Specific frequencies via pulse testing

provide intelligent information.

Bassett, CA. Beneficial Effects of Electromagnetic Fields. J of Cell Biochemistry. 1993; 51:387-393.

Holden, K. Pulsed Electromagnetic Field Therapy With the Ondamed – A Tool for Integrative Biophysics. http://www.ondamed.net/web/publications/articles.html. 2009.

Shupak, N. Therapeutic Uses of Pulsed Magentic-Field Exposure: A Review. The Radio Science Bulletin. 2003 Dec; (307): 9-32.

Keith R. Holden, M.D.

Resonance Center496 Osceola Avenue

Jacksonville Beach, FL 32250(904) 694-0378

krholden@gmail.com

www.ResonanceCenterJax.com