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Jeanne-Marie Guise, M.D., M.P.H.
Director, Oregon BIRCWH and Comparative Effectiveness K12 Programs
Cynthia Morris, PhD, M.P.H.
Director, OCTRI Education and Career Development Core
Darlene Kitterman, MBA
Director, OCTRI Investigator Support and Integration Services
Rachel Dresbeck, Ph.D.
Director, Research Development and Communication Services
October 2010
Institutional Resources to Help With Research
Predoctoral Individual NRSA (F31)Predoctoral Individual MD/PhD NRSA (F30)
T32: Postdoctoral Institutional Training Grant F32: Postdoctoral Individual NRSA
Small Grant (R03)
Research Project Grant (R01)
K02: Independent Scientist Award
K05: Senior Scientist Award
Fellowships & Career Awards
GRADUATE/MEDICALSTUDENT
POST-DOCTORAL
FACULTY
Predoctoral Institutional Training Grant (T32)
K01: Mentored Research Scientist Development Award K08: Mentored Clinical Scientist Development Award K23: Mentored Patient-Oriented RCDA
K24: Midcareer Investigator Award in Patient-Oriented Research
Exploratory/Developmental
Grant (R21)
Training and Career Development Pathway
Trai
ning
Inde
pend
ent
Research Grants T
rans
ition
K99/R00: NIH Pathway to Independence (PI) AwardK22: NIAAA Career Transition Award
Research Center Grant (U and P series)
K Support
• Salary Support– Low (supplement clinically)– 75% time (50% for some specialties)– For training– For conducting research
• Research funding– Up to $25,000 per year for research and training
expenses (e.g. tuition, books, supplies)• Training is an expected part of Ks
– Must describe a training plan in the proposal
Institutional K vs. Independent K vs. R01
Independent K• Higher probability of
funding (vs. R01)• Your previous track
record can be slim• Limited research funding• Can get an R01 later• Requires NCR yearly
R01• More difficult to get
funding• Rating depends in part
on PI experience• No limit on research
funding• Cannot get a K later• Requires NCR yearly
Institutional K• Highest probability of
funding• Your previous track
record can be slim• Limited research
funding• Can get an independent
K or R01 later• Requires annual update
of information & competitive renewal after 2nd year
Institutional Ks• BIRCWH (Dorsa,Guise) – Building Interdisciplinary
Research Careers in Women’s Health (NICHD) Basic, Translational, Clinical, Behavioral 4 slots
• OCTRI KL2 (Morris)– Designed for Career Development in Translational Research 6 slots
• Child Health Research Center K12 ( Nicholson,Marks) 3 slots
• Comparative Effectiveness K12 (Guise,Morris) 4 slots
Independent Ks• K01: Mentored Research Scientist• K02: Independent Scientists Award• K08: Mentored Clinical Scientist• K22: Career Transition award
– Postdoctoral fellows in transition to a faculty position• K23: Mentored Patient Oriented Research Career
Development• K24: Mid Career Investigator Award in Patient Oriented
Research• K25: Mentored Quantitative Research Career Development• K99/R01 Pathway to Independence Award
– 1-2 years mentored 3 years independent (intended for postdocs)
CD 7
NUMBER OF ENTRY LEVEL RESEARCH CAREER AWARDS
0
250
500
750
1,000
1,250
1998 1999 2000 2001 2002 2003 2004 2005 2006 2007
K08 K23 K01 K25 K99
Fiscal Year
Num
ber o
f Aw
ards
CD 8
SELECT RESEARCH CAREER DEVELOPMENT AWARDSAPPLICATIONS, AWARDS, AND SUCCESS RATES
0%
20%
40%
60%
80%
100%
1998 1999 2000 2001 2002 2003 2004 2005 2006 2007
Fiscal Year
Succ
ess
Rate
K01 K02 K08 K23 K24
CD 9
NUMBER OF INDIVIDUAL RESEARCH CAREER AWARDS BY INSTITUTES AND CENTERS
20070
100
200
300
400
500
600
Fiscal Year
NIH Institutes and Centers
Num
ber o
f Aw
ards
199819992000200120022003200420052006
NCMHD
NCCAMFICNIBIBNLMNHGRI
NIGM
SNINR
NIEHS
NCRRNEINID
CRNID
CDNIA
AANIA
MS
NICHDNIANID
ANIN
DSNIA
IDNID
DKNCINIM
HNHLB
I
0
100
200
300
400
500
600
CD 10
K01 APPLICATIONS AND AWARDS BY PARTICIPATING INSTITUTES AND CENTERS
FY 2007
0
20
40
60
80
100
120
NIDDKNIM
H NCINIA
NIDANHLBI
NIAMSNINDS
NICHDNIAID
NINRNCRR
NIAAANIBIB
NCCAMNIEHS
NIDCDNIGMS FIC
Participating NIH Institutes and Centers
Num
ber o
f App
licati
ons/
Awar
ds
Applications Awards
CD 11
K08 APPLICATIONS AND AWARDSBY PARTICIPATING INSTITUTES AND CENTERS
FY 2007
0
25
50
75
100
125
NHLBINIAID NCI
NIDDKNINDS
NIAMSNIM
HNICHD NIA
NIDCRNIGMS
NIDA NEINIDCD
NIAAANIBIB
NIEHS
NCCAM
Participating NIH Institutes and Centers
Num
ber o
f App
licati
ons/
Awar
ds
Applications Awards
CD 12
K23 APPLICATIONS AND AWARDS BY PARTICIPATING INSTITUTES AND CENTERS
FY 2007
0
20
40
60
80
100
120
Participating NIH Institutes and Centers
Num
ber o
f App
licati
ons/
Awar
ds
Applications Awards
CD 13
K24 APPLICATIONS AND AWARDS BY PARTICIPATING INSTITUTES AND CENTERS
FY 2007
0
5
10
15
20
25
NIDDKNIM
HNHLBI
NICHD NCINIAID NIA
NIDANINDS
NCRRNIAMS
NIAAA NEI
NCCAMNIDCD
NIDCRNINR
Participating NIH Institutes and Centers
Num
ber o
f App
licati
ons/
Awar
ds
Applications Awards
Educational PlatformHealth ProfessionalStudents, PredoctoralStudents
Clinical andPostdoctoral Fellows
OHSU andKP faculty
Educational PlatformHIP Curriculum
HIP Symposium, Seminars
Master of Clinical Research
Certificate in Human Investigations
T32 OSLER program OCTRI KL2 program
Clinical Research Education at OHSU
Master of Clinical Research• Certificate program (2 years)• Focused education in informatics,
epidemiology, biostatistics, basic sciences• Mentored capstoneCertificate in Human Investigations• Required didactic coursework (2 years)• Mentored capstoneNon-degree• Attend courses in C/T research
Core Competencies• Identify major clinical or public health problems and
relevant research questions.• Identify, interpret, and critique the state of knowledge
regarding a question.• Design and write a research proposal.• Identify appropriate study methods (study design) for a
research question considering feasibility, efficiency, and bias-free inference.
• Evaluate the reliability and validity of measures.• Use appropriate sample size, power and apply basic
statistical principles.
Core Competencies, continued• Employ effective information management. • Identify, evaluate, and minimize risks to research
subjects.• Effectively communicate orally and in writing with
colleagues and the public.• Work effectively with the diverse community.• Work effectively within a multidisciplinary research
team.• Manage a research project (personnel, budget)
HIP Capstone
• This mentored project pairs one or more mentors with trainee
• End product: NIH R01 or K grant (or equivalent) • End product: Manuscript suitable for
publication. Trainee must have designed project, implemented study, directed or conducted statistical analysis, written manuscript
HIP Buffet
• An informal forum to lean about practical topics for research
• Alternate Tues/Weds at noon• Examples:
– Developing a research budget– Finding funding for your study– Time management– Organizing your references– Creating a publication strategy
OCTRI SCHOLARS PROGRAMWho can participate?
• Anyone at OHSU or VA who is applying for a career development award or first R01.– “Temporary OCTRI Scholar” status during
application • Anyone at OHSU or VA who receives a career
development award or first R01• This includes VA CDA, NIH K awards, and
lookalike career development awards
OCTRI SCHOLARS: What is available?
• Educational program• Support of the scholar through
supplemental mentoring activities. – An informal, monthly noon seminar– A smaller, intensive group who commit to meet
biweekly for manuscript and grant development
• Support of career development award research through research support. – Talk with research navigator
• Support to maximize odds of research success – OCTRI Design Studio– Career Development Award (CDA) Library– Targeted information dissemination via listserv on funding
opportunities, seminars and conference
• Support to improve mentoring quality– Participation in an electronic "learning community" for mentors
and mentees– Participation in OHSU institutional programs that deliver
workshops and seminars targeted to mentors and mentees.
OCTRI SCHOLARS: What is available?
Grow from Within to ExcellenceA Mentoring Initiative
• Lead Mentor Program (cohort of 15-18)– Take responsibility for developing mentoring
programs within dept or organization. – Mentors share best practices, learn new strategies
• Career & Mentoring Series– Seminars and workshops on mentoring
• Work-life balance; Coaching through active listening; Mentoring across differences
• Mentoring website (www.ohsu.edu/mentoring)
OHSU Clinical & Translational Research Resources
Darlene KittermanProgram Director, OCTRI Investigator Support & Integration Services (ISIS)
Accessing OHSU Research Resources
• Women’s Health Research Unit (WHRU): Single point of contact to coordinate resources for ob/gyn students and faculty.– Access to WHRU departmental research resources– Triage to OHSU institutional research resources
• Oregon Clinical & Translational Research Institute (OCTRI)• Institutional core resources• Navigate research administration
– Assist investigators in finding collaborators• Contact
– Tracy Lawson, WHRU Administrative Manager– 4-0111– lawsontr@ohsu.edu
OCTRI Research Navigator Program
• Gateway to OCTRI Resources: Single point-of-contact for OCTRI services• Facilitates access to OCTRI and Kaiser Permanente resources:
– Resource availability and suitability for the research– Resource costs– OCTRI scientific review process, when applicable
• Studies using more than one OCTRI program and;• The study has not received scientific review (Knight Institute, NIH, FDA) or a career development
award– OCTRI support for new investigators: some services may be free or subsidized– OCTRI letters of support
• Assists investigators in finding collaborators at OHSU and Kaiser Permanente
• Contacts– Navigator Service staff
• Navigation Manager: Joanne Price• Navigation assistants: Sunitha Jagannathan and Cynthia Malain
– Call 503-418-9790 or email OCTRI@ohsu.edu
OHSU resources for all stages of translational research
Design and planning
Funding application
Pre-study and start-up
Carrying out the research
Analysis and publications
Design and Planning
• Finding collaborators– Ob/gyn, OHSU & Kaiser Permanente
• Statistical support– Design– Sample calculations– OCTRI free Drop-in sessions: Wednesdays, 4-5pm, HRC14D80
• Patient population feasibility– OCTRI virtual data warehouses (OHSU & KP)– ResearchMatch.org: Julie Mitchell, OCTRI BMIP
• Guidance in community and practice-based research
Design and
planning
Funding applicati
on
Pre-study and start-
up
Carrying out the
research
Analysis and
publications
Funding Application
• Statistical support• Grant development
– Writing/editing– Budget development (grant and industry)
• Regulatory assistance– Human subject regulation guidance– IND/IDE requirements guidance– Data & Safety Monitoring Plan development
Design and
planning
Funding applicati
on
Pre-study and start-
up
Carrying out the
research
Analysis and
publications
Pre-study & Start-Up
• Compliance submission services– Protocol development– IRB submissions (OHSU, KPCHR, VA)– IND/IDE submissions to FDA
• OCTRI informatics solutions:– Database development:
• REDCap: Free basic access– Database: online, webbased data forms and database– Survey: Sophisticated online, webbased survey tool
• Free REDCap Tutorials: 1st Tuesday/3rd Monday, 2-4pm, HRC10D03
– Scannable forms– Virtual Data Warehouse: Data from Epic (OHSU & Kaiser)
Design and
planning
Funding applicati
on
Pre-study and start-
up
Carrying out the
research
Analysis and
publications
Implementation Stage
• Research space– OCTRI CTRC inpatient (MPV2SE)– Outpatient
• WHRU MPV• OCTRI CTRC: HRC & CHH
• Research nursing services• Study coordinator pool• OCTRI bionutrition services
– Dietitian consultations– Patient meals and snacks
• Energy expenditure and body composition procedures
• OCTRI core laboratory services– Assays– Sample processing and shipping– Genetic analyses
Design and
planning
Funding applicati
on
Pre-study and start-
up
Carrying out the
research
Analysis and
publications
• Limited OCTRI funding to support costs of OHSU hospital tests and pharmacy services
• Regulatory services– IND/IDE annual updates to FDA– GCP monitoring for IND/IDEs
• Data & Safety Monitoring Board coordination
• OCTRI Biolibrary (OHSU & KP)– Sample access– Sample banking
Analysis & Publication
• Statistical services– Data analysis– Manuscript preparation
Design and
planning
Funding applicati
on
Pre-study and start-
up
Carrying out the
research
Analysis and
publications
Research Funding & Development Services
Rachel Dresbeck, Ph.D.Director
Currently HiringProgram Manager
Katie WilkesAdministrative Coordinator
Contact us: funding@ohsu.edu
Research Funding & Development Services
RFDS
Grant Funding
Proposal Developmen
t
Research Communicat
ions
Grant Funding
• Funding Database• Weekly Funding Alerts• Limited Submission Program• Presidential Bridge Funding• Internal funding opportunities• Visit the funding portal on our website!
– http://www.ohsu.edu/xd/research/administration/research-funding-development/
Proposal Development
• Help with grant writing• Workshops
– Specific Aims Workshop– NIH Format Change Workshop
• Funding Focus and other forums– Sample topics: Grant Writing 101, Foundation
Funding, NIH Public Access Policy, and more!• Vollum Writing Class
Where to get help
Research Funding and Development Serviceswww.ohsu.edu/xd/research/administration/research-funding-development/index.cfm
Email us: funding@ohsu.edu
Research Development & Administrationwww.ohsu.edu/xd/research/administration/index.cfm
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