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www.immunoprecise.com
TSX.V : IPA OTC : IPATF
IMMUNOPRECISE ANTIBODIES, LTD.UNIT 3204-4464 MARKHAM STREET
VICTORIA, BRITISH COLUMBIA V8Z 7X8, CANADA
IMMUNOPRECISE.COM
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INVESTOR PRESENTATION 2018
Disclosures
www.immunoprecise.com
DISCLAIMER
This presentation is not, and nothing in it should be construed as, an offer, invitation or recommendation in respect of ImmunoPrecise Antibodies Ltd. (the “Company”) securities, or an offer, invitation or recommendation tosell, or solicitation of an offer to buy, the facilities or of the Company’s securities in any jurisdiction. Neither this presentation nor anything in it shall form the basis of any contract or commitment. This presentation is notintended to be relied upon as advice to investors or potential investors and does not take into account the investment objectives, financial situation or needs of any investor. All investors should consider such factors inconsultation with a professional advisor of their choosing when deciding if an investment is appropriate. The Company has prepared this presentation based on information available to it, including information derived frompublic sources that have not been independently verified. No representation or warranty, express or implied, is provided in relation to the fairness, accuracy, correctness, completeness or reliability of the information,opinions or conclusions expressed herein. These projections should not be considered a representation of the Company’s potential cash generation performance in any way.
FORWARD LOOKING STATEMENTS
This presentation includes forward-looking statements, including future-oriented financial information (“FOFI”). Forward-looking statements can generally be identified by the use of language such as “may”, “expect”,“estimate”, “anticipate”, “intend”, “believe”, “potential” and “continue” or the negative thereof or similar variations. Forward-looking statements are not statements of historical fact or assurances of future performance.They are based on the current beliefs, expectations and assumptions of the Company’s management about the Company’s business, planned acquisitions, future plans, anticipated events and other future conditions. Allforward–looking statements attributable to the Company or persons acting on its behalf apply only as of the date of this document, and are expressly qualified in their entirety by the cautionary statements included in thispresentation. The Company undertakes no obligation to update or revise these forward–looking statements to reflect events or circumstances that arise after the date made or to reflect the occurrence of unanticipatedevents. Inevitably, some assumptions will not materialize, and anticipated events and circumstances may affect the ultimate financial results. Projections are inherently subject to substantial and numerous uncertaintiesand to a wide variety of significant business, economic and competitive risks, and the assumptions underlying the projections may be inaccurate in any material respect, including, but not limited to, those risks set forth inthe Company’s Management Discussion and Analysis for the interim period ended October 31, 2017, a copy of which may be obtained from SEDAR.com. In addition, the forward-looking statements, including FOFI, containedin this presentation assume that the Company’s proposed acquisitions of ModiQuest Research BV (“ModiQuest”) and Preclinics Gesellshaft fuer praeklinische Forschung mbH (“Preclinics”) are completed as planned. TheCompany has not yet entered into definitive agreements for these acquisitions and there are no assurances that they will complete as planned or on the terms previously announced by the Company. Therefore, the actualresults achieved may vary significantly from the forecasts, and the variations may be material.
The purpose of FOFI provided in this presentation is to provide prospective investors with information pertaining to the Company’s long term business objectives. Readers are cautioned that this information may not beappropriate for other purposes.
TSX.V : IPA OTC : IPATF
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About ImmunoPrecise
www.immunoprecise.com
TSX.V : IPA OTC : IPATF
Who we are:• An integrated antibody solutions company which serves as a single source provider of services across
the full antibody discovery value chain (antigen design, hit generation, lead selection, lead optimization and lead characterization).
Our Focus: • Full spectrum of antibody production methodologies; library-based technologies, hybridoma methods,
transgenic animal-based platforms and single B cell-based technology• Growing focus on generating therapeutic, human antibodies
Growth: • IPA has unique capabilities in the antibody discovery space, and is focused on strategic growth in next
generation of human, therapeutic antibody discovery - from target identification through pre-clinicals.
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Management and Board of Directors
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Dr. Jennifer BathPRESIDENT AND CHIEF EXECUTIVE OFFICER
James Kuo, MD, MBACHAIRMAN
Robert BeecroftCHIEF TECHNICAL OFFICER AND DIRECTOR
Dr. Robert BurkeDIRECTOR
Greg SmithDIRECTOR AND AUDIT COMMITTEE CHAIR
Guy ChampagneDIRECTOR
Dr. Deanna DryhurstCHIEF SCIENTIFIC OFFICER
Reg Beniac, MBA, CPACHIEF COMMERCIAL OFFICER
Natasha Tsai, CPA, CACHIEF FINANCIAL OFFICER
Teri OttoVP, MARKETING AND SALES SUPPORT
Dr. Kevin WongVP, CORPORATE SERVICES
TSX.V : IPA OTC : IPATF
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Founded in 1989, ImmunoPrecise Antibodies, Ltd. (IPA) has focused on delivering the highest standard of excellence in the antibody discovery process while serving clinical research and biological markets worldwide.
Since that time, IPA has expanded significantly, with multiple laboratories in Victoria, Canada and Utrecht & Oss, Netherlands.
Robert Beecroft, Founder, Chief Technical Officer and Director is an innovator who helped developed key methodologies that have set IPA apart from other antibody companies:
1. Rapid Prime immunization strategy in mice and rats
2. Expansive, therapeutically-relevant immunization approaches
3. Single-Step Cloning for HAT selection of hybridomas
4. Recombinant monoclonal antibody technology for the generation of Rabbit Monoclonal Antibodies
Quality and Innovation
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Our Vision:To be the industry’s ‘partner of choice’ for the development of therapeutics for major diseases (immuno-oncology, inflammatory, neurodegenerative and autoimmune)
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ImmunoPrecise’s Vision TSX.V : IPA OTC : IPATF
Accomplished by:Offering the most comprehensive collection of antibody discovery platforms combined with state of the art lead candidate optimization and characterization. This allows us to assist clients from the moment they identify a therapeutic target to the time they are preparing to apply for investigation review of the clinical product.
The Market:Therapeutic monoclonal antibody CRO’s are growing three time faster than any CRO in an any CRO space
IPA is poised to become the premier single-source service provider for the therapeutic antibody discovery industry
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TSX.V : IPA OTC : IPATF
No single antibody discovery platform can be representative of the full repertoire of antibodies present in-vivo
The Problem
Therapeutic Antibody Discovery can be a long process with uncertain outcomes• Traditional hybridoma, recombinant single B-cell and library technologies should be used in a complimentary fashion• Pharma companies are required to use a number of CRO’s to complete the value chain:
➢ Antibody Discovery➢ Candidate Characterization➢ Optimization / Humanization➢ Antibody Production
Conclusion:
• Process can be laborious, time-consuming, and unreliable• Multiple discovery platforms should be used to ensure greatest chance of success • Pharma and biotech have been actively demanding more services under one roof
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The Gap in the Market TSX.V : IPA OTC : IPATF
Pharma rely heavily on CROs for antibody discovery• Lowers their cost• Faster turn around time• Access to advanced, integrated expertise
A pioneering CRO should:
• Produce fully human antibodies• Use immunization technologies that optimize chances of a clinical therapeutic• Move beyond traditional hybridoma technology• Guide candidate selection through powerful, high-throughput antibody characterization, to select antibodies with most
promise for clinic
Due to the rapid advancement of technology and a lack of qualified personnel, many biopharmaceutical companies find it difficult to undertake all drug discovery operations in-house
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IPA offers a complete portfolio of antibody discovery, characterization and production technologies• Human Antibodies
➢ Recently designated a preferred CRO for the leading, global transgenic animal platform➢ Offer humanization of animal-derived antibodies
• Multiple immunization methods optimized for therapeutic targets
• Full spectrum of antibody production methodologies➢ library-based technologies, hybridoma methods, single B cell-based technology➢ New techniques offer a ‘deeper’ selection of antibodies with a greater repertoire of therapeutic properties
• High-throughput antibody characterization
TSX.V : IPA OTC : IPATFThe Solution
IPA possess next generation technologies and the expertise required to assist in the development of novel antibody-based therapies
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www.immunoprecise.com
TSX.V : IPA OTC : IPATFUS and Canada Antibody Clinicals 2013-2017
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clinicaltrials.gov
The Success of Antibodies TSX.V : IPA OTC : IPATF
www.immunoprecise.com
Transgenic animals are proving to be more effective for the production of therapeutics
• There are two competing technologies for therapeutic antibody discovery• Transgenic animals• Display technology
• Of the 28 FDA approved human antibodies • 21 generated with transgenic animals • 6 using display technology
The number of antibody-based therapeutics in clinical trials has grown from 150 in 2008 to over 500 in 2017
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• Antibodies as drugs• Nine of the top-selling fifteen drugs in 2022 are predicted to be monoclonal antibodies
• Therapeutic market• $50 billion in 2011• Estimated at $150 billion in 2020
• Increasing financial health of pharmaceutical companies• Profitable growth due to increasing R&D efforts in the therapeutics industrya
• Growing emphasis on antibody development at CROs
TSX.V : IPA OTC : IPATFAntibodies and the Market
Monoclonal antibodies have emerged as a major class of therapeutics for immunological infectious diseases and cancer
aGrand View Research, Inc. 11
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The Golden Age of Monoclonal Antibodies
• Record year in 2017• FDA and EMA approved ten monoclonal antibody drugs globallyb
• Total number has reached 73 (as of Dec. 31st, 2017)
• The key players serving the Monoclonal Antibodies Market are:
12bThe Antibody Society
TSX.V : IPA OTC : IPATF
Pfizer Inc.GlaxoSmithKline plc.
Novartis AG.Merck & Co Inc.
Amgen Inc. Abbott Laboratories
AstraZenecaEli Lilly and Company
Mylan N.V. Daiichi Sankyo Company Ltd.
Bayer AG, Bristol Myers Squibb Co. Johnson & Johnson Services Inc.
Biogen Inc.Thermo Fisher Scientific Inc.
Sanofi Genzyme F. Hoffmann-La Roche Ltd.
Novo Nordisk A/S.
ImmunoPrecise provides state-of-the-art therapeutic antibody discovery across the entire discovery and validation pipeline.
• IPA will become an industry leading CRO by providing:✓ Advanced therapeutic immunization strategies in transgenic animals ✓ Accelerated B-Cell screening✓ Multiple antibody discovery platforms✓ Guidance in lead candidate selection✓ In vitro and in vivo characterization✓ Strategic investments
• This will result in high throughput and deep output comprehensive antibody discovery program to enhance the discovery of therapeutically-relevant antibodies
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In Summary
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TSX.V : IPA OTC : IPATF
Mailing Address:
ImmunoPrecise Antibodies, Ltd.Vancouver Island Technology ParkUnit 3204-4464 Markham StreetVictoria, British Columbia,V8Z 7X8, Canada
ImmunoPrecise Antibodies, Ltd.Jennifer L. Bath, Ph.D.Telephone: +1-778-966-1252E-mail: jennifer@immunoprecise.com
Contact FinancialFrédérick ChabotTelephone: +1-438-863-7071Email: frederick@contactfinancial.com
Contact Information
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