Institutional Animal Care and Use Committee (IACUC) The IACUC provides internal oversight of animal:...

Institutional Animal Care and Use Committee (IACUC)Institutional Animal Care and Use Committee (IACUC)

The IACUC provides internal oversight of animal:- husbandry- facilities- use in teaching & research

The ASU IACUC consists of 11 voting members plus other supporting participants who include:

- faculty representing the various departments and uses of animals

- representatives of relevant ASU service departments

- DACT (including the Attending Veterinarian)

- EH&S- Campus Health- VPREA Office- Risk Management

- non-affiliated member

http://researchintegrity.asu.edu/

Institutional Animal Care and Use Committee (IACUC)Institutional Animal Care and Use Committee (IACUC)

animalsiacuc

Web site includes:- Policy and Procedure Manual

- forms

- training instructions and exams

- Occupational Health & Safety Program documents

- Standard Institutional Guidelines

- protocol due dates & meeting dates

- Animal Welfare Assurance & USDA certificate numbers

- society non-traditional species guidelines

- AVMA euthanasia guidelines

- federal regulations

- etc.

Last year’s 2 aims as the new Chair:

1) To assure that ASU meets all regulatory requirements

- USDA – enforces the Animal Welfare Act. Definition of “animal”?

- OLAW (Office of Laboratory Animal Welfare) – oversees the use of non-human vertebrates in PHS-supported research (PHS Policy on Humane Care and Use of Laboratory Animals, 2002)

- AAALACi (Association for the Assessment & Accreditation of Laboratory Animal Care International) – voluntary, covers all non-human vertebrates at the institution

- U.S. Fish & Wildlife Service – oversees federally protected species and international transport of all vertebrate animals and their parts

- Arizona Game & Fish Department – oversees the capture & holding of native wildlife, as well as the holding of restricted non-native wildlife

- Arizona Department of Health Services – covers species where there is a concern for zoonotic disease

Institutional Animal Care and Use Committee (IACUC)Institutional Animal Care and Use Committee (IACUC)

March 5-6, 2009

October 28-29, 2009All mammals except laboratory mice & rats

Institutional Animal Care and Use Committee (IACUC)Institutional Animal Care and Use Committee (IACUC)

Last year’s 2 aims as the new Chair:

2) To minimize the burden on investigators (provided it does not interfere with Aim 1)

- Require IACUC training and certification specific to the investigator, not the protocol.

- Eliminate the need for duplicative protocols in situations where a PI conducts work at multiple local institutions.

- ??

Name Title     

Role in Protocol (What procedures will each person be doing?)

Species with which individual will have direct contact (“all” or list species)*

IACUCUSE ONLY Training(mm/yy)

 Dale DeNardo Associate Professor

PI, no procedures

none 

Joe Shmoe Graduate Student

 all  rats, mice

ASU-BNI agreement

Institutional Animal Care and Use Committee (IACUC)Institutional Animal Care and Use Committee (IACUC)

The review process (details in the Policy & Procedure Manual):

Protocols:- pre-reviewed by the Attending Veterinarian, then one other IACUC member (assigned by the Chair as the Primary Reviewer)- reviewed by the full committee at a convened meeting in the presence of the PI or designee

Amendments:- Minor – administratively approved by the Chair- Significant – with the approval of the full committee, reviewed by a Designated Reviewer (assigned by the Chair) and the Attending Veterinarian- Major – reviewed by full committee at a convened meeting

- the rationale for the new procedure is consistent with the research goals in the approved protocol

- involves no increased risk of pain, distress, or discomfort to animals

- does not markedly increase, by absolute or relative terms, the number of animals involved in the project

- a change that does not in any way effect the animals

Changes to the Protocol FormChanges to the Protocol Form

- section for Additional Contact information

- split the literature search into two separate searches

- duplicative research

- alternatives to animal use and painful procedures

- includes section to summarize results

- pay close attention to the search words used

- method of animal identification, if any

Regulatory oversight is very dynamic, expect more changes!

- qualifications and training of all participants (in protocols and added in an amendment)

Why were there changes?

MAKE SURE TO USE THE MOST CURRENT FORM! (available on the web site)