Infographic- Mapping the Interplay of Viral and Host Genomics with HiFi Sequencing · 2020. 4....

Vir

al G

eno

mic

s

Hum

an G

eno

mics &

Tran

scriptom

ics

Immune Resp

onse

Vir

us S

eque

ncin

g

Vaccine

Development

Host Genetics

Highly accurate long reads (HiFi reads) enable

every aspect of your viral research

DeletionSNP

Inversion

Insertion Tandem Duplication

Interspersed Duplication

Translocation

Find all the variants that impact susceptibility, immune response,

and disease progression

Chromosome 6

HLA region6p21.1-21.3

Class IClass II

DP DM DQ DR B C E A G F

Explore how allelic variation in HLA genes correlates with susceptibility

or disease progression

Sequence full-length B cell receptor repertoires

Understand how the germline IGH locus impacts

the immune response

Identify conserved regions and mutational hotspots

Immune escape Drug resistance

Rx

Monitor quasispecies dynamics or the emergence of minor variants

under selective pressure

For Research Use Only. Not for use in diagnostic procedures. PN: INF105-042720pacb.com/COVID-19

Mapping the Interplay of Viral and Host Genomicswith HiFi Sequencing

HiFi reads span viral genomes

Understand the spread of a novel virus or strain through

communities

New Virus Discovered

Understand the efficacy of vaccines

Intact genes

Explore links between metagenomes and all aspects of virus infection and

treatment response

HiFi reads provide reference-quality

assemblies

HiFi Reads