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I nstitut des N eurosciences de M ontpellier. The large maf protein family in the development and the physiopathology of somatosensory circuitry. Pr. Martyn Goulding. Dr. P. Carroll. Pr. Jean Valmier. P. Carroll. I nstitut des N eurosciences de M ontpellier. Somesthesia. - PowerPoint PPT Presentation
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Institut des Neurosciences de Montpellier
The large maf protein family in the development and the physiopathology of somatosensory circuitry
Pr. Martyn GouldingPr. Jean ValmierDr. P. Carroll
• Somatosensory system = perception of the environment
• Sensory modalities:
Mechanoception(touch)
Thermoception(temperature)
Proprioception(muscle and joints)
Nociception (pain)
Somesthesia
Institut des Neurosciences de Montpellier P. Carroll
Arrangement of spinal nerves
Specific types of mechanosensory stimulation are transduced by specific types of receptor cells.
Spinal cord Dorsal root ganglion (DRG)
ProprioceptorsTrkC/NT-3
Nociceptors
ThermoceptorsTrkA/NGF
Ret/GDNF
MechanoreceptorsTrkB/BDNF
Flexion Reflex: Withdrawal from Painful Stimuli
Figure 13-8: Flexion reflex and the crossed extensor reflex
Institut des Neurosciences de Montpellier P. Carroll
History of the collaboration
Symposium “Somatosensation and Pain”
Max-Delbruck Centre, Berlin - May 2008
P. CarrollJ. ValmierINM/UMIIMontpellierFrance
M. GouldingSalk Institute/UCSDSan DiegoUSA
Hypothesis: MafA labels neurons connected in Sensori-motor circuits
I
II
IIIIV
DRG
Spinal Cord
Hypothetic
known
Spinal Cord
DRG
Discovery of marker of I° touch sensing neuronsCarroll/ValmierINM/UMII, Montpellier
Discovery of marker of 2° touch sensing neuronsGouldingSalk/UCSD
I/II
III/IV
Why collaborate?
Institut des Neurosciences de Montpellier P. Carroll
Institut des Neurosciences de Montpellier P. Carroll
People involved
P. Carroll (DR2 CNRS)J. Valmier (Pr UMII)
I. Méchaly (MCU, UMII)A. Fichard (MCU, UMII)A. Garces(Chercheur INSERM)S. Venteo (IE INSERM)S. Moussa (Ph.D. Student UMII)
M. Goulding
M. Garcia del BarrioK. GrossmannS. Bourane
Team: Neural differentiation and connectivity
in the somatosensory system
Team:Molecular Neurobiology Lab
Institut des Neurosciences de Montpellier P. Carroll
Funding
• Mobility• Shared tools• Running costs
• 1 Ph. D. student salary for 3 years Montpellier
220 k$
~ 100 k€
Institut des Neurosciences de Montpellier P. Carroll
• Scientific collaboration - from Sept 2009
Assessment of the project so far
2010 Montpellier: Validation of MafA-GFP transgenic mice April 2011: send mice to Salk Institut
2011 San Diego: Finish creation of MafA-flipase transgenic mice July 2011: send mice to Montpellier
2011 San Diego: June 2011. S. Moussa will do neuronal tracing studies on MafA-GFP mice in San Diego
Institut des Neurosciences de Montpellier P. Carroll
• Mobility
Assessment of the project so far
Jan 2010 S. Bourane
France USA
Sept 2009 Meeting M. Goulding
July 2010 Meeting M. GouldingS. Bourane
Nov 2010 P. Carroll A. Garces S. Venteo S. Moussa
Post-doc training
Meeting
June 2011 S. Moussa Experiments on tracing neuronalconnection
Institut des Neurosciences de Montpellier P. Carroll
Benefits of PUF program
• Structuration of the collaboration
• Maintain our leader position in this research area
• Mobility – discussions, training, motivation ….
• New collaborators – Birchmeier group in Berlin - future network on somatosensation research?
Institut des Neurosciences de Montpellier P. Carroll
MERCI!
Somatosensory system
Institut des Neurosciences de Montpellier
Muscle spindle
• Thermonociception
• Mechanoception
• Proprioception
Skin
P. Carroll
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