Gut Microbiome and Mucosal or Systemic Dysfunction ......5 Symposium 207 Gut Microbiome and Mucosal...

Preliminary Program

Application for CME credits submitted

Symposium 207

Gut Microbiome and Mucosal or Systemic Dysfunction: Mechanisms, Clinical Manifestations and Interventions

May 19 – 20, 2017Brisbane Convention &Exhibition CentreBrisbane, Australia

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Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4

Scientific Program . . . . . . . . . . . . . . . . . . . . . . . . . 6

Posters . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11

List of Speakers . . . . . . . . . . . . . . . . . . . . . . . . . . . 12

Information . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17

CME credits for the Symposium 207 have been applied for at the European Union of Medical Specialists (UEMS) – European Board of Gastroenterology (EBG). The number of credits awarded will be printed in the final program.

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Preface

In recent years medicine has witnessed an astonishing paradigm shift. For decades it was believed that for most diseases the individual risk was defined by the genetic make-up, potentially modified by the environment and lifestyle-factors. It has now emerged that the gut microbiome plays an equally important role for many gastrointestinal and non-gastrointestinal disorders. This opens astonishing new avenues to understand and target disease mechanisms in particular in relation to immune mediated diseases but might be equally important for the prevention of disease. Thus the organisers Gerald Holtmann and Mark Morrison from Brisbane, Nicholas Talley from Newcastle, William Chey from Ann Arbor, and Peter Gibson from Melbourne in close collaboration with other experts in the field have developed a scientific program that brings together basic scientists and clinicians from many disciplines to define our current knowledge and define future directions that are relevant for the translation of this knowledge into clinical practice.

On behalf of the scientific committee

Prof. Gerald Holtmann, Brisbane

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Symposium 207

Gut Microbiome and Mucosal or Systemic Dysfunction: Mechanisms, Clinical Manifestations and Interventions

May 19 – 20, 2017Brisbane Convention &Exhibition CentreBrisbane, Australia

Registration:Thursday, May 18, 201716.00 – 21.00 h at the congress offi ce

Congress Venue:Brisbane Convention & Exhibition CentreMerivale St & Glenelg StreetSouth Brisbane, QLD 4101Australia

The Symposium 207 is organized by Falk Foundation e.V.

Scientifi c Organization:Prof. Gerald HoltmannPrincess Alexandra HospitalUniversity of Queensland199 Ipswich RoadBrisbane, QLD 4102, AustraliaTelephone: +617 31 76 77 92 Telefax: +617 31 76 51 11 E-Mail: g.holtmann@uq.edu.au

Scientifi c Co-Organization:W.D. Chey, Ann Arbor (USA)P.R. Gibson, Melbourne (Australia)M. Morrison, Brisbane (Australia)M. Simrén, Gothenburg (Sweden)N.J. Talley, Newcastle (Australia)

Offi cial Language:English

Call for Posters:A poster session will take place. For details see page 11.

Publication Date of the Final Program: May 2017

The fi nal program will be available on the homepage www.falk-foundation-symposia.org one week before.

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Friday, May 19, 2017

8.30 Welcome G. Holtmann, Brisbane

8.40 Minster for innovation, science and digital economy Hon Leanne Enoch, Brisbane

Session I The fundamentals and how to determine what really matters

Chair: P. Hugenholtz, Brisbane; H.M. Mitchell, Sydney

8.50 State-of-the-Art Lecture: G. Tyson, Ecogenomics and its applications to health and disease Brisbane

9.25 Crosstalk between microbiota, pathogens and the J. Wehkamp, innate immune responses Tübingen

9.45 Morphology of inflammatory changes of the mucosa: M. Walker, Time to reassess inflammatory responses of the mucosa Newcastle

10.05 Making it all fit - New data analysis methods for K.-A. Le Cao, integrating microbiome data with other clinical measures Brisbane

10.25 Assessment of symptoms in FGID and IBD studies M.P. Jones, that target the GI microbiome Sydney

10.45 Coffee break with poster session

Session II Microbiome-host interactions

Chair: M. Morrison, Brisbane; C. O’Brien, Canberra

11.15 State-of-the-Art Lecture: P. Langella, Commensal microbes, GI immunity, and homeostasis Paris

11.45 Does host genotype shape the gut microbiota? M. Brown, Brisbane

12.05 How does the gut microbiota affect the epigenome? M.V. Joglekar, Sydney

12.25 A question of culture? Development and differentiation P. O Cuiv, of the mucosal and luminal microbiomes Brisbane

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Friday, May 19, 2017 12.45 The role of mucins in shaping the microbiome? M. McGuckin, Brisbane

13.05 How does epithelial cell stress affect the nutrient and S. Keely, physical landscapes of the microbiome? Newcastle

13.25 Oral poster presentation N.N.

13.45 Lunch with poster session

Session III The gastrointestinal microbiome, diet and management of chronic diseases

Chair: E. Powell, Brisbane; S. Roberts, Melbourne

14.45 Diet, microbiome, and Aryl hydrocarbon receptor S. Pettersson, biology: What are the links? Singapore

15.05 Diets, functional foods, such as EEN or PEN and P. Lewindon, inflammatory bowel diseases Brisbane

15.25 Pre-, pro- and synbiotics for chronic kidney disease K. Campbell, Brisbane

15.45 The microbiome and obesity: cause, consequence A. Holmes, or both? Sydney

16.05 Oral poster presentation N.N.

16.25 Coffee break with poster session

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Friday, May 19, 2017

Session IV Intended and unintended alterations of the human microbiome

Chair: N.N.; M. Grimm, Sydney

16.45 State-of-the-Art Lecture: P. Moayyedi, Comparative efficacy of traditional treatments and Hamilton treatments targeting the microbiome in IBD and IBS

17.15 The FODMAP diet - A microbiome targeted intervention M. Chen, and what could be the consequences? Guangzhou

17.35 Debate: Faecal microbiota transplantation: Are we ready for prime–time?

Chair: W.D. Chey, Ann Arbor

PRO M.A. Kamm, Melbourne

CONTRA J. Andrews, Adelaide

17.55 Summary of the day M. Simrén, Gothenburg

18.00 Scientific discussion with snacks

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Saturday, May 20, 2017

Session V The gastrointestinal microbiome and extraintestinal diseases

Chair: B. Kendall, Brisbane; N.N.

8.30 State-of-the-Art Lecture: E.A. Mayer, Microbiome and brain function in health and disease Los Angeles

9.00 Anxiety and depressive disorders, the inflammasome, N.N. and the gut microbiome

9.20 The microbiome and immune-mediated diseases R. Thomas, Brisbane

9.40 Friend or foe: The microbiome in liver disease L. Adams, Perth

10.00 Oral poster presentation N.N.

10.20 Coffee break with poster session

Session VI Targeting the mucosal microbiome and mucosal immune responses

Chair: T. Florin, Brisbane; R. Leong, Sydney

10.50 State-of-the-Art Lecture: H. Ohno, The function of M cells in host-microbe interactions Yokohama

11.20 The mucosal microbiome of the upper GI tract and E. Shanahan, its role in FGIDs Brisbane

11.40 The gut-lung axes and COPD K.M. Fock, Singapore

12.00 The microbiome, autophagy and IBD J. Begun, Brisbane

12.20 Characterising local and systemic immune response in A. Do, functional dyspepsia Brisbane

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Saturday, May 20, 2017

12.40 Oral poster presentation N.N.

13.00 Presentation of poster awards P.R. Gibson, Melbourne

13.15 Lunch break with poster session

Session VII What are the challenges and opportunities of future approaches to maintain or improve health and wellbeing by targeting the microbiome?

Chair: K.M. Fock, Singapore; R. Ward, Brisbane

14.10 State-of-the-Art Lecture: E.M.M. Quigley, The current and future assessment and targeted Houston modulation of the gastrointestinal microbiome in the clinical setting

14.40 The host genes and associations with the microbiome: N.N. Implications for targeted interventions

15.00 The effect of eradication therapy of H. pylori on the K. Sugano, gut microbiota Tochigi

15.20 Coffee break with poster session

15.50 Translational research strategies to fight the spread I. Autenrieth, of antimicrobial resistance Tübingen

16.10 The clinician’s perspective of needs and opportunities N.N. in developing countries

16.30 Oral poster presentation N.N.

16.50 Summary & conclusions G. Holtmann, Brisbane

N.J. Talley, Newcastle

M. Morrison, Brisbane

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Poster SessionPosters will be exhibited on May 19 and May 20, 2017 in the Brisbane Convention & Exhibition Centre. The authors will be in attendance during coffee and lunch breaks on both days.

Call for PostersPlease submit your poster abstract before February 15, 2017. Only one-page abstracts not exceeding 300 words, written in English and saved in Microsoft Word format will be accepted.

Abstracts must be submitted via our Internet Abstract Submission System (http://www.falkfoundation.org/poster) where further information regarding the submission format and the submission process is available.

The abstracts will be selected by the scientific organizers, preference being given to those thematically related to one of the sessions of the program.

The accepted abstracts will be printed and distributed to the participants of the congress together with the documents of the meeting.

The authors will receive notification about acceptance and further instructions in March 2017.

Contact address for further information on the poster session:

Falk Foundation e.V.Congress DepartmentLeinenweberstr. 579108 Freiburg (Germany)Telephone: +49 (0)761/1514-125Telefax: +49 (0)761/1514-359

Web address for submitting poster abstracts: http://www.falkfoundation.com/poster

For the first author of an accepted poster, expenses for accommodation (May 18-21, 2017) and fees for the scientific program will be covered during the Symposium 207. Travel expenses will not be covered.

Poster AwardsThree prizes will be awarded for the best poster abstracts. During the presentation of poster awards, award winners will be asked to give a short presentation (2-5 min.) of their poster. Award winners will be presented with a certificate and prize money for EUR 1.500,-, EUR 1.000,- and EUR 500,- respectively. Travel expenses will be covered additionally for the first author of an awarded poster.

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List of Speakers, Moderators and Scientific Organizers

Assoc. Prof. Leon AdamsSchool of Medicine and Pharmacology University of Western AustraliaVerdun St.Nedlands, WA 6009Australialeon.adams@uwa.edu.au

Prof. Jane AndrewsDept. of Gastroenterology & HepatologyRoyal Adelaide Hospital North TerraceAdelaide, SA 5000Australiajane.andrews@sa.gov.au

Prof. Ingo AutenriethMedizinische MikrobiologieUniversitätsklinikum TübingenElfriede-Aulhorn-Str. 672076 TübingenGermanyingo.autenrieth@med.uni-tuebingen.de

Dr. Jakob BegunMater Research InstituteUniversity of QueenslandAubigny Bldg., Level 3Raymond TerraceSouth Brisbane, QLD 4101Australiajakob.begun@mater.uq.edu.au

Prof. Matt BrownTranslational Research Institute Queenland University of Technology37 Kent St.Woolloongabba, QLD 4102Australiamatt.brown@qut.edu.au

Dr. Katrina CampbellNutrition and DieteticsPrincess Alexandra Hospital199 Ipswich Rd,Woolloongabba, QLD 4102katrina.campbell@health.qld.gov.au

Prof. Minhu ChenDept. of Gastroenterology and HepatologyThe First University Hospital of Sun Yat-sen UniversityGuangzhouRepublic of China chenminhu@vip.163.com

William D. Chey, M.D.Professor of Internal MedicineDivision of GastroenterologyUniversity of Michigan3912 Taubman Center, SPC 5362Ann Arbor, MI 48109USAwchey@med.umich.edu

Dr. Anh DoPAH, Dept. of Gastroenterology & HepatologyTranslational Research InstituteUniversity of Queensland37 Kent St.Woolloongabba, QLD 4102Australiaa.do@uq.edu.au

Prof. Tim FlorinInflammatory Bowel Diseases GroupMater Research InstituteUniversity of QueenslandTranslational Research Institute37 Kent St.Woolloongabba, QLD 4102Australiat.florin@uq.edu.au

Prof. Kwong M. FockNational University of Singapore21 Lower Kent Ridge Rd,Singapore 119077Singaporekwong_ming_fock@cgh.com.sg

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Prof. Peter R. GibsonDept. of Gastroenterology The Alfred HospitalMonash UniversityMonash Medical School BuildingMelbourne, VIC 3800Australia

Prof. Michael GrimmSt George and Sutherland Clinical SchoolUniversity of NSWGray St.Kogarah, NSW 2217Australiam.grimm@unsw.edu.au

Assoc. Prof. Andrew HolmesDiscipline of MicrobiologyFaculty of ScienceUniversity of SydneyRm 4113, Charles Perkins CentreSydney, NSW 2006Australiaandrew.holmes@sydney.edu.au

Prof. Gerald HoltmannPrincess Alexandra HospitalUniversity of Queensland199 Ipswich RoadBrisbane, QLD 4102Australiag.holtmann@uq.edu.au

Dr. Philip HugenholtzSchool of Chemistry & Molecular BiosciencesAustralian Centre for Ecogenomics University of QueenslandSt Lucia, QLD 4072Australia p.hugenholtz@uq.edu.au

Dr. Mugdha V. JoglekarDiabetes and Islet BiologyNHMRC Clinical Trials CentreFaculty of MedicineUniversity of SydneyLevel 1, Medical Foundation Bldg.92-94 Parramatta Road, Camperdown, NSW 2050 Australiamugdha.joglekar@ctc.usyd.edu.au

Prof. Michael P. JonesPsychology DepartmentFaculty of Human SciencesMacquarie UniversityNorth Ryde, NSW 2109Australiamike.jones@mq.edu.au

Prof. Michael A. KammSt. Vincent‘s HospitalUniversity Dept. of MedicineDepartment of GastroenterologyVictoria ParadeMelbourne 3065Australiamkamm@unimelb.edu.au

Dr. Simon KeelyFaculty of Health and MedicineSchool of Biomedical Sciences and PharmacyUniversity of NewcastleUniversity DriveCallaghan, NSW 2308Australia simon.keely@newcastle.edu.au

Dr. Bradley KendallDept. of Gastroenterology and HepatologyPrincess Alexandra Hospital199 Ipswich RoadBrisbane, QLD 4102Australiabradley.kendall@health.qld.gov.au

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Dr. Philippe LangellaMicalis InstituteLaboratory of Commensals and Probiotics-Host InteractionsJouy en JosasFrancephilippe@langella@jouy.inra.fr

Dr. Kim-Anh Le CaoTranslational Research InstituteUniversity of Queensland37 Kent St,Woolloongabba, QLD 4102Australia k.lecao@uq.edu.au

Prof. Rupert Leong Concord HospitalUniversity of Sydney Sydney, NSW 2139 Australia rupert.leong@sswahs.nsw.gov.au

Assoc. Prof. Peter LewindonDept. of GastroenterologyLady Cilento Children’s Hospital501 Stanley StreetBrisbane, QLD 4101Australiapeter.lewindon@health.qld.gov.au

Emeran A. Mayer, M.D.Dept. of GastroenterologyRonald Reagan UCLA Medical Center757 Westwood Plaza Los Angeles, CA 90095 USA emayer@ucla.edu

Prof. Michael McGuckinMater Research InstituteUniversity of QueenslandLevel 3, Aubigny PlaceSouth Brisbane QLD 4101Australiamichael.mcguckin@mater.uq.edu.au

Prof. Hazel M. MitchellSchool of Biotechnology and Biomolecular SciencesUniversity of New South WalesSydney, NSW 2052Australiah.mitchell@unsw.edu.au

Prof. Paul MoayyediDivision of GastroenterologyMcMaster University1280 Main St. W. HSC-3V3 Hamilton, ON L8S 4K1Canadamoayyep@mcmaster.ca

Prof. Mark MorrisonUniversity of Qeensland Diamantina Inst.Translational Research Institute,37 Kent StWoolloongabba, QLD 4102Australiam.morrison1@uq.edu.au

Dr. Claire O’BrienANU College of Medicine, Biology and Environment Australian National UniversityFlorey Building 54 Mills Rd.Acton, ACT 2601Australiaclaire.obrien@anu.edu.au

Dr. Paraic O CuivTranslational Research University of Queensland Diamantina Inst.37 Kent Street Woolloongabba, QLD 4102Australiap.ocuiv@uq.edu.au

Dr. Hiroshi OhnoLaboratory for Intestinal EcosystemRIKEN Center for Integrative Medical Sciences (IMS)1-7-22 SuehiroTsurumi, Yokohama 230-0045Japanhiroshi.ohno@riken.jp

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Prof. Sven PetterssonLee Kong Chian School of MedicineNanyang Technological University50 Nanyang AvenueSingapore 639798Singaporesven.pettersson@ki.se

Prof. Elizabeth PowellPrincess Alexandra Hospital199 Ipswich Rd.Woolloongabba, QLD 4102Australiae.powell@uq.edu.au

Eamonn M.M. Quigley, M.D.Professor of MedicineGastroenterology and HepatologyThe Methodist Hospital, 6565 Fannin St,Houston, Texas 77030USAequigley@houstonmethodist.org

Prof. Stuart RobertsDept. of Gastroenterologyand HepatologyThe Alfred Centre99 Commercial Rd, Melbourne, VIC 3004Australias.roberts@alfred.org.au

Prof. Magnus SimrénSahlgrenska SjukhusetGastroenterology & HepatologyDepartment of Internal Medicine413 45 GothenburgSwedenmagnus.simren@medicine.gu.se

Dr. Erin ShanahanDept. of Gastroenterology and HepatologyPrincess Alexandra HospitalUniversity of Queensland 37 Kent StWoolloongabba, QLD 4102Australiae.shanahan@uq.edu.au

Prof. Kentaro Sugano Department of MedicineDivision of GastroenterologyJichi Medical University3311-1 Yakushiji, ShimotsukeTochigi 329-0498 Japansugano@jichi.ac.jp

Prof. Nicholas J. TalleyFaculty of Health and MedicineUniversity of NewcastleUniversity DriveCallaghan, NSW 2308Australianicholas.talley@newcastle.edu.au

Prof. Ranjeny ThomasDiamantina InstituteUniversity of Queensland37 Kent StWoolloongabba, QLD 4102Australiaranjeny.thomas@uq.edu.au

Prof. Gene TysonAustralian Centre for EcogenomicsLevel 5, Molecular Biosciences Bldg.University of Queensland St Lucia, QLD 4072Australiag.tyson@uq.edu.au

Prof. Marjorie WalkerAnatomical PathologySchool of Medicine and Public Health Faculty of Health and Medicine University of Newcastle University DriveCallaghan, NSW 2308 Australiamarjorie.walker@newcastle.edu.au

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Prof. Robyn WardFaculty of MedicineBiomedical Sciences University of QueenslandUQ Oral Health Centre,Building 883, Herston Rd,Herston, QLD 4006Australiambs.execdean@uq.edu.au

Prof. Jan WehkampUniversitätsklinikum TübingenDepartment of Internal Medicine IHepatology, Gastroenterology, Infectious DiseasesOtfried-Müller-Str. 1072076 TübingenGermanyjan.wehkamp@med.uni-tuebingen.de

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General InformationPrior to the opening of the congress in Brisbane

Falk Foundation e.V. Telephone: +49 (0)0761/1514-125Congress Department Telefax: +49 (0)761/1514-359Leinenweberstr. 5 E-mail: symposia@falk-foundation-symposia.org79108 FreiburgGermany

Congress OfficeDuring the Symposium in Brisbane

Congress Office Telephone: +49 (0)175/7795327

Opening Hours:Thursday, May 18, 2017 16.00 – 21.00 hFriday, May 19, 2017 7.00 – 18.00 hSaturday, May 20, 2017 8.00 – 17.00 h

Brisbane Convention & Exhibition CentreMerivale St & Glenelg StreetSouth Brisbane, QLD 4101Australia

Congress FeesScientific program of Symposium 207 EUR 200,-For students (copy of student ID required) EUR 100,-

Day Ticket EUR 120,-For students (copy of student ID required) EUR 60,-

The congress fees include:- Pre-Opening and Welcome on May 18, 2017- Refreshments during coffee breaks- Lunch on May 19 and May 20, 2017- Snacks during scientific discussion on May 19, 2017- A copy of the abstract volume- A copy of the final program

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RegistrationCongress registrations must reach the Falk Foundation e.V. by March 31, 2017 at the latest.

After receipt of the registration form each participant will be provided with confirmation of his registration/invoice. On presentation of this confirmation at the congress office in Brisbane participants will receive the congress folder containing name badge and the abstract volume.

All participants will receive a written confirmation of attendance and CME credits at the meeting.

Admission to Scientific ProgramFor admission to scientific program your name badge should be clearly visible.

AirportBrisbane Airport: http://www.bne.com.au/(approx. 18 km from the congress venue)

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Organized by:

FALK FOUNDATION e.V.Leinenweberstr. 579108 FreiburgGermany

Congress DepartmentTelephone: +49 (0) 761/15 14-125Telefax: +49 (0) 761/15 14-359E-Mail: symposia@falk-foundation-symposia.orgwww.falk-foundation-symposia.org