Graft Rejection 1990-2008

Graft Rejection 1990-2008

James Heaf

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Patient Survival

90-94 95-99 00-04 >2004

0,0 0,5 1,0 1,5 2,0 2,5 3,0 3,5 4,0

Time

0,85

0,86

0,87

0,88

0,89

0,90

0,91

0,92

0,93

0,94

0,95

0,96

0,97

0,98

0,99

1,00

Cu

mu

lativ

e P

rop

ort

ion

Su

rviv

ing

Graft Survival

90-94 95-99 00-04 >2004

0 1 2 3 4 5 6 7 8

Time

0,50

0,55

0,60

0,65

0,70

0,75

0,80

0,85

0,90

0,95

1,00

Cu

mu

lativ

e P

rop

ort

ion

Su

rviv

ing

Combined Patient and Graft Survival

90-94 95-99 00-04 >2004

0,0 0,5 1,0 1,5 2,0 2,5 3,0 3,5 4,0 4,5 5,0

Time (years)

0,50

0,55

0,60

0,65

0,70

0,75

0,80

0,85

0,90

0,95

1,00

Cu

mu

lativ

e P

rop

ort

ion

Su

rviv

ing

Combined Survival after One Year

90-94 95-99 00-04 >2004

1 2 3 4 5 6

Time

0,60

0,65

0,70

0,75

0,80

0,85

0,90

0,95

1,00

Cu

mu

lativ

e P

rop

ort

ion

Su

rviv

ing

Donor Type & Graft Loss

Prognosis

Donor Type & Death

Prognosis

Donor Height & Graft Survival

<170 170-180 >180

0 1 2 3 4 5 6 7 8

Time

0,60

0,65

0,70

0,75

0,80

0,85

0,90

0,95

1,00

Cu

mu

lativ

e P

rop

ort

ion

Su

rviv

ing

cm

p<0.06

Censored for DeathNS

Donor Relation, Rejection & Graft Loss

Rejection Graft Loss

Donor AgeRejection Graft Loss

Donor Age & Rejection

Donor Age and Delayed Graft Function

<40 40-50 >50

0 5 10 15 20 25 30

Time (Days)

0,05

0,10

0,15

0,20

0,25

0,30

0,35

0,40

Pro

po

rtio

n w

itho

ut

Fu

nct

ion

Age(years)

Rejection Number and Banff Grade

Rejection & Cohort

90-94 95-99 00-04 >2004

0,00 0,25 0,50 0,75 1,00 1,25 1,50 1,75 2,00

Time

0,65

0,70

0,75

0,80

0,85

0,90

0,95

1,00

Re

ject

ion

-fre

e S

urv

iva

l

Graft Survival after 1st Rejection & Cohort

90-94 95-99 00-04 >2004

0 1 2 3 4 5 6

Time

0,35

0,40

0,45

0,50

0,55

0,60

0,65

0,70

0,75

0,80

0,85

0,90

0,95

1,00

Cu

mu

lativ

e P

rop

ort

ion

Su

rviv

ing

Graft Survival after Rejection

4 3 2 1 0

0 1 2 3 4 5

Survival Time (Years)

0,4

0,5

0,6

0,7

0,8

0,9

1,0

Cu

mu

lativ

e P

rop

ort

ion

Su

rviv

ing

RejectionNumber

Censored for Death

Rejection Frequency & Cohort

% 90-94 95-99 00-04 04-07

3 mth 28 26 23 14

1 yr 33 31 29 20

2 yr 35 33 31 22

Time to 1st Rejection & Graft Loss

<1 week 1-52 weeks >1 year

0 1 2 3 4 5 6

Time (years)

0,1

0,2

0,3

0,4

0,5

0,6

0,7

0,8

0,9

1,0

Cu

mu

lativ

e P

rop

ort

ion

Su

rviv

ing

Delayed Graft Function & Cohort

90-94 95-99 00-04 >2004

0 5 10 15 20 25 30

Time (Days)

0,05

0,10

0,15

0,20

0,25

0,30

0,35

0,40

0,45

0,50

Pro

po

rtio

n w

itho

ut

Fu

nct

ion

Delayed Graft Function & Donor Type

Delayed Graft FunctionRejection Graft Loss

Prognosis

Delayed Graft Function and Banff Grade

Delayed Graft Function andSurvival after First Rejection

no yes

0 2 4 6 8

Time (years)

0,40

0,45

0,50

0,55

0,60

0,65

0,70

0,75

0,80

0,85

0,90

0,95

1,00

Gra

ft S

urv

iva

l

Censored for DeathP<0.001

AB Mismatch Number

DR Mismatch Number

Immunisation, Rejection & Graft Loss

Banff Grade & Rejection Number

Banff Grade & Graft SurvivalAll Rejections

Borderline 1 2 3

0,00 0,25 0,50 0,75 1,00 1,25 1,50 1,75 2,00

Time (years)

0,60

0,65

0,70

0,75

0,80

0,85

0,90

0,95

1,00

Cu

mu

lativ

e P

rop

ort

ion

Su

rviv

ing

Chronic Rejection, Rejection Number & Graft Loss

Banff Grade & Cohort

Rejection and Transplant Center Transplants after 2000 Only

Rigshospital Herlev Odense Skejby

0,00 0,25 0,50 0,75 1,00 1,25 1,50 1,75 2,00

Time

0,65

0,70

0,75

0,80

0,85

0,90

0,95

1,00

1,05

Rej

ectio

n-fr

ee S

urvi

val

NotSignificant

Recipient Age & Rejection

<20 20-40 40-60 >60

0 1 2 3 4 5 6 7 8

Time (years)

0,60

0,65

0,70

0,75

0,80

0,85

0,90

0,95

1,00

Re

ject

ion

-fre

e S

urv

iva

l

Pretransplant ESRD and Rejection

Preemptive <5 years >5 years

0,00 0,25 0,50 0,75 1,00 1,25 1,50 1,75 2,00

Time (years)

0,65

0,70

0,75

0,80

0,85

0,90

0,95

1,00

Re

ject

ion

-fre

e S

urv

iva

l

Risk Factors for Rejection

*

*

*

**

***

***

* p<0.05; **p<0.01; ***p<0.001

Risk Factors for Graft Loss

****

***

***

***

***

* p<0.05; **p<0.01; ***p<0.001

****

*

Risk Factors for Graft Loss + Death

****

***

*

***

*

* p<0.05; **p<0.01; ***p<0.001

*

***

Risk Factors for Death

***

***

* p<0.05; **p<0.01; ***p<0.001

***