Giant of female tract temporal arteritis · Lhote,Mainguene,Griselle-Wiseler, etal few affected...

Annals ofthe Rheumatic Diseases 1992; 51: 900-903

CASE REPORTS

Giant cell arteritis of the female genital tract withtemporal arteritis

Franqois Lhote, Claire Mainguene, Valerie Griselle-Wiseler, Renato Fior,Marie-Jose Feintuch, Isabelle Royer, Bernard Jarrousse, Jacques Amouroux, Loic Guillevin

Service deMedecine Interne,Hopital Avicenne,125 route de Stalingrad,93009 Bobigny Cedex,FranceF LhoteV Griselle-WiselerR FiorI RoyerB JarrousseL GuillevinService d'AnatomiePathologique,Hopital Avicenne,125 route de Stalingrad,93009 Bobigny Cedex,FranceC MaingueneM-J FeintuchJ AmourouxCorrespondence to:Dr Lhote.

Accepted for publication15 October 1991

AbstractThe clinical and pathological features of a

patient with giant cell arteritis of the uterusand ovaries are described. A 61 year oldwoman had fever and weight loss over a

period of eight months. A hysterectomy withbilateral salpingo-oophorectomy was per-

formed for a large cystic ovarian mass.

Histological examination showed a benignovarian cyst and unexpected giant cell arteritisaffecting numerous small to medium sizedarteries in the ovaries and myometrium. Thediagnosis of temporal arteritis was confirmedby a random temporal artery biopsy, despitethe absence ofsymptoms oftemporal arteritis.This observation is compared with previouslyreported cases and the relation betweengranulomatous arteritis of the genital tractand temporal arteritis is discussed. The maindifferential diagnosis in this localisationwas represented by Wegener's granulomatosisand periarteritis nodosa.

(Ann Rheum Dis 1992; 51: 900-903)

Giant cell arteritis is a systemic vasculitis thatprimarily affects large and medium sized arteries.The most characteristic clinical features of giantcell arteritis are seen when the cranial arteries,particularly the temporal arteries, are affected.Occasionally, giant cell arteritis may affect theaorta and its branches,' but the pelvic arteries

Figure 1 Computed tomography scan ofthe abdomen and pelvis showing a wellcircumscribed rounded mass oflow attenuation, lOx 10 cm, in the posterior and middleportion ofthe pelvis.

are rarely affected by the inflammatory process 2Most examples of giant cell arteritis of thegenital tract are incidental findings in samplesremoved during operations. We describe herethe clinical and pathological features of giantcell arteritis, fortuitously discovered in theuterus and ovaries, and preceding the diagnosisof temporal arteritis which was proved bytaking a biopsy sample. In view of similar casesreported previously, we discuss the relationbetween giant cell arteritis of the female genitaltract, temporal arteritis, and polymyalgiarheumatica.

Case reportA 61 year old white woman was referred to us inJanuary 1991 because of a fever of unknownorigin and a five month history of declininggeneral health. Her past medical history was notunusual. Menopause had occurred in 1980. Shewas in good health until five months earlier,when she consulted her doctor because of fever,major asthenia, anorexia, and weight loss. Onadmission, a physical examination was normal.Laboratory results were as follows: haemoglobin103 g/l; white blood cell count 7 8x 109/l (60%neutrophils, 6% eosinophils, 30% lymphocytes,and 4% monocytes); erythrocyte sedimentation,112 mm/hour; fibrinogen 9-14 g/l; haptoglobin8-7 g/l; alkaline phosphatase 494 IU/l (normalrange <220 IU/1). A chest radiograph wasnormal. An ultrasound examination of theabdomen and pelvis showed the presence of acystic left ovarian mass, 8 x9 cm, withoutevidence of intracystic vegetations. A computedtomographic scan of the pelvis disclosed a wellcircumscribed rounded mass of low attenuation,lOx 10 cm, in the posterior and middle portionof the pelvis (fig 1). A left temporal arterybiopsy sample was normal. A diagnosis ofovarian malignancy was suspected and alaparotomy was performed on 13 March 1991.The left ovarian mass was cystic, withoutadherence to the parietal peritoneum anduterus. The uterus and the right ovary appearednormal, and no other abnormalities were found.A bilateral salpingo-oophorectomy and hys-terectomy were performed. Microscopicexamination of the left ovarian mass showed itto be a benign cyst. The uterus presentedseveral benign uterine leiomyomas. Extensivegiant cell arteritis of the small to medium sizedarteries was found unexpectedly in the uterusand both ovaries (figs 2 and 3).

Recovery after the operation was uneventful,and the patient progressively improved. Onemonth after the hysterectomy, a biopsy sample

900

on Decem

ber 11, 2020 by guest. Protected by copyright.

http://ard.bmj.com

/A

nn Rheum

Dis: first published as 10.1136/ard.51.7.900 on 1 July 1992. D

ownloaded from

Giant cell arteritis ofthefemale genital tract

-fromthe right temporal artery was taken which

,-,.%-,

lv-- showed;' the characteristic pathological features

of giant cell arteritis. Treatment with prednisone

a(07 mg/kg daily) was then started.

"S" ~~~~~~Pathological findings

Figure2EtnieTe removed uterus weighed 58 g and measured

10cm in length. Three uterine leiomyomas, 1-2

cm in diameter, were found in the corpus.

Examination of the left ovary disclosed a

-~unilocular cyst measuring 10 cm in diameter

and filled with a yellowish necrotic material.

Figure 2 Exwtensve giant cell arteritis ofsmall to medium The cyst wall was smooth without papillations.sized arteries of the ovarian htilus. Also seen are intimalfibrotic narrowing ofthe lumen and a dense granulomatous No epithelial linig was found, and no precise

infiltrate with giant cells affecting part ofthe media and the diagnosis could be made for the ovarian benignadventttta. Haematoxylin-eosin statn. cyst. The right ovary and fallopian tubes were

normal.The microscopic examination showed a wide-

spread and active giant cell arteritis affectinggnumerous small to medium sized arteries of the

uterus and ovaries. In most of the affected

arteries, a dense inflammatory infiltrate,

predominantly composed of lymphocytes,

i histiocytes and rare plasma cells, was seen

l mainly in the media, extending to the adventitia.

The granulomatous inflammation was oftenfocal, affecting a localised area of the media, but

in some arteries the media was replaced circum-

ferentially by granulomatous tissue. Multi-nucleated giant cells often abutted against the

|W1111__0 fragmented internal elastic lamina. Elastictissue stains underlined the focal disruption and

Figure 3 Giant cell arteritis of the ovary. The media ofthis loss of elastic fibres. An intimal fibrosis resultedmedium sized artery was infiltrated with lymphocytes,

ls featcfbe.A nia irssrsle

histiocytes, and giant cells, abutting against the fragmented in luminal narrowing and thromboses wereinternal elastic lamina. Haematoxylin-eosin stain. rarely seen. Fibrinoid necrosis was noted in a

Clinical and pathological features of 19 women with genital tract giant cell arteritis

Reference Age Symptoms Pelvic organs affected 7emporal artery Treatment and(years) ky giant cell arteritis biopsv sample results follow up

7 82 Weakness, weight loss, Uterus Not performed Prednisone (30 mg/day);polymyalgia rheumatica improvement (8 mo)

8 Weight loss, fever, metrorragia Uterus, ovaries Temporal arteritis Prednisone;polymyalgia rheumatica improvement

9 66 Shoulder pain, tiredness, vaginal Uterus Not performed No treatment;spotting, prolapsed uterus improvement (one year)

79 Prolapsed uterus Uterus Not performed No treatmentimprovement

10 66 Ovarian cyst, Ovary Temporal arteritis Prednisone;symptoms of temporal arteritis improvement

11 78 Resection of a residual cervix, Cervixsymptoms of temporal arteritis

12 61 Endometrial adenocarcinoma, Uterus, cervix ovaries, Not performed Aspirin;polymyalgia rheumatica fallopian tubes improvement

13 76 Ovarian cyst, Uterus, ovaries, Prednisone;polymyalgia rheumatica fallopian tubes improvement

14 Polymyalgia rheumatica, Ovaries, cervix, fallopian No temporalcervical carcinoma tubes, myometrium arteritis

15 78 Fatigue, weight loss, fever, Left ovary, mesosalpinx, Not performed Prednisone (50 mg/day);ovarian cyst (CT scan)* fallopian tubes improvement (one year)

75 Polymyalgia rheumatica, benign Uterus, ovaries, Not performed Prednisone;leiomyoma of the uterus fallopian tubes improvement (six years)

16 80 Fatigue, anaemia, weakness, Ovarian cyst, ovaries, Not performed Prednisone (20 mg/day);ovarian cyst (CT scan)* myometrium, fallopian tubes, improvement

cervix17 64 Fatigue, lower abdominal mass, Ovaries, fallopian tubes Not performed No treatment;

ovarian fibromas improvement (17 years)57 Fever, weight loss, abdominal Cyst wall, right ovary, Not performed No treatment, dissecting

mass (left ovarian cyst) fallopian tubes, mesosalpinx aneurysm of aorta (seven years)18 73 Prolapsed uterus and bleeding from Myometrium Not performed Prednisolone (60 mg/day);

cervical polyps, bilateral axillary improvementarteritis (angiogram)

19 68 Unexplained fever, Cervix, myometrium, Bilateral temporal Prednisone (1 mg/kg daily);left ovarian cyst (CT scan)* ovaries, broad ligaments arteritis improvement

20 65 Polymyalgia rheumatica Myometrium, Not performed Prednisolone;abdominal pain, left ovarian cyst parametrium, ovaries 'improvement (one year)

21 69 Cystocele, postoperative Myometrium Temporal arteritisfever, temporal pain

This 61 Fever, fatigue, weight loss, Uterus, ovaries Temporal arteritis Prednisone (0-7 mg/kg daily);paper ovarian cyst (CT scan)* improvement

*CT=computed tomography.

901

on Decem

ber 11, 2020 by guest. Protected by copyright.

http://ard.bmj.com

/A

nn Rheum

Dis: first published as 10.1136/ard.51.7.900 on 1 July 1992. D

ownloaded from

Lhote, Mainguene, Griselle-Wiseler, et al

few affected myometrial arteries. Venules andveins were normal.The temporal artery biopsy sample showed

the same inflammatory changes, occurringmainly in the media, with multinucleated giantcells lying adjacent to the fragmented elasticinternal lamina. These features are in agreementwith the diagnosis of granulomatous and giantcell arteritis.

DiscussionThese pathological findings led us to questionthe possible relation between granulomatousand giant cell arteritis of the uterus and ovaries,and temporal arteritis.

Giant cell arteritis, first described by Hutch-inson' and later by Horton et al,4 is a disease ofthe elderly that typically affects the cranialarteries. In 1946, however, Cooke et al Sdescribed two patients with temporal granulo-matous arteritis also affecting multiple mediumand large sized arteries 'at necropsy.5 Sincethen, involvement of other extra cranialmedium and large sized arteries has beendescribed in four to 14% of patients with giantcell arteritis,1 2 6 supporting the idea thattemporal arteritis and giant cell arteritis are

manifestations of a systemic arterial disease.Localisation of giant cell arteritis in the

female genital tract has rarely been reported.The first case of giant cell arteritis affecting thecervix and corpus of the uterus was describedby Polasky et al in an 82 year old woman withpolymyalgia rheumatica.7 Including ourpatient, 19 cases7-2 have been reported andthese are summarised in the table. All caseswere postmenopausal women ranging in agefrom 57 to 82 years (average 70). None of thepatients had pelvic symptoms that could beattributable to the vasculitis and, in mostinstances, the genital organs were removed forgynaecological lesions unrelated to giantcell arteritis. Nine of the 19 women hadabnormal ovarian tissue: seven had simplecysts,'0 13 16 17 19 20 one had a paratubal cyst,'5and one had ovarian fibromas.'7 For theremaining women, hysterectomies wereperformed for benign or malignant uterinetumour, 14 15 18 prolapsed uterus,7 9 Ixincarcerated pessary," and cystocele,2' Thevascular lesions were incidental findings notedat microscopic examination. Most of the patientshad systemic symptoms. Seven of the 19 patientshad symptoms suggestive of polymyalgiarheumatica,7 8 12-15 20 and three patients hadsymptoms of temporal arteritis,'0 11 21 but giantcell arteritis was never diagnosed before surgery.Seven patients,8 15-17 19 including the one

reported here, were in deteriorating generalhealth with minor8 or no gynaecologicalsymptoms, 15-7 19 and a hysterectomy wasperformed after the discovery of a uterine orovarian mass to exclude malignancy. The absenceof specific signs and symptoms of temporalarteritis is well known during giant cell arteritisand its onset can be insidious. In 30 of 74patients with giant cell arteritis proved bytaking a biopsy sample and reported by Healeyand Wilske,22 the cardinal manifestations oftemporal headache, blindness, or polymyalgia

rheumatica were absent. Twelve ofthese patientspresented with fever, and like our patient,seven had a 'malignoid' syndrome of malaise,anorexia, low grade fever, weight loss and, infive patients, increased alkaline phosphatase. Ina retrospective study of the histories of 100patients with giant cell arteritis proved bytaking a biopsy sample, Calamia and Hunder23described 15 patients who had fever of un-determined origin, in a similar manner to ourpatient. Other extragenital localisations of thegiant cell arteritis were found in six patients. Atemporal artery biopsy sample was taken sixtimes following the finding of giant cell arteritisof the reproductive tract. In five instances,temporal arteritis was found,8 10 19 21 withoutany cranial symptoms in three cases.8 19 Onehad bilateral axillary artery stenosis which wasseen on the angiogram,18 with clinical symptomsof ischaemia of the arms. In some cases,9 15-17in the absence of symptoms of temporal arteritisor polymyalgia rheumatica, giant cell arteritisaffecting the female genital tract may be limitedto this area.Treatment and follow up studies of patients

with giant cell arteritis of the female genitaltract have not been reported in detail. Tenof the previously described patients7 I 10 13 15 161820 improved symptomatically after treatmentwith steroids. Four asymptomatic patients9 17were not treated with steroids and did notdevelop systemic manifestations, even after afollow up of 17-5 years in one patient.

Pathologically, giant cell arteritis is charac-terised by an inflammatory granulomatousinfiltrate of the arterial wall, fibrous intimalproliferation, and fragmentation of the internalelastic lamina often associated with multi-nucleated giant cells. Fibrinoid necrosis of themedia is rare. Segments of the blood vessels arecommonly affected. Histological examination ofgenital samples disclosed the same lesions,affecting predominantly the media of small tomedium sized arteries. The organs affectedin the vascular process were the uterus (13patients), the ovaries (13 patients), the fallopiantubes (seven patients), and the cervix (fourpatients). Eight women had a benign adnexalcyst.'o 13 15-17 19 20

The differential diagnosis of genital giant cellarteritis includes rare patients with the genitalsaffected by other forms of vasculitis, namelyWegener's granulomatosis and polyarteritisnodosa.24 25 In addition to its distinctive clinicalsymptoms and types of vessels affected, giantcell arteritis differs from other necrotising andgranulomatous vasculitides, by the presence ofgiant cells and the absence of vascular fibrinoidnecrosis and eosinophilic infiltrates. InWegener's granulomatosis, histological featuresinclude extensive necrosis and granulomatousinflammation affecting the arteries and thesurrounding parenchyma. Polyarteritis nodosatypically shows prominent fibrinoid necrosisand a mixed inflammatory infiltrate, witheosinophils and no giant cells. In our patientthe histological aspect of the ovarian and uterinevasculitis and the discovery of temporal arteritisprovided solid arguments for the diagnosis ofgiant cell arteritis.

902

on Decem

ber 11, 2020 by guest. Protected by copyright.

http://ard.bmj.com

/A

nn Rheum

Dis: first published as 10.1136/ard.51.7.900 on 1 July 1992. D

ownloaded from

Giant cell arteritis ofthe female genital tract

In most instances of female genital tract giantcell arteritis the presence of systemic manifes-tations and classical symptoms of polymyalgiarheumatica or temporal arteritis underlines thesystemic nature of the vasculitis but, in some

patients, the female genital tract may be theonly area affected. Preoperative diagnosis ofgenital tract giant cell arteritis is difficult in theabsence of specific morphological lesions. Thediscovery of giant cell arteritis in the genitaltract led us to take a biopsy sample of thetemporal artery to determine the extent of thevasculitis and the indications for systemictreatment.

1 Klein R G, Hunder G G, Stanson A W, et al. Large arteryinvolvement in giant cell (temporal) arteritis. Ann InternMed 1975; 83: 806-12.

2 Liozon F. La maladie de Horton. Ann Med Interne (Paris)1989; 140: 122-41.

3 Hutchinson J. Disease of the arteries. On a peculiar form ofthrombotic arteritis of the aged which is sometimesproductive of gangrene. Archives Surgery (London) 1890; 1:323-9.

4 Horton B T, Magath T B, Brown G E. An undescribed formof arteritis of the temporal 'vessels'. Proceedings of StaffMeetings Mayo Clinic 1932; 7: 700-1.

5 Cooke W T, Cloake P C P, Govan A D T, et al. Temporalarteritis. A generalized vascular disease. QJI Med 1946; 15:47-76.

6 Godeau P, Aubert L, Guillevin L, et al. Aspect clinique,evolution et pronostic de la maladie de Horton. Ann MedInterne (Panrs) 1982; 133: 393-400.

7 Polasky N, Polasky S H, Magenheim H, et al. Giant cellarteritis: review and report of case. JAMA 1%5; 191:341-3.

8 Leng-Levy J, David-Chausse J, Lagoarde J, et al. L'arteritetemporale. Cah Coll Med Hop Paris 1%7; 8: 207-17.

9 Pirozynski W J. Giant-cell arteritis of the uterus: report oftwo cases. AmJf Clin Pathol 1976; 65: 308-13.

10 Hugod C, Scheibel M. Kxmpecellarteritis i ovarie. UgeskrLaeger 1978; 140: 1093-4.

11 Schiffman R. Giant cell arteritis involving uterine cervix.7ournal of the Medical Society of New Jfersey 1979; 76:676-7.

12 Petrides M, Robertson I G, Fox H. Giant-cell arteritis of thefemale genital tract. BrJf Obstet Gynaecol 1979; 86: 148-51.

13 Evans C E, Flight G H, Neufeld V R, et al. Giant cell arteritisof the uterus and adnexa. Paroi ArteriellelArterial Wall1980; 26: 27-33.

14 Schneider V. Visceral giant cell arteritis limited to the femalegenital tract: a case report. ReprodMed 1981; 26: 328-31.

15 Gloor E, Schaller M D, Dubuis P Y. Arterite a cellulesgeantes a localisation gynecologique: presentation de 2 cas.

JCGvnecol Obstet Biol Reprod (Paris) 1982; 11: 785-8.16 Case records of the Massachusetts General Hospital (case

23-1986). N EnglJ7 Med 1986; 314: 1564-72.17 Bell D A, Monschein M, Scully R E. Giant cell arteritis of the

female genital tract: a report of three cases. Am SurgPathol 1986; 10: 696-701.

18 Kyle V, Hamilton Dutoit S, Elias-Jones J, et al. Giant cellarteritis of myometrial and axillary arteries and polymyalgiarheumatica. Ann Rheum Dis 1987; 46: 256-8.

19 Kohn N N. Giant cell arteritis of the female reproductivetract associated with temporal arteritis. Rheumatol 1989;16: 832-3.

20 Birch P J, Buchanan R. A gynaecological complication ofpolymyalgia rheumatica/giant cell arteritis. Br J(ObstetGynaecol 1989; %: 1356-8.

21 Nehra P C, Ramus D M, Peterson J. Giant cell arteritis of theuterus with associated temporal arteritis: a case report.Obstet Gynecol 1990; 76; 935-8.

22 Healey L A, Wilske K R. Presentation of occult giant cellarteritis. Arthritis Rheum 1980; 23: 641-3.

23 Calamia K T, Hunder G G. Giant cell arteritis (temporalarteritis) presenting as fever of undetermined origin.Arthritis Rheum 1981; 24: 1414-8.

24 Ansell I D, Evans D J, Wright D G D. Asymptomaticarteritis of the cervix. J(Clin Pathol 1974; 27: 664-8.

25 Piette J Ch, Bourgault I, Legrain S, et al. Systemicpolyarteritis nodosa diagnosed at hysterectomy. Am Med1987; 82: 836-8.

903

on Decem

ber 11, 2020 by guest. Protected by copyright.

http://ard.bmj.com

/A

nn Rheum

Dis: first published as 10.1136/ard.51.7.900 on 1 July 1992. D

ownloaded from