Extraction Met h on Green Chemistry

Fulgentius N. L

Pennsylvania State

(717) 77

ful4@p

24 Jun

Extraction Methon Green C

______________ugemwa, Ph.D.

e University –York

71-8409

psu.edu

e 2009

hods that FocusChemistry______________

Acknowle

Eric J. LUndergraduate Studen

edgment

Lawrencent at Penn State, York

Summ

• A brief overview of ex• Evidence that extrac

and/or ethyl alcohol w• Where do we go from

mary

xtraction methodsctions using water work

m here?

Extraction Using G

Useful methods inclu• Steam distillation, hydr• Vacuum & atmospheric• Supercritical fluids

Carbon dioxide

Green Chemistry

de rodistillationc sublimation

Other Extract

Some of the organic extract natural products

• Acetone, benzene, 1-bdichloromethane, ethanacetate, hexanes, methxylene.

tion Methods

solvents used to s utanol, chloroform, nol, ether, ethyl hanol, toluene &

Green extractioon by the barrel

Soxhlet eextractor

We use ethyl alcacetone

to extract trimyris

cohol instead of or ether tin from nutmeg

Betulin from White Birch

Betuulin

Carnosic acid frrom Rosemary

Carnossic acid

Betulin e

Solvent system (200 mL) T

45% EtOH/45% EtAc/10% water 4

50% EtOH/50% EtAc 4

EtOH 2

EtAc 2

extracts

Total extract (g) from 20g after 96 hours at room temperature

4.0 ± 0.4

4.4 ± 0.5

2.2 ± 0.2

2.5 ± 0.3

Pure BSolvent system

45% EtOH/45% EtAc/10% water

50% EtOH/50% EtAc

Hot toluene

Betulin Betulin, g /4 g

2.8 ± 0.4

3.0 ± 0.5

3.2 ± 0.6

Carnos

Solvent system A

45% EtOH/45% EtAc/10% water 4

SC-CO2

Acetone 2

Methanol

Butanone 2

ic acid

Amount of carnosic acid- 96 hours, mg/g ± SD 40.5 ± 1.5

35.7 ± 1.6

26.2 ± 1.5

15.9 ± 1.3 13.2 ± 1.5

20.5 ± 1.2

ApplicNatural products arNutraceuticalsCosmeceuticalsPharmaceuticalsInsecticidesInsect repellants

cationsre used as

Application of G

D. Adairs Cosmeticssolventshttp://dadairs.comMoisturizing Ginseng GChamomile MoisturizingOther products contain geranium, white oak bawitch hazel, sage, whitegrass and jasmine.

reen Chemistry

, Inc. uses green

Gelg Cleanserextracts from

rk, horsetail, comfrey, e pine, fennel, lemon

Take-home

The extraction of manatural sources can green solvents. Experiment with watbefore using other s

e message

ny compounds from be carried out using

ter or ethyl alcohol solvents.