Extensive labial necrosis as initial manifestation of acute lymphoblastic leukemia

OOOO ORAL ABSTRACTSVolume 114, Number 4 Abstracts e105

LPLUNC2 IS EXPRESSED IN PERITUMORAL MASTCELLS OF MUCOEPIDERMOID CARCINOMAS OF SAL-IVARY GLANDS González-Arriagada WA1, Santos-SilvaAR1, Silva AA1, Vargas PA2, Bingle L3, Speight P3, LopesMA1 - 1FOP-UNICAMP - ESTOMATOPATOLOGIA, 2F -ESTOMATOPATOLOGIA, 3UNIVERSITY OF SHEFFIELD -ORAL PATHOLOGY

Background: Recently was reported the LPLUNC2 immu-nohistochemical expression of mast cells in mucoepidermoidcarcinoma (MEC).

Objectives: The aim of this study was to compare theexpression of LPLUNC2 and trypsine of mast cells in MEC ofsalivary glands.

Study design: The immunohistochemical expression ofLPLUNC2 and trypsine was evaluated in 30 MECs. The evalu-ation considered the number and patterns of distribution of thepositive cells.

Results: LPLUNC2 showed specific positivity in cells thatresemble mast cells in 83.33% of the samples. Subsequently,immunohistochemistry for trypsine was performed, showing pos-itivity in the LPLUNC2-positive cells.

Conclusions: The expression of LPLUNC2 in mast cells isa previously unrecognized event. We suggest that LPLUNC2 canbe considered as a new potential marker that aids in the identi-fication of mast cells and that this protein may play a role in thefunction of these cells in the host tumoral immune response.

HEAD AND NECK VASCULAR LEIOMYOMA IN A BRA-ZILIAN POPULATION Alves AM1, Gomes APN1, Etges A1,Furuse C1, Vasconcelos ACU1, Tarquinio SBC1 - 1UNIVER-SIDADE FEDERAL DE PELOTAS - SEMIOLOGIA ECLÍNICA

Objective: the aim of this study was to determine the prev-alence of head and neck vascular leiomyoma and their clinicaland epidemiological characteristics from Center of DiagnosisOral Diagnosis – Pelotas/Brazil.

Study design: biopsies files from CDOD were evaluated inthe period between 1959 and 2012. Data about sex, age, site andlesion were collected and submitted to descriptive analysis.

Results: from a total of 20,022 biopsies analyzed, 13 (0.1%)were vascular leiomyoma, being male 61.5% of the patients. Theaverage age was 44.2 years (varying from 14 to 73 years-old). Inorder of prevalence, were found 4 cases in lower lip (30.7%), 2in upper lip (15.4%), 2 in buccal mucosa (15.4%), 2 in palate(15.4%), 1 in ear (7.7%), 1 in maxillary sinus (7,7%), and 1 inlower gutter (7.7%).

Conclusion: head and neck vascular leiomyomas are veryuncommon lesions, and the most affected site was lower lip.

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[2] Wang CP, Chang YL, Sheen TS. Vascular leiomyoma ofthe head and neck. Laryngoscope 2004 Apr;114(4):661-5.

[3] Gaitan Cepeda LA, Quezada Rivera D, Tenorio Rocha F,Leyva Huerta ER, Mendez Sanchez ER. Vascular leiomyoma ofthe oral cavity. Clinical, histopathological and immunohisto-chemical characteristics. Presentation of five cases and review ofthe literature. Med Oral Patol Oral Cir Bucal 2008 Aug;13(8):

[4] Nonaka CF, Pereira KM, Miguel MC. Oral vascularleiomyoma with extensive calcification areas. Braz J Otorhino-laryngol 2010 Jul-Aug;76(4):539.

EXTENSIVE LABIAL NECROSIS AS INITIAL MANIFESTA-TION OF ACUTE LYMPHOBLASTIC LEUKEMIA OliveiraDT1, Garcia AS2, Andrea MLM1, Oliveira DT2 - 1DARCYVARGAS CHILDREN HOSPITAL - PEDIATRIC ONCOL-OGY, 2BAURU SCHOOL OF DENTISTRY, UNIVERSITY OFSÃO PAULO, BRAZIL - DEPARTMENT OF STOMATOL-OGY - AREA OF PATHOLOGY

A ten year-old girl sought medical care by lesion in theinferior lip associated to local trauma and cervical lymphadenop-athy. After one day, there was increase of the signs including,local edema and cervical/submandibular lymphadenopathy. Thepatient was submitted to pharmacological treatment with ibupro-fen and hexamidine. Two days later the patient was hospitalizedpresenting labial necrosis, petechiae in the body, pancytopenia,coagulation abnormalities and prostration. She received bloodtransfusion and evolved with gastric and labial bleeding. Due thepersistence of pancytopenia by five days, a myelogram wasperformed and revealed 90% of the blasts presented lymphoid L3aspect. Then established the diagnosis of acute lymphoblasticleukemia (ALL). The patient underwent treatment for ALL inaccording to the ALL-BFM-02 protocol with disease remissionand total regression of the lip lesion.

KERATOACANTHOMA IN THE LOWER LIP - CASEREPORT Paiva K1, Ferreira SMS1, Farias AC1, AlbuquerqueECS1, Vasconcelos MLAA1, Beder C1 - 1CENTRO DE ES-TUDOS SUPERIORES DE MACEIÓ - ODONTOLOGIA

The keratoacanthoma is a benign tumor of rapid growth thathas clinical and pathologic features similar to squamous cellcarcinoma. In most cases affects older patients with white skinphotosensitivity in areas exposed to the face and upper extrem-ities. This paper reports a case of keratoacanthoma in the lowerlip. Patient E.S.S., female, 61 years old, attended the dentalspecialty center complaining of a ”sign in your mouth.” Thelesion is approximately one month in duration, is painless, raisedborders and rapidly growing. The extra-oral examination showednodular reddish, firm, painless, bleeding surface, one measuring1.0 cm x 0.5 cm in the lower lip. The treatment was surgicalexcision of the entire lesion, which provided definitive histo-pathological diagnosis beyond the cure of disease.

HRPT2 AND CYCLIN D1 MOLECULAR INVESTIGA-TION IN FIBROUS DYSPLASIA, OSSIFYING FIBROMAAND OSTEOSARCOMA OF THE JAWS Netto ACM1, Go-mez RS1, Silva TF1, Diniz MG1, Campos K1, Carlos R2,Gomes CC3 - 1DEPARTMENT OF ORAL SURGERY ANDPATHOLOGY, SCHOOL OF DENTISTRY, UNIVERSIDADEFEDERAL DE MINAS GERAIS, BELO HORIZONTE-MG,MINAS GERAIS, BRAZIL, 2CENTRO CLÍNICO DE CABEZAY CUELLO / HOSPITAL HERRERA-LLERANDI, GUATE-MALA, 3DEPARTMENT OF PATHOLOGY, BIOLOGICALSCIENCES INSTITUTE, UNIVERSIDADE FEDERAL DEMINAS GERAIS, BELO HORIZONTE-MG, MINAS GERAIS,BRAZIL

Background: Studies demonstrate genetic alterations of the