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ADULT DARK SPERMATOGONIA AND FERTILITY POTENTIAL IN CRYPTORCHID TESTES 1571
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EDITORIAL COMMENT
Testicular biopsies have implicated a decreased germ (reference 18 in article). Nonetheless, these results
cell count as the histological basis of subfertility inpatients with undescended testes. The authorsconvincingly report that the presence and number ofPLAP positive germ cells should be consideredadditional histological parameters when assessingfertility potential in bilateral cryptorchidism cases.Including adult hormone levels, semen analysis orpaternity data in this cohort would further clarifythe clinical relevance of these findings, particularlysince associations between germ cell histology andthese variables suggest that testicular biopsy atbilateral orchiopexy may help predict future fertilityunderscore the value of reviewing testis histology inpatients with bilateral cryptorchidism when coun-seling families about fertility potential. Furtherinvestigation is warranted to determine whethertesticular biopsy at bilateral orchiopexy should beroutine clinical practice for detecting boys at risk forfuture infertility.
Kate H. KraftDepartment of Urology
University of Michigan Health System
Ann Arbor, Michigan
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