Drugs effecting the digestive organs function Lector prof. Posokhova K.A

Drugs effecting the digestive organs

function

Lector prof. Posokhova K.A.

Among substances that influence on functioning of digestive organs there are

following groups of drugs:Drugs which influence on appetite;

Emetic and antiemetic drugs;

Drugs which are used in case of disturbed function of gastric glands;

Drugs effecting liver function;

Drugs used in case of disturbed excretory function of pancreas;

Laxative agents;

Drugs which influence on motor function of intestines

Drugs which influence on

appetite:

Drugs which improve appetite

Drugs which depress appetite

Гіркоти

Полин гіркий

Золототисячник малий

Деревій звичайний

PhepranonumForm of production - 0,025 g tablets

Mechanism of action of emetic and antiemetic drugs

Metoclopramide, reglan and cerucalFrom of production: 0,01 g tablets, ampoules with 2 ml of 0,5 % solution.

MotiliumForm of production: 0,01 g tablets

Drugs which stimulate gastric secretion:

With diagnostic aim: caffeine, histamine, gastrin.With treating aim: plantain juice, plantaglucide, natural gastric juice, pepsin, hydrochloric acid.

Drugs which depress gastric secretion:

Drugs which block choline receptros:M-cholinoblockers (nonselective cholionolyutics): atropine sulfateM1-cholinoblockers with selective action (selective cholinolytics): gastrozepinganglioblockers: pirilen, benzohexonium

Drugs which block histamine-Н2-receptors: cimetidine, renitidine, famotidine, nizatidine, rexatidineInhibitors of proton pump: omeprazole, controlokProstaglandines and their synthetic derivatives: misoprostolAntacid drugs:

System: sodium hydrocarbonateNonsystem: aluminum hydroxide, magnesium oxide, almagel, maalox, renni

Gastroprotectors:Drugs which form mechanic protection of mucous membrane of stomach: sucralfate, de-nolDrugs which increase protective function of mucous barrier and stability of mucous membrane towards action of damaging factor: carbenoxolon, misoprostol

Atropine sulfate (Atropini sulfas). Powder for preparation of 0,5 % and 1 % eye drops, 1% eye

ointment, 0,0005 g tablets, ampoules with 1 ml of 0,1 % solution.

Gastrozepin (Gastrocepinum) Forms of production: 0,025 g and 0,05 g tablets; ampoules

with 0,01 g of dry substance.

Cimetidine Form of production: 0, 2 g tablets.

Ranitidine (Ranitidin) Forms of production: 0,15 g and 0,3 g tablets and ampoules with 2 ml of

2,5 % solution.

FamotidinForms of production: 0,02 g and 0,04 g tablets.

Omeprazole Form of production – 0,02 g capsules.

Antaciddrugs

Systemantacids

Nonsystemantacids

AlmagelCombined drug which contains gel of aluminum hydroxide,

magnesium oxide and D-sorbit. Form of production: 170 ml bottles.

Antacid drugs

Maalox Combined rugs which contains gel of aluminum hydroxide,

magnesium oxide.

Sucralfate Form of production: 1 g tablets

De-nolForm of production: 0,12g tablets.

Pylobact Omeprazole + Clarythromycin + Tinidazole

Schemes of combined treatment of gastric ulcer

De-nol + amoxycillin

De-nol + metronidazole

Omeprazole + amoxycillin + clarythromycin

De-nol + clarythromycin + metronidazole

De-nol + controlok + amoxycilin + clarythromycin

Drugs which influence on functioning of digestive organs

Part 2

Among substances that influence on functioning of digestive organs there are

following groups of drugs:Drugs which influence on appetite;

Emetic and antiemetic drugs;

Drugs which are used in case of disturbed function of gastric glands;

Hepatotropic drugs;

Drugs used in case of disturbed excretory function of pancreas;

проносні засоби;

Drugs which influence on motor function of intestines

Hepatotropicdrugs

Jaundice (?)

Liver protectors

Cholelytholytic

Classification of жовчогінних drugs: Drugs which stimulate bile ptoduction (choleretics,

cholesecretors)Drugs which increase secretion of bile and stimulate production of

bile acids (true choleretics)а) drugs which include bile acids (allochol, cholenzyme)б) synthetic drugs (nicodine, oxafenamide)в) drugs of plant origin (безсмертник піщаний, кукурудзяні

приймочки, pepper mint, піжмо, dog-rose, cholagol)Drugs which increase secretion of bile primarily due to water

component (hydrocholeretics: mineral waters, valerian drugs)Drugs which stimulate bile secretion

(cholekinetics) drugs which cause increasing of gall-bladder tone and decreasing

of bile ducts tone (cholekinetics: magnesium sulfate, sorbit, barberries). drugs which cause relaxation of bile ducts tone

(cholespasmolytics: M-cholinoblockers, euphyllin, nitroglycerine).

Allochol (Allocholum)

Drugs of plant origin

Кукурудзяні

приймочкиБезсмертник

піщаний Dog-rose

Cholagol

Pharmacodynamics of magnesium sulfate depending of way of administration

Clinical classification of antioxidants Antioxidants of direct action

Drugs which contain vitamin E (tocopherole acetate, aevit).Vitamin C drugs (acrobatic acid, galascorbin, ascorutin).Bioflavonoids (legalon, flamin, flakumin, sylibor, convaflavin).Drugs which include thiol groups (unithiol, thiosulfate sodium).

Antioxidants of indirect actionDrugs which regulate phospholipid contents of cell membranes (essentiale, lipin, retinol, aevit).Precursors of pyridine nucleotides (nicotinic acid, nocotinamid).Precursors of glutation (metionin, cystein, glutamic acid).Drugs which induct glutationperoxydase (selenium containing drugs).Other drugs which increase antioxidating potential of blood and tissues (lipoic acid, lilamid, organic drugs of liver).

Tocopherole acetate (Tocopheroli acetas)Vitamin E is produced in many forms: 5 %, 10 % and 30 % oil solution in 10, 20 and 50 ml bottles; elastic capsules with 0,1 and 0,2 ml of 50 % solution in oil; ampoules with 1 ml of 5

%, 10 % and 30 % oil solutions.

Розтропша плямиста

Carsil Legalon

Mechanism of action of legalon

Essentiale Is produced in 5 ml ampoules and in capsules

Lipostabil

Pancreatin (Panсreatinum) Is produced in 0,25 g and 0,5 g dragee (tablets).

Panzynorm forte

Festal, Enzistal, Mezym-forte

No-spa, nicospan

Baralgin

Крушина звичайна

Bisakodil

Guttalax

Bil-berries St. John’s wort

Pepper mint Chamomile

Imodium