Diabetes & Pregnanc y Women with diabetes in the first trimester would be classified as having type...
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- Slide 1
- Slide 2
- Diabetes & Pregnanc y
- Slide 3
- Women with diabetes in the first trimester would be classified
as having type 2 diabetes. Women with diabetes in the first
trimester would be classified as having type 2 diabetes. GDM is
diabetes diagnosed in the second or third trimester of pregnancy
that is not clearly overt diabetes. GDM is diabetes diagnosed in
the second or third trimester of pregnancy that is not clearly
overt diabetes.
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- Epidemiology of glucose intolerance and GDM in women of child
bearing age, Diabetes Care, 21, 1998 Prevalence of GDM Prevalence
of GDM
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- Preval ence of GDM% Diagnostic method yea r Population
0.6Chinese Melborne-Australia(Indian-born) 15.0 4.7-8.9IRAN
4.750&100g GTT2003TehranLarijani 8.950&100g
GTT2005Bandar-abbasHadaegh 4.850&100g GTT2005ShahroodKeshavarz
750&100g GTT2007TehranMaghbooli 6.175g GTT2008TehranShirazian
7.475g GTT2009TehranShirazian
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- Why Diagnose and Treat GDM?
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- Dysglycemia in Pregnancy can Result in Adverse Pregnancy
Outcome Elevated glucose levels can have adverse effects on the
fetus 1 st trimester fetal malformations 2 nd and 3 rd trimester:
risk of macrosomia and metabolic complications
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- Risk of Fetal Anomaly Relative to Peri-conceptional A1C Guerin
A et al. Diabetes Care 2007;30:1-6. Glycemic control pre-conception
= essential
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- Risks of Gestational Diabetes Risks of Gestational Diabetes
MotherFetusNewbornChild/Adult Birth trauma Hyperinsulinemia
Hyperinsulinemia HypoglycemiaObesity Increased cesarean delivery
Cardiomyopathy Cardiomyopathy Respiratory distress Respiratory
distresssyndrome Type 2 diabetes
Preeclampsia/Gestationalhypertension Fetal organomegaly
Hypocalcemia Metabolic syndrome Hydramnios Hyperviscosity impaired
fine and gross motor functions impaired fine and gross motor
functions Stillbirth Hypomagnesemia Type 2 diabetes LGA/macrosomia
CardiomyopathyHyperbilirubinemia Perinatal mortality higher rates
of inattention and/or hyperactivity higher rates of inattention
and/or hyperactivity Metabolic syndrome Birth trauma Polycythemia
Polycythemia
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- GDM Pathogenesis Pregnancy is characterized by insulin
resistance and hyperinsulinemia due to: placental secretion of
diabetogenic hormones including: GH CRH Human placental lactogen
(hPL) Progesterone increased maternal adipose deposition decreased
exercise increased caloric intake These and other endocrinologic
and metabolic changes ensure that the fetus has an ample supply of
fuel and nutrients at all times. GDM occurs when pancreatic
function is not sufficient to overcome the insulin resistance
created by changes in diabetogenic hormones during pregnancy.
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- Risk Factors for Gestational Diabetes Risk Factors for
Gestational Diabetes
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- Diabetes in Pregnancy: 2 Categories Pregestational
diabetesGestational diabetes Pregnancy in pre-existing diabetes
Type 1 diabetes Type 2 diabetes Diabetes diagnosed in
pregnancy
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- Women with diabetes in the first trimester would be classified
as having type 2 diabetes. GDM is diabetes diagnosed in the second
or third trimester of pregnancy that is not clearly overt
diabetes.
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- Need a Preconception Checklist for Women with Pre-existing
Diabetes 1. Attain a preconception A1C of 7.0% (if safe) 2. Assess
for and manage any complications 3. Switch to insulin if on oral
agents 4. Folic Acid 5 mg/d: 3 months pre-conception to 12 weeks
post-conception 5. Discontinue potential embryopathic meds:
Ace-inhibitors/ARB (prior to or upon detection of pregnancy) Statin
therapy
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- PRECONCEPTION COUNSELING All women of childbearing age with
diabetes should be counseled about the importance of strict
glycemic control prior to conception. Observational studies show an
increased risk of diabetic embryopathy, especially anencephaly,
microcephaly, and congenital heart disease, that increases directly
with elevations in A1C. Spontaneous abortion is also increased in
the setting of uncontrolled diabetes.
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- A1C
- Presentation titleSlide no 67Date n=28 n=41 n=110 n=93 0 10 20
30 40 50 60 70 80 90 Pre-term (< week 37) At term (> week
3742) % of deliveries (live or still births 22 weeks) NovoRapid HI
Pre-term delivery lower frequency Hod M et al. Am J Obs Gyn,2007 *p
= 0.053
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- Presentation titleSlide no 68Date NovoRapid HI Neonatal
hypoglycaemia Plasma glucose < 50 mg/dl Treatment given No
treatment given 0 10 20 30 40 50 % of live births n=8 n=12 n=46
n=52 Hod M et al, Am J Obs Gyn,2007
- Slide 69
- Longer-acting insulin analogs (insulin glargine, insulin
detemir) have not been studied extensively in randomized trials of
pregnant women.insulin glargineinsulin detemir A meta-analysis of
observational data from 331 pregnancies with glargine exposure
during the first, second, and/or third trimester showed no
statistical increase in any maternal or neonatal adverse outcome
compared with use of NPH. However, the number of women who have
been treated with this drug in the first trimester is too
small.
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- The incidence of macrosomia was high in both glargine treated
women (23.6 percent) and women treated with NPH (19.7 percent), and
several-fold higher than the