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Comparative & Experimental Approaches in Aging Biology Research
2018 Schedule
A course by:
Aric N. Rogers, Assistant Professor, MDI Biological Laboratory
&
Ron Korstanje, Assistant Professor, The Jackson Laboratory
Partners
THE JACKSON LABORATORY NATHAN SHOCK CENTER
2
July 28, 2018 (Sat)
Event Location
5PM – 6PM Student arrival, check-in
Information provided by Judi Alexander in the student packet
Smith Office
6PM – 7PM Dinner Dining Hall
7PM – 9PM Round table discussion with introductions and course overview Maine Center for Biomedical Innovation, second floor
July 29, 2018 Sunday
Before 9AM Self-service breakfast Dining Hall
9AM – 10:30AM A Brief History of Aging Research & The Revolution Sparked by a Microscopic Roundworm
Aric Rogers
Maine Center for Biomedical Innovation, second floor
10:30AM – 10:45AM
Break
10:45AM – Noon CRISPR in C. elegans
Dustin Updike
(At the end of the presentation, students will be led to the Maine Center for Biomedical Innovation, first floor for a brief tour to know where to go after lunch)
Maine Center for Biomedical Innovation, second floor
Noon – 1PM Lunch Dining Hall
1PM – 5PM Microinjection of CRISPR Constructs in C. elegans
Dustin Updike and Catherine Sharp
Maine Center for Biomedical Innovation, first floor
5PM – 6PM Roundtable discussion - refreshments Dining Hall
6PM – 7PM Dinner Dining Hall
7PM – 9PM Microinjection of CRISPR Constructs in C. elegans
Microinjection of CRISPR constructs
Maine Center for Biomedical Innovation, first floor
3
July 30, 2018 Monday
Before 8:30AM Self-service breakfast Dining Hall
8:30AM – 10AM Introduction to Mouse Genetics
Ron Korstanje
Maine Center for Biomedical Innovation, second floor
10AM – 10:30AM Break
10:30AM – Noon Aging Studies in Mice
George Sutphin
Maine Center for Biomedical Innovation, second floor
Noon – 1PM Lunch Dining Hall
1PM – 3:45PM R for data analysis
Yuka Takemon
Maine Center for Biomedical Innovation, second floor
4PM - 5PM Autophagy and Aging (official title TBD)
Dana Miller
Maren Auditorium
5PM – 6PM Roundtable discussion and refreshments with Dana Miller Dining Hall
6PM – 7PM Private Dining with Dana Miller Dining Hall
7PM – 9PM Free Time / CRISPR construct Microinjection (optional)
Catherine Sharp
Maine Center for Biomedical Innovation, first floor
July 31, 2018 Tuesday
Before 8:30AM Self-service breakfast Dining Hall
8:30AM – 10AM Dietary Restriction in Mice
Ron Korstanje
Maine Center for Biomedical Innovation, second floor
10AM – 10:30AM Break
10:30AM – Noon Pharmacological Aging Intervention Studies in Mice
George Sutphin
Maine Center for Biomedical Innovation, second floor
Noon – 1PM Lunch Dining Hall
1PM – 3:50PM Workshop: Mouse aging study design
George Sutphin
Maine Center for Biomedical Innovation, second floor
4PM – 5PM Nutrition and Aging (official title TBD)
Dudley Lamming
Maren Auditorium
5PM – 6PM Roundtable discussion and refreshments with Dudley Lamming Dining Hall
6PM – 7PM Private dining with Dudley Lamming Dining Hall
After 7PM Free Time
4
August 1, 2018 Wednesday
Before 8:30AM Self-service breakfast Dining Hall
8:30AM – 10AM Neurological Disease and Aging
Catherine Kaczarowski
Maine Center for Biomedical Innovation, second floor
10AM – 10:30AM Break
10:30AM – Noon Renal and Cardiovascular Disease and Aging
Ron Korstanje
Maine Center for Biomedical Innovation, second floor
Noon – 1PM Lunch Dining Hall
1PM – 3:50PM Survival Analysis
George Sutphin
Maine Center for Biomedical Innovation, second floor
4PM – 5PM Neurodegeneration and Aging (official title TBD)
Duygu Ucar
Maren Auditorium
5PM – 6PM Roundtable discussion and refreshments with Duygu Ucar Dining Hall
6PM – 7PM Private dining Duygu Ucar Dining Hall
After 7PM Free Time
August 2, 2018 Thursday
Before 8:30AM Self-service breakfast Dining Hall
8:30AM – 10AM Aging and Immune Function
Candice Smith
Maine Center for Biomedical Innovation, second floor
10AM – 10:30AM Break
10:30AM – Noon Bone and Aging
Cheryl Ackert-Bicknell
Maine Center for Biomedical Innovation, second floor
Noon – 1PM Lunch Dining Hall
1PM – 3:45PM Genetic Mapping and Aging
Dan Gatti
Maine Center for Biomedical Innovation, second floor
4PM – 5PM Unique Aging Insights from the Nake Mole-Rat (official title TBD)
Rochelle (Shelley) Buffenstein
Maren Auditorium
5PM - 6PM Roundtable discussion and refreshments with Shelley Buffenstein Dining Hall
6PM – 7PM Private dining with Shelley Buffenstein Dining Hall
After 7PM Free Time
5
August 3, 2018 Friday
Before 9AM Self-service breakfast Dining Hall
9AM – 10AM Targeting mRNA Translation in Aging Research
Aric Rogers
Maine Center for Biomedical Innovation, second floor
10AM – 10:15AM Break
10:15AM – Noon Targeting mRNA Translation in Aging Research
Polysome profiling in C. elegans
Aric Rogers and Jarod Rollins
Maine Center for Biomedical Innovation, first floor
Noon – 1PM Lunch Dining Hall
1PM – 3:45PM Targeting mRNA Translation in Aging Research
Polysome profiling in C. elegans
Aric Rogers and Jarod Rollins
Maine Center for Biomedical Innovation, first floor
4PM – 5PM The Role of Protein Aggregation in Age-related Disease
Robert Shmookler Reis
Maren Auditorium
5PM – 6PM Roundtable discussion and refreshments with Robert Shmookler Reis
Dining Hall
6PM – 7PM Private Dining with Robert Shmookler Reis Dining Hall
After 7PM Free time
August 4, 2018 Saturday
Before 10AM Free morning / self-service breakfast Dining Hall
10AM – 11AM Addressing Healthspan and Gerospan in Invertebrate Models
Assessing health and stress tolerance in C. elegans
Jarod Rollins
Maine Center for Biomedical Innovation, second floor
11 – Noon Introduction to Cell Nonautonomous Mechanisms of Aging
Brief Introduction and Laboratory Prep
Kris Burkewitz
Maine Center for Biomedical Innovation, first floor
Noon – 1PM Lunch Dining Hall
1PM – 6PM Outing to Acadia National Park
Ron Korstanje
Acadia National Park
6PM – 7PM Dinner Dining Hall
After 7PM Free Time
6
August 5, 2018 Sunday
Before 9AM Self-service breakfast Dining Hall
9AM – 10AM C. elegans and Cell Nonautonomous Mechanisms of Aging & Longevity
Introduction
Kris Burkewitz
Maine Center for Biomedical Innovation, second floor
10AM – 10:15AM Break
10:15AM – Noon C. elegans and Cell Nonautonomous Mechanisms of Aging & Longevity
C. elegans anatomy and in vivo quantitative fluorescence microscopy, Part 1
Kris Burkewitz
Maine Center for Biomedical Innovation, first floor
Noon – 1PM Lunch Dining Hall
1PM – 4PM C. elegans and Cell Nonautonomous Mechanisms of Aging & Longevity
Lab: C. elegans anatomy and in vivo quantitative fluorescence microscopy, Part 2
Kris Burkewitz
Maine Center for Biomedical Innovation, first floor
4PM – 6PM Break
6PM – 7:00PM Dinner Dining Hall
7PM – 9PM C. elegans and Cell Nonautonomous Mechanisms of Aging & Longevity
C. elegans genetic mini-screen via dsRNA feeding
Kris Burkewitz
Maine Center for Biomedical Innovation, first floor
August 6, 2018 Monday
Before 9AM Self-service breakfast Dining Hall
9AM – 10AM Introduction to the Turquoise Killifish Model of Aging
Dario Valenzano
Maine Center for Biomedical Innovation, second floor
10AM – 10:15AM Break
10:15AM – Noon The Turquoise Killifish Model of Aging
Microbiota transfer and analysis of age-related changes in composition
Dario Valenzano
Maine Center for Biomedical Innovation, first floor
Noon – 1PM Lunch Dining Hall
1PM – 4PM Break
4PM – 5PM Science Café – Sirtuins and Aging
David Sinclair
Dining Hall
5PM – 6PM Roundtable discussion and refreshments with David Sinclair Maren Auditorium
6PM – 7PM Private dining with David Sinclair Dining Hall
August 7, 2018 Tuesday
Before 9AM Self-service breakfast Dining Hall
7
9AM – 10AM C. elegans and Cell Nonautonomous Mechanisms of Aging and Longevity - Part 2
Kris Burkewitz
Maine Center for Biomedical Innovation, second floor
10AM-10:15AM Break
10:15 – Noon C. elegans and Cell Nonautonomous Mechanisms of Aging and Longevity - Part 2 (continued)
Kris Burkewitz
Maine Center for Biomedical Innovation, first floor
Noon – 1PM Lunch Dining Hall
1PM – 3:50PM Using Drosophila to Explore the Systemic Coordination of Metabolic Homeostasis During Aging
Rapid analysis of ‘fat’ metabolism for high-throughput screening - Drosophila Lab, Part 2
Maine Center for Biomedical Innovation, first floor
4PM – 5PM Rapamycin and Aging (official title TBD)
Matt Kaeberlein
Maine Center for Biomedical Innovation, first floor Conference Center
5PM – 6PM Roundtable discussion and refreshments with Matt Kaeberlein Dining Hall
6PM – 7PM Private Dining with Matt Kaeberlein Dining Hall
August 8, 2018 Wednesday
Before 9AM Self-service breakfast Dining Hall
9AM – 10AM Turquoise Killifish Model of Aging - Part 2
Dario Valenzano
Davis Classroom
10AM – Noon Break
Noon – 1PM Lunch Dining Hall
1PM – 3:30PM Turquoise Killifish Model of Aging
Comparison of microbiome changes – short-lived killifish versus longer lived zebrafish
Dario Valenzano
Davis Classroom
3:30PM – 3:45PM Break
4PM – 5PM Neurological Maintenance and Aging (official title TBD)
Coleen Murphy
Maren Auditorium
5PM – 6PM Roundtable discussion and refreshments with Coleen Murphy Dining Hall
6PM – 7PM Private Dining with Coleen Murphy Dining Hall
August 9, 2018 Thursday
Before 9AM Self-service breakfast Dining Hall
9AM – 10AM Using Drosophila to Explore the Systemic Coordination of Metabolic Homeostasis During Aging
Jason Karpac
Maine Center for Biomedical Innovation, second floor
10AM – 10:15AM Break
10:15AM – Noon Using Drosophila to Explore the Systemic Coordination of Metabolic Homeostasis During Aging
Rapid Analysis of ‘fat’ Metabolism for High-Throughput Screening - Drosophila Lab, Part 1
Jason Karpac
Maine Center for Biomedical Innovation, first floor
8
Noon – 1PM Lunch Dining Hall
1PM – 3:30PM Using Drosophila to Explore the Systemic Coordination of Metabolic Homeostasis During Aging
Rapid analysis of ‘fat’ metabolism for high-throughput screening - Drosophila Lab, Part 2
Jason Karpac
Maine Center for Biomedical Innovation, first floor
3:30PM – 3:45PM Break
4PM – 5PM Senescence, Senolytics and Aging (official title TBD)
Judith Campisi
Maren Auditorium
5PM – 6PM Roundtable discussion and refreshments with Judith Campisi Dining Hall
6PM – 7PM Private dining with Judith Campisi Dining Hall
7PM – 9PM Using Drosophila to Explore the Systemic Coordination of Metabolic Homeostasis During Aging
Imaging and quantification of ‘fat phenotypes’
Jason Karpac
Maine Center for Biomedical Innovation, first floor
August 10, 2018 Friday
Before 9AM Self-service breakfast Dining Hall
9AM – 10AM Wound-induced Polyploidy: A New Way to Heal
Vicki Losick
Maine Center for Biomedical Innovation, second floor
10AM – 10:15AM Break
10:15AM – Noon Using Drosophila to Explore the Systemic Coordination of Metabolic Homeostasis During Aging
‘Fly Tools’ for studying tissue crosstalk
Jason Karpac
Maine Center for Biomedical Innovation, first floor
Noon – 1PM Lunch Dining Hall
1PM – 3:30PM Analysis and recap of laboratory training
Aric Rogers
Maine Center for Biomedical Innovation, second floor
3:30PM – 3:45PM Break
4PM – 5PM Stem Cells and Aging (official title TBD)
Henry Jasper
Maren Auditorium
5PM – 6PM Roundtable discussion and refreshments with Henry Jasper Dining Hall
6PM onward Dining [Lobster Bake] and partying with Henry Jasper Dining Hall
August 11, 2018 Saturday
Students Depart
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