Cognivue - Critical Path Institute...2017/07/10  · Cognitive Disorders –Dementias, Deliriums,...

Cognivue®

Charles J. Duffy, MD, PhD

Founder and CEO

May 10, 2017

Cognivue is an artificial intelligence neurological tool,

not a computerized psychological questionnaire

COGNIVUE ENABLES CARE

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Cognivue promotes cost-effective dementia care

in primary care office practices

Cognivue aligns patients, families, and practitioners by

moving beyond dementia as an accusation

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LocalMotion

GlobalPattern

LocalMotion

GlobalPattern

LocalMotion

GlobalPattern

Psychophysics Distinguishes Aging and AD

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ORIGINS OF COGNIVUE

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UTILITY OF COGNIVUE

Year in Study (off treatment)

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10

20

30

40

50

60

70

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ON Radial IO

ON Radial Out

ON Planar

AD Radial IO

AD Radial Out

AD Planar

NAD = 12

NON = 31

One Year Longitudinal Study in Aging and AD M

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One Year Longitudinal Study in Aging and AD

Stability in normal aging

Decline in early Alzheimer’s

Detect and monitor disease neurological deficits

Monitor

Detect

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NEURAL MECHANISMS OF COGNIVUE

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LINKS TO AGING AND ALZHEIMER’S

Hyperactivity of soluble AβLoss od activity with Aβ plaques

Loss of signal coherencein aging and early AD

SIX KEY POINTS

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1. Detect functional impairment

2. Monitor disease progression

3. Assess therapeutic efficacy

4. Access neural mechanisms

5. Foundation of complex behaviors

6. Domain-specific impairment measures

Shape Processing

Occipital

Language

Parietal

Temporal

Language Processing

cat

dal

daf

cbt

gca

erfltv

kif

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Visuo-Motor Function

Motion Processing

Dynamic Adaptation

Spatial Attention

Temporal Integration

Learning & Memory

Bottom-Up Processing

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COGNIVUE COMMERCIALIZATION

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COGNIVUE PSYCHOPHYSICAL TESTING

Motor

Control Report Generation

Visual

Salience

Sensory-Motor Testing

Calibrate

to Patient

Perceptual Testing Shapes

Motion

Letters

Words

Calibrate

to Patient

Memory Testing Shapes

Motion

Letters

Words

Calibrate

to Patient

Cloud Archives

Post-hocAnalyses

Contextualized

F/U Testing

Practitioners& Researchers

Doe, John02-01-1956

Secure access on Cognivue, desktops, and portable devices

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THE COGNIVUE SYSTEM

N = 356 subjects tested twice

Cognivue re-test correlation = .90

PPA = .89, NPA = .93, ICC = .94

SLUMs re-test correlation = .82

PPA = .87, NPA = .87, ICC = .87

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COGNIVUE’S FDA VALIDATION

N = 401 subjects 55- 95 yo

impaired vs. unimpaired

Cognivue vs. SLUMS

PPA & NPA

.82 & .98

1) Objective psychophysics

2) Neurological assessment

3) Linked to brain electrical activity

4) 10 minute testing in doctor’s office

5) Simple test interpretation algorithm

6) Easily explained to patients and families

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COGNIVUE’S ADVANTAGES

Cognitive Disorders – Dementias, Deliriums, Syndromes

Movement Disorders – Parkinsonism and overlap syndromes

Affective Disorders – Depressions, Manias, Psychoses

Acquired Disorders – Head injury and medicinal SEs

Developmental Disorders – Conditions and Pathopotential

PLATFORM TECHNOLOGY TARGETS

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COGNIVUE CONTINUING EXPANSION

Domain-specific cortical function

Bringing cognitive care to primary care

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