Clinical Research Platform Center for Biomedical Informatics (CBMI)

Clinical Research Platform

http://catalyst.harvard.edu

Center for Biomedical Informatics (CBMI)

Introduction

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RIMResistance is Futile, you Will be Assimilated!

Agenda

BusinessArchitectureAgile RIMApplication

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Clinical Research Platform

BusinessArchitectureAgile RIMApplications

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5

BIDMC BWH CHB MGH MIT

Study Grants Study Grants Study Grants Study Grants Study Grants

General Clinical Research Center (GCRC)

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Clinical Research CenterCTSA Grant

Harvard Catalyst

BIDMC BWH CHB MGH MIT

Study Grants

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Clinical Research Center Data Access

Harvard Catalyst

BIDMC BWH CHB MGH MIT

Data

Data Data DataData Data

Study Grants

Aggregate

Local LocalLocal LocalLocal

CRC

Sites

Study StaffCRC Staff

Hospital

OutPatientRooms

Kitchen

Lab

MRI

Services

CoreLab

Services

OutPatientRooms

Kitchen

Dexa

InPatientRooms

MaterialsMaterials

LocalCRC Resources

Create/ModifyStudy

Templates

Schedule VisitsCompare study visit needs with

resource availability

MonitorActivities

StudyActive

Reports

WorkflowIn Development

Local CRC Resources

View Calendar &

Request Visits

per subject availability & study templates

StudyReview

Clinical Research Platform

BusinessArchitectureAgile RIMApplication

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Architecture

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InfoQ – Domain Driven Design

Architecture

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http://domaindrivendesign.org/

• Ubiquitous Language– Language structured around the

Domain Model– Domain experts express their jargon

while developers speak another– The Domain Model is the backbone, use

the same language in diagrams, writing and speech!

Architecture

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• The Domain Model influence– Create a model from scratch?– Wait till we have a “good enough”

model to start development?– Developers, “I can’t start, don’t have all

the requirements!”– Stakeholders, “What have you done for

me lately?”– “Hey have you heard of RIM?” - George

Architecture

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• The RIM Domain!– The Domain is ready now!– Nails the “Think Globally, Act Locally”

adage!– Incredible design hints in the form of

RMIM’s – The RIM in the context of application

development is very productive!– The RIM in the context of integration and

messaging, oh well…

Architecture

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• The RIM & Domain Driven Design– Focus on the Domain and Domain Logic– Complex design based on Model– Logic is separated from Infrastructure– Vital DDD Patterns

• Bounded Context• Aggregate Root• Command and Query Seperation*• Services, Specification and more…

Clinical Research Platform

BusinessRIMBAA ApproachAgile RIMApplication

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Agile RIM

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“If you don’t know where you are going, any road will take you there.”

- Lewis Carroll

Agile RIM

• An agile process that emphasizes frequent feedback from users and domain experts,

• the availability of real domain experts and a creative collaboration with them,

• a single and shared version of the model (in the application and test code) precisely defined in terms of the Ubiquitous Language, and

• an open and transparent environment that promotes learning and exploration.

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InfoQ – Domain Driven Design

Agile RIM

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User Interface

User Interface

View ModelView ModelRIMRIM

RIM Services

RIM Services

Events

Commands Query

Agile RIM

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User Interface

User Interface

View ModelView ModelRIMRIM

RIM Services

RIM Services

Events

Commands Query

View ModelView Model

User Interface

User Interface

Agile RIM

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Harvard CatalystHarvard Catalyst

MGHMGH

BWHBWH

Roles

Organizations

Scoper

Player

Player

Agile RIM

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MGHMGH

MGH Room 101

MGH Room 101

BWH Room 201

BWH Room 201

Roles

Organization

Scoper

Player

Player

Places

Agile RIM

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Agile RIM

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Bone Mass Study

Bone Mass Study

ScreeningScreening

Visit 1Visit 1

Relationships

Acts

Source

Target

Target

Visit 2Visit 2Target

Agile RIM

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Agile RIM

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Agile RIM

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Show Actual Scheduler

Open Source Platform - Java Enterprise Edition 6

Web User InterfaceJSF 2.0 Facelets

Web User InterfaceJSF 2.0 Facelets

Java

EE

6 G

lassfi

sh v3

Java

EE

6 G

lassfi

sh v3

RIM ServicesJava Services Objects, JBI, Camel

RIM ServicesJava Services Objects, JBI, Camel

HL7 v3 Domain ModelJPA 2.0/EJB 3.1

HL7 v3 Domain ModelJPA 2.0/EJB 3.1

MySQL 5.1MySQL 5.1

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Hybrid Deployments

Harvard Catalyst

BIDMC BWH CHB MGH MIT

De-Identified Layer

Local Deployments behind Firewall

Firewall Firewall Firewall Firewall Firewall