Clinical dilemma/research opportunities

2021 LINC SHOWCASEClinical dilemma/researchopportunities

Leading Innovations throughNew Collaborations

Leading Innovations through New Collaborations

ExpressionOf Interest

Due17 Aug 2021

OPTIO

NAL

IdeasShowcase

16 Sept 2021

OPTIONA

L

Collaboration

LINC GrantApplications due

1 Nov 2021

ACKNOWLEDGEMENT OF COUNTRY

TRI acknowledges the traditional custodians of country throughout Australia and recognises their continuing connection to land, waters and community. We pay our respects to them and their cultures and to Elders past, present and future.

www.tri.edu.au/LINC 1

www.tri.edu.au/LINC 2

We are delighted to welcome you to the inaugural LINC Showcase event. It is our hope that this event will become a popular annual fixture in the calendars of TRI-based researchers and Queensland clinicians.

The LINC Showcase and grant scheme is the realisation of more than 12 months research and planning by Metro South Health and TRI, and more recently Mater Research.

The LINC or ‘Leading Innovations through New Collaborations’ program is a unique initiative for Queensland and possibly Australia. Our intent is to drive and foster new, translational research collaborations between early to mid-career researchers based at TRI and early to mid-career clinicians.

We believe nurturing collaborations between TRI researchers and clinicians will lead to targeted solutions to clinical needs and see the faster and more effective translation of research into the clinic. The outcome will be improved detection, diagnosis and treatment of diseases and improved health outcomes for Australians.

In the short-term, these vital collaborations will also help our developing researchers and clinician-researchers develop their careers and improve their ability to secure funding from the National Health and Medical Research Council (NHMRC) and Medical Research Future Fund (MRFF).

In time, we hope to expand the LINC program to include clinicians from across South-East Queensland. In the meantime, we encourage you to form a collaboration and submit a LINC grant application.

Thank you for supporting LINC.

Welcome

Professor Scott BellCEO

Translational Research Institute

Professor John UphamChair of Research

Metro South Health

Professor Maher GandhiExecutive Director and Director

of Clinical ResearchMater Research

www.tri.edu.au/LINC 3

LINC Showcase program

Time Talk Speaker/s

1600 Welcome A/Prof Helen BenhamProf John UphamProf Maher Gandhi

1612 Exemplar 1 A/Prof Fiona Simpson

1618 Exemplar 2 Prof Rik Thompson

1624 Harnessing oxidised cholesterols to improve respiratory infection outcomes

Dr Stavey Bartlett

1634 Individualising perioperative blood pressure to prevent secondary end-organ dysfunction.

Dr David Highton

1644 Identifying mechanism and new therapies to treat anemia of inflammation in Inflammatory Bowel Disease

Dr Kavita Busht

1154 Negative Pressure Neurogenesis 2 (Stimulating and facilitating nerve axonal growth and regeneration after complete transection injury using negative pressure: phase 2)

Dr Tamar Mettyas

1704 Elucidating the Role of Adipokine Axis Dysregulation in Bone Metastatic Cancer to Develop Strategic New Therapeutics

Dr Lisa Philp

1714 From alcohol to cirrhosis- applying translational "omics" platforms to understand how host transcriptional and gut microbiome factors modify liver injury effects of alcohol exposure

Dr Paul Clark

1724 Investigating antibody mediated exacerbation of Gram-negative infections.

Dr Von Torres

1734 Reward learning as a potential mechanism for improvement following cognitive remediation

Dr Timothy Edwards

1745 Exemplar 3 Dr Kate Irvine

1750 Exemplar 4 Dr Ian Vela and A/Prof Elizabeth Williams

1755 Concluding remarks A/Prof Helen Benham

1800 Networking in the atrium

Details for collaborationsProfessor Rik ThompsonProfessor in Breast Cancer Research and Research Lead, QUTE: e2.thompson@qut.edu.auProject: The Centre for Personalised Analysis of Cancers (CPAC): Clinical Research and Training at the Translational Interface.

Dr Stacey BartlettResearch Officer, Mater ResearchE: stacey.bartlett@mater.uq.edu.auProject: Harnessing oxidised cholesterols to improve respiratory infection outcomes.

Dr David HightonStaff Specialist, Princess Alexandra HospitalE: david.highton@health.qld.gov.auProject: Individualising perioperative blood pressure to prevent secondary end-organdysfunction.

Dr Tamar MettyasFellow, Orthopaedics Department, Princess Alexandra HospitalE: tameradeldawoud@yahoo.comProject: Identifying mechanism and new therapies to treat anaemia of inflammation in Inflammatory Bowel Disease.

Dr Kavita BishtResearch Officer, Mater ResearchE: Kavita.Bisht@mater.uq.edu.auProject: Identifying mechanism and new therapies to treat anaemia of inflammation in Inflammatory Bowel Disease.

We are seeking clinicians interested in joining a collaborative program to develop and evaluate personalised, laboratory-based assays using cancer patient biospecimens. Experience in or a strong interest in developing skills in participant recruitment and clinical database entry and management is highly valued.

We are seeking clinicians with access to bronchoalveolar lavage samples and blood samples from individuals with respiratory tract infections.

We are looking for collaborators with expertise in biomarkers brain (especially neuro-imaging), cardiac and renal injury.

I’m looking for a statistical collaboration, possible pathology collaboration, and possible engineering collaboration.

I need a clinical collaborator with a strong knowledge of IBD. The collaborator will be essential to develop IBD preclinical models and analyse human IBD patients. The collaborator will bring new skills such as knowledge of IBD pathology, analysis of IBD biomarkers and interpret the research findings for successful execution and completion of proposed project.

www.tri.edu.au/LINC 4

Dr Lisa PhilpPostdoctoral Research Fellow, Australian Prostate Cancer Research Centre, QUTE: lisa.philp@qut.edu.auProject: Elucidating the Role of Adipokine Axis Dysregulation in Bone Metastatic Cancer to Develop Strategic New Therapeutics.

Dr Von TorresResearch Officer, Timothy Wells Group, The University of QueenslandE: v.torres@uq.edu.auProject: Investigating antibody mediated exacerbation of Gram-negative infections.

Dr Snehlata KumariSenior Research Fellow, Kumari Group, The University of QueenslandE: s.kumari@uq.edu.auProject: Hidradenitis Suppurativa: An orphan disease in desperate need of some love

Dr Timothy EdwardsPsychiatry Registrar, Metro South Addiction and Mental HealthE: timjedwar@gmail.comProject: Reward learning as a potential mechanism for improvement following cognitiveremediation.

I’m eager to build an ongoing research collaboration with clinicians with expertise in bone and/or bone cancer, and endocrinology. I hope to gain expert clinical insight to position my research concepts, centred around therapeutic development, for impact in the clinic. I also hope to access bone biopsy tissue, either normal bone from orthopaedic surgery or cancerous bone.

I’m looking for in a collaborator skilled in Next Generation Sequencing, metabolics, gut microbiome assessment.

We aim to collaborate with a clinical microbiologist/infectious disease specialist, especially if they have problems with chronic or recurrent Gram-negative bacterial infections. Expertise in MALDI-TOF in a clinical microbiology context or direct access to the equipment is desirable but not essential.

I have identified several novel mechanisms and pathways controlling inflammation; I am looking for clinical collaborations to address the challenges in the treatment of skin cancer and skin inflammation, and how I could help in addressing those unmet needs.

We are seeking a collaborator with expertise in functional and diffusion neuroimaging, computational neuroscience; potentially a background in psychosis and schizophrenia research.

Dr Paul ClarkSenior Staff SpecialistGastroenterology and Alcohol and Drug Assessment Unit, Princess Alexandra HospitalE: paul.j.clark@uq.edu.auProject: From alcohol to cirrhosis - applying translational “omics” platforms to understand how host transcriptional and gut microbiome factors modify liver injury effects of alcohol exposure.

www.tri.edu.au/LINC 5

Dr Ahmed MehdiJDRF Research Fellow, The University of QueenslandE: a.mehdi@uq.edu.auProject: Developing novel virtual reality maps of tumour microenvironment using multi-omics biomarker signatures discovery in cancer studies.

Mr Chamikara LiyanagePhD Student (with A/Prof Jyotsna Batra), School of Biomedical Sciences, QUTE: chamikara.liyanage@hdr.qut.edu.auProject: Identification and characterization of micro peptides involve in developing treatment resistance to hormone therapy in prostate cancer.

Dr Emily SteelClinical Governance Research and Policy Officer, Princess Alexandra Hospital, Metro South HealthE: emily.steel@health.qld.gov.auProject: Clinical Governance at Metro South Health - how can we understand and use our data in partnership with consumers to improve quality and safety?

I am looking for a clinical collaborator to collect patient samples. I also need collaborators with single-cell spatial transcriptomics/ proteomics data and expertise.

I’m looking for clinical collaborators to apply omics immune profiling and new analytic methods to: stratify their patients for immune physiopathology, and response to immunotherapies, either suppressive or stimulating. My laboratory has been working on different CD4 and CD8 T cell functional subsets in allergic, autoimmune and infectious diseases and cancer to understand the immune landscape that underlies heterogeneity in patients.

We are looking for clinicians to be involved in the clinical validation (through molecular pathology approaches) and the translation into potential clinical applications of potential prostate cancer therapeutics.

I am looking for collaborators with a passion for data management and visualisation and translational research to help us understand and use our data in new and better ways.

Professor Di YuGroup Leader, The University of QueenslandE: di.yu@uq.edu.auProject: Diversity in T cell function and heterogeneity in immune-mediated diseases andimmunotherapies.

LINC grant applications open 17 September Get yours in soon!

www.tri.edu.au/LINC 6

Do you sharea passion

for the science?

Allocate tasksat the start

Stick to yourtasks

Be open and honest

Communicate Protect yourself against risks

Acknowledge and cite yourcollaboration

Seek advice

Translational Research Institute 37 Kent Street, Woolloongabba Queensland 4102 AustraliaT +61 7 3443 7000F +61 7 3443 7779E info@tri.edu.auwww.tri.edu.au

ABN 58 155 991 662

Tips for successful research collaborationsVicens Q, Bourne PE (2007),”Ten Simple Rules for a Successful Collaboration”, PLoS Comput Biol 3(3): e44. https://doi.org/10.1371/journal.pcbi.0030044