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Clinical application of Revitalrex inj.
(polydeoxyribonucleotide)
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- Classification : Ethical drug
- Efficacy :
-Administration∙Dosage :
- Volume : 3ml / 5,625ug (10Vials/Box, 1Syr./Box)
Product Placentex inj. Rejuvenex inj. New-DN Nucleo inj. Poly-DN HiDR inj. Revitalrex inj.
Manuafacturer Pharmaresearch Pharmaresearch BMI BMI BMI BMI Humedix
Formulation Ampoule Ampoule Vial Vial Vial Vial, Prefilled Vial, Prefilled
Volume 3mL 3mL 3mL 3mL 3mL 3mL 3mL
Basic information of PDRN and competitors
1. Basic information
2. PDRN Product in the market
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Comparison of molecule size (Electrophoresis)
bp
5000
1500
100
500
PDRN in size confirmed by electrophoresis
Product Electrophoresis Size Molecular weight
Revitalrex Appx. 50~300 bp 33 ~ 198 kDa
Product A Appx. 50~300 bp 33 ~ 198 kDa
Product B Appx.100~1,000 bp* 66 ~ 660 kDa**
PDRN applies to A2A receptor on the cell surface and shows efficacy of inflammation inhibition, cell regeneration and angiogenesis.
PDRN necessarily decomposes into very small particles in order to apply to A2A receptor. In case of Product B, it comparatively
takes longer to apply due to bigger size in molecule.
Accordingly Revitalrex inj. which is smaller molecule in size, possibly takes faster effect.
* bp: abbreviation of base pair (size unit of DNA) ** kDa: kilodalton
Fast efficacy of Revitalrex inj.
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Efficacy evaluation of cell regeneration of PDRN
In case of treating 10ug/mL Revitalrex, cell regeneration begins while Product B shows cell regeneration efficacy by treating 100ug/mL on the same condition.
Revitalrex Product A
Ce
ll re
gen
erat
ion
rat
e(%
)
Product B
Untreated
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PDRN-Efficacy evaluation for wrinkle improvement
Inhibition of MMP-1 as wrinkle formation index was confirmed to the equivalent level.
Revitalrex has better efficacy in collagen formation.
Excellent efficacy of Revitalrex in collagen formation
If expression decreases with treating wrinkle formation factor, improvement against wrinkles is confirmed.
리비탈렉스 A 제품 B 제품 아데노신
Revitalrex Product A Product B Adenosine
MM
P-1
Exp
ress
ion
(%
) P
roco
llage
n f
orm
atio
n (
%)
Untreated
(Wrinke formation condition)
Untreated
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Efficacy of PDRN : Literature in brief
For Aesthetic: Novel Anti-Melanogenesis Properties of Polydeoxyribonucleotide, a Popular Wound Healing Booster.
https://www.ncbi.nlm.nih.gov/pubmed/27598132
PDRN injection treatment also reported improvement of photoaging-associated mottled pigmentation (PMP).
PDRN has been reported for prompt treatment of skin wound and improvement of pigmentation.
PDRN and Placentex® led to decreases in melanin content, tyrosinase activity, and MITF and TRP-1 expression
with concomitant increases in phosphorylated forms of extracellular signal-regulated protein kinase (ERK) and
AKT in mouse melanocytes. More importantly, both PDRN and Placentex® significantly suppressed the
melanin content in human melanocyte–keratinocyte cocultures.
Clinical evaluation of six female patients with facial hyperpigmentation after three sessions of intradermal PDRN
injections using a 5-point scale revealed that PDRN led to more than noticeable improvements in
hyperpigmented lesions.
As a result of injecting PDRN and Placentex® for 6 female patients 3times, it markedly shows improvement of pigmentation.
This is the first study to demonstrate that PDRN, which is known for its wound-healing properties, may
have novel anti-melanogenesis and potential skin whitening properties.
This research reveals that PDRN has capability for melanin formation and skin brightening while is known for wound healing.
Allergic reaction possibly occurs caused by antigen of fish extracted ingredients.(Caution)
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Figure 5. Standard digital photography images of patient number 1 (a), 5 (b) and 6 (c) at baseline and 4 weeks after 3 times of intradermal PDRN injection treatment. The clinical photographs of right side demonstrate significant improvement after 3 sessions of intralesional injection of Placentex® treatment.
- PDRN 0.05 – 0.1ml per 1-cm2 interval for injection. 3times over 4weeks
Efficacy of PDRN – Before / After www.vianacare.com
Key Message from Revitalrex inj.
1) Fast effect and low pain by low molecule.
2) Excellent efficacty for wrinkle improvement and collagen formation in addition to
skin brightening.
3) Various application for treatment mixing with Hyaluronic accid
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Basic Mix Protocol
HA 10mg + PDRN 1.5cc
PDRN Mix Protocol
Mix Protocol
1. Hydro lifting –skin brightening injection
HA 20mg/ml 1.5ml + PDRN 1.5ml = 3ml (80 shots)
HA 20mg/ml 1.5ml + PDRN 1.0ml + Sodium bicarbonate 0.5ml = 3ml (80 shots)
HA 20mg/ml 1.5ml + PDRN 1.0ml + Ascorbic acid 0.5ml = 3ml (80 shots)
HA 20mg/ml 1.5ml + PDRN 2.0ml + Sodium bicarbonate 0.5ml + Ascorbic acid 0.5ml = 5ml (140 shots)
2. Lifting injection
HA 20mg/ml 1.5ml + PDRN 1.0ml + Botulinum toxin (10unit, 0.5ml) = 3ml (80 shots)
3. Freckle improvement inejction
HA 20mg/ml 1.5ml + PDRN 1.0ml + Botulinum toxin (10unit, 0.5ml) = 3ml (80 shots)
4. Neck wrinkle improvement injection
HA 20mg/ml 1.5ml + PDRN 1.0ml + Botulinum toxin (20unit, 0.5ml) = 3ml (80 shots)
5. Ultra Hydro lifting
HA 20mg/ml 1.5ml *2 + PDRN 1.5ml + Botulinum toxin (20unit, 0.5ml) = 5ml (140 shots)
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