ChemInform Abstract: Cytotoxic Activity of 3-(5-Phenyl-3H-[1,2,4]dithiazol-3-yl)chromen-4-ones and...

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Anticancer activityX 0070 DOI: 10.1002/chin.201023190

Cytotoxic Activity of 3-(5-Phenyl-3H-[1,2,4]dithiazol-3-yl)chromen-4-ones and 4-Oxo-4H-chromene-3-carbothioic Acid N-Phenylamides. — A series of chroma-nyl-1,2,4-dithiazoles (I) and N-phenylthioamides (II) respectively is completed using an earlier described synthetic pathway. All compounds are evaluated for their cytotoxic activity against different human cancer cell lines. (Ia) and (Ib) show maximum cyto-toxic activity on neuroblastoma whereas (Ic) has cytotoxic activity on ovarian cancer cell line. — (RAJ, T.; BHATIA, R. K.; KAPUR, A.; SHARMA, M.; SAXENA, A. K.; ISHAR*, M. P. S.; Eur. J. Med. Chem. 45 (2010) 2, 790-794; Bio-org. Photochem. Lab., Dep. Pharm. Sci., Guru Nanak Dev Univ., Amritsar 143 005, India; Eng.) —H. Haber

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ChemInform 2010, 41, issue 23 © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim