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Bruker Corporation (NASDAQ: BRKR)
Bruker CALID Group update
Juergen Srega, President, Bruker CALID GroupJune 2, 2015
Bruker CALID roadmap to success
Streamline Business and Operating Model
Exit Products
Exit Factories
Outsource
Quality
Lean Ops
Commercial Ops
Invest in high-value positions
MALDI BioTyper
- Geo-Expansion
- Capabilities
- Claim-Expansion
- New Indications
- Replacement
- Consumables
New Products
UHR QTOF Portfolio
MALDI Portfolio
- MBT SMART
- rapifleX
- MPP PharmaPulse
FTIR & NIR
IMS/ETD Solutions
© Bruker Corporation
Bruker CALID update
3© Bruker Corporation
• Great progress made in streamlining the portfolio and footprint
Divested GC and ICP product lines
Eliminated one division organization
Exited 4 factories across the divisions
Closed all machine shops
Outsourced most of low-level assembly work
• Significant YoY improvements on GM and OM
Clinical expansion
MBT Microbial ID global expansion
MBT Microbial expansion beyond ID into AST
(resistance testing) and Food and Pharma
MTT MALDI TissueTyper
ToxTyper adoption in toxicology testing labs
Triple Quad MS assay expansion
Assays and Consumables
MALDI assays and consumables
New Biomarker ImunoMALDI assays
Bruker CALID Growth Platform
Clinical MALDI
© Bruker Corporation
Microscopy and Imaging portfolio
Raman microscopes and imaging techniques
FTIR microscopes and imaging techniques
rapifleX all new MALDI Tof instrument and imaging
technique
MS Processing
Global MBT Sites (May 2015)
Globally: 1682Europe: 957
Americas: 335
Asia/Pacific: 348
IMEA: 42
5
MALDI Biotyper References
Regulatory Affairs:
Libraries of MBT
6
0
500
1000
1500
2000
2500
FDA IVD FDA Claim 1 FDA Claim 2 FDA Total IVD
Vitek-MS MBT
• MBT is leading by far for IVD-CE systems
• MBT is also leading concerning US FDA-cleared species
• MBT is covering now 280 species for US-FDA in total
• 98% coverage of the typical bacterial identification
workflow of clinical microbiology laboratories
Mycobacteria Library 3.0
A Quantum Leap in Mycobacteria IDMycobacteria Library 3.0 for MALDI Biotyper®
• Contains almost all described
Mycobacteria species (149 entries)
• Excellent coverage of strain variation
• Several hundred references from well
characterized isolates by 24
cooperation partners in 9 countries
• Launch at ASM 2015 on June 1, 2015
7For Research Use Only. Not for Use in Diagnostic Procedures
All new MALDI TissueTyper rapifleX –
Expanding into clinical pathology
8
rapifleX™• Game-changing instrument for early
markets
• Proprietary 10 kHz smartbeam® laser
• Substantially improved image quality!
• Early wins with the MTT based on
rapifleX
• Introduction at ASMS 2015 in St. Louis
© Bruker Corporation
Pharma HTS workflow solution
MALDI PharmaPulse™
9© Bruker Corporation
• Fast to meet the needs of true HTS applications (less than 1 sec per sample) and replace Fluorescence • 10-100 times faster than multiplexed
LC/SPE-MS
• Label free detection accelerates assay development, reduces complexity of screening and potentially minimizes artifacts from label interference
• Low consumable costs (and less waste) since it uses 100x less solvent than multiplexed LC/SPE-MS• No need for SPE cartridges or LC columns!
February 2011
10 Bruker Confidential2. Juni 2015 10© Copyright Bruker Corporation. All rights reserved
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