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Blumenfeld – Chapter 18 Limbic System: Homeostasis, Olfaction, Memory, and Emotion. Chenjie Xia (R2) Academic ½ Day Wednesday, April 7 th , 2010. Review of key structures. Overview of limbic structures. Overview of limbic structures. Overview of limbic structures. Limbic structures. - PowerPoint PPT Presentation
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Blumenfeld – Chapter 18
Limbic System: Homeostasis, Olfaction, Memory, and Emotion
Chenjie Xia (R2)Academic ½ Day
Wednesday, April 7th, 2010
Review of key structures
Overview of limbic structures
Overview of limbic structures
Overview of limbic structures
Limbic structures
• Amygdala nuclei– Corticomedial, basolateral, central, bed nucleus of the
stria terminalis
• Diencephalon– Hypothalamus, thalamus (anterior and mediodorsal
nuclei), habenula
• Basal ganglia – Ventral striatum, ventral pallidum
Limbic structures • Basal forebrain
– Nucleus basalis of Meynert, olfactory tubercle, nucleus of diagonal band of Broca, preoptic area, portions of amygdala
• Septal Region– Medial septal nucleus, lateral septal nucleus, nucleus
accumbens
• Brainstem nuclei– Interpeduncular, superior central, dorsal and ventral tegmental,
parabrachial, periaqueductal gray, reticular formation, nucleus solitarius, dorsal motor nucleus of vagus
Overview of limbic circuitry
The Return of Neuro-Jeopardy!
(No more Meryl Streep questions…)
Neuro-JeopardyClinical anatomy
Book anatomy
Syndromes Miscellaneous
100 100 100 100
200 200 200 200
300 300 300 300
400 400 400 400
500 500 500 500
Clinical Anatomy
Clinical Anatomy 100
• Where did Dr. Brenda Milner obtain her undergraduate degree and what did she major in?– A) Oxford, philosophy– B) Cambridge, psychology– C) McGill, physiology– D) University of Montreal, biology
Clinical Anatomy 100
• Where did Dr. Brenda Milner obtain her undergraduate degree and what did she major in?– A) Oxford, philosophy– B) Cambridge, psychology– C) McGill, physiology– D) University of Montreal, biology
Clinical Anatomy 200
• Bilateral lesions of medial temporal and diencephalic structures would impair which of the following?– A) Mediate working memory– B) Consolidate long-term explicit memory– C) Consolidate long-term implicit memory– D) Retrieve long-term explicit memory– E) Retrieve long-term implicit memory
Clinical Anatomy 200
• Bilateral lesions of medial temporal and diencephalic structures would impair which of the following?– A) Mediate working memory– B) Consolidate long-term explicit memory– C) Consolidate long-term implicit memory– D) Retrieve long-term explicit memory– E) Retrieve long-term implicit memory
Clinical Anatomy 300
• Name 2 intracerebral vascular lesions which could lead to memory deficits
Clinical Anatomy 300
1) Rupture of A-com aneurysm (disrupt basal forebrain, medial diencephalon, and frontal lobes)
2) Top of the basilar artery lesions (b/l medial temporal or medial diencephalic supplied by PCA)
3) Artery of Percheron lesion / single paramedian thalamoperforator artery (b/l medial thalami)
Clinical Anatomy 300
http://www.ajnr.org/cgi/content-nw/full/24/10/2005/F4
Clinical Anatomy 400
• Which function has Dr. Brenda Milner has discovered for each of the following structures?– 1) Medial temporal lobes– 2) Right temporal lobe– 3) Left frontal lobe– 4) Dorsolateral frontal lobes
Clinical Anatomy 400
• Which function has Dr. Brenda Milner discovered for each of the following structures?– 1) Medial temporal lobes explicit memory– 2) Right temporal lobe visuospatial memory– 3) Left frontal lobe verbal fluency– 4) Dorsolateral frontal lobes reversal-
learning / task switching
Clinical Anatomy 500
• Which pattern of olfactory loss (left, right, bilateral) would be caused by lesions at the following sites?
1) Left olfactory mucosa2) Left olfactory bulb3) Left olfactory tract4) Left primary olfactory cortex5) Left thalamus
Clinical Anatomy 500
Clinical Anatomy 500
1) Left olfactory mucosa left sided loss2) Left olfactory bulb left sided loss3) Left olfactory tract left sided loss4) Left primary olfactory cortex no loss5) Left thalamus no loss
Book Anatomy
Book Anatomy 100
• What are the two main pathways connecting the hippocampal formation and the entorhinal cortex?
Book Anatomy 100
Book Anatomy 1001) Perforant pathway
Entorhinal cortex
Dentate gyrus
Hippocampus (CA1&3)
Subiculum
Entorhinal cortex
2) Alvear pathway
Entorhinal cortex
Hippocampus (CA1&3)
Subiculum
Entorhinal cortex
Book Anatomy 200
• What are the 3 main targets of axons travelling forward in the fornix?
• Where do axons travelling backward in the fornix originate from?
Book Anatomy 200
Book Anatomy 200
• Axons travelling forward in the fornix:– 1) subiculum postcommissural fornix
mammillary nuclei– 2) subiculum & hippocampus precommissural
fornix lateral septal nucleus– 3) Fornix anterior thalamic nucleus
• Axons travelling backward in the fornix:– Medial septal nucleus hippocampal formation
Book Anatomy 300
• True or False: HM’s bilateral medial temporal lobectomy was performed by Dr. Wilder Penfield at the Montreal Neurological Institute.
Book Anatomy 300
• False. It was done by Dr. William Scoville in Hartford, Connecticut
Book Anatomy 400
PathwayA. Uncinate fasciculusB. Stria terminalis and
amygdalofugal pathway
C. Medial forebrain bundle
Structure 1. Orbital frontal cortex2. Hypothalamus and
the septal region3. Brainstem
Which pathway connects the following structure to the amygdala?
Book Anatomy 400
Book Anatomy 500
• Name all the structures involved in the Papez circuit
• BONUS: Describe the connections between these structures in the Papez circuit…
Book Anatomy 500
http://upload.wikimedia.org/wikipedia/commons/thumb/9/95/Papez_Circuit.jpg/400px-Papez_Circuit.jpg
Syndromes
Syndromes 100
• Which syndrome is caused by bilateral lesions of the amygdala and adjacent temporal structures?
• What are its main characteristics?
Syndromes 100
Kluver-Bucy syndrome:Placid, tame, non-aggressive behaviourHyperoralityHypersexualityVisual agnosia
Syndromes 200
• Who was Dr. Milner’s PhD thesis supervisor?– A) Dr. Donald Hebb– B) Dr. Wilder Penfield– C) Dr. Herbert Jasper– D) Dr. Henry Gustave Molaison– E) Dr. William Osler
Syndromes 200
• Who was Dr. Milner’s PhD thesis supervisor?– A) Dr. Donald Hebb– B) Dr. Wilder Penfield– C) Dr. Herbert Jasper– D) Dr. Henry Gustave Molaison– E) Dr. William Osler
Syndromes 300
• Regarding the Wernicke Korsakoff syndrome:– 1) Which substance is deficient?– 2) Who are at risk for developing it?– 3) What is the typical clinical triad?
Syndromes 300
1) Thiamine2) Alcoholics and patients with malnutrition3) Confusion, opthalmoplegia, ataxia
Syndromes 400
A previously healthy 64 yo man presents with an episode of 4 hours during which the wife witnessed him as repeatedly asking the same questions. He then returned to normal, but with complete amnesia of the episode.
What is the most likely diagnosis?What are the main DDx?
Syndromes 400
• TGA
• DDx: – TIA– Seizure– Migraine
Syndromes 500
• Which of the following tasks completed by HM provided Dr. Milner the insight for the theory of multi-system memory?– A) Learning a maze path through trial and
error– B) Learning to trace a star shape through a
mirror reflection– C) Successfully completing the Wisconsin
Card Sorting Test
Syndromes 500
• Which of the following tasks completed by HM provided Dr. Milner the insight for the theory of multi-system memory?– A) Learning a maze path through trial and
error– B) Learning to trace a star shape through a
mirror reflection– C) Successfully completing the Wisconsin
Card Sorting Test
Miscellaneous
Miscellaneous 100
What are the 4 main functions of limbic system and their corresponding key structure?
Miscellaneous 100
Mnemonic: HOME
Miscellaneous 200
• Which type of memory is invoked in the following situations (explicit vs implicit)?– 1) A medical student impressing the attending
by listing a full list of DDx for HA at neurology rounds
– 2) A neurology resident successfully retrieving CSF on first attempt in a agitated encephalopathic patient with a BMI of 35
– 3) An IM resident breaking into cold sweats every time a Code Blue is called
Miscellaneous 200– 1) A medical student impressing the attending
by listing a full list of DDx for HA at neurology rounds Explicit
– 2) A neurology resident successfully retrieving CSF on first attempt in a agitated encephalopathic patient with a BMI of 35 Implicit (skills)
– 3) An IM resident breaking into cold sweats every time a Code Blue is called Implicit memory (classical conditioning)
Miscellaneous 200
Miscellaneous 300
• Which region of the parahippocampal gyrus serves as the most important relay between the hippocampal formation and association cortices?– A) Piriform and periamygdaloid cortex– B) Entorhinal cortex– C) Parahippocampal cortex– D) Perirhinal cortex– E) Orbital frontal cortex
Miscellaneous 300
Miscellaneous 400
• Name the 3 components of the hippocampal formation?
Miscellaneous 400
• 3 components of the hippocampal formation:– 1) Subiculum– 2) Hippocampus (proper)– 3) Dentate gyrus
Miscellaneous 400
Miscellaneous 400
Miscellaneous 500
• Who were PB and FC?
Miscellaneous 500
• Who were PB and FC?– PB: civil engineer; FC: glove-cutter– Patients with anterograde amnesia following
left medial temporal lobectomy (1941) performed by Dr. Penfield for refractory epilepsy
– Hypothesized to have baseline right medial temporal atrophy, thus functional bilateral medial temporal lesions following Sx
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