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BISPHENOL A:
WHAT WE KNOW FROM ANIMAL STUDIES
Patricia Hunt School of Molecular Biosciences
Washington State University
What and where is BPA?
What we know from animal studies
What do YOU need to know
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47 XX,+21
ONE IN TEN CLINICALLY RECOGNIZED HUMAN PREGNANCIES IS CHROMOSOMALLY ABNORMAL
DO CHANGING HORMONE LEVELS INFLUENCE THE EGG?
Volarcik et al, 1998
Altering the hormone environment affects the mouse egg
1-2% 40%
EFFECTS IN CONTROL ANIMALS
Hunt et al, 2003
BISPHENOL A (BPA)
BISPHENOL A (BPA)
1936BISPHENOL A
(BPA)
WHAT DO WE KNOW FROM ANIMAL STUDIES?
WHAT DO WE KNOW FROM ANIMAL STUDIES?
“Low dose” exposures to the fetus/neonate:
female reproductive tract
male reproductive tract
brain
heart
lungs
WHAT DO WE KNOW FROM ANIMAL STUDIES?
“Low dose” exposures to the fetus/neonate translate in the adult to:
Increased cancer risk
Adult obesity
Metabolic changes
Behavior changes
Is the mouse a relevant model?
How do our bodies handle BPA?
Is the mouse a relevant model?
How do our bodies handle BPA?
WHAT ABOUT HUMANS?
WHAT ABOUT HUMANS?
U.S. National Health and Nutrition Survey (NHANES)
2003-2004
2005-2006
WHAT YOU NEED TO KNOW
WHAT YOU NEED TO KNOW
How much BPA exposure do we receive in a day?
WHAT YOU NEED TO KNOW
Removing BPA from baby bottles and sippy cups is
NOT enough!
WHAT YOU NEED TO KNOW
The most rapid path to change is educating
consumers!
WHAT YOU NEED TO KNOW
‘BPA free’ – what does it mean?
WHAT YOU NEED TO KNOW
‘BPA free’ – what does it mean?
WHAT YOU NEED TO KNOW
‘BPA free’ – what does it mean?
WHAT YOU NEED TO KNOW
What a difference new labeling would make!
WHAT YOU NEED TO KNOW
Do we really need more studies?
http://advancinggreenchemistry.org/
Our collaborators:
Vic Fujimoto, UCSFMike Griswold, WSUCarmen Rubio, IVI,
ValenciaMartha Susiarjo, U. PennCathi VandeVoort, UC,
DavisFred vom Saal, Univ of
MissouriCarmen Williams, NIEHSDavid Albertini, Univ of
Kansas *NICHD and NIEHS
The Hunt/Hassold Laboratory*
pathunt@wsu.edu
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