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0
10
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c-Srcwt
K442A D518A
0
50
100
150
200
250
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350
400
Csk wt R279A R281A R283A R384A R389A
Helix I
Arg 389
Arg 384
Glu 517
Asp 518
Figure 3 A
180°
Helix I'90°
D
Helix D
Arg 283 Glu 510
Lys 442Arg 281
Glu 504αH/αI loop
Helix I
E
Binding of Csk to interface mutants of c-SrcBinding of interface mutants of Csk to c-Src
B Cc-Src Csk
Res
po
nse
Un
its
Res
po
nse
Un
its
Arg 279
Tyr 511
Helix D
Helix I
αH/αI loop
Helix DHelix C
Helix I
0
0.2
0.4
0.6
0.8
1
1.2
wt K442A E510A D518A
Src construct
Phosphorylation of mutants of c-Src by Csk
Rel
ativ
e Ph
osp
ho
ryla
tio
n
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