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AMINO ACID ANABOLISM. it ’ s a legume!. fixes nitrogen. The nitrogen cycle. fig 22-1. Annamox Bacteria! Nature ’ s rocket scientists. Box 22-1. Annamox Bacteria! Nature ’ s rocket scientists. Box 22-1. Annamox Bacteria! Nature ’ s rocket scientists. Hydrazine-proof chamber. - PowerPoint PPT Presentation
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Lecture 15 Slides
AMINO ACID CATABOLISM
fig 18-1
fate of amino nitrogen in mammals
fig 18-2
metabolism of amino nitrogen in liver
fig 18-2
nitrogen removal molecules…
fig 18-2
metabolism of amino nitrogen in liver
pg 677
transamination reaction
fig 18-5
fig 18-5
chemistry of the PLP aldehyde:Schiff base formation
fig 18-6
PLP reactions: decarboxylation, deamination, racemazation
fig 18-6
PLP reactions: the transamination two-step...
fig 18-7
oxidative deamination: from amino group to ammonia
fig 18-7 NOT
oxidative deamination: from amino group to ammonia
genetic disorder from loss ofGTP allosteric control…
fig 18-2
metabolism of amino nitrogen in liver
glutamine as a carrier of NH3 from tissue to liver
fig 18-8
fig 18-2
metabolism of amino nitrogen in liver
actual fig 18-9
shuttling ofNH4+ frommuscle toliver
reminiscentof the Coricycle, yes?
fig 18-19
the urea cycleas amethodof safelydisposingof all thatNH3
+
fig 18-10
fig 18-10
logic of the urea cycle: NH4+, aspartate, and CO2
fig 18-11
making a transferable carbamoyl group…
transferring that carbamoyl group…
ornithine
citruline
transfering that carbamoyl group…
citruline
ATP
adding a good leaving group…
using that good leaving group to do chemistry…
using that good leaving group to do chemistry…
fig 18-11
arginine
+ fumarate
production of arginine…
arginine
H2O
urea!! ornithine
liberation of urea…
fig 18-12
coupling between the “Krebs cycles”
fig 18-13
a signal for increased urea production…
pg 689
administering a synthetic allosteric regulator
we must consume amino acids…
fig 18-15
catabolism of amino acids: (most) roads lead to the Krebs cycle
one-carbon metabolism cofactors
fig 18-16
fig 18-16
one-carbon metabolism cofactors
fig 18-16
fig 18-22
amino acids are usedto make many things
fig 18-23
diseases of amino acid catabolism
fig 18-23
an example:pheylketonureaor PKU
fig 18-23
an example:pheylketonureaor PKU
aspartame
AMINO ACIDANABOLISM
it’s alegume!
fixes nitrogen
The nitrogen cycle
fig 22-1
Annamox Bacteria! Nature’s rocket scientists
Box 22-1
Annamox Bacteria! Nature’s rocket scientists
Box 22-1
Annamox Bacteria! Nature’s rocket scientists
Box 22-1Hydrazine-proof chamber
N2
NOxNH4
+
conversionto needed compounds
NH4+
in a.a.
nitrogenfixation
nitrifyingbacteria
plants,somebacteria
mammaliandiet
Usual route of N from atmosphere to mammalian metabolism
fig 22-2
nitrogenaseat the heartof N2 fixation
very sensitiveto O2!!!!!
symbiosis of N2 fixing bacteria
fig 22-4a protected environment: leghemoglobin
fig 22-5
glutamine synthetase
glutamate + ATP + NH4+
glutamine + ADP + Pi
fig 22-6
allostericregulationof glutaminesynthetase
fig 22-7
adenylylation (often “adenylation”)
adenylylation regulates GS, and…
uridylylation regulates adenylylation of GS!!fig 22-7
glutamine amidotransferases
Sglnglu S NH3+
S NH3+
amino acids are synthesizefrom Krebs,glycolysis and pentosephosphatepathways
fig 22-21
classic allosteric regulation of amino acid synthesis
fig 22-22
interlockingregulation ofmultiple pathwaysby allostericregulation
thingsfromaminoacids…
fig 22-27 glutathione!
thingsfromaminoacids…
tyrosineepinephrinenorepinephrinedopamine
glutamategaminobuterate(glutamate)
tryptophan serotonin
neurotransmitters!
arginine NO
thingsfromaminoacids…
arginine creatine
glycine porphyrins
glycine
stop
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